Abstract: Disclosed are a drill and an insert for a drill having improved centering capability and cutting performance. In the drill of the present disclosure, central relief surfaces of cutting parts are processed as flat relief surfaces, and outer circumferential relief surfaces continuing from the center part to the outer circumferential surface of the drill are processed as curved relief surfaces, thereby enhancing the centering capability of the drill and minimizing the generation of drill vibration and burrs. In addition, in the drill of the present disclosure, the outer relief surfaces of the drill in contact with a hole to be drilled are processed such that an angle between the tangential lines of the outer relief surfaces is constant regardless of the size of the outer diameter of the drill, thereby achieving consistent performance of the drill despite change in the outer diameter of the drill.

Abstract: Provided is a process for preparing a compound, comprising the steps of a) Reacting a compound of Formula A (Formula A) with the compound 3 (3) to provide the compound 5 (5) or a salt or solvate thereof, wherein R is a linear or branched C1-C5 alkyl. Further provided is the compound 5 or a salt or solvate thereof. (5) The use of these compounds in the synthesis of 3-[5-Amino-4-(3-Cyanobenzoyl)-Pyrazol-1-yl]-N-Cyclopropyl-4-Methylbenzamide is also provided.

Abstract: An electronic smoking device includes an elongate housing sleeve accommodating at least part of the following components: a battery as an electric power source powering an electrically activatable atomizer including an electric heater adapted to atomize a liquid supplied from a reservoir to provide an aerosol exiting from the atomizer; a puff detector adapted to indicate an aerosol inhaling puff; and control electronics connected to the puff detector and adapted to control the heater of the atomizer. At least part of the battery, the puff detector, the control electronics and/or the atomizer is mounted on an elongate insert permitting lateral access and fitting into the housing sleeve via one of the ends of the housing sleeve.

Abstract: A novel and useful quantum computing machine architecture that includes a classic computing core as well as a quantum computing core. A programmable pattern generator executes sequences of instructions that control the quantum core. In accordance with the sequences, a pulse generator functions to generate the control signals that are input to the quantum core to perform quantum operations. A partial readout of the quantum state in the quantum core is generated that is subsequently re-injected back into the quantum core to extend decoherence time. Access gates control movement of quantum particles in the quantum core. Errors are corrected from the partial readout before being re-injected back into the quantum core. Internal and external calibration loops calculate error syndromes and calibrate the control pulses input to the quantum core.

Abstract: Disinfectors that are touchless, high speed, or both for personal electronic devices and the like. A housing defines an internal volume including a disinfection zone and an object entry port of a size to permit entry by an object of interest with exposed surface area. At least one emitter projects a stripe of UV-C light into the disinfection zone. Wherein the apparatus has a small footprint and the emitter to exposes the surface area to greater than 3 mJ/cm2 of UV-C light in less than 90 seconds.

Abstract: The present invention relates to a system and assembly for refilling a reservoir with liquid dispensed from a dispenser, in particular, but not exclusively, to a system and assembly for the substantially leak-free refilling of the reservoir of a smoking-substitute device with a liquid comprising nicotine from a refill dispenser. The assembly is configured to provide a gas communication pathway through the assembly and physically separate from the liquid communication pathway for venting gas from an end of the assembly proximal the first aperture to an exterior of the assembly responsive to the movement of the assembly to the secured and open configuration, the assembly configured to close the gas communication pathway in the unsecured and closed configuration.

Abstract: Hazard-resultant effects to land and buildings are predicted based on various inputs. Hazards may include any appropriate type of hazard (e.g., flood, wildfire, climate-related hazards, or the like). Inputs may include the likelihood that that a specific type of hazard may occur for various scenarios, terrestrial boundaries, property boundaries, census geographies, or the like. Relationships between the inputs are determined and used to quantify parameters pertaining to a specific type of hazard. For example, the depth of flood water may be predicted for a particular terrestrial boundary, a city or town, or a building, for specific climate scenarios. A risk likelihood of the quantified parameter may be determined for a particular period of time and environment. For example, flooding to a building may be determined, broken down by depth threshold and year of annual risk for specific climate scenarios. Economic loss also may be predicted.

Abstract: An electronic vaping device is provided including a power supply portion comprising a power supply, an atomizer/liquid reservoir portion comprising a liquid reservoir storing a liquid, and an atomizer adapted to atomize the liquid stored in the liquid reservoir when operated by the power supply. The atomizer is adapted to float on the surface of the liquid in the liquid reservoir.

Abstract: A system for supplying power transcutaneously to an implantable device implanted within a subject is provided. The system includes an external connector including one of a microneedle array and a microwire holder. The system further includes a power cable electrically coupled to the external connector and configured to supply power to the one of the microneedle array and the microwire holder, and an internal connector configured to be implanted within the subject and electrically coupled to the implantable device, the internal connector including the other of the microneedle array and the microwire holder. The microneedle array includes a plurality of electrically conductive microneedles, the microwire holder includes a plurality of electrical contacts, and the microwire holder is configured to engage the microneedle array such that the plurality of electrically conductive microneedles extend through the skin of the subject and electrically couple to the plurality of electrical contacts.

