Abstract: The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation between ICOS and ICOS-L and abrogate proliferation of Treg induced by plasmacytoid dendritic cells. The present invention further provides antibodies directed against ICOS or a derivative thereof which induce IL-10 and IFN? production, induce CD4+ T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg.

Abstract: A method for assisting blood circulation in a patient includes drawing a flow of blood from a patient's heart into a blood flow channel formed by a housing. The flow of blood is passed through a motor stator to a rotor disposed within the blood flow channel. The motor stator is arranged circumferentially around the blood flow channel. The rotor has permanent magnetic poles for magnetic levitation and rotation of the rotor. The motor stator is controlled to act as a radial bearing for magnetic levitation of the rotor and to rotate the rotor within the blood flow channel. The rotor is levitated within the blood flow channel in the direction of the rotor axis of rotation via passive magnetic interaction between the rotor and the motor stator. The flow of blood is output from the blood flow channel to the patient.

Abstract: A catheter pump includes an impeller and a drive shaft coupled with the impeller. The catheter pump includes a motor assembly coupled with the drive shaft. The motor assembly includes a motor housing having an opening through a wall of the motor housing and a flexible member disposed about the opening, the flexible member configured to engage a connection portion of a platform.

Abstract: A catheter pump is disclosed. The catheter pump can include an impeller and a catheter body having a lumen therethrough. The catheter pump can also include a drive shaft disposed inside the catheter body. A motor assembly can include a chamber. The motor assembly can include a rotor disposed in the at least a portion of the chamber, the rotor mechanically coupled with a proximal portion of the drive shaft such that rotation of the rotor causes the drive shaft to rotate. The motor assembly can also comprise a stator assembly disposed about the rotor. The motor assembly can also include a heat exchanger disposed about the stator assembly, the heat exchanger may be configured to direct heat radially outward away from the stator assembly, the rotor, and the chamber.

Abstract: A wireless apparatus may receive scheduling definitions from a networking device. The wireless apparatus may determine, from the scheduling definitions, downlink transmission times and to start a timer at one of the determined downlink transmission times. The wireless apparatus may discontinue reception at expiration of the timer. The wireless apparatus may also, in response to reception of a downlink transmission, transmit an acknowledgement and to discontinue reception before the timer has expired.

Abstract: The invention relates to a device for detecting analytes, including a plastic substrate at least partially covered by bonding polymers attached to the substrate in a non-covalent manner, said bonding polymers comprising a polysaccharide backbone provided with aromatic groupings and carboxylic acid groupings.

Abstract: A method for the production of a biofilm at the surface of an electrode in a liquid medium containing bacteria and a substrate for growth of the bacteria, in which a system of electrodes constituted of two electrodes, which are connected to a direct electric current source, is used, these two electrodes are placed in the medium and a predetermined and constant potential difference is applied between the electrodes, by virtue of which biofilms form at the surface of the electrodes. Resulting electrodes and biocells.

Abstract: In an embodiment, a data processing method providing an improvement in computer security comprises selecting, from a queue identifying a plurality of web pages, a particular web page to retrieve from one of a plurality of internet sources; causing retrieving a copy of the particular web page from a particular internet source; determining a hierarchical structure of the particular web page; based upon a hierarchical structure of the particular web page and without consideration of content of the particular web page, identifying one or more features, of links in the particular web page or files referenced in the particular web page, that indicate one or more security threats; determining a reputation score for the particular web page; determining a specified remediation measure, based upon the reputation score, to remediate a security threat that is identified in the particular web page; providing the specified remediation measure to one or more of a compromised computer, a sensor computer and an enterprise com

Abstract: A manufacturing method for reverse conducting insulated gate bipolar transistor, the manufacturing method is characterized by the use of polysilicon for filling in grooves on the back of a reverse conducting insulated gate bipolar transistor. The parameters of reverse conducting diodes on the back of the reverse conducting insulated gate bipolar transistor can be controlled simply by controlling the doping concentration of the polysilicon accurately, indicating relatively low requirements for process control. The reverse conducting insulated gate bipolar transistor manufacturing method is relatively low in requirements for process control and relatively small in manufacturing difficulty.

Abstract: In MIMO communication, a communication device is provided that transmits a transfer rate request signal while reducing it and reducing the interference and power consumption when the transfer rate request signal is transmitted substantially without lowering the transmission efficiency. A modulation encoding unit encodes and modulates transmission data transmitted to a communication partner and the transfer rate request signal is the plurality of transmission antennas. A transmission unit and a transmission antenna transmit a signal from the modulation encoding unit. A transmission control unit controls transmission of a signal transmitted from the transmission antenna and transmits a transfer rate request signal of one transmission antenna via the transmission antenna according to a comparison result between a difference of the transfer rate request signal in the respective transmission antenna of the communication partner and a predetermined value.

