Patents Assigned to Academia Sinica
  • METHODS AND KITS FOR DIAGNOSING AND/OR TREATING PERIPHERAL NEUROPATHY
    Publication number: 20210355207
    Abstract: Disclosed herein are method and/or kit for rendering a diagnosis on whether a subject is suffering from peripheral neuropathy pain. The method comprises detecting the presence of advillin in a biological sample by forming an immune complex between advillin and a monoclonal antibody specifically binds thereto. Also disclosed herein is a method of treating a subject suffering from peripheral neuropathy pain.
    Type: Application
    Filed: March 5, 2019
    Publication date: November 18, 2021
    Applicant: Academia Sinica
    Inventors: Chih-Cheng CHEN, Yu-Chia CHUANG
  • Mixing circuit
    Patent number: 11171608
    Abstract: The present invention is to provide a mixing circuit, comprising: a first transistor; a second transistor; a third transistor; a first connection point connected to a gate terminal of the first transistor, a drain terminal of the second transistor and a source terminal of the third transistor; a second connection point connected to a source terminal of the first transistor and a gate terminal of the second transistor; and a third connection point connected to a drain terminal of the first transistor and a drain terminal of the third transistor.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: November 9, 2021
    Assignee: ACADEMIA SINICA
    Inventors: Yi-Ching Wu, Yuh-Jing Hwang, Chau-Ching Chiong, Bo-Ze Lu, Huei Wang
  • DIGITAL POLYMERASE CHAIN REACTION METHOD FOR DETECTING NUCLEIC ACIDS IN SAMPLES
    Publication number: 20210340611
    Abstract: The present invention relates to a method for detecting nucleic acid (NA) molecules in samples. More particularly, the present invention relates to an improved digital PCR-based method for detecting specific nucleic acid sequence(s). The present invention is useful for research and diagnostic applications with increased sensitivity and accuracy. The present invention also provides a kit for performing the method for assessingnucleic acids in samples as described herein.
    Type: Application
    Filed: October 9, 2019
    Publication date: November 4, 2021
    Applicant: ACADEMIA SINICA
    Inventor: Kuo-Ping CHIU
  • MEDIUM COMPOSITION AND METHOD FOR CULTURING MESENCHYMAL STEM CELLS
    Publication number: 20210324335
    Abstract: The present invention generally relates to a medium composition and method for culturing mesenchymal stem cells (MSCs), in which the medium comprises an epithelial cell adhesion molecule (EpCAM) peptide, particularly a truncated EpCAM polypeptide containing the extracellular domain (EpEX). It significantly enhances cell proliferation and multipotency of the MSCs.
    Type: Application
    Filed: September 3, 2019
    Publication date: October 21, 2021
    Applicant: ACADEMIA SINICA
    Inventors: Han-Chung WU, I-I KUAN, Chien-Hsu CHEN
  • Methods of treating viral infection
    Patent number: 11142795
    Abstract: Disclosed herein is a novel use of C-type lectin 18 (CLEC18) in disease prognosis. According to embodiments of the present disclosure, the mRNA or protein level of CLEC18 may serve as an indicator for diagnosing hepatitis B virus (HBV) infection, hepatitis B e antigen (HBeAg) loss and seroconversion, and/or liver fibrosis.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: October 12, 2021
    Assignee: ACADEMIA SINICA
    Inventors: Shie-Liang Hsieh, Ya-Lang Huang, Tsung-Yu Tsai
  • Octasaccharides and uses thereof
    Patent number: 11141428
    Abstract: Disclosed herein is a sulfated octasacchande of formula (I), a pharmaceutically acceptable salt, solvate or ester thereof: wherein R1 is —NHAc or —NHSO3H; and R2 and R3 are independently H, or —SO3H. Also encompasses herein is a method of treating neuron injury and/or diseases associated with a disrupted autophagy flux. The method includes administering an effective amount of the sulfated octasaccharide of formula (I) to a subject in need of such treatment.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: October 12, 2021
    Assignee: Academia Sinica
    Inventors: Shang-Cheng Hung, Kenji Kadomatsu, Kazuma Sakamoto, Yen-Chun Ko, Cheng-Fang Tsai, Chiao-Yuan Fan
  • Reloadable hydrogel system comprising an anti-PEG antibody for treating myocardial infarction
    Patent number: 11135164
    Abstract: A drug delivery system and methods of using such for delivering a peglyated therapeutic agent to heart. The drug delivery system may comprise an antibody embedded in a hydrogel, comprising one or more biodegradable polymers, up to about 60% of which contain inter-chain or intra-chain covalent crosslinks.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: October 5, 2021
    Assignee: ACADEMIA SINICA
    Inventors: Patrick C. H. Hsieh, David Lundy, Christopher Yu-Tai Yen
  • A BIOMARKER AND TARGET FOR DIAGNOSIS, PROGNOSIS AND TREATMENT OF ANKYLOSING SPONDYLITIS
    Publication number: 20210301318
    Abstract: The present invention relates to a biomarker and target for diagnosis, prognosis and treatment of ankylosing spondylitis (AS). The present invention also relates to a method for producing an animal model for AS, an animal model produced therefrom, and a method for screening for an agent pharmaceutically active in the treatment of A S using such animal model.
