Patents Assigned to ADIR
  • Disubstituted polymethyleneimines
    Patent number: 5225411
    Abstract: The compounds are 2,4-(optionally substituted amino)-6-substituted s.triazines, useful for suppressing the resistance of tumour cells to anti-cancer agents and for suppressing the resistance of parasites to anti-parasitic agents.A compound disclosed is 1-[4,6-bis(allylamino)-2-s-triazinyl]-4-[2,2-bis(p.fluorophenyl)ethylamino ]piperidine.
    Type: Grant
    Filed: July 10, 1991
    Date of Patent: July 6, 1993
    Assignee: Adir et Compagnie
    Inventors: Gilbert Regnier, Alain Dhainaut, Ghanem Atassi, Alain Pierre, Stephane Leonce
  • Aminopiperidine 4-oxo-4H-chromen-2-yl compounds
    Patent number: 5214055
    Abstract: The invention relates to new compounds of formula I: ##STR1## in which: m represents zero, 1, 2, 3 or 4,n and p represent zero, 1 or 2,W represents an oxygen atom, an --NH-- radical, or a single bond,R represents a 4-oxo-4H-chromen-2-yl radical,R.sub.1 represents a hydrogen atom, an alkyl radical having from 1 to 6 carbon atoms, or an aryl radical, andR.sub.2 represents a hydrogen atom, an alkyl radical, an alkenyl radical, a cycloalkyl radical, a benzyl radical, a phenyl radical, an aralkyl radical, an alkoxyalkyl radical or a polyhalogenated alkyl radical, the optical isomers thereof and the addition salts thereof with a pharmaceutically acceptable organic or mineral acid,and medicaments containing the same, are disclosed.
    Type: Grant
    Filed: April 15, 1992
    Date of Patent: May 25, 1993
    Assignee: Adir et Compagnie
    Inventors: Jean-Louis Peglion, Francis Colpaert
  • 4-aminobutyric acid compounds, compositions and methods of use for treating disorders related to a dysfunction of GABA.sub.B receptors
    Patent number: 5214063
    Abstract: A compound of formula (I): ##STR1## in which R, R.sub.1 and R.sub.2 are as defined in the description. Medicinal product, which is useful in treating disorders related to a dysfunction of GABA.sub.B receptors.
    Type: Grant
    Filed: July 28, 1992
    Date of Patent: May 25, 1993
    Assignee: Adir et Compagnie
    Inventors: Michel Debaert, Pascal Berthelot, Claude Vaccher
  • 5-isoquinolinesulfonamides
    Patent number: 5208243
    Abstract: Compounds of formula (I): ##STR1## with R.sub.1, R.sub.2, U, X, Y, Z, n, m, p and r as defined in the description.Medicinal products.
    Type: Grant
    Filed: July 30, 1992
    Date of Patent: May 4, 1993
    Assignee: Adir et Compagnie
    Inventors: Jean-Louis Peglion, Jean-Paul Vilaine, Nicole Villeneuve, Philip Janiak
  • Spiro(4.5.)decane compounds
    Patent number: 5206247
    Abstract: The compounds are 8-substituted 1-oxa-2-oxo-3,8-diazaspiro [4.5]decanes useful for the treatment of dyslipidaemiae, atherosclerosis and pathologies in which membrane lipid peroxidation plays an initiating and/or aggravating role.A compound disclosed is (R,S)-8-[3(3,5-di-tert.-butyl-4-hydroxyphenylthio)-2-hydroxypropyl]-1-oxa- 2oxo-3,8-diazaspiro [4.5]decane.
    Type: Grant
    Filed: September 5, 1991
    Date of Patent: April 27, 1993
    Assignee: Adir Et Compagnie
    Inventors: Gilbert Regnier, Claude Guillonneau, Jean-Paul Vilaine, Albert Lenaers, Jean-Pierre Iliou
  • Use of N-(1-hexahydroazepinylalkyl) acetamides for the treatment of cholinergic transmission disorders
    Patent number: 5200405
    Abstract: The invention relates to the use of a compound selected from those of formula (I): ##STR1## in which R, R.sub.1, R.sub.2 and n are as defined in the description, for the treatment of cholinergic transmission disorders.