Abstract: The present invention relates to a method for the accurate, rapid and sensitive detection of breast or ovarian cancers from body fluid samples of a mammalian subject and related assay, kits and peptides suitable for such a method.

Abstract: Apparatuses and methods relating to interfacing and controlling external batteries are described. In one embodiment, an external battery is integrated with a touch screen display. In one embodiment, the external battery provides an infrared communication link with a detachable device or system controller. In one embodiment, the external battery touch screen interface provides data received from a detachable device or system controller.

Abstract: A fluid treatment system for a percutaneous cable and methods of assembly and use are described herein. In one aspect, the fluid treatment system includes a delivery tube comprising a distal end and a proximal end. The distal end is configured to surround at least a portion of the percutaneous cable. The percutaneous cable extends from within a patient to outside the patient through tissue at an exit site. The proximal end is connectable to a fluid source. Fluid from the fluid source is configured to be delivered to the exit site through the delivery tube. The fluid treatment system includes an anchor coupleable to the percutaneous cable to secure the percutaneous cable to the tissue at the exit site.

Abstract: An optical apparatus includes a substrate that is configured to redirect a predetermined percentage of an input light beam at a plurality of angles to form a set of output beams at each of the angles such that light beams redirected at each of the angles cooperate to form bands of light at a range of predetermined distances from the optical apparatus.

Abstract: A method and device for conveying tracking and communicating information concerning a dispensed fluid, the device including a measured dispensing device attached to a flexible collapsible container, the device including a sensor for measuring a physical property relating to the dispensing operation, and a communication device configured to communicate information determined by the sensor to a remote device.

Abstract: Hydrogen purification devices and their components are disclosed. In some embodiments, the devices may include at least one foil-microscreen assembly disposed between and secured to first and second end frames. The at least one foil-microscreen assembly may include at least one hydrogen-selective membrane and at least one microscreen structure including a non-porous planar sheet having a plurality of apertures forming a plurality of fluid passages. The planar sheet may include generally opposed planar surfaces configured to provide support to the permeate side. The plurality of fluid passages may extend between the opposed surfaces. The at least one hydrogen-selective membrane may be metallurgically bonded to the at least one microscreen structure. In some embodiments, the devices may include a permeate frame having at least one membrane support structure that spans at least a substantial portion of an open region and that is configured to support at least one foil-microscreen assembly.

Abstract: A dynamic output power management unit for a heating circuit of an electronic smoking device is disclosed, the heating circuit having a heating element connected to a power source via a first switching element, the unit having at least one voltage detection device to detect voltage values at various points of the heating circuit; and a controller configured to deriving a resistance of the heating element, estimating a discharge time or a power consumption value of the power source such that an energy converted in a period of time is substantially identical to a predetermined energy conversion value for a same period of time.

Abstract: A process cartridge includes: a toner cartridge including: a toner housing accommodating toner and having a toner discharge hole; and a toner shutter movable between a closed position closing the toner discharge hole and an opened position opening the toner discharge hole with respect to the toner discharge hole; and a drum cartridge including: a photosensitive drum rotatable about a drum axis extending in a first direction; and a drum frame supporting the photosensitive drum, wherein in a state the toner cartridge is mounted to the drum cartridge, the toner housing is rotatable about an axis between a first position in which the toner shutter is located in the closed position and a second position in which the toner shutter is located in the opened position, the axis extending in a second direction intersecting with the first direction.

Abstract: An implantable system includes a ventricular assist device and a cuff for attachment to a heart. The ventricular assist device includes an inlet cannula. The cuff defines an opening for insertion of the inlet cannula into the opening. The cuff includes an annular fastening member and an attachment member. The annular fastening member is configured to be sutured to heart tissue. The attachment member includes flexible extensions. Each of the flexible extensions is configured to interface with the inlet cannula during insertion of the inlet cannula into the opening so as to cause the flexible extension to flex outward to accommodate passing of the inlet cannula along the opening. Each of the flexible extensions is configured to interface with the inlet cannula to impede extraction of the inlet cannula from the opening.

Abstract: A multilayer scintillation detector, includes at least three layers superposed on one another, and each extending parallel to a plane, called the detection plane, wherein each layer is formed by a first material, called a scintillation material, capable of interacting with an ionizing radiation and of forming, following the interaction, a scintillation light in a scintillation spectral band; each layer has a plurality of light guides, respectively extending parallel to the detection plane, according to a length, the light guides being disposed, over all or part of their length, parallel to an axis of orientation; the axis of orientation of the light guides of each layer is oriented, in the detection plane, according to an orientation, the orientations of the respective axes of orientation of at least three layers being different from one another, such that each layer has an associated orientation; and the scintillation material has a first refractive index.