Abstract: Peptide co-agonists of the human GLP-1 and GIP receptors suitable for oral delivery, including long-acting derivatives, and their medical use in treatment and/or prevention of obesity, diabetes, and/or liver diseases are described.

Abstract: A process of recovering oil, comprising (a) converting a starch-containing material into dextrins with an alpha-amylase; (b) saccharifying the dextrins using a carbohydrate source generating enzyme to form a sugar; (c) fermenting the sugar in a fermentation medium into a fermentation product using a fermenting organism; (d) recovering the fermentation product to form a whole stillage; (e) separating the whole stillage into thin stillage and wet cake; (e?) optionally concentrating the thin stillage into syrup; (f) recovering oil from the thin stillage and/or optionally the syrup, wherein a phospholipase is present and/or added during steps (a) to (c). Use of phospholipase for increasing oil recovery yields from thin stillage and/or syrup in a fermentation product production process.

Abstract: A method for analyzing a virtual object in a virtual environment includes obtaining an image of a first real-world object and transmitting, to a data processing system, the image of the first real-world object. The method includes creating a digital representation of the first real-world object and assigning local attributes to one or more portions of the digital representation corresponding to elements of the first real-world object. The method includes obtaining an image of an updated configuration of the first real-world object and transmitting, to the data processing system, the image of the updated configuration. The method includes creating, by the data processing system, a digital representation, of the updated configuration. The method includes comparing, by the data processing system, the digital representation of the first real-world object and the digital representation of the updated first real-world object to identify rearranged parts and assign local attributes.

Abstract: Disclosed is a method of generating and modifying a virtual model of a set of teeth, where the method provides that a restoration can be inserted into a physical model of the set of teeth manufactured from the virtual model of the set of teeth. A method of and a system for generating a virtual model of a set of teeth for manufacturing a physical model of the set of teeth, and to a physical model of a set of teeth.

Abstract: The present invention relates to novel monovalent anti-ANGPTL3 antibodies for use in medicine and in particular for lowering of plasma triglycerides levels in patients in need thereof, such as patients suffering from or at risk of hypertriglyceridemia and/or cardiovascular disease, such as atherosclerotic cardiovascular disease (ASCVD) as well as pharmaceutical compositions suitable for subcutaneous administration and kits comprising such compounds and compositions.

Abstract: The present invention relates to a microfluidic particle analysis device comprising an inlet and an outlet in fluid communication via a main channel defining a main flow direction from an inlet end to an outlet end, the main channel being defined by a main channel wall extending from the inlet end to the outlet end and having a first cross-sectional dimension in the range of 20 ?m to 120 ?m and a second cross-sectional dimension of at least 100 ?m, the main channel wall at a vertex having an opening extending along the main flow direction and being open to an analysis section having surfaces at an analytical distance in the range of 5 ?m to 50 ?m and a sensor system for detecting a particle. The present invention also relates to a method of using the microfluidic particle analysis device for detecting particles or monitoring the concentration of particles.

Abstract: The invention relates to a toy building block system (100) comprising one or more building blocks (200); and one or more wheels (300); wherein each said building block (200) comprises: a first elongate portion (2) extending in a longitudinal direction (X); a second elongate portion (4) extending in said longitudinal direction (X); an intermediate portion (6) connecting said first elongate portion (2) with said second elongate portion (4) at a middle position (8) thereof; a first end portion (10) extending in a transverse direction (Y), perpendicular to said longitudinal direction (X), from said first elongate portion (2), at a side thereof opposite to said intermediate portion (6), and at a middle position thereof; a second end portion (12) extending in said transverse direction (Y), perpendicular to said longitudinal direction (X), from said second elongate portion (4), at a side opposite to said intermediate portion (6), and at a middle position thereof; said building block thereby comprises six protrusio

Abstract: The invention relates to a nonwoven fabric sheet comprising at least two adjacent layers of spunbonded nonwoven webs, one of which is an elastic layer in the form of a spunbonded nonwoven web comprising elastic fibers formed from a thermoplastic elastomer polymer material. The invention further relates to a method of manufacturing such nonwoven and the use of such nonwoven.