    Type: Grant
    Filed: September 11, 1991
    Date of Patent: April 6, 1993
    Assignee: Adir et Compagnie
    Inventors: Maurice Israel, Yvette Morot-Gaudry, Max Robba, Gerard Adam, Pierre Renard
  • Heterocycle-substituted alkylamines compounds
    Patent number: 5196434
    Abstract: Compound of general formula (I): ##STR1## where R.sub.1, R.sub.2, R.sub.3, n, X and A are defined in the description.Medicinal products.
    Type: Grant
    Filed: September 26, 1991
    Date of Patent: March 23, 1993
    Assignee: Adir et Compagnie
    Inventors: Thierry Taverne, Isabelle Lesieur, Patrick Depreux, Daniel H. Caignard, Beatrice Guardiola, Gerard Adam, Pierre Renard
  • 1,4-disubstituted piperazines
    Patent number: 5194437
    Abstract: The compounds are 1,4-disubstituted piperazines useful for the treatment of disorders of central nervous system and neuroendocrine disorders.A compound disclosed is (R,S)-4-(benzodioxan-5-yl)-1-[(benzocyclobutan-1-yl)methyl]piperazine.
    Type: Grant
    Filed: December 13, 1991
    Date of Patent: March 16, 1993
    Assignee: Adir et Compagnie
    Inventors: Jean-Louis Peglion, Mark Millan, Jean-Michel Rivet
  • Compounds having a naphthalene structure
    Patent number: 5194614
    Abstract: Compounds of general formula: ##STR1## in which A and R are defined in the description.
    Type: Grant
    Filed: February 26, 1991
    Date of Patent: March 16, 1993
    Assignee: Adir et Compagnie
    Inventors: Jean Andrieux, Raymond Houssin, Said Yous, Beatrice Guardiola, Daniel Lesieur
  • New aminomethylpiperidine compounds
    Patent number: 5192775
    Abstract: The invention relates to compounds of general formula (I). ##STR1## in which X represents an atom of sulfur or oxygen, or a substituted or unsubstituted amino group;R represents a hydrogen atom or any one of groups A, B, C, D, E, F, or G;R' represents a hydrogen atom, an alkyl group or any one of groups A, B, C, D, E or F, with R'=H when R=G;or R and R' form, with the nitrogen atom to which they are attached, an optionally substituted piperazine ring. Medicaments.
    Type: Grant
    Filed: February 26, 1991
    Date of Patent: March 9, 1993
    Assignee: Adir et Compagnie
    Inventors: Charles Malen, Guillaume de Nanteuil, Francis Colpaert
  • Medicinal oxazolopyridine compounds
    Patent number: 5190960
    Abstract: Compounds of general formula (I): ##STR1## in which: R.sub.1 and R.sub.2 each represent a hydrogen atom or, with the nitrogen and oxygen which bear them, form an --O--CO--N link,W represents a halogen atom or a lower alkyl or alkoxy group optionally substituted with one or more halogen atoms, such as trifluoromethyl, and m being between 0 and 3,A is a linear or branched alkyl radical comprising from 1 to 6 carbon atoms,R.sub.3 and R.sub.4 are defined in the description.
    Type: Grant
    Filed: November 12, 1991
    Date of Patent: March 2, 1993
    Assignee: Adir et Compagnie
    Inventors: Gerald Guillaumet, Christine Flouzat, Daniel H. Caignard, Pierre Renard, Michelle Devissaguet, Beatrice Guardiola
  • Pyrrolo [1,2-a] thieno [3,2-f] (1,4) diazepines
    Patent number: 5190939
    Abstract: The invention relates to compounds of general formula I: ##STR1## in which: R.sub.1 represents a radical of general formula (Z.sub.0), (Z.sub.1), (Z.sub.2), (Z.sub.3) or (Z.sub.4) ##STR2## R.sub.2 represents a methylene radical, a hydroxymethylene radical, a carbonyl radical or a radical of general formula (Y.sub.1), (Y.sub.2), (Y.sub.3) or (Y.sub.4): ##STR3## or, with R.sub.12 and the nitrogen atom to which they are attached, forms a radical of general formula (W): ##STR4## R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12 and n being as defined in the description, medicinal products containing the same and a method-of-treating metabolic ailments therewith.
