Patents Represented by Attorney, Agent or Law Firm William T. King
  • EPO primary response gene, EPRG3Spt
    Patent number: 6306604
    Abstract: EPRG3Spt polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing EPRG3Spt polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: January 31, 2000
    Date of Patent: October 23, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Susan B Dillon, Kenneth A Lord
  • Compounds
    Patent number: 6303124
    Abstract: The invention provides lysS polypeptides and DNA (RNA) encoding lysS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing lysS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 13, 2000
    Date of Patent: October 16, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Elizabeth Jane Lawlor
  • LicC
    Patent number: 6303571
    Abstract: The invention provides licC polypeptides and polynucleotides encoding licC polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing licC polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: October 16, 2001
    Inventor: Michael Arthur Lonetto
  • SBHWSB2: a new member of the WD40 SOCS box family
    Patent number: 6303333
    Abstract: SBHWSB2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SBHWSB2 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: November 2, 1998
    Date of Patent: October 16, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventors: David Michalovich, Matthew Alan Sims, Narjis Shaikh
  • Pth
    Patent number: 6303771
    Abstract: The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 18, 1998
    Date of Patent: October 16, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Christine Debouck, Deborah Dee Jaworski, Elizabeth Jane Lawlor, Jeffrey Mooney, Lisa Kathleen Shilling, Min Wang, Richard Lloyd Warren, Magdalena Zalacain, Yi Yi Zhong, John Peter Throup, Karen Anne Ingraham, Alison Frances Chalker, David John Holmes, Christopher Michael Traini
  • Pharmaceutical aminophosphonic acid derivatives
    Patent number: 6303784
    Abstract: Aminophosphonates alpha substituted by phenol groups, of formula (I) have lipoprotein(a) lowering activity.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: October 16, 2001
    Assignees: SmithKline Beecham p.l.c., Symphar SA
    Inventors: Lan Mong Nguyen, Hieu Trung Phan, Vinh Van Diep, Simon Floret, Raymond Azoulay, Eric Niesor, Craig Leigh Bentzen, Robert John Ife
  • Polynucleotides encoding a novel ABC transporter
    Patent number: 6300094
    Abstract: The invention provides Novel ABC transporter polypeptides and polynucleotides encoding Novel ABC transporter polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Novel ABC transporter polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: December 18, 1997
    Date of Patent: October 9, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Richard Lloyd Warren, Christopher Michael Traini
  • Stretococcal ERS
    Patent number: 6300119
    Abstract: The invention provides gluS polypeptides and DNA (RNA) encoding gluS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gluS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: October 9, 2001
    Inventors: Deborah D. Jaworski, Elizabeth J. Lawlor, Min Wang
  • Signal peptidase polypeptides of Staphylococcus aureus
    Patent number: 6300097
    Abstract: spsB polypeptides and DNA (RNA) encoding such spsB and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such spsB for the treatment of infection, particularly bacterial infections. Antagonists against such spsB and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of spsB nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding spsB and for detecting the polypeptide in a host.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: October 9, 2001
    Assignee: SmithKline Beecham PLC
    Inventors: Michael T. Black, Karen M. O'Dwyer
  • Cell surface protein compounds
    Patent number: 6299880
    Abstract: Novel cell surface protein polypeptides and DNA (RNA) encoding such novel cell surface protein and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such novel cell surface protein for the treatment of infection, particularly bacterial infections. Antagonists against such novel cell surface protein and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of novel cell surface protein nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding cell surface protein family and for detecting the polypeptide in a host.
