Abstract: Methods and devices measure eye blinks and tear film lipid and aqueous layer thickness before and following ophthalmic formula application onto the ocular surface, especially wherein the ophthalmic formula is an artificial tear. The methods and devices are suitable for dry eye diagnosis. The methods and devices are suitable for use to evaluate ophthalmic formula effects on the tear film and to use such information to diagnose ophthalmic formula treatment of ocular disease conditions such as dry eye in the absence of contact lens wear or post-surgical eye drop treatment and diagnosis. The methods and devices are also suitable for use in the optimization of ophthalmic drug dosage forms and sustained drug release.

Abstract: A system for measuring the size of a capsular bag of an eye of a subject includes a size indicator and a sizing gauge. The size indicator is configured for insertion into a capsular bag and includes a peripheral portion and a pair of arms. The peripheral portion is configured to engage the capsular bag. Each of the arms has a proximal end and a distal end, the arms being joined to one another at the proximal ends. The peripheral portion is joined to the distal ends of the arms. The arms form an angle that depends on a size of the capsular bag into which the size indicator is placed. The sizing gauge has a body having a front surface, along with first and second features disposed along or behind the front surface. The features are configured to correspond to an angle that is within a predetermined range of angles of the arms of the size indicator when the size indicator is placed within a capsular bag.

Abstract: An eye treatment system includes an eye treatment probe and a console. The console has a cassette receptacle and a fluid drive system including a first peristaltic drive rotor and a second peristaltic drive rotor. The first and second drive rotors are exposed to the receptacle and are substantially coaxial. The cassette includes a cassette body and a fluid pathway network for coupling the fluid drive system of the console with the probe. The cassette body has cassette positioning surface for fittingly engaging the receptacle. The fluid pathway network has a first resilient tubing segment and a second resilient tubing segment, the first and second tubing segments are configured for peristaltic driving engagement by the first and second rotors, respectively, when the cassette is mounted to the console. Various elements of the cassette are configured for interfacing with the components of the console when the cassette is mounted to the console.

Abstract: Implantation of an accommodating intraocular lens in an eye may require the accurate measurement of the size, circumference, or diameter of the capsular bag of the eye. A flexible ring or ring portion may be temporarily or permanently inserted into the capsular bag for measuring the circumference of the capsular bag, for example, after extraction of a natural lens from the capsular bag. The ring or ring portion is generally compressible to fit through a surgical incision, then expands to fill the capsular bag along an equatorial region. The ring or ring portion includes a central component that changes shape and/or angle as the ring or ring portion is compressed. The shape change is generally correlated to the size of the capsular bag and may be visually measured through the cornea, the measurement being generally independent of corneal magnification. The measurement may be used to determine or calculate information about the capsular bag such as its size, elasticity, accommodative range, and so forth.

Abstract: A cartridge for an intraocular lens insertion device is disclosed. An example cartridge may include an intraocular lens insertion cartridge body having a distal end and a proximal end and configured to receive an intraocular lens for insertion into a patient's eye through an incision; the intraocular lens insertion cartridge body having an inner surface comprising at least one polymeric material having a hardness greater than about 50 D and an elongation at break greater than about 150%; the inner surface of the intraocular lens insertion cartridge body defining an at least partially tapering insertion pathway disposed within the intraocular lens insertion cartridge body and extending from the proximal end to the distal end of the intraocular lens insertion cartridge body.

Abstract: A method and apparatus for precisely controlling particle movement relative to a phacoemulsification needle tip is provided. The design monitors actual vacuum present and calculates a pulse shape amplitude waveform proportional to the amount of measured vacuum. An increase in vacuum indicates that the handpiece/needle is becoming occluded by a large particle. The present design determines whether additional power is required to bump or move a large particle away from the needle tip. The present design may employ a control loop that senses and continuously monitors vacuum. The design may dynamically vary the amount of ultrasonic energy delivered to the surgical area in response to the observed actual vacuum, and can actively vary the amount of power delivered to the surgical area based on the size of the particle and the resultant vacuum realized.

Abstract: An intraocular lens for implantation in a capsular bag of an eye includes an optic disposed about an optical axis and a haptic including a protruding portion disposed inside the optic. The optic has an anterior face and an opposing posterior face that are configured to provide a lens power. In response to an ocular force of the eye, the haptic transmits a force that alters one or more of a shape of the optic and an axial thickness of the optic. The protruding portion of the haptic has a refractive index that is equal to a refraction index of the optic for at least one wavelength within the visible spectrum.

Abstract: Disclosed are accommodating intraocular lenses for implantation in an eye having an optical axis. In certain embodiments, an intraocular lens includes an anterior optic, a posterior optic, and a support structure configured to move the optics relative to each other along an optical axis between an accommodated state and an unaccommodated state. In certain embodiments, at least a portion of the support structure can be modified in situ to alter reaction forces between the support structure and at least one structure of the eye. In certain embodiments, a refractive property of one of the anterior or posterior optics can be modified in situ while leaving the refractive properties of the remaining one of the anterior or posterior optics substantially unaffected. Additional embodiments and methods are also disclosed.

Abstract: The present invention relates to ultraviolet light-activated disinfectants, and more particularly to a light-activated disinfection system for contact lens disinfection.

Abstract: A system and method for performing an ocular surgical procedure is provided. The system is configured to provide an IOL having a trailing haptic to an eye and includes a pair of interlockable telescoping elements, having generally an inner and outer component configured to hold the IOL and be brought together into a locking position, the locking position maintaining the trailing haptic in an advantageously altered orientation. The system also includes a plunger configured to receive force and transmit the force to the IOL and the trailing haptic in the advantageously altered orientation.

