Patents Assigned to Academia Sinica
  • MOLTEN SALT SYSTEM AND METHOD AND APPARATUS OF TRANSFORMATION FOR MULTI-CARBON PRODUCTION BY USING THE SAME
    Publication number: 20200299249
    Abstract: This invention relates to a novel molten salt system in chemical transformation of saccharides and a method as well as an apparatus for multi carbon production by the molten salt system. It is found that an eutectic molten salt composition is advantageous for multi-carbon productions through chemical transformation under mild conditions. This invention further provides a method and an apparatus for preparing 5-hydroxymethylfurfural (HMF) and HMF-derived chemicals from saccharides by the said molten salt system.
    Type: Application
    Filed: March 22, 2019
    Publication date: September 24, 2020
    Applicant: ACADEMIA SINICA
    Inventors: Po-Wen CHUNG, Prasenjit BHAUMIK, Hao-Ju CHOU
  • Nanowire field effect transistor detection device and the detection method thereof
    Patent number: 10784343
    Abstract: The present invention discloses a Nanowire Field Effect Transistor Detection Device and the Detection Method thereof. The Nanowire Field Effect Transistor Detection Device of the present invention comprises: gate oxide, SiNW chip, surface oxide, and surface molecule layer. The circuit structure of the Nanowire Field Effect Transistor Detection Device comprises a first resistor, a second resistor, a first capacitor, a second capacitor, a third capacitor, a fourth capacitor, an AC voltage source, and an ammeter. In addition, the present invention provides a method for attaching the probe Ni-NTA to the Nanowire Field Effect Transistor Detection Device. Furthermore, the present invention provides a method for attaching the isooctyl trimethoxysilane molecule to the Nanowire Field Effect Transistor Detection Device.
    Type: Grant
    Filed: December 28, 2017
    Date of Patent: September 22, 2020
    Assignee: ACADEMIA SINICA
    Inventors: Chii Dong Chen, Li Chu Tsai, Chia Jung Chu, Ying Pin Wu
  • GLYCOPEPTIDE COMPOUNDS, METHODS FOR PRODUCING THE SAME, AND USES THEREOF
    Publication number: 20200291071
    Abstract: Disclosed herein are novel compounds and uses thereof. The present compounds are useful in suppressing the growth of various bacteria, including gram-positive and gram-negative bacteria. Accordingly, these compounds may be used to manufacture a medicament or pharmaceutic composition for treating disease and/or disorders associated with bacterial infection, especially antibiotic-resistant bacterial infection. Al so disclosed herein are methods for treating infectious diseases by use of the present compounds, medicament or pharmaceutical composition.
    Type: Application
    Filed: December 31, 2019
    Publication date: September 17, 2020
    Applicant: Academia Sinica
    Inventors: Tsung-Lin LI, Chun-Man HUANG, Kuan-Hung LIN
  • USE OF BENZOFURAN LIGNANS TO INDUCE IL-25 EXPRESSION AND SUPPRESS MAMMARY TUMOR METASTASIS
    Publication number: 20200289454
    Abstract: A method for suppressing tumor metastasis, in which an effective amount of a compound of formula (I) is administered to a subject in need thereof. Also disclosed is a method of treating cancer, in which an effective amount of a chemotherapy agent and an effective amount of a compound of formula (I) is administered to a subject in need thereof. Further disclosed are pharmaceutical compositions for suppressing tumor metastasis and for treating cancer, each of the compositions containing a compound of formula (I).
