Abstract: The invention relates to the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention provides compounds of general formula (A) wherein A1 is sulfur, A3 is CH, A2 is CH, D is heterocycle, Z is oxygen, SO0-2 or NR, Ar is phenyl and G is not a ring, and methods for inhibiting VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

Abstract: The invention relates to a fixation device for bones, consisting of all implant (1; 11), having at least one through hole (2; 12), to be fastened to the bone, and of at least one bone screw (3; 13) to be fastened in said through hole (2; 12), fastening elements (5; 15) being arranged in the through hole (2; 12) and at the top end of the bone screw (3; 13) and engaging with each other. In order to allow various angular positions of the bone screw (3; 13) relative to the implant (1; 11) without cold welding, interlocking earns (6, 7; 16, 17) are arranged on the associated surfaces of the through hole (2; 12) and the bone screw (3; 13) as the fastening elements (5; 15).

Abstract: A shipping and storage drum comprises a unitary base of synthetic resin comprising a circular center wall connected at a peripheral edge to a connecting ring having an upwardly opening threaded annular channel. A tubular fiberboard sidewall defines a peripherally closed space having open opposite upper and lower ends. The tubular sidewall lower end is threaded into the threaded annular channel to close the sidewall lower end. The shipping and storage drum may also comprise a chime of synthetic resin comprising a connecting ring having a downwardly opening threaded annular channel receiving the upper end of the tubular sidewall, the chime for removably receiving a cover.

Abstract: The invention relates to a method for determining a pathology in a subject, said method comprising: a) correlating N-N intervals with rate dependent fluctuations of electrocardiographic parameters derived from an electrocardiogram (ECG) of said subject or other recordings reflecting cardiac activity of said subject to derive electrocardiographic parameters correlation values, wherein said pathology is determined based on said correlation values.

Abstract: System and method for electronically identifying and analyzing the type and frequency of errors and mismatches in a stenographically or voice written text against a stored master file and dynamically creating personalized user feedback, drills, and practice based on identified errors and mismatches from within the context of the stored master file. The system provides the user with a plurality of methods to enter a text file for error identification and analysis including both realtime and non-realtime input. The text input is then compared to a stored master file through a word-by-word iterative process which produces a comparison of writing input and stored master wherein errors and mismatches are identified and grouped in a plurality of pre-defined and user-selected categories, each of which is color-coded to facilitate pattern recognition of type and frequency of errors and mismatches in the submitted writing.

Abstract: A port closure system (20) including a port structure (22), and a valve (24). The port structure (22) includes a port (28) for establishing communication between an exterior environment (30) and interior volume (32) that can receive a fluent substance. The valve (24) includes a flexible, resilient, self-closing, slit-type valve head (36) with an orifice that is normally closed in an unconstrained condition. The port (28) has a laterally inwardly facing engaging surface (34) and the valve has a laterally outwardly facing peripheral surface (54) that is compressed laterally inwardly by engagement with the surface (34) to increase the resistance of the normally closed orifice to opening when the head (36) is subjected to a pressure differential.

Abstract: The present invention generally relates to salts of S-(+)-abscisic acid, aqueous liquid compositions containing salts of S-(+)-abscisic acid and methods of their preparation for agricultural use.

Abstract: The invention relates to low VOC plant growth regulator compositions comprising less than about 25% of volatile organic compounds (VOCs). The compositions comprise forchlorfenuron (CPPU). Also provided are methods of using the compositions.

Abstract: The present invention relates to pharmaceutical compositions containing at least one protein active ingredient protected from digestive enzymes. The pharmaceutical compositions contain the at least one protein active ingredient, in free form, as well as, for liquids, a system that buffers them to a pH greater than 4 and less than or equal to 8 or, for solids, a system that exerts, when they are placed in a liquid medium, a buffer effect between a pH greater than 4 and a pH less than or equal to 8.

Abstract: An apparatus for delivering humidified air to a surrounding space and having a housing defining a space within which incoming air is treated, a receptacle for a supply of fluid, and an outlet. A plurality of operating components are supported by the housing, including a nebulizer that causes fluid in the receptacle to become entrained in incoming air. The treated air flows through the housing outlet to the surrounding space. The nebulizer operable by at least one electronic component that generates heat as the nebulizer is operated. The apparatus further has a heat sink assembly on the housing in heat exchange relationship with the at least one electronic heat generating component. The heat sink assembly is: a) cooled by air moving through the housing space; and b) not directly exposed to fluid in the receptacle.

Abstract: In accordance with the principles of the present invention, breathing aid is provided. The breathing aid includes a middle portion that defines a breathing aperture that provides air flow out of the mouth of the user. An incisor is defined on the top of the middle portion and sized to receive the upper incisors teeth of the user. The location of the incisor aperture along the middle portion providing proper placement of the breathing aid in the user's mouth. An inside end of the middle portion is provided at an angle. A pair of wing-like protrusions extend sideward from the middle portion, the protrusions sized to extend outwardly beyond the sides of a user's mouth in order to prevent the breathing aid from entering the mouth.

Abstract: A closure has a body and a lid is molded with the body. A utensil, such as a scoop or spear, is integrally formed with the closure body, and connected to the closure body via frangible connections. The lid includes a utensil-receiving structure for releasably holding the utensil, once it is initially broken away from the closure body, such that the utensil can be attached to the closure lid for storage.

Abstract: A method of insulating a space including the steps of: forming an insulation piece using at least one base material that are interlocked so as to produce a body with a predetermined starting shape; and placing the insulation piece in a space to define an insulating barrier between first and second regions between which the space resides.

Abstract: The invention provides a formulation of one or more antineoplastic drugs encapsulated in liposomes including at least a lipid fraction in addition to the antineoplastic drug, wherein the composition is stable in an aqueous solution at room temperature.

Abstract: A protective garment (10) is provided for use by a firefighter or other emergency worker. The garment includes a torso covering portion (20, 50), a belt (24, 54) having a length extending around the torso covering portion, an attachment (25, 56) between the belt and the torso covering portion to limit relative movement of the belt along the length of the belt relative to the torso covering portion, and a belt receiving tunnel (28, 58) on the torso covering portion, the tunnel including a wall portion (40) that is movable between a closed position enclosing the belt in the tunnel and an open position allowing access to the attachment.

Abstract: A liquid applicator adapted to prevent an application liquid from leaking or drying with a small biasing force. A tip unit for a liquid applicator of the present invention includes a tubular member and a valve member. The valve member is biased toward a distal end thereof by a biasing member so as to seal a distal opening portion of the tubular member. The distal opening portion includes a first tapered surface and a second tapered surface located at a proximal side of the first tapered surface. The first and the second tapered surfaces are in contact with a tapered area and a ring of the valve member, respectively, so as to seal the distal opening portion.

Abstract: The invention generally relates to compositions and methods for preferential vasoconstriction of smaller blood vessels relative to larger blood vessels. The compositions comprise highly selective alpha-2 adrenergic receptor agonists, at low concentrations, such as below 0.05% weight by volume. The compositions preferably comprise brimonidine. The compositions preferably have pH between about 5.5 and about 6.5.