Abstract: An infusion source provides for a fluid supply and an irrigation line interconnecting the fluid supply with an irrigation lumen of an ocular handpiece. An accumulator is disposed in fluid communication with irrigation line and the irrigation lumen includes an expandable wall for enabling accumulation of fluid within the tubular member during occlusion of the aspiration lumen, and enhanced flow of the fluid of the irrigation lumen upon clearing of the occlusion.

Abstract: A method and apparatus for performing modulated fluid delivery and aspiration during a surgical procedure such as phacoemulsification is provided. The method and apparatus include delivering fluid and/or aspirating fluid in a modulated or pulsed manner during a surgical procedure, including applying fluid and/or aspirating fluid in connection with ultrasonic energy at a level and for a time period sufficient to induce transient cavitation. Fluid may be applied and/or aspirated at a timing sequence and duty cycle similar to or different from application of ultrasonic energy delivery.

Abstract: Disclosed herein are non-irritating ophthalmic emulsion compositions useful for treating ocular disorders including dry eye and related methods. More specifically, the ophthalmic compositions disclosed herein combine a high HLB surfactant and a low HLB surfactant together with a plant-derived triglyceride having non-polar aliphatic side chains to form a therapeutic non-irritating eye drop.

Abstract: Disclosed herein are non-irritating ophthalmic emulsion compositions useful for treating ocular disorders including dry eye. More specifically, the ophthalmic compositions disclosed herein combine a high HLB surfactant and a low HLB surfactant together with an omega-3 fatty acid-containing oil having non-polar aliphatic side chains to form a therapeutic non-irritating eye drop.

Abstract: Disclosed herein are stable oil-in-water emulsion ophthalmic topical liquid compositions having an average particle size less than 1 ?m including at least one plant-derived oil other than castor oil wherein the oil comprises only aliphatic side chains free of polar pendent groups. The oil-in-water emulsion ophthalmic topical liquid compositions also include a hydrophilic surfactant having an HLB value between approximately 10 and 14, a vegetable oil-derived hydrophobic non-co-block surfactant having unsaturated side chains that contain less than four oxygen atoms having an HLB value between approximately 4 and 6 and is a liquid at room temperature. The oil-in-water emulsion ophthalmic topical liquid compositions disclosed herein can further include an amount of cyclosporine A effective to relieve dry eye symptoms.

Abstract: A method and apparatus for delivering energy during a surgical procedure such as phacoemulsification is provided. The method and apparatus include delivering energy during a surgical procedure, including applying energy at a level and for a time period sufficient to induce transient cavitation, and reducing applied energy after applying energy during a second nonzero lower energy period.

Abstract: The present invention pertains to a system (or engine) that monitors a system's performance during a surgery, analyzes that performance, and makes recommendations to the user/surgeon for changes in his settings and/or programs that will result in more effective and time-efficient surgeries. Further, the system may comprise one or more components, including, but not limited to, a user preference filter, a surgical circumstances filter, a surgical instrument, a real time data collection module, and an analysis module.

Abstract: Methods and systems for automatically pulsing different aspiration levels to an ocular probe are disclosed. The probe may be a phacoemulsification probe. A first aspiration level, supplied by a first pump, may be applied to the probe simultaneously with ultrasonic energy. A second aspiration level, supplied by a second pump, may be automatically switched from the first aspiration level, and applied to the probe in a pulsed manner.

Abstract: Methods and apparatuses for automatically switching different aspiration levels to an ocular probe are disclosed herein. The probe may be a phacoemulsification probe. A first aspiration level, supplied by a first pump, may be applied to the probe simultaneously with ultrasonic energy. A second aspiration level, supplied by a second pump, may be automatically switched from the first aspiration level. Control feed back of the pumps may be varied according to set thresholds.

Abstract: A multipurpose solution for contact lens care, comprising: an aqueous liquid medium; a quaternary ammonium polymer having an average molecular weight as determined by the proton NMR method of at least 28 k, and methods for making the same.

Abstract: An intraocular lens for insertion into a capsular bag in order to focus incoming light toward a retina and process for manufacturing thereof along with concomitant reduced glare and improved vision provides for a center lens portion of a lens for focusing incoming light toward the retina and the surrounding lens portion for mounting the lens within the capsular bag. A surface roughness disposed on the surrounding lens portion is provided for reducing the glare due to non-focused light directed toward the retina from the intraocular lens with the roughness having a roughness level of between about Ra 45 and about Ra 350.

