Abstract: Macromolecules are provided that have increased nuclease resistance, increasing binding affinity to a complementary strand, and that activate RNase H enzyme. The macromolecules have the structure PNA-DNA-PNA where the DNA portion is composed of subunits of 2′-deoxy-erythro-pento-furanosyl nucleotides and the PNA portions are composed of subunits of peptide nucleic acids. Such macromolecules are useful for diagnostics and other research purposes, for modulating protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to therapeutics.

Abstract: Methods for the alkylation of alcohols, amines and thiols by the use of cyclic sulfates are disclosed. The alkylated sulfates formed are versatile intermediates which may be further elaborated by methods of the invention. In particular, methods for the alkylation of the 2′, 3′ or 5′-hydroxy position of nucleosides and nucleoside analogs with cyclic sulfates to form the 2′, 3′ or 5′-O-alkyl sulfate modified compounds are disclosed. Displacement of the 2′,3′ or 5′-O-sulfate with a nucleophile provides 2′, 3′ or 5′-O-modified nucleosides and nucleoside analogs useful for the synthesis of oligomeric compounds having improved hybridization affinity and nuclease resistance.

Abstract: A system provides for mounting a removable media disk cartridge in a disk drive without translating the cartridge or spindle motor in a Z-axis relative to each other. The system comprises a spindle in the drive having a substantially planar top surface with an annular groove disposed and an datum ring disposed thereon. The annular groove accepts an inner ring surface of a media disk hub. The disk cartridge has a hub with an inner ring that engages the annular groove in the spindle. Additionally the hub has an outer peripheral edge that has an angled surface. During disengagement of the hub from the spindle, the hub is tilted when the cartridge shell engages the outer peripheral edge. The datum ring acts as a fulcrum while the inner ring is tilted out of the annular groove.

Abstract: A system and method of detecting anomalies and/or grain variations in a wooden member. At least one ultrasonic transmitter applies an ultrasound waveform into a surface of a wooden member so as to generate a multiplicity of ultrasonic waves including, e.g., longitudinal and shear ultrasonic waves. These ultrasonic waves are measured after propagation through the wooden member by at least one ultrasonic receiver disposed on the same surface of the wooden member. At least one ultrasonic receiver may also be placed opposite the ultrasonic transmitter so as to detect radial transmission of the longitudinal ultrasonic wave at a point across from the wooden member. The received ultrasonic waves are processed to determine anomalies and/or grain variations in the wooden member at positions of the wooden member between the ultrasonic transmitter and the ultrasonic receiver(s). The ultrasonic transmitters and receivers may be placed in rollers to facilitate high-speed, in-line processing of wooden members.

Abstract: A maximum inclination setting projection comes into contact with a rotary support in a region closer to a point corresponding to a top dead center than an imaginary two-part dividing plane, thereby establishing a maximum angle of inclination of a cam plate. Thus, a hinge mechanism is not required to support any proportion of a compressive load in the region closer to the point corresponding to the top dead center than the imaginary two-part dividing plane when the cam plate is in its maximum angle of inclination. Bulbous parts of guide pins do not come in contact with halves of cylindrical inside surfaces of guide holes closer to the rotary support, and there is made a clearance between the bulbous part of the guide pin and the guide hole and between the bulbous part of the guide pin and the guide hole, interrupting transmission of the compressive load between them.

Abstract: A process for assembling a disk cartridge is disclosed. The process includes the steps of snapping a top shell half of the disk cartridge over a bottom shell half of the disk cartridge; adjusting the shell halves until the shell halves are in abutment contact with each other at a weld site; and directing an energy beam at the weld site until a portion of the top shell half and a portion of the bottom shell half fuse so that the top shell half is fixed to the bottom shell half. The process is repeated for each of a plurality of weld sites located on the perimeter of the disk cartridge. A process for assembling a disk cartridge is disclosed in which an energy beam is split into a plurality of split energy beams. The plurality of split energy beams are focused on a plurality of weld sites until a portion of the top shell half and a portion of the bottom shell half fuse so that the top shell half is fixed to the bottom shell half.