    Type: Grant
    Filed: March 7, 1991
    Date of Patent: March 2, 1993
    Assignee: Adir et Compagnie
    Inventors: Sylvain Rault, Michel Boulouard, Patrick Dallemagne, Max Robba, Beatrice Guardiola, Michelle Devissaguet
  • Peptide compounds containing a cyclic amide structure
    Patent number: 5190923
    Abstract: The invention relates to compounds of formula (I): ##STR1## in which: A represents, with the carbon and nitrogen atoms to which it is linked, cyclic amide as defined in the description,B represents, with the nitrogen and carbon atoms to which it is linked, saturated polycyclic structure as defined in the description,R represents hydrogen, optionally substituted lower alkyl, optionally substituted (4-imidazolyl)methyl, (3-pyrazolyl)methyl or optionally substituted (2-pyridyl)methyl,their enantiomers, diastereoisomers and epimers as well as their addition salts with a pharmaceutically acceptable acid.Medicinal products.
    Type: Grant
    Filed: June 4, 1991
    Date of Patent: March 2, 1993
    Assignee: Adir Et Compagnie
    Inventors: Michel Vincent, Georges Remond, Bernard Portevin, Yolande Herve, Jean Lepagnol
  • Aminopiperidine indanyl and benzocyclobutene compounds
    Patent number: 5189045
    Abstract: The invention relates to new compounds of formula I: ##STR1## in which: m represents zero, 1, 2, 3 or 4,n and p represent zero, 1 or 2,W represents an oxygen atom, an --NH-- radical, or a single bond,R represents a benzocyclobuten-1-yl radical, or an indanyl radical, a 2,3-dihydrobenzofuran-2-ylR.sub.1 represents a hydrogen atom, an alkyl radical having from 1 to 6 carbon atoms, or an aryl radical, andR.sub.2 represents a hydrogen atom, an alkyl radical, an alkenyl radical, a cycloalkyl radical, a benzyl radical, a phenyl radical, an aralkyl radical, an alkoxyalkyl radical or a polyhalogenated alkyl radical, the optical isomers thereof and the addition salts thereof with a pharmaceutically acceptable organic or mineral acid, and medicaments containing the same.
    Type: Grant
    Filed: May 17, 1991
    Date of Patent: February 23, 1993
    Assignee: Adir et Compagnie
    Inventors: Jean-Louis Peglion, Francis Colpaert
  • Analgesic benzoxazolinones having at the 6-position a 1-hydroxy-3-morpholinopropyl side chain
    Patent number: 5182278
    Abstract: Compounds of general formula (I): ##STR1## in which: R.sub.1 denotes a hydrogen atom or a lower alkyl optionally substituted with a hydroxyl group,R.sub.2 and R.sub.3 :a- identical or different, denote a hydrogen atom, a lower alkyl, a lower alkenyl, a substituted or unsubstituted aryl, a substituted or unsubstituted (lower alkyl)aryl,b- are such that they form, with the nitrogen which carries them, a saturated or unsaturated, mono- or bicyclic heterocyclic system containing at most 3 hetero atoms per ring, substituted or unsubstituted, with the exception of 1-arylpiperazine systems,X denotes a hydrogen atom,Y denotes a hydrogen atom or a hydroxyl,or alternatively X and Y denote an oxygen atom, provided thatR.sub.1 is then other than a methyl group,Z denotes a hydrogen atom or forms a .pi.
    Type: Grant
    Filed: July 29, 1991
    Date of Patent: January 26, 1993
    Assignee: Adir et Compagnie
    Inventors: Daniel Lesieur, Charles Lespagnol, Jacqueline Bonnet
  • Chalcones
    Patent number: 5179091
    Abstract: Compounds of general formula (I): in which: ##STR1## R.sub.1, X, Y, Z, T, R.sub.2, R.sub.3 and R.sub.4 are defined in the description. Medicinal products.