    Type: Application
    Filed: July 10, 2019
    Publication date: September 30, 2021
    Applicants: ACADEMIA SINICA, BUDDHIST TZU CHI MEDICAL FOUNDATION, CHINA MEDICAL UNIVERSITY
    Inventors: Kuo-I LIN, Shih-Chieh HUNG, Chin-Hsiu LIU
  • ANTI-SIGLEC ANTIBODY, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USES THEREOF
    Publication number: 20210292413
    Abstract: Disclosed herein is a novel monoclonal antibody exhibiting binding affinity to Siglec-3 receptor. According to the embodiment, the monoclonal antibody is capable of reversing HBV-induced immunosuppression. Accordingly, also disclosed herein are the uses thereof in the treatment and/or prophylaxis of hepatitis B virus (HBV) infection.
    Type: Application
    Filed: September 25, 2018
    Publication date: September 23, 2021
    Applicant: Academia Sinica
    Inventors: Shie-Liang HSIEH, Tsung-Yu TSAI, An-Suei YANG, Chung-Ming YU, Cheng-Yuan PENG
  • CONDITIONAL INTERNALIZATION OF PEGYLATED AGENTS BY PRETARGETING BI-SPECIFIC PEG-BINDING ANTIBODIES FOR DIAGNOSIS AND THERAPY
    Publication number: 20210292438
    Abstract: A monomeric bispecific polyethylene glycol (PEG) engager that includes an anti-PEG Fab fused to a disulfide stabilized scFv that specifically binds to a cell surface antigen. The PEG engager, in the absence of PEG, remains monomeric upon binding to the cell surface antigen on a cell and remains on the surface of the cell. Also disclosed is a method for treating cancer by administering a PEG engager followed by a PEGylated anti-cancer agent. Further disclosed is a method for diagnosing a cell-mediated disorder by administering a PEG engager followed by a PEGylated diagnostic agent.
    Type: Application
    Filed: June 7, 2021
    Publication date: September 23, 2021
    Applicant: ACADEMIA SINICA
    Inventors: Steve ROFFLER, Tian-Lu Cheng, Yu-Cheng Su, Kuo-Hsiang Chuang
  • Baculovirus and composition for detection and preventing of porcine epidemic diarrhea virus infection
    Patent number: 11123424
    Abstract: A baculovirus displaying a porcine epidemic diarrhea virus S protein or S1 domain thereof is provided for preventing porcine epidemic diarrhea virus infection.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: September 21, 2021
    Assignee: ACADEMIA SINICA
    Inventors: Yu-Chan Chao, Wei-Ting Hsu, Hui-Wen Chang, Chia-Yu Chang
  • High performance liquid chromatography with UV-visible detection
    Patent number: 11119078
    Abstract: Apparatus and methods for high performance liquid chromatography. The apparatus includes a preparation loop comprising two linear stepping pumps, a sample loop comprising a sample injector, a chromatography column, and a detector device. The detector device can include a flash lamp, a flow cell, and a light sensor comprising an entrance slit, a grating; and a charge-coupled device array.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: September 14, 2021
    Assignee: ACADEMIA SINICA
    Inventors: Chung-Hsuan Chen, Chen-Yu Hsieh, Jung-Lee Lin
  • METHODS FOR ENHANCING PERMEABILITY TO BLOOD-BRAIN BARRIER, AND USES THEREOF
    Publication number: 20210275640
    Abstract: Disclosed herein is a method of facilitating the delivery of an agent across blood-brain barrier (BBB) of a subject. The method includes administering to the subject in sequence or concomitantly, an effective amount of a growth factor selected from the group consisting of, vascular endothelial growth factor (VEGF), insulin-like growth factor I (IGF-1), IGF-II, a portion thereof and a combination thereof; and an agent that is any of a therapeutic agent or an imaging agent. The administered amount of the growth factor is capable of transiently increasing BBB permeability of the subject and thereby allowing the agent to be delivered across BBB. Also disclosed herein is a method of treating a subject suffering from a brain tumor, a brain stroke, a neuropsychiatric disorder and/or a neurodegenerative disease.
