Abstract: The invention relates to compounds of the formula I: ##STR1## in which R.sub.1 is as defined in the description, their optical isomers and their addition salts with a pharmaceutically-acceptable acid or base, andmedicinal products which are useful for treating Central Nervous System disorders.
Type:
Grant
Filed:
October 12, 1993
Date of Patent:
December 6, 1994
Assignee:
Adir et Compagnie
Inventors:
Gerald Guillaumet, Gerard Coudert, Tchao Podona, Beatrice Guardiola-Lemaitre, Pierre Renard, Gerard Adam, Daniel Henri-Caignard
Abstract: The invention relates to a compound of formula (I): ##STR1## in which: R.sub.1 represents hydrogen or halogen, alkyl, alkoxy, cyano or aminocarbonyl or any one of the following: ##STR2## in which: m is equal to 1, 2 or 3,n is equal to 0, 1 or 2,T represents a CO or SO.sub.2,R.sub.4 or R.sub.5, which are identical or different, represent hydrogen or alkyl or phenyl,R.sub.2 represents hydrogen or alkyl, phenyl or acyl,R.sub.3 represents hydrogen, alkyl (optionally substituted by hydroxyl or phenyl) or alkoxycarbonyl,--X--Y.dbd. represents --N--C.dbd., --N--N.dbd.or else ##STR3## represents --O--N.dbd.; to its enantiomers, diastereoisomers and epimers and to its addition salts with a pharmaceutically acceptable acid.
Type:
Grant
Filed:
February 1, 1994
Date of Patent:
September 20, 1994
Assignee:
Adir et Compagnie
Inventors:
Gilbert Lavielle, Philippe Maillos, Olivier Muller, Michel Laubie, Tony Verbeuren, Jean-Jacques Descombes
Abstract: The invention relates to compounds of the formula (I): ##STR1## in which: Z represents an oxygen atom or a sulfur atom,R.sub.1 represents a hydrogen atom or an alkyl group,R.sub.2 represents a hydrogen atom or an alkyl group,n is one to six, inclusive,R.sub.3 represents an amino group, substituted with phenylsulfonyl, andmedicinal products containing the same.
Abstract: A compound selected from those of formula (I): ##STR1## with R.sub.1, R.sub.2 and n as defined in the description, and medicinal products containing the same useful in treating or in preventing a disorder resulting from cellular damages following upon ischemia, hypoxia, or anoxia.
Type:
Grant
Filed:
August 13, 1992
Date of Patent:
August 23, 1994
Assignee:
ADIR et Compagnie
Inventors:
Michel Gaudry, Bruno Pfeiffer, Pierre Renard, Jean-Francois Renaud de la Faverie, Gerard Adam
Abstract: The invention relates to a matrix tablet for the sustained release of indapamide which ensures a continuous and uniform release of the active principle after oral administration.
Type:
Grant
Filed:
June 9, 1992
Date of Patent:
August 2, 1994
Assignee:
Adir et Compagnie
Inventors:
Alain Cuine, Bruno H. de Barochez, David Guez
Abstract: The invention relates to compounds of the formula I: ##STR1## in which R.sub.1 is as defined in the description, their optical isomers and their addition salts with a pharmaceutically-acceptable acid or base, andmedicinal products which are useful for treating Central Nervous System disorders.
Type:
Grant
Filed:
May 17, 1993
Date of Patent:
July 26, 1994
Assignee:
Adir et Compagnie
Inventors:
Gerald Guillaumet, Gerard Coudert, Tchao Podona, Beatrice Guardiola-Lemaitre, Pierre Renard, Gerard Adam, Daniel Henri-Caignard
Abstract: Compounds of the general formula (I): ##STR1## where A, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are defined in the description.Medicinal products.
Type:
Grant
Filed:
November 14, 1991
Date of Patent:
July 26, 1994
Assignee:
Adir et Compagnie
Inventors:
Sylvain Rault, Marie P. Foloppe, Max Robba, Michel Boulouard, Pierre Renard, Michelle Devissaguet, Gerard Adam
Abstract: The invention relates to compounds of the general formula (I): ##STR1## wherein R.sub.3 represents a group ##STR2## R.sub.1, R.sub.2, R.sub.6, R.sub.7 being as defined in the description. Medicinal product useful in treating a disorder due to vasodilatation of the vascular system.
Type:
Grant
Filed:
January 21, 1993
Date of Patent:
July 26, 1994
Assignee:
Adir et Compagnie
Inventors:
Patrick Depreux, Daniel Lesieur, Habib Abdellaoui, Beatrice Guardiola, Gerard Adam, Pierre Renard, Bruno Pfeiffer
Abstract: Compounds of general formula (I): ##STR1## where R, X, A, B and p are defined in the description. Medicinal products useful for treating sleep disorders comprising the same.
Type:
Grant
Filed:
April 28, 1993
Date of Patent:
July 5, 1994
Assignee:
Adir et Compagnie
Inventors:
Said Yous, Isabelle Lesieur, Patrick Depreux, Daniel H. Caignard, Beatrice Guardiola, Gerard Adam, Pierre Renard
Abstract: Compounds of general formula (I): ##STR1## wherein R, X, A, B and p are defined in the description. Medicinal products useful for treating sleep disorders comprising the same.