Abstract: The present invention relates to improved methods for the preparation of nucleoside phosphoramidites and oligonucleotides. In one aspect, the methods of the invention are used to prepare phosphitylating reagents using pyridinium salts as activators. In a further aspect, the methods of the invention are used to prepare internucleoside linkages using activators which include at least one pyridinium salt and at least one substituted imidazole. In a further aspect, methods are provided preparation of internucleoside linkages between nucleosides having 2′-substituents using imidazolium or benzimidazolium salts as an activator. In a further aspect, methods are provided preparation of internucleoside linkages between nucleosides having bioreversible protecting group that confers enhanced chemical and biophysical properties, without exocyclic amine protection, using imidazolium or benzimidazolium salts as an activator.

Abstract: A portable, self-learning adaptive weight bearing monitoring system for personal use during rehabilitation of orthopedic patients with fractures of the lower extremities. The system includes a flexible insole which is worn inside the shoe. The insole includes pressure and/or force sensor that measure the GRF force applied at key bearing points under the foot or other portions of the patient's lower extremity. The sensors are, in turn, connected through an A/D converter to a CPU that is connected so as to drive a stimulator that delivers closed-loop sensory stimulation (electrical, mechanical, and/or audio) as feedback to encourage the patient to load the optimal target weight for the limb for which the weight bearing force is being measured. Accurate real-time monitoring of the weight bearing during physical rehabilitation is also provided, and, through the use of closed-loop sensory stimulation, the patient is given continuous feedback for improving rehabilitation.

Abstract: Benzodiazapine derivatives of formula (1) are described: wherein Ar1 is an aromatic or heteroaromatic group; L1 is a linker atom or group; Ar2 is an optionally substituted aromatic or heteroaromatic group; R5 is a carboxylic acid (—CO2H) or a derivative thereof; The compounds are able to inhibit the binding of alpha 4 integrins to their ligands and are of use in the prophylaxis and treatment of immune in inflammatory disorders.

Abstract: High oleic acid triglyceride compositions that comprise fatty acid components of at least 75% oleic acid, less than 10% diunsaturated fatty acid component; less than 3% triunsaturated fatty acid component; and less than 8% saturated fatty acid component; and having the properties of a dielectric strength of at least 35 KV/100 mil gap, a dissipation factor of less than 0.05% at 25° C., acidity of less than 0.03 mg KOH/g, electrical conductivity of less than 1 pS/m at 25° C., a flash point of at least 250° C. and a pour point of at least −15° C. are disclosed. Electrical insulation fluids comprising the triglyceride composition are disclosed. Electrical insulation fluids that comprise the triglyceride composition and a combination of additives are disclosed. Electrical apparatuses comprising the electrical insulation fluids and the use of electrical insulation fluids to provide insulation in electrical apparatuses are disclosed.

Abstract: A through mount electrical connector with an alignment device is disclosed. According to the invention, the connector is mountable to a substrate and includes a housing through which a plurality of contacts extend. Each contact has a contact tail that extends beyond a face of the housing. The connector includes an alignment device having a first face adjacent the housing, a second face positionable adjacent the substrate, and a plurality of apertures extending between the first face and the second face for receiving a respective contact tail. At least one latch slidably couples the alignment device to ends of the housing such that the alignment device is selectively disposable between a first position in which the contact tails generally do not extend beyond the second face of the alignment device, and a second position in which the contact tails generally extend beyond the second face of the alignment device.

Abstract: A blow-pin assembly includes a circular body, a ring member, and a seal assembly. The body and the ring member define a central passage. The seal assembly comprises a seal band. The body and the ring member retain the seal band proximate an outer circumferential surface of the body. A neck portion of a parison is positioned over the outer circumferential surface. Pressurized air is routed through the central passage and into the parison during blow-molding operations. The pressurized air causes the parison to expand into the sides of a surrounding mold, thus forming the parison into a hollow object such as a container. The pressurized air also urges the seal band into the parison neck portion, thereby inhibiting leakage of the pressurized air between the neck portion and the blow-pin assembly.

Abstract: A radio frequency filter having at least two dielectric resonators in juxtaposition, each resonator including a tubular dielectric body. Formed on the dielectric body of each resonator are an inner and an outer conductors and various other conductors including a terminal conductor for connection of the filter to external circuitry. In order to assure positive isolation of the terminal conductors of both resonators from each other, the outer conductors are provided with extensions which intervene between the terminal conductors for preventing then from being capacitively coupled together.