    Type: Application
    Filed: May 21, 2021
    Publication date: September 9, 2021
    Applicant: ACADEMIA SINICA
    Inventors: Patrick C.H. Hsieh, David Lundy
  • Epitope-substituted vaccine for use in improving safety and immunogenicity against dengue viruses
    Patent number: 11111276
    Abstract: Isolated mutant dengue virus E protein variants are disclosed. The variant comprises an amino acid sequence that is at least 80% identical to SEQ ID NO: 1 and has one or more amino acid residue substitutions at position corresponding to Asn8 (N8), Arg9 (R9), Val12 (V 12) and/or Glu13 (E13). The variant may comprise an amino acid sequence that is at least 90% identical to the SEQ ID NO: 1 and lack an infection-enhancing antibody-binding motif comprising the amino acid sequence of SEQ ID NO: 28 at domain I. An isolated nucleic acid sequence encoding the variant, a plasmid expressing the variant, a plasmid expressing a virus-like particle comprising the variant, a DNA vaccine, and a method of detecting the presence of a dengue virus in a biological sample are also disclosed.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: September 7, 2021
    Assignee: ACADEMIA SINICA
    Inventors: Han-Chung Wu, Chung-Tao Tang
  • Glycoconjugate vaccines, preparation method and uses thereof
    Patent number: 11103567
    Abstract: Disclosed herein is a glycoconjugate vaccine conferring protection against a Gram negative pathogen infection, a method of manufacturing the glycoconjugate vaccine, and use of the glycoconjugate vaccine for treating bacterial infection. The glycoconjugate vaccine of the present disclosure has the structure of formula (I), wherein, L is a maleimide-type linker, which is connected to the carrier protein via a maleimide bond formed therebetween; and n and m are independently an integral or a non-integral number between 2 and 20.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: August 31, 2021
    Assignee: ACADEMIA SINICA
    Inventors: Shih-Hsiung Wu, Chung-Yi Wu, I-Ming Lee, Feng-Ling Yang
  • Apparatus and method for enhancing figure of merit in composite thermoelectric materials with aerogel
    Patent number: 11107963
    Abstract: At least one of the present embodiments generally relates to an apparatus and a method for enhancing the figure of merit (zT) in composite thermoelectric materials using aerogel such as e.g., silicate/silica aerogel, carbon aerogel, chalcogenide aerogel and metal oxide aerogel. For example, the present embodiments provide apparatuses and methods for the addition of aerogels to two commonly used p and n type thermoelectric materials and thereby enhancing their thermoelectric figure of merits to record levels.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: August 31, 2021
    Assignee: ACADEMIA SINICA
    Inventors: Maw-Kuen Wu, Phillip M Wu, Yang-Yuan Chen, Chung-Chieh Chang, Pai-Chun Wei, Tian-Wey Lan, Yu-Ruei Wu
  • Development of a standardized and effect-optimized herbal extract of and its use for treating disease
    Patent number: 11096977
    Abstract: A composition including a standardized Wedelia chinensis extract and a method of treating an androgen-stimulated disorder with such a composition. Also provided are a method for qualifying a standardized preparation of a Wedelia chinensis extract for treating an androgen-stimulated disorder and a method for treating said disorder with a thus qualified preparation.
    Type: Grant
    Filed: February 25, 2020
    Date of Patent: August 24, 2021
    Assignee: Academia Sinica
    Inventors: Pei-wen Hsiao, Chin-Hsien Tsai, Shih-Chuan Hsieh
  • capsule polysaccharide vaccines
    Patent number: 11097000
    Abstract: The disclosure provides various immunogens comprising a repeat unit of saccharide of Klebsiella pneumoniae CPS, which has a formula selected from the group consisting of Formulae (I) to (VI) as described herein. Also provided are vaccines including one or more immunogens selected from Formula (I) to (VI) and methods of eliciting an immune response against a Klebsiella pneumoniae and preventing infection of Klebsiella pneumoniae by using an immunogen of the invention.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: August 24, 2021
    Assignees: NATIONAL TAIWAN UNIVERSITY, ACADEMIA SINICA
    Inventors: Jin-Town Wang, Shih-Hsiung Wu, Chung-Yi Wu
  • Caveolin-1 antibody for use in treating brain inflammation and injury and improving functional recovery
    Patent number: 11097134
    Abstract: A method for treating a neurological disorder, symptom or disease that is associated with an increase in the brain levels of caveolin-1 (Cav-1) in a subject in need thereof is disclosed. The method comprises administering to the subject in need thereof a composition comprising: (a) a therapeutically effective amount of an antibody specific against the Cav-1 or an antigen-binding fragment thereof; and (b) a pharmaceutically acceptable carrier. Methods for reducing cerebral inflammation, brain tissue damage, brain neuronal death, and improving behavioral outcomes or functional recovery related to a hemorrhagic stroke in a subject in need thereof are also disclosed.
    Type: Grant
    Filed: May 14, 2020
    Date of Patent: August 24, 2021
    Assignee: ACADEMIA SINICA
    Inventors: Song-Kun Shyue, Szu-Fu Chen, Chun-Hu Wu, Che-Feng Chang
  • BIOMARKERS FOR PREDICTING PROSTATE CANCER PROGRESSION
    Publication number: 20210254168
    Abstract: The present invention relates to biomarkers, methods and assay kits for predicting prognosis and/or monitoring progression of prostate cancer. The biomarkers include a glycosyltransferases [core 1 beta-3-galactosyltransferase (C1GALT1) and/or ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3GAL1)] gene product, its saccharide substrate/product, and/or a galectin-4 gene product.
    Type: Application
    Filed: June 10, 2019
    Publication date: August 19, 2021
    Applicant: ACADEMIA SINICA
    Inventors: Pei-Wen HSIAO, Chin-Hsien TSAI, Sheue-Fen TZENG, Shih-Chuan HSIEH, Ming-Shyue LEE