Abstract: An intraocular lens having a light-transmitting optic (32, 94a, 94b, 142, 148, 216) comprised of a synthetic light-refractive material (40, 102) operably coupled with a flexible optic positioning member (34, 62, 74, 84, 100, 150, 210) to refract light onto the retina in order to correct refractive errors in the eye (10). The refractive material has an index of refraction of from about 1.36 to 1.5 or higher. The optic positioning member (34, 62, 74, 84, 100, 150, 210) is constructed of a flexible synthetic resin material such as polymethylmethacrylate and permits focusing upon objects located near to and far from the viewer. The optic (32, 94a, 94b, 142, 148, 216) of the present invention possess greater refractive capability than optics conventionally used in IOL construction, and permits retinal receipt of the image being viewed in order to correct refractive errors.

Abstract: Soft, flexible highly lubricious coatings for polymeric IOL insertion cartridges that allow IOLs to be easily inserted through small bore cartridges suitable for use with small (less than 3 mm) incisions are provided. These lubricious coatings allow IOLs to be inserted into the eye of a patient without the risk of lens damage or transfer of lubricants to the lens surface during implantation. Specifically, polymeric coatings comprising a matrix polymer having an equivalent weight greater than 5000 g/eq are used to form interpenetrating networks (IPN) on the surface of hydrophobic structural polymers. The IPNs thus formed entrap highly lubricious hydrophilic compounds within the IPN using multi-functional cross linkers.

Abstract: Ophthalmic devices are provided having a violet-light vertical cut-off filter abruptly absorbs light between the wave lengths of between approximately and 400 nm and 450 nm such that a curve when plotted as percent transmission versus wavelength has the shape as depicted in FIG. 2. In one embodiment the ophthalmic devices are made from acrylates and the light absorbing compound is an Eastman Yellow 035 MA dye.

Abstract: An intraocular lens for providing accommodative visions to a subject includes an adjustable optic and a haptic that is operably coupled to the optic. The adjustable optic comprises an optical axis, a central zone disposed about the optical axis, and an annular zone surrounding the central zone. The optic may also comprise additional annular zones disposed about the central zone and the first annular zone. The haptic comprises a transparent portion protruding into the adjustable optic. The intraocular lens has a disaccommodative configuration in which the central zone has a base optical power and an accommodative configuration in which the central zone has an add optical power that is at least about 1 Diopter greater than the base optical power, preferably at least about 2 Diopters greater than the base optical power. In some embodiments, the add optical power is at least 3 Diopters, or even 4 Diopters, greater than the base optical power.

Abstract: A cartridge for delivering an intraocular lens into the eye of a subject that comprises a body disposed along a longitudinal axis having a distal end and a proximal end, and a tapered lumen disposed along the longitudinal axis having an aperture at the distal end of the body. The aperture and at least a portion of the tapered lumen each consist of an upper portion and a lower portion. The upper portions of the aperture and lumen each have a first width and a cross-section that is generally arcuate. The lower portions of the aperture and lumen each have a cross-section that is generally horizontally disposed and have a second width that is greater than the first width of the aperture and lumen. The cartridge may be loaded with an intraocular lens using a packaging system. The intraocular lens may be placed into the eye of a subject using a corresponding inserter having a pushrod with a saddle disposed at the tip thereof. The intraocular lens is preferably draped over the saddle during insertion.

Abstract: A system and method for performing an ocular surgical procedure is provided. The design maintains IOL temperature prior to implantation by assessing a desired IOL temperature, sensing existing IOL temperature, and maintaining the IOL substantially at the desired IOL temperature based at least in part on said existing IOL temperature. The method of maintaining desired IOL temperature involves comparing current IOL temperature with pre-established desired temperature conditions to determine a temperature change. The IOL is maintained substantially at the desired temperature based at least in part on the existing IOL temperature.

Abstract: A system and method for performing an ocular surgical procedure is provided. The design provides an intra-ocular lens (IOL) to an eye through an incision in the eye by assessing IOL insertion conditions, translating said IOL insertion conditions into a desired force range for insertion of the IOL via the incision, controlling a power source to move the IOL to the eye, monitoring conditions, such as force encountered, while controlling the power source. The design employs feedback of the force encountered and selectively alters force applied based on force encountered.

Abstract: A device includes a plurality of ringlets connected together to form a ring having a longitudinal axis. Each ringlet includes a first element and a second element. The first and second elements each extend from a first end through a central portion to a second end. The first and second ends are disposed at radially outer positions with respect to the ring than the central portion. The central portion is longitudinally displaced from the first and second ends. The first and second elements are separated and spaced apart from each other at the central portions thereof and are joined together at the first ends thereof and the second ends thereof. The ringlets are connected together such that the first ends of the elements of one ringlet are connected to the second ends of the elements of an adjacent ringlet.

Abstract: Intraocular lenses are provided having a visible-light selective transmissive zone defined therein. The visible light-selective transmissive zone can be located near the lens center and designed to reduce the transmission of any wave-length of visible light specifically light in the blue light region having wavelength between approximately 400? to 550?. In one embodiment he IOLs are made from acrylates and the light absorbing compound is a yellow dye.

Abstract: An intraocular lens is disclosed, with an optic that changes shape in response to a deforming force exerted by the zonules of the eye. A haptic supports the optic around its equator and couples the optic to the capsular bag of the eye. Certain haptic features improve the accommodative performance of the haptic, such that compressive/tensile forces may be more efficiently transferred from the haptic to optic. Furthermore, certain aspects also provide enhanced bag-sizing capability so that the IOL better fits within the capsular bag.