    Type: Application
    Filed: March 17, 2017
    Publication date: September 17, 2020
    Applicants: ACADEMIA, Sinica
    Inventors: Ning-Sun Yang, Yueh-Hsiung Kuo, Shu-Yi Yin, Yung-Hsiang Chen
  • Purine compounds possessing anticancer activity
    Patent number: 10765681
    Abstract: The present disclosure provides compounds of Formulas (I?) and (I), and pharmaceutically acceptable salts thereof. The compounds described herein may be useful in treating and/or preventing proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions, kits, and uses thereof for treating proliferative diseases.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: September 8, 2020
    Assignees: Academia Sinica, National Taiwan University
    Inventors: Chi-Huey Wong, Pan-Chyr Yang, Jim-Min Fang, Szu-Hua Pan, Ting-Jen R. Cheng, Ling-Wei Li
  • High-throughput screening of functional antibody fragments, immunoconjugate comprising the same, and adaptor-drug conjugate for screening
    Patent number: 10752673
    Abstract: Disclosed herein are methods for high-throughput screening of a functional antibody fragment for an immunoconjugate that targets a protein antigen. The method combines a phage-displayed synthetic antibody library and high-throughput cytotoxicity screening of non-covalently assembled immunotoxins or cytotoxic drug to identify highly functional synthetic antibody fragments for delivering toxin payloads.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: August 25, 2020
    Assignee: ACADEMIA SINICA
    Inventors: An-Suei Yang, Hong-Sen Chen, Chung-Ming Yu, Shin-Chen Hou, Wei-Ying Kuo, Yi-Kai Chiu, Yueh-Liang Tsou, Hung-Ju Hsu, Hwei-Jiung Wang, Shih-Hsien Chuang, Chao-Pin Lee
  • Antimicrobial peptides derived from hepatitis B virus core protein arginine-rich domain
    Patent number: 10752657
    Abstract: A pharmaceutical composition comprising: (a) an isolated peptide, wherein the peptide includes three or four arginine-rich domains (ARDs) from the carboxy-terminal region of hepatitis B virus core protein (HBc) and exhibits an anti-microbial activity; and (b) a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: August 25, 2020
    Assignee: Academia Sinica
    Inventors: Chiaho Shih, Heng-Li Chen, Pei-Yi Su
  • Mutated nucleotide molecule, and transformed plant cells and plants comprising the same
    Patent number: 10683518
    Abstract: The present invention relates to a method for producing male sterile plant, a mutated nucleotide molecule comprising a nucleotide sequence of the transcription factor bHLH142 and an inserted T-DNA segment, and a novel transformed plant cell and a male-sterile mutant plant comprising the mutated nucleotide molecule, in which the transcription factor bHLH142 is not expressed. The present invention also relates to a novel reversible male sterile transgenic plant, wherein the transcription factor bHLH142 is overexpressed, and its preparation method. The bHLH gene is tissue specifically expresses in the anther and it plays a pivotal role in pollen development. Both the male sterile and reversible male sterile transgenic plants showed a completely male sterile phenotype, but the fertility of the reversible male sterile transgenic plant can be restored under low temperature.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: June 16, 2020
    Assignee: ACADEMIA SINICA
    Inventors: Swee-Suak Ko, Min-Jeng Li
  • COMPOSITIONS AND METHODS RELATING TO UNIVERSAL GLYCOFORMS FOR ENHANCED ANTIBODY EFFICACY
    Publication number: 20200165649
    Abstract: The present disclosure relates to glycoproteins, particularly monoclonal antibodies, comprising a glycoengineered Fc region, wherein said Fc region comprises an optimized N-glycan having the structure of Sia2(?2-6)Gal2GlcNAc2Man3GlcNAc2. The glycoengineered Fc region binds Fc?RIIA or Fc?RIIIA with a greater affinity, relative to comparable monoclonal antibodies comprising the wild-type Fc region. The monoclonal antibodies of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by Fc?R is desired, e.g., cancer, autoimmune, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC.
    Type: Application
    Filed: October 2, 2019
    Publication date: May 28, 2020
    Applicant: Academia Sinica
    Inventors: Chi-Huey WONG, Chung-Yi WU, Che MA
  • DEVICE FOR CHARACTERIZING PARTICLES AND USES THEREOF
    Publication number: 20200161110
    Abstract: Disclosed herein is a device for characterizing a biological sample or an airborne sample. According to embodiments of the present disclosure, the device comprises an electrospray source, a mass analyzer, a charge detector, and optionally, an ion guide. The present device is useful in analyzing the particle population in the biological or airborne sample based on the mass to charge (m/z) ratio and the charge (z) of each particle. Also disclosed herein are the methods of making a diagnosis of cancer by use of the present device, and methods of determining the mass distribution of particles in an airborne sample.
