Abstract: Described herein is a comprehensive novel amplification system that can employ novel nucleic acid constructs as blocked primers, such constructs including a target-specific region, wherein the target-specific region comprises a target-specific cleavage domain, and a universal adapter sequence located 5? of the target-specific region, wherein the universal adapter sequence comprises a non-natural nucleotide base. Also described is a fusion protein between a polymerase and an endonuclease, which is useful in this system, as well as related methods and kits.

Abstract: Among the various aspects of the present disclosure is the provision of methods of diagnosing and treating inflammatory bowel disease (IBD) including ulcerative colitis (UC) or Crohn's disease (CD). In particular, the present disclosure provides in part a panel of IBD biomarkers useful in diagnosing and making treatment decisions. In addition, the present disclosure provides methods of treating IBD with a plasminogen activator inhibitor-1 (PAI-1) inhibitor or tissue plasminogen activator (tPA).

Abstract: Temporal information is traversed and manipulated in response to user input and the advancement of time. A timeline is traversed by a present or user-specified time and by upwards and downwards traversal from there for the appearance of anterior and posterior temporal information. An initial positioning toward the center of this timeline permits its bidirectional traversal without the necessity of prepending or appending additional temporal information. Temporal strings are populated with dynamic references to a present date and syntactically normalized. Timetables containing dates are compressed to the eviction of dates absent of temporal information; moreover, they skip over empty periods and efface indicia for traversal toward posterior and anterior periods barring temporal information on them. A plurality of timetables concurrently display and up-date.

Abstract: An expansion control assembly may include a stabilizer connected to a deck frame, the stabilizer having a lateral receiver and a sliding member extending through the lateral receiver, the sliding member connected to an adjustable side deck. An expansion control assembly may include a bottom bracket connected to the stabilizer, the bottom bracket comprising a first retaining element and a second retaining element. An expansion control assembly may include a latch pivotally connected to the adjustable side deck, the latch comprising a first tab and an engaging element configured to engage the first retaining element and the second retaining element. Methods of moving an adjustable side deck may include rotation of the latch away from the bottom bracket and sliding the latch away from, or towards, the deck frame.

Abstract: A base for a rear-mounted bicycle rack, ski rack, baggage rack, or baggage carrier for a motor vehicle includes: a portion for association with a tow hook of the motor vehicle; and a frame. The base includes means for a horizontal translation of the frame, and means for a rotation of the frame about a substantially horizontal axis.

Abstract: The invention relates to a method for optimizing the energy consumption of a motor vehicle comprising a battery (30), an internal combustion engine (M), an electric machine (ME), a plurality of devices, each characterized by at least one state variable, and a computer (40) capable of controlling the internal combustion engine (M) and the electric machine (ME), said method being notable in that it comprises the steps of: a) defining a prediction period, b) determining the maximum theoretical variation of each state variable over