Type:
Grant
Filed:
April 28, 1993
Date of Patent:
June 21, 1994
Assignee:
Adir et Compagnie
Inventors:
Said Yous, Isabelle Lesieur, Patrick Depreux, Daniel H. Caignard, Beatrice Guardiola, Gerard Adam, Pierre Renard
Abstract: Compounds of general formula (I): ##STR1## where R, X, A, B and p are defined in the description. Medicinal products useful for treating sleep disorders comprising the same.
Type:
Grant
Filed:
April 28, 1993
Date of Patent:
June 21, 1994
Assignee:
Adir Et Compagnie
Inventors:
Said Yous, Isabelle Lesieur, Patrick Depreux, Daniel H. Caignard, Beatrice Guardiola, Gerard Adam, Pierre Renard
Abstract: Process for preparing enantiomers of general formula (I): ##STR1## where Z, R.sub.1, R.sub.2, R.sub.3 and n are defined in the description. The compounds obtained according to the invention are useful as medicinal products.
Type:
Grant
Filed:
June 30, 1992
Date of Patent:
June 21, 1994
Assignee:
Adir et Compagnie
Inventors:
Gerald Guillaumet, Claude Fugier, Jean-Claude J. Souvie, Gerard Adam, Pierre Renard, Daniel-Henri Caignard
Abstract: Compounds of the formula: ##STR1## in which: A represents ##STR2## R represents linear or branched lower alkyl, R.sub.1 represents hydrogen or linear or branched lower alkyl, andR.sub.2 represents aryl or lower arylalkyl or aryl or lower arylalkyl substituted by lower alkyl, lower alkoxy, trifluoromethyl, or halogen, aryl means phenyl or naphthyl, as well as optical isomers, epimers and diastereoisomers and addition salts thereof with a pharmaceutically-acceptable acid, lower alkyl and lower alkoxy having 1 to 6 carbon atoms inclusive, andmedicaments containing the same which are useful for the treatment of disorders of the melatoninergic system.
Type:
Grant
Filed:
November 3, 1992
Date of Patent:
June 7, 1994
Assignee:
Adir et Compagnie
Inventors:
Jean Andrieux, Raymond Houssin, Said Yous, Beatrice Guardiola, Daniel Lesieur
Abstract: A compound of formula (I): ##STR1## in which: R.sub.1 and R.sub.2, which are identical or different, represent hydrogen, or alkyl, cycloalkyl or benzyl,B represents a residue of an aromatic amino acid,A represents a peptide residue comprising from one to three amino acids, in cyclic or linear form, and medicaments containing the same, are disclosed.
Type:
Grant
Filed:
June 3, 1992
Date of Patent:
May 31, 1994
Assignee:
Adir et Compagnie
Inventors:
Jean-Luc Fauchere, Nathalie Kucharczyk, Angela D. Morris, Joseph Paladino, Jacqueline Bonnet, Christophe Thurieau
Abstract: The invention relates to the derivatives of general formula (I): ##STR1## in which: Z represents an oxygen atom or a sulfur atom,R.sub.1 represents a hydrogen atom or an alkyl group,R.sub.2 represents a hydrogen atom or an alkyl group,1.ltoreq.n.ltoreq.6,R.sub.3 represents a nitrile group, an optionally substituted amino group or any one of the groups described in the description andmedicinal products containing the same.
Abstract: A compound selected from the group consisting of those of formula I ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, X and n are defined in the description, an optical isomer thereof, and an addition salt thereof with a pharmaceutically-acceptable base or acid.Medicinal product which is useful in treating or in preventing a disorder due to or linked to the phenomena of peroxidation and to the disturbance of the eicosanoid biosynthesis.
Type:
Grant
Filed:
May 1, 1992
Date of Patent:
May 24, 1994
Assignee:
Adir Et Compagnie
Inventors:
Guillaume Le Baut, Jean-Paul Babingui, Jacqueline Courant, Jean-Michel Robert, Pierre Renard, Daniel-Henri Caignard, Jean-Francois R. de la Faverie, Gerard Adam
Abstract: The invention relates to the compounds of general formula ##STR1## in which R.sub.1, R.sub.2, R.sub.4, R.sub.5 and A are as defined in the description.their isomers, diastereoisomers, and enantiomers as well as their addition salts with a pharmaceutically acceptable inorganic or organic acid, andmedicinal products containing the same which are usable for the treatment of psycho-behavioral disorders.
Type:
Grant
Filed:
May 13, 1992
Date of Patent:
May 10, 1994
Assignee:
Adir et Compagnie
Inventors:
Henri P. Husson, Jean C. Quirion, Martine Bonin, Beatrice Guardiola, Gerard Adam, Pierre Renard
Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## in which Ar', R.sub.1 and R.sub.2 are as defined in the specification, an optical isomer,and an addition salt thereof with a pharmaceutically-acceptable acid or base.Medicinal product which is useful in treating or in preventing a disorder of the melatoninergic system.
Type:
Grant
Filed:
July 19, 1993
Date of Patent:
May 3, 1994
Assignee:
Adir et Compagnie
Inventors:
Daniel Lesieur, Said Yous, Patrick Depreux, Jean Andrieux, Gerard Adam, Daniel H. Caignard, Beatrice Guardiola
Abstract: Compounds of general formula (I): ##STR1## where R, X, A, B and p are defined in the description. Medicinal products useful for treating sleeping disorders comprising the same.
Type:
Grant
Filed:
April 28, 1993
Date of Patent:
April 5, 1994
Assignee:
Adir et Compagnie
Inventors:
Said Yous, Isabelle Lesieur, Patrick Depreux, Daniel H. Caignard, Beatrice Guardiola, Gerard Adam, Pierre Renard