    Type: Application
    Filed: November 17, 2019
    Publication date: May 21, 2020
    Applicant: Academia Sinica
    Inventors: Abdil OZDEMIR, Jung-Lee LIN, Chung-Hsuan CHEN
  • CONDITIONAL INTERNALIZATION OF PEGYLATED AGENTS BY PRETARGETING BI-SPECIFIC PEG-BINDING ANTIBODIES FOR DIAGNOSIS AND THERAPY
    Publication number: 20200140572
    Abstract: A monomeric bispecific polyethylene glycol (PEG) engager that includes an anti-PEG Fab fused to a disulfide stabilized scFv that specifically binds to a cell surface antigen. The PEG engager, in the absence of PEG, remains monomeric upon binding to the cell surface antigen on a cell and remains on the surface of the cell. Also provided is a method for treating cancer by administering a PEG engager followed by a PEGylated anti-cancer agent. A kit that contains a PEG engager and a PEGylated anti-cancer agent is also disclosed. Further disclosed are methods for imaging cells and diagnosing cancer by administering a PEG engager followed by a PEGylated imaging agent. Another kit is provided that includes the PEG engager and the PEGylated imaging agent.
    Type: Application
    Filed: May 9, 2018
    Publication date: May 7, 2020
    Applicants: KAOHSIUNG MEDICAL UNIVERSITY, ACADEMIA SINICA
    Inventors: Steve ROFFLER, Tian-Lu Cheng, Yu-Cheng Su, Kuo-Hsiang Chuang
  • Beneficial effect of on fat decrease and muscle increase
    Patent number: 10632165
    Abstract: A composition comprising a therapeutically effective amount of Bidens pilosa extract, or an active compound isolated from the Bidens pilosa extract for use in treating obesity, reducing body weight or body weight gain, and/or gaining muscle mass or muscle content in a subject in need thereof is disclosed. The composition is useful for reducing fat cell size and/or fat accumulation in the fat cell in a subject in need thereof. The composition may further comprises an animal feed. A polyacetylenic compound for use in treating obesity, gaining muscle mass or muscle content, and/or increasing lean tissue protein content in a subject in need thereof is also disclosed. In one embodiment, the polyacetylenic compound is cytopiloyne.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: April 28, 2020
    Assignees: Academia Sinica, NATIONAL CHUNG HSING UNIVERSITY
    Inventors: Wen-Chin Yang, Lee-Tian Chang, Yu-Chuan Liang
  • IMPROVED RELOADABLE HYDROGEL SYSTEM FOR TREATING BRAIN CONDITIONS
    Publication number: 20200121799
    Abstract: A drug delivery system and methods of using such for delivering a peglyated therapeutic agent to brain. The drug delivery system may comprise an antibody, which binds polyethylene glycol (PEG), wherein the antibody is embedded in a hydrogel, which may comprises one or more biodegradable polymers, up to 60% of which contain inter-chain or intra-chain covalent crosslinks. The amount of the antibody in the drug delivery system can be about 1-2 ?g per ?l of the hydrogel.
    Type: Application
    Filed: January 12, 2018
    Publication date: April 23, 2020
    Applicant: Academia Sinica
    Inventors: Patrick C.H. Hsieh, David Lundy, Christopher Yu-Tai Yen
  • ANTIBODY, KIT COMPRISING THE SAME, AND USES THEREOF
    Publication number: 20200115456
    Abstract: Provided herein is a novel antibody exhibiting binding affinity and specificity to galectin-7. Also provided herein are methods for treating psoriasis or cancer in a subject by administering to the subject a drug selected with the aid of the present anti-galectin-7 antibody.