Abstract: A tray assembly includes an articulatable arm assembly coupled with a tray and selectively held in place by a locking mechanism (e.g., a locking gas spring). A release mechanism coupled with the tray selectively activates and deactivates the gas shock mechanism and is coaxial with and free rotating with respect to an axis of rotation of the tray. The tray may rotate between a horizontal position and a stored position substantially orthogonal to the horizontal position. The arm assembly may include at least one frictional hinge comprising a tapered pin, a tapered bushing in rotational frictional contact with the tapered pin, and an adjustment mechanism coupled to the tapered pin to provide adjustable contact force between the tapered pin and the tapered bushing.

Abstract: The present invention pertains to a cassette capture mechanism for uniting a cassette with a console to prevent jamming or damage to the console and/or cassette. The cassette capture mechanism comprises a cassette receptacle, an axial translation linkage, a first sensor apparatus, and a second sensor apparatus. The cassette receptacle is configured to couple with a cassette having a positioning surface. The axial translation linkage is configured to couple the cassette with the cassette receptacle. The first sensor apparatus is configured to detect alignment of the cassette in a horizontal plane with respect to the cassette receptacle when the cassette is initially coupled with the cassette receptacle; and the second sensor apparatus is configured to detect activation of the first sensor apparatus and detect alignment of the cassette in a vertical plane with respect to the cassette receptacle.

Abstract: A method of treating glaucoma in an eye by managing fluid flow past an implanted shunt having an elastomeric plate and a non-valved elastomeric drainage tube. The plate is positioned over a sclera of the eye with an outflow end of the elastomeric drainage tube open to an outer face of the plate. An inflow end of the drainage tube tunnels through the sclera to the anterior chamber of the eye. The plate may have regions of greater propensity for cell adhesion alternating with regions of lesser cell adhesion. For example, regions of texturing around the plate or drainage tube may be provided to control the size of a bleb that forms over the implant. The effective surface area of the plate may be balanced against a number of fenestrations. The drainage tube has a reduced profile and may be shaped with a non-circular external cross-section to reduce its height. A scleral groove may be used to further reduce the height of the drainage tube on the sclera.

Abstract: Disclosed herein are ophthalmic solutions and methods of using the solutions which comprise a complex of at least one cationic component and an anionic polymer, wherein the complex can be used as an antimicrobial agent. The solutions described have complexes which can be dissolved in aqueous ophthalmic solutions due to both lower charge load and lower total polymer concentrations than commonly taught. The complexes display different antimicrobial profiles than the non-complexed antimicrobial agents.

Abstract: The present invention addresses the treatment of ocular conditions by the enhancement of lens regeneration. Enhancement of lens regeneration is accomplished by the administration of a composition comprising a polysiloxane polymer having functional acryl groups useful in the preparation of intraocular lenses (IOLs).

Abstract: An apparatus for sizing an intraocular lens and/or an ocular region of the eye of a subject, such as the anterior chamber, contains a sizing device and a measurement device. In one embodiment, the sizing device comprises a first leg having a first contact portion for operably engaging the ocular portion and a second leg having a second contact portion for operably engaging the ocular portion. The sizing device has a test geometry when placed within the ocular portion. The measurement device is adapted for determining a dimension of the sizing device based at least in part on the test geometry. The sizing device may also have a reference geometry when the sizing device in a reference condition. In certain embodiments, the difference between the reference geometry and the test geometry may be used for sizing the intraocular lens and/or the ocular portion.

Abstract: A method of making antimicrobial quaternary ammonium polymers, comprising: a) mixing 1,4-bis-dimethylamino-2-butene, water, a first portion of triethanolamine and a first portion of acid; b) adding a 1,4-dihalo-2-butene and heating the reaction mixture; c) adding a second portion of triethanolamine and a second portion of acid, and d) isolating a quaternary ammonium polymer having a molecular weight of at least 26 k.

Abstract: A method and apparatus for precisely controlling particle movement relative to a phacoemulsification needle tip is provided. The design monitors actual vacuum present and calculates a pulse shape amplitude waveform proportional to the amount of measured vacuum. An increase in vacuum indicates that the handpiece/needle is becoming occluded by a large particle. The present design determines whether additional power is required to bump or move a large particle away from the needle tip. The present design may employ a control loop that senses and continuously monitors vacuum. The design may dynamically vary the amount of ultrasonic energy delivered to the surgical area in response to the observed actual vacuum, and can actively vary the amount of power delivered to the surgical area based on the size of the particle and the resultant vacuum realized.

Abstract: A method for operating a surgical system including placing a handpiece in an operative relationship with an eye for a surgical procedure. The method also comprises supplying irrigation fluid from an irrigation fluid source to the eye and applying vacuum from an aspiration source to the handpiece in order to aspirate the irrigation fluid from the eye through the handpiece. The method further comprises sensing a value of an occlusion indicating parameter corresponding to an occlusion of the handpiece and, from the sensing of the value, determining a duration of occlusion. The method additionally comprises controlling a controlled system parameter based at least in part on the duration of occlusion.