    Type: Grant
    Filed: August 4, 1999
    Date of Patent: October 9, 2001
    Assignee: SmithKline Beecham PLC
    Inventors: John Edward Hodgson, Martin Karl Russell Burnham
  • Tarf
    Patent number: 6299883
    Abstract: The invention provides tarF polypeptides and DNA (RNA) encoding tarF polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tarF polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 28, 1999
    Date of Patent: October 9, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Alison Frances Chalker, Stephanie Van Horn, Andrew Peter Fosberry, Michael Ovari
  • RsbV-1 from staphylococcus aureus
    Patent number: 6297358
    Abstract: RsbV-1 polypeptides and DNA (RNA) encoding such RsbV-1 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such RsbV-1 for the treatment of infection, particularly bacterial infections. Antagonists against such RsbV-1 and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of RsbV-1 nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding SigB operon and for detecting the polypeptide in a host.
    Type: Grant
    Filed: August 23, 1999
    Date of Patent: October 2, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Andrew P Fosberry, Elizabeth J Lawlor, Richard O Nicholas
  • YAK-1 related serine/threonine protein kinase-HTLAR33
    Patent number: 6297036
    Abstract: HTLAR33 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also, disclosed are methods for utilizing HTLAR33 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: March 18, 1999
    Date of Patent: October 2, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Derk Bergsma, Usman Shabon
  • Protein phosphatase 1 binding protein, R5
    Patent number: 6297359
    Abstract: Human PPP1R5 polypeptides and DNA (RNA) encoding such PPP1R5 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such PPP1R5, or compounds which inhibit or stimulate PPP1R5 for dysfunctions or diseases which involve resistance to the action of insulin on glycogen synthesis are also disclosed. Agonist and antagonists of these PPP1R5 proteins and methods of their use are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the PPP1R5 and for detecting altered levels of the polypeptide in a host.
    Type: Grant
    Filed: January 10, 2000
    Date of Patent: October 2, 2001
    Assignee: SmithKline Beecham Corporation, et al.
    Inventors: Peter R. Young, Patricia T. W. Cohen, Phillip Cohen
  • Method of identifying agonists and antagonists for tumor necrosis related receptor TR1
    Patent number: 6297022
    Abstract: The present invention relates to tumor necrosis factor receptor (TNF-R) related polypeptide and its ligand, hereinafter referred to as TR1 and TL3. The invention relates to methods to identify agonists and antagonists of TR1 and TL3.
    Type: Grant
    Filed: September 16, 1998
    Date of Patent: October 2, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Peter C. McDonnell, Peter R Young, Jun Zou
  • Human Wnt-7a polynucleotides
    Patent number: 6297030
    Abstract: Wnt-7a polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Wnt-7a polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: December 13, 1999
    Date of Patent: October 2, 2001
    Assignee: SmithKline Beecham plc
    Inventors: Michael Robert Barnes, Tania Tamson Testa
  • Amps from Streptococcus pneumoniae
    Patent number: 6297039
    Abstract: The invention provides ampS polypeptides and DNA (RNA) encoding ampS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ampS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: October 2, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Magdalena Zalacain, James Raymond Brown
  • Integral membrane proteins of Staphylococcus aureus
    Patent number: 6296851
    Abstract: The invention provides integral membrane protein polypeptides and DNA (RNA) encoding integral membrane protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing integral membrane protein polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: February 23, 1999
    Date of Patent: October 2, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Richard Lloyd Warren
  • Calcilytic compounds
    Patent number: 6294531
    Abstract: Novel arylalkylamino compounds exhibiting calcilytic properties are provided.
    Type: Grant
    Filed: October 1, 1999
    Date of Patent: September 25, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Robert M. Barmore, Pradip Kumar Bhatnagar, William M. Bryan, Joelle Lorraine Burgess, James Francis Callahan, Raul Rolando Calvo, Eric G. Del Mar, Maria Amparo Lago, Thomas The Nguyen, Derek Sheehan, Robert Lawrence Smith, Linda Sue Southall, Bradford C. Van Wagenen
  • Response regulator
    Patent number: 6294652
    Abstract: The invention provides Response regulator polypeptides and polynucleotides encoding Response regulator polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Response regulator polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 18, 2000
    Date of Patent: September 25, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Yigong Ge, David John Holmes, Karen A Ingraham, John Throup, Nicola Gail Wallis, Magdalena Zalacain