    Type: Application
    Filed: October 15, 2019
    Publication date: April 16, 2020
    Applicant: Academia Sinica
    Inventors: Fu-Tong LIU, Hung-Lin CHEN, Po-Cheng CHIANG
  • Anti-HER2 glycoantibodies and uses thereof
    Patent number: 10618973
    Abstract: The present disclosure relates to a novel class of anti-HER2 monoclonal antibodies comprising a homogeneous population of anti-HER2 IgG molecules having the same N-glycan on each of Fc. The antibodies of the invention can be produced from anti-HER2 monoclonal antibodies by Fc glycoengineering. Importantly, the antibodies of the invention have improved therapeutic values with increased ADCC activity and increased Fc receptor binding affinity compared to the corresponding monoclonal antibodies that have not been glycoengineered.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: April 14, 2020
    Assignee: ACADEMIA SINICA
    Inventors: Chi-Huey Wong, Chung-Yi Wu
  • extract and uses thereof
    Patent number: 10610557
    Abstract: Disclosed herein is the novel use of use of a Bauhinia spp. extract, which may upregulate neprilysin, induce autophagy, protect neuron from amyloidopathy or tauopathy, and/or promote neurite outgrowth, thus the Bauhinia spp. extract of the present disclosure may be used as a dietary supplement for the prophylaxis or treatment of amyloid related neurodegenerative diseases so as to ameliorate or alleviate symptoms associated with the amyloid related neurodegenerative diseases.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: April 7, 2020
    Assignees: ACADEMIA SINICA, INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Chang-Jen Huang, Rita P.-Y. Chen, Yung-Feng Liao, Bo-Kai Wu, Po-Ting Chen, Hui-Ping Tsai, Yi-Cheng Cheng, Cheng-Li Fang, Hung-Chi Chien, Tien-Soung Tong, Ting-Shou Chen, Shu-Jiau Chiou
  • Method and device for detecting charged particles
    Patent number: 10605755
    Abstract: The present invention relates to a device for detecting charged particles (e.g., ions). The device includes components arranged to neutralize or strip the charges of ions generated from a sample material, in which the charge stripping events produce signals that can be detected subsequently by a detector. A method for detecting charged particles generated from a sample material using the device is also provided.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: March 31, 2020
    Assignee: Academia Sinica
    Inventor: Yi-Sheng Wang
  • Development of a standardized and effect-optimized herbal extract of and its use for treating disease
    Patent number: 10603346
    Abstract: A method for preparing a standardized Wedelia chinensis extract and an extract prepared by the method. Also provided is a method for qualifying the standardized extract by characterizing its most abundant compounds and its biological activity in vitro. Additionally, a method is provided for treating an androgen-stimulated disorder with the qualified Wedelia chinensis extract.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: March 31, 2020
    Assignee: Academia Sinica
    Inventors: Pei-wen Hsiao, Chin-hsien Tsai, Shih-chuan Hsieh
  • Engineered enzyme for enzyme replacement therapy
    Patent number: 10604747
    Abstract: An engineered enzyme, comprising an amino acid sequence that is at least 80% identical to the amino acid sequence of a human beta-glucuronidase, wherein the engineered enzyme exhibits a higher level of alpha-iduronidase enzymatic activity as compared to the human beta-glucuronidase.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: March 31, 2020
    Assignee: Academia Sinica
    Inventors: Steve Roffler, Huai-Yao Chuang
  • 4,9-DIOXO-4,9-DIHYDRONAPHTHO[2,3-B]FURAN-3-CARBOXAMIDE DERIVATIVES AND USES THEREOF FOR TREATING PROLIFERATIVE DISEASES AND INFECTIOUS DISEASES
    Publication number: 20200095233
    Abstract: The present disclosure provides compounds of Formulas (I), (II), and pharmaceutically acceptable salts thereof. The compounds described herein are useful in treating proliferative diseases, for example, cancer (e.g., lung cancer), and infectious diseases (e.g., bacterial infections).
    Type: Application
    Filed: February 28, 2017
    Publication date: March 26, 2020
    Applicants: Academia Sinica, National Taiwan University
    Inventors: Chi-Huey Wong, Pan-Chyr Yang, Rong-Jie Chein, Szu-Hua Pan, Ting-Jen R. Cheng