    Type: Grant
    Filed: June 3, 1991
    Date of Patent: January 12, 1993
    Assignee: Adir et Compagnie
    Inventors: Daniel Lesieur, Daniel H. Caignard, Isabelle Lesieur, Michelle Devissaguet, Beatrice Guardiola
  • New thiophene compounds as intermediates
    Patent number: 5175294
    Abstract: New thiophene compounds of the formula: ##STR1## in which: X represents hydrogen, halogen, C.sub.1 -C.sub.5 alkyl or alkoxy or dialkylamino;n represents 1 or 2;a represents an integer of from 2 to 6;b represents 2 or 3;c represents 1 or 2, and is such that b+c=4;R.sub.1 and R.sub.2 represent hydrogen or (C.sub.1 -C.sub.5)alkyl, or together with the carbon atom to which they are bonded form a hydrocarbon ring containing from 3 to 6 carbon atoms; andR and R' represent hydrogen or (C.sub.1 -C.sub.5)alkyl, or together with the nitrogen atom to which they are bonded form a pentagonal or hexagonal heterocycle optionally containing an oxygen atom or a second nitrogen atom which may itself be substituted; and their physiologically tolerable salts.The products of the invention can be used therapeutically especially in the treatment of pathologies that are characterized by a loss of bone tissue.
    Type: Grant
    Filed: August 5, 1991
    Date of Patent: December 29, 1992
    Assignee: Adir et Compagnie
    Inventors: Michel Wierzbicki, Frederic Sauveur, Jacqueline Bonnet, Martine Brisset, Charles Tordjman
  • Benzisoxazole and benzisothiazole compounds
    Patent number: 5173490
    Abstract: The compounds are N-substituted N'-(benzisoxazolyl or benzisothiazolyl) piperazines useful as sedative, anxiolytic, anti-aggressive and analgesic agents and for the treatment of schizophrenia and depression.A compound disclosed is (R,S)-3-{1-[(benzocyclobutan-1-yl)methyl]piperazin-4-yl}-6-fluoro-1,2-benz isoxazole.
    Type: Grant
    Filed: January 7, 1992
    Date of Patent: December 22, 1992
    Assignee: Adir et Compagnie
    Inventors: Jean-Louis Peglion, Joel Vian
  • Pharmaceutical compositions and a method for the treatment of memory disorders, intellectual disorders of ageing and Alzheimer's disease
    Patent number: 5173491
    Abstract: 1,3,7-trimethyl-8-[3-(4-diethylaminocarbonyl-piperazino) propyl] xanthine and physiologically tolerable acid addition salts thereof may be used for the preparation of medicaments for the treatment of memory disorders, intellectual disorders of ageing, and Alzheimer's disease.
    Type: Grant
    Filed: September 20, 1990
    Date of Patent: December 22, 1992
    Assignee: Adir et Compagnie
    Inventors: Annie Kamoun, Elisabeth Mocaer, Gilbert Regnier, Claude Guillonneau, Jacques Duhault
  • Substituted trifluoropropan-1-yl-imidazole alpha 2-receptor anagonists
    Patent number: 5173502
    Abstract: A compound selected from those of formula (I): ##STR1## in which R represents straight-chain or branched lower (C.sub.1 -C.sub.6) alkyl, (C.sub.3 -C.sub.8) cycloalkyl, optionally substituted phenyl, pyridyl or naphthyl, andR.sub.1 and R.sub.2, which are the same or different, each represents hydrogen, straight-chain or branched (C.sub.1 -C.sub.6) alkyl, or straight-chain or branched (C.sub.1 -C.sub.6) acyl,an enantiomer, diastereoisomer and epimer, and an addition salt thereof with a pharmaceutically-acceptable acid.Medicinal product, which is useful as .alpha..sub.2 -antagonist.
    Type: Grant
    Filed: November 1, 1991
    Date of Patent: December 22, 1992
    Assignee: Adir et Compagnie
    Inventors: Charles Malen, Guillaume de Nanteuil