Abstract: The present application relates to a system comprising a hearing aid, the hearing aid configured to be operated based on an estimation of a current listening effort of a hearing aid user.

Abstract: There is presented a tower element, such as a tower element for a tower for a wind turbine generator, said tower element comprising a hollow, tubular element, a flange on an inside surface of the hollow, tubular shell, a unit comprising a platform and a fixation element, such as a plurality of fixation elements, attached to the platform, wherein the unit is arranged with respect to the flange, so that the flange prevents movement of the platform in both directions along an axis being parallel with an axis of the tubular element, and movement of the platform is allowed in at least one direction along an axis being orthogonal to the axis of the tubular element. There is furthermore presented a tower, a wind turbine generator and a method for providing a tower element.

Abstract: The present invention provides novel blockers of the potassium channel Kv1.3, polynucleotides encoding them, and methods of making and using them.

Abstract: The invention relates to a method and a wind turbine system reducing, preventing or mitigating vibrations due to wind induced vibrations. The wind turbine system includes a wind turbine tower 102, a sensor arrangement 304 for sensing vibrations of the wind turbine tower, a nacelle 104 mounted to the wind turbine tower via a yaw bearing 310 and a control system 306 for controlling yawing of the nacelle relative to the wind turbine tower. The system is adapted for sensing 402 a vibration of the wind turbine tower using the sensor arrangement, providing 404 an input for the control system in response to the vibration of the wind turbine tower as sensed by the sensor arrangement, and providing 406 an output by the control system based on the input, and yawing 408 the wind turbine nacelle based on the output from the control system, and hereby reducing wind induced vibrations of the tower and nacelle, particularly vortex induced vibrations and/or vibrations due to galloping.

Abstract: The present invention relates to animal feed and animal feed additives comprising polypeptides having protease activity, as well as methods of producing proteases, methods of producing animal feed and animal feed additives comprising proteases, and methods of using proteases to improve animal performance and the nutritional value of animal feed.

Abstract: An endoscope and a method of assembling the endoscope, the endoscope including a handle including a wire receiving unit rotatably connected to an operating unit; a distal tip unit configured to be inserted into a patient’s body cavity; -an endoscope shaft connecting the endoscope handle and the distal tip unit; and at least one steering wire, a proximal end portion of which being held by or fixed to the wire receiving unit, the steering wire being configured to be pulled by rotating the operating unit, thereby tilting the distal tip unit in at least a defined first direction, wherein the proximal end portion of the at least one steering wire is wound around/on the wire receiving unit for at least one full turn.

Abstract: A video processing apparatus includes a housing defining an interior space, the housing having first, second, third, and fourth sides and a back side extending between the first, second, third and fourth sides, the back side including a back wall having a main portion laying on a back plane, a recessed portion recessed from the back plane and defining a video connection recess, and a recessed wall extending from the main portion to the recessed portion, the recessed wall having a video connector opening, and the recessed portion having an angled surface lying at an angle of at least 5 degrees relative to the back plane; and a video output socket in the interior space and aligned with the video connector opening of the recessed wall, whereby the angled surface facilitates insertion of a video connector into the video output socket.

Abstract: The present disclosure relates to xyloglucanase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.

Abstract: Provided is a hearing device comprising an earmould. The earmould comprises a front end, a rear end opposite the front end, and a middle part arranged in-between the front and a rear end. The front end comprises a front opening, and the rear end comprises a rear opening. The earmould is configured for the front end to be positioned facing a tympanic membrane of the user during use. The hearing device further comprises a receiver housing arranged at least partly within the earmould, and a supporting structure configured to hold the receiver housing in place within the earmould. At least part of the supporting structure comprises a material that is softer than the material used to make the middle part of the earmould.

Abstract: The present invention relates to nucleic acid constructs comprising a first polynucleotide encoding a signal peptide from a bacterial alpha-amylase a second polynucleotide encoding a polypeptide having hexosaminidase activity; expression vectors and host cells comprising said nucleic acid constructs; and methods for producing polypeptides having hexosaminidase activity.