Abstract: An apparatus includes a housing and a pushrod. The housing defines a delivery passage and an exit port in fluid communication with the delivery passage. At least a portion of the pushrod is movably disposed in the delivery passage. A distal end portion of the pushrod is configured to move a drug dosage form through at least a portion of the delivery passage to convey the drug dosage form through the exit port when the distal end portion of the pushrod is moved from a first position to a second position. A surface of at least one of the pushrod or the housing defining the delivery passage is nonplanar, curved and/or contoured.
Abstract: Dispensing devices and systems for oral transmucosal administration of small volume drug dosage forms to the oral mucosa are provided. The dispensing device may be a single dose applicator (SDA), or an electromechanical device comprising a means for patient identification such as a wrist worn RFID tag and annular bidirectional antenna together with a lock-out feature.
Type:
Application
Filed:
January 15, 2021
Publication date:
May 20, 2021
Applicant:
AcelRx Pharmaceuticals, Inc.
Inventors:
Andrew POUTIATINE, Bruce EDWARDS, Charles RAMPERSAUD, Pamela PALMER, Bradley BLACKWOOD, Benjamin K. YAFFE
Abstract: Dispensing devices and systems for oral transmucosal administration of small volume drug dosage forms to the oral mucosa are provided. The dispensing device may be a single dose applicator (SDA), or an electromechanical device comprising a means for patient identification such as a wrist worn RFID tag and annular bidirectional antenna together with a lock-out feature.
Type:
Grant
Filed:
September 26, 2018
Date of Patent:
January 19, 2021
Assignee:
AcelRx Pharmaceuticals, Inc.
Inventors:
Andrew Poutiatine, Bruce Edwards, Charles Rampersaud, Pamela Palmer, Bradley Blackwood, Benjamin K. Yaffe
Abstract: Systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject using a device are disclosed. The dispensing device includes a lock-out feature and a means to retard or prevent saliva and/or moisture ingress such that the drug dosage forms in the device remain dry prior to administration.
Type:
Grant
Filed:
May 8, 2017
Date of Patent:
July 14, 2020
Assignee:
AcelRx Pharmaceuticals, Inc.
Inventors:
Pamela Palmer, Andrew Poutiatine, Charles Rampersaud, Bruce Edwards, Edmond Chiu, Thomas Schreck, Stelios Tzannis, Lawrence Hamel, William Kolosi, Sascha Retailleau
Abstract: Small-volume oral transmucosal dosage forms or NanoTabs® comprising a predetermined amount of a pharmaceutically active drug are provided. Exemplary applications include use of the NanoTabs® to administer a drug for the treatment of acute, post-operative or breakthrough pain.
Type:
Application
Filed:
January 9, 2019
Publication date:
January 23, 2020
Applicant:
AcelRx Pharmaceuticals, Inc.
Inventors:
Pamela PALMER, Thomas SCHRECK, Stelios TZANNIS, Lawrence HAMEL, Andrew I. POUTIATINE
Abstract: Compositions, systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject for treatment of pain using a device are disclosed.
Type:
Grant
Filed:
October 5, 2018
Date of Patent:
December 17, 2019
Assignee:
AcelRx Pharmaceuticals, Inc.
Inventors:
Pamela Palmer, Thomas Schreck, Stelios Tzannis, Larry Hamel, Andrew I. Poutiatine
Abstract: Small-volume oral transmucosal dosage forms or NanoTabs® comprising a predetermined amount of a pharmaceutically active drug are provided. Exemplary applications include use of the NanoTabs® to administer a drug for the treatment of acute, post-operative or breakthrough pain.
Type:
Grant
Filed:
June 5, 2014
Date of Patent:
July 9, 2019
Assignee:
AcelRx Pharmaceuticals, Inc.
Inventors:
Pamela Palmer, Thomas Schreck, Stelios Tzannis, Lawrence Hamel, Andrew I. Poutiatine
Abstract: Compositions, systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject for treatment of pain using a device are disclosed.
Type:
Application
Filed:
October 5, 2018
Publication date:
May 2, 2019
Applicant:
AcelRx Pharmaceuticals, Inc.
Inventors:
Pamela PALMER, Thomas SCHRECK, Stelios TZANNIS, Larry HAMEL, Andrew I. POUTIATINE
Abstract: Compositions, systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject for treatment of pain using a device are disclosed.
Type:
Grant
Filed:
July 20, 2017
Date of Patent:
April 2, 2019
Assignee:
AcelRx Pharmaceuticals, Inc.
Inventors:
Pamela Palmer, Thomas Schreck, Stelios Tzannis, Larry Hamel, Andrew I. Poutiatine
Abstract: Dispensing devices and systems for oral transmucosal administration of small volume drug dosage forms to the oral mucosa are provided. The dispensing device may be a single dose applicator (SDA), or an electromechanical device comprising a means for patient identification such as a wrist worn RFID tag and annular bidirectional antenna together with a lock-out feature.
Type:
Application
Filed:
September 26, 2018
Publication date:
January 24, 2019
Applicant:
AcelRx Pharmaceuticals, Inc.