Abstract: A reverse conducting insulated gate bipolar transistor (IGBT) manufacturing method, comprising the following steps: providing a substrate having an IGBT structure formed on the front surface thereof; implanting P+ ions onto the back surface of the substrate; forming a channel on the back surface of the substrate through photolithography and etching processes; planarizing the back surface of the substrate through a laser scanning process to form P-type and N-type interval structures; and forming a back surface collector by conducting a back metalizing process on the back surface of the substrate. Laser scanning process can process only the back surface structure requiring annealing, thus solve the problem of the front surface structure of the reverse conducting IGBT restricting back surface annealing to a low temperature, improving the P-type and N-type impurity activation efficiency in the back surface structure of the reverse conducting IGBT, and enhancing the performance of the reverse conducting IGBT.

Abstract: A machine-learning engine is disclosed that is configured to recognize and learn behaviors, as well as to identify and distinguish between normal and abnormal behavior within a scene, by analyzing movements and/or activities (or absence of such) over time. The machine-learning engine may be configured to evaluate a sequence of primitive events and associated kinematic data generated for an object depicted in a sequence of video frames and a related vector representation. The vector representation is generated from a primitive event symbol stream and a phase space symbol stream, and the streams describe actions of the objects depicted in the sequence of video frames.

Abstract: Hydrogen generation assemblies, hydrogen purification devices, and their components, and methods of manufacturing those assemblies, devices, and components are disclosed. In some embodiments, the devices may include frames with membrane support structures and/or may include a microscreen structure configured to prevent intermetallic diffusion.

Abstract: The present disclosure relates to a method for identifying the presence or absence of anti-Toxoplasma gondii antibodies in a human or animal serum, including placing the previously drawn serum in contact with antigens capable of binding with the anti-Toxoplasma gondii antibodies, and the observation of a bond or of an absence of a bond of antibodies with the antigens, and a combination of two recombinant GRA2 and GRA6 proteins. In particular, the antigens are attached to a support, in particular an ELISA plate. This test is preferably carried out as a supplement to another test for diagnosing toxoplasmosis.

Abstract: The present disclosure provides methods, systems, and media for allowing access to quantum computers in a distributed computing environment (e.g., the cloud). Such methods and systems may provide optimization and computational services on the cloud. Methods and systems of the present disclosure may enable quantum computing to be relatively and readily scaled across various types of quantum computers and users at various locations, in some cases without the need for users to have a deep understanding of the resources, implementation or the knowledge that may be required for solving optimization problems using a quantum computer. Systems provided herein may include user interfaces that enable users to perform data analysis in a distributed computing environment while taking advantage of quantum technology in the backend.

Abstract: The present invention is a variable length coding method for coding coefficients in each block which are obtained by performing frequency transformation on picture data of a moving picture per block having a predetermined size, and comprises: a coefficient scanning step of scanning the coefficients in the block in a predetermined order; and a coding step of coding the coefficients scanned in the coefficient scanning step into variable length codes in a predetermined order by switching a plurality of tables to be used for coding. Here, a direction of switching between the tables may be one-directional. Also, the coding may be non-arithmetic coding.

Abstract: The invention relates to new PI3K/AKT/m TOR inhibitors and their use for the prevention and/or the treatment of a disease selected from the group consisting of: inflammatory diseases, autoimmune diseases, neurodegenerative diseases, cancers, transplant rejection, diseases characterized by a premature aging and tuberous sclerosis.

Abstract: A blood pump controller includes a microcontroller and a communication interface. The microcontroller is configured to communicate with various types of blood pump communication modules. The microcontroller is further configured to determine, based on communication with a particular type of blood pump communication module, the particular type of blood pump communication module communicated with. The microcontroller is further configured to select, based on the determination of the particular type of blood pump communication module, control logic used to control the particular type of blood pump communication module. The microcontroller is further configured to generate, based on the selected control logic, commands for controlling the blood pump communication module. The communication interface is configured to connect the microcontroller to the particular type of blood pump communication module.

Abstract: An automotive vehicle drive unit, comprising a fuel cell whose control input is a setpoint of the electrical power to be delivered by the fuel cell. There is a reversible electrical energy storage system and an electric motor to propel the wheels of a vehicle. An electrical connection element selectively connects the fuel cell and/or the energy storage system to the electric motor. A control circuit stores a model of the consumption of dihydrogen as a function of the power delivered by this fuel cell, in the form of a second-degree polynomial and is configured to compute a coefficient of power distribution ?1 between the fuel cell and the electrical energy storage system pursuant to a defined equation. The control circuit controls the electrical connection element to recharge the energy storage system when the value of the power setpoint Pfc* is greater than the power demanded by the electric motor.

Abstract: An image coding and decoding system is provided that includes an image coding apparatus and an image decoding apparatus. The image coding apparatus includes a coder that codes an input image, a first decoder that decodes the coded image to obtain a first reconstructed image, a first pixel difference value obtainer, a first average deriver, a first threshold value setter, a first comparator, and a first remover that removes a coding distortion. The image decoding apparatus includes an obtainer that obtains the first quantization parameter of the first block and the second quantization parameter of the second block, a second decoder that decodes the coded image, a second pixel difference value obtainer, a second average deriver, a second comparator, and a second remover that removes a coding distortion in an area disposed on both sides of a block boundary between the first block and the second block.