Abstract: A method of inhibiting the proliferation and causing the differentiation of undifferentiated cells comprising contacting the undifferentiated cells with an effective amount of an antisense oligonucleotide having a sequence which is complementary to a region of the IGF-1 receptor RNA. The sequence of the antisense oligonucleotide is selected from an oligodeoxynucleotide sequence complementary to codons −29 to −24 of the signal sequence of the IGF-1 receptor and an oligoribodeoxynucleotide sequence complementary to codons 1 to 309 of the sequence of the IGF-1 receptor. The oligoribodeoxynucleotide sequence may be provided by an expression vector.

Abstract: A receptacle has a housing that defines a connector-receiving cavity for receiving a connector therein. The housing has a front face and the cavity has a mouth thereof at the front face of the housing. A conductive exterior shield is fitted over the housing and has a pair of opposing side faces, each of which includes a rear edge opposite the mouth of the cavity and a slot at such rear edge. A conductive cavity insertion piece is inserted into the housing and has an interior arm and a pair of wings. The interior arm extends toward the mouth of the cavity and is in communication with the cavity to conductively contact an outer portion of the received connector. The interior arm releasably locks the connector as received within the cavity. Each wing is fitted within a respective slot at the rear edge of a side face of the exterior shield, whereby the wings conductively couple the arm to the exterior shield.

Abstract: Apparatus and methods for reducing data flow through a signal processing system are disclosed. A method according to the invention includes receiving a set of tags from an input system, where each tag is associated with a pulse and includes a pulse characterization parameter that characterizes the associated pulse. The pulse characterization parameter can be based on, for example, pulse center frequency, duration, or angle of arrival. The method includes identifying a subset of tags from the set of tags, where each tag in the subset includes a predefined value of the pulse characterization parameter. The subset of tags can be identified by histogramming the set of tags based on the pulse characterization parameter. If the number of tags in the subset exceeds a threshold number, then the number of tags from the subset that is forwarded through the system is limited to no more than the threshold number of tags.

Abstract: A chromokeying panel for use in conjunction with a chromakeying system includes a plurality of first and second location. Each of the first and the second locations has a color within the color of a color keying spectrum of the chromakeying system. In addition, each of the first and the second locations are arranged to define a coded pattern for a computation of a perspective of the chromakeying panel with respect to a camera independently in each video field produced by the camera. The coded pattern may include a plurality of straight lines that intersect to define vertices. The plurality of straight lines may be spaced apart from each other so that for a given vertex, a ratio of the distance of one of the lines extending from the given vertex to a first adjacent vertex, to the distance of another of the lines from the given vertex to a second adjacent vertex is unique.

Abstract: An oil filled power bushing for a transformer in which the oil and nitrogen are separated by a movable piston within an expansion chamber for dividing said expansion chamber into a liquid filled section and a gas filled section, and means for sealing said piston with respect to a conductor and said expansion chamber.

Abstract: Apparatus and methods for processing RF signals are disclosed. A method according to the invention includes receiving a set of time domain energy samples representing signal energy present in an RF spectrum, transforming the set of time domain energy samples into a set of frequency domain power samples, determining from the set of frequency domain power samples whether a signal of interest is present in the RF spectrum, and forwarding to a follow on system a subset of the set of frequency domain power samples, wherein the subset corresponds to the signal of interest. Transforming the time domain samples can include dividing the set of time domain energy samples into a plurality of N windows, each of which is associated with a predefined window period, and performing an FFT on each said window to generate a set of K frequency bins, wherein each frequency bin has a value based on energy present in a predefined frequency band during the corresponding window period.

Abstract: An adjustable throat for protecting electrical connections between two mating pieces of electrical equipment such as a transformer and associated switchgear is disclosed. The adjustable throat includes two telescoping tubular members each having flanges at one end thereof with oversized holes for connection respectively to a transformer and associated switchgear. The holes allow for vertical and horizontal adjustment to provide for final adjustment in these directions. One of the tubular members also has elongated open ended slots to allow the throat to be adjusted in and out to allow final connection to the switchgear without the need for minor movement of the gear.