Abstract: Methods and therapeutic combinations useful for increasing cell-mediated anti-tumor responses are described. The methods include administering to a subject a therapeutically effective amount of an Immune Response Modifier Compound and a therapeutically effective amount of one or more immune checkpoint inhibitor compounds.

Abstract: The present disclosure relates to a magnetic shielding tape, which is capable of shielding a high-to-low frequency of a signal transmitted through a cable in shielding of a magnetic field which flows in such a cable or is emitted therefrom, and a method for manufacturing the same. The basic magnetic shielding tape comprises: —a thin film magnetic layer including at least one metal ribbon sheet which is divided into a plurality of fine pieces by flaking process, and a gap provided between adjacent fine pieces among the plurality of fine pieces; —a cover film layer adhered to one side surface of the thin film magnetic layer through a first adhesive layer; and—a conductive layer adhered to the other side surface of the thin film magnetic layer through a second adhesive layer, wherein a size of the gap is determined according to a frequency band of the signal.

Abstract: A magnetic isolator includes a dielectric film having a layer of electrically-conductive soft magnetic material bonded thereto. The layer of electrically-conductive soft magnetic material comprises substantially coplanar electrically-conductive soft magnetic islands separated one from another by a network of interconnected gaps. The interconnected gaps are at least partially filled with a thermoset dielectric material. The network of interconnected gaps at least partially suppresses electrical eddy current induced within the layer of soft magnetic material when in the presence of applied external magnetic field. An electronic device including the magnetic isolator and a method of making the magnetic isolator are also disclosed.

Abstract: Disclosed is an identification system to improve safety on roads and allow for the driver or for the vehicle itself, if it is autonomous or semi-autonomous, to have readable and useful information about road signs, roadways, and adjacent roadway information. The disclosed identification system comprises a marker with marker communication information that can be read by a vehicle information system to provide information to the vehicle. Information that the marker communication information may convey would allow the vehicle information system to detect or recognize, or both detect and recognize critical road sign, roadway information, and adjacent roadway information. Then, the vehicle information system could respond to the information received from the marker communication information.

Abstract: Articles subject to ice formation during normal use are described. The article comprises a repellent surface such that the receding contact angle of the surface with water ranges from 90 degrees to 135 degrees. The repellent surface comprises a fluorochemical material, typically in combination with a non-fluorinated organic polymeric binder. The fluorochemical material is prefer-ably a compound having the formula: (Rf-L-P)nA Rf is a fluorinated group; L is independently an organic divalent linking group; P is a catenary, divalent heteroatom-containing carbonyl moiety, such as —C(O)O—; A is hydrocarbon moiety; and n typically ranges from 1 to 3. Also described are methods of making an article comprising providing an article subject to ice formation during normal use and providing a liquid repellent surface, as described herein, on at least a portion of the article.

Abstract: A film (50) processing apparatus (20) including a film stretching device (22) and a take-away device (24) and a film processing method using the apparatus. The take-away device receives the film after the stretching device and transports the film along a conveying region in a direction of transport (X). The take-away device includes opposing, first and second conveyor assemblies. The first conveyor assembly has a continuous belt driving a plurality of discrete pads (180a, 180b). Each pad forms a contact face (194a, 194b) extending between leading (200b) and trailing edges (202a). The pads are configured and arranged such that the trailing edge (202a) of a first pad (180a) overlaps the leading edge (200b) of an immediately adjacent second pad (180b) as the first and second pads traverse the conveying region. The overlap is characterized by a line (322) perpendicular to the direction of transport passing at any given moment through the first and second pads.

Abstract: Systems and methods for displaying subsets of electronic documents generated in association with a patient's encounter with a healthcare organization.

Abstract: A hardcoat composition is described comprising urethane (meth)acrylate oligomer having a first functional groups; an acrylic polymer having second functional groups; wherein the first and second functional groups form a hydrogen bond; and silica nanoparticles. The hardcoat composition may be cured by actinic radiation, upon which the acrylic polymer may be removed by solvent extraction. Also described are articles comprising the cured hardcoat described herein disposed on a surface of a substrate and methods of making an article.

Abstract: Aspects of the present disclosure relate to a multicomponent filament and articles thereof. The multicomponent filament comprises at least a first component and a second component. The first component includes a thermoplastic polymer. The second component includes a hydrophilic thermoplastic polymer comprising 65% (w/w) to 90% (w/w) (inclusive) hydrophilic segments. The first component is capable of forming a continuous filament with the second component.

Abstract: Trimmable conformable wound dressings, kits containing the same and methods of using the same. The wound dressings may protect a treatment site from microbial contamination or other disturbances while a wound heals or to enable the application and maintenance of vacuum over the treatment site. The wound dressings may include first and second sections of support layer material on opposite sides of one or more intermediate sections of support layer material. The first and second sections of support layer material meet the intermediate sections of support layer material along peel tab junctions that provide peel tabs.