Inventors:
Andrew POUTIATINE, Bruce EDWARDS, Charles RAMPERSAUD, Pamela PALMER, Bradley BLACKWOOD, Benjamin K. YAFFE
Abstract: Single dose drug dosage form dispensing devices, and methods for operating such devices are disclosed herein. In one embodiment, an apparatus includes a housing defining an actuation pathway and a pusher. At least a portion of the pusher is disposed within the actuation pathway such that a distal end portion of the pusher and a distal end portion of the housing define a volume configured to contain a drug-containing tablet. The pusher is configured to move relative to the housing in a distal direction from a first position to a second position to expel the drug-containing tablet from the volume. The distal end portion of the pusher is extended from an opening in the housing when the pusher is in its second position. The housing is configured to limit movement of the pusher relative to the housing in a proximal direction from the second position of the pusher towards the first position of the pusher after the drug-containing tablet is expelled from the volume.
Abstract: Systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject using a device are disclosed. The dispensing device includes a lock-out feature and a means to retard or prevent saliva and/or moisture ingress such that the drug dosage forms in the device remain dry prior to administration.
Type:
Application
Filed:
May 8, 2017
Publication date:
September 14, 2017
Applicant:
AcelRx Pharmaceuticals, Inc.
Inventors:
Pamela PALMER, Andrew POUTIATINE, Charles RAMPERSAUD, Bruce EDWARDS, Edmond CHIU, Thomas SCHRECK, Stelios TZANNIS, Lawrence HAMEL, William KOLOSI, Sascha RETAILLEAU
Abstract: Compositions, systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject for treatment of pain using a device are disclosed.
Type:
Grant
Filed:
April 6, 2016
Date of Patent:
August 29, 2017
Assignee:
AcelRx Pharmaceuticals, Inc.
Inventors:
Pamela Palmer, Thomas Schreck, Stelios Tzannis, Larry Hamel, Andrew I. Poutiatine
Abstract: Systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject using a device are disclosed. The dispensing device includes a lock-out feature and a means to retard or prevent saliva and/or moisture ingress such that the drug dosage forms in the device remain dry prior to administration.
Type:
Grant
Filed:
June 16, 2014
Date of Patent:
May 9, 2017
Assignee:
AcelRx Pharmaceuticals, Inc.
Inventors:
Pamela Palmer, Andrew Poutiatine, Charles Rampersaud, Bruce Edwards, Edmond Chiu, Thomas Schreck, Stelios Tzannis, Lawrence Hamel, William Kolosi, Sascha Retailleau
Abstract: Dispensing devices and systems for oral transmucosal administration of small volume drug dosage forms to the oral mucosa are provided. The dispensing device may be a single dose applicator (SDA), or an electromechanical device comprising a means for patient identification such as a wrist worn RFID tag and annular bidirectional antenna together with a lock-out feature.
Type:
Application
Filed:
October 13, 2016
Publication date:
April 6, 2017
Applicant:
AcelRx Pharmaceuticals, Inc.
Inventors:
Andrew POUTIATINE, Bruce EDWARDS, Charles RAMPERSAUD, Pamela PALMER, Bradley BLACKWOOD, Benjamin K. YAFFE
Abstract: Compositions, systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject for treatment of pain using a device are disclosed.
Type:
Application
Filed:
April 6, 2016
Publication date:
July 28, 2016
Applicant:
AcelRx Pharmaceuticals, Inc.
Inventors:
Pamela PALMER, Thomas SCHRECK, Stelios TZANNIS, Larry HAMEL, Andrew I. POUTIATINE
Abstract: An apparatus includes a housing and a pushrod. The housing defines a delivery passage and an exit port in fluid communication with the delivery passage. At least a portion of the pushrod is movably disposed in the delivery passage. A distal end portion of the pushrod is configured to move a drug dosage form through at least a portion of the delivery passage to convey the drug dosage form through the exit port when the distal end portion of the pushrod is moved from a first position to a second position. A surface of at least one of the pushrod or the housing defining the delivery passage is nonplanar, curved and/or contoured.
Abstract: Compositions, systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject for treatment of pain using a device are disclosed.
Type:
Grant
Filed:
October 17, 2014
Date of Patent:
April 26, 2016
Assignee:
AcelRX Pharmaceuticals, Inc.
Inventors:
Pamela Palmer, Thomas Schreck, Stelios Tzannis, Larry Hamel, Andrew I. Poutiatine
Abstract: Systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject using a device are disclosed. The dispensing device includes a lock-out feature and a means to retard or prevent saliva and/or moisture ingress such that the drug dosage forms in the device remain dry prior to administration.
Type:
Grant
Filed:
October 30, 2007
Date of Patent:
March 22, 2016
Assignee:
AcelRx Pharmaceuticals, Inc.
Inventors:
Pamela Palmer, Andrew I Poutiatine, Charles Rampersaud, Bruce Edwards, Edmond Chiu, Thomas Schreck, Stelios Tzannis, Larry Hamel
Abstract: Compositions, systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject for treatment of pain using a device are disclosed.
Type:
Application
Filed:
October 17, 2014
Publication date:
April 16, 2015
Applicant:
AcelRx Pharmaceuticals, Inc.
Inventors:
Pamela Palmer, Thomas Schreck, Stelios Tzannis, Larry Hamel, Andrew I. Poutiatine