Abstract: An optical component array and method of making an optical component array includes a plurality of optical components useful for projection devices or other optical devices.

Abstract: Thermally stable microstructured layers comprising polyurethane, polyurea and/or polyurethane/urea semi-IPN materials are provided which have microstructured surfaces which are highly durable, erosion resistant, and thermally stable. The microstructured layer comprises a semi-IPN of a polymer network selected from the group consisting of urethane acrylate polymer networks, urethane/urea acrylate polymer networks and urea acrylate polymer networks and a linear or branched polymer that is a thermoplastic polymer selected from the group consisting of thermoplastic polyurethanes, thermoplastic polyurethane/polyureas, thermoplastic polyureas, and combinations thereof. The microstructures are thermally stable at temperatures above the crossover point of the thermoplastic polymer, despite comprising a majority of such thermoplastic material. In another aspect, the present disclosure provides methods of making microstructured layers according to the present disclosure.

Abstract: The present invention relates to cable-to-board connectors for fine pitch, high speed connector assemblies. The exemplary connector assembly includes an insulative housing, a plurality of first contacts disposed in the housing wherein at least a portion of the contacts are adapted to terminate at a conductive trace on a printed circuit board and a first cable comprising a plurality of first wires. Each of the first contacts has a first mating portion for making electrical contact with a corresponding contact of a mating connector; and a first terminal portion extending along a housing bottom wherein the first terminal portion is adapted to terminate at a conductive trace on a printed circuit board. In the exemplary cable assembly, each first wire of the first cable is terminated at the first terminal portion of a different first contact.

Abstract: This disclosure relates generally to methods and systems for determining whether at least a first component and a second component of a personal protection (PP) configuration are compatible so as to be assembled into an approved PP configuration, responsive to being compared against at least one predetermined criterion. Included is a smart tag for each of the first and second components. The first and second smart tags include respective first and second data. A data acquiring system is provided for acquiring the first and second data and a data processing system processes the acquired first and second data for determining if the first and second components are compatible to be assembled as an approved PP configuration.

Abstract: A flat-fold respirator is made from a stiff filtration panel joined to the remainder of the respirator through at least one line of demarcation. The panel contains a porous monocomponent monolayer nonwoven web that contains charged intermingled continuous monocomponent polymeric fibers of the same polymeric composition and that has sufficient basis weight or inter-fiber bonding so that the web exhibits a Gurley Stiffness greater than 200 mg and the respirator exhibits less than 20 mm H2O pressure drop. The respirator may be formed without requiring additional stiffening layers, bicomponent fibers, or other reinforcement and can be flat-folded for storage. Scrap from the manufacturing process may be recycled to make additional stiff filtration panel web.

Abstract: A flexible dielectric substrate (102) defines a LESD mounting region (120) including two conductive filled vias (105, 106) extending through the flexible dielectric substrate (102) and the LESD mounting region is substantially surrounded by two conductive frame portions (112, 116). The frame portions are in electrical connection with the conductive filled vias (105, 106), respectively. The conductive filled vias (105, 106) form conductive features in the mounting region (120) that are co-planar with each other.

Abstract: An article comprising at least one microneedle is provided. The article can comprises a first side and a second side opposite the first side. The first side comprises a central cavity portion and a platform portion, with at least one microneedle extending therefrom, wherein the platform portion is not coplanar with the central cavity portion. The platform portion substantially surrounds the central cavity portion. The at least one microneedle comprises a body comprising an outer surface; a base segment having a base and a first shape; a tip segment having a tip and a second shape, wherein the second shape is distinct from the first shape; a transition plane that delineates the base segment and the tip segment; and a central axis. Methods of using the article are also provided.

Abstract: A composition is described comprising semicrystalline polylactic acid polymer; polyvinyl acetate polymer having a glass transition temperature (Tg) of at least 25 C; plasticizer; and optionally amorphous polylactic acid polymer. In another embodiment the composition further comprises nucleating agent. Also described are films comprising the composition as well as articles, such as a tape or sheet, comprising the film described herein and a layer of pressure sensitive adhesive disposed on the film.

Abstract: The present disclosure includes a retrofit sensor module for use with a protective head top with a helmet and a visor. The sensor module includes a sensor housing and an attachment mechanism. The sensor housing encloses a head presence sensor to sense when the protective head top is being worn. The sensor housing also encloses a position sensor to sense the position of the visor relative to the helmet. The retrofit sensor module further comprises an attachment mechanism secured to the housing. The attachment mechanism mates with a first hinge component of a hinge assembly in the protective head top to removably install the sensor module into the protective head top, wherein the hinge assembly allows the visor to move relative to the helmet.

Abstract: A barrier film construction comprises an ultra-barrier film and a barrier adhesive. The adhesive layer comprises a barrier adhesive composition comprising a resin system and organically modified nanoclay; wherein the resin system comprises a first polyisobutylene resin having a viscosity average molecular weight of about 100,000 to about 1,200,000 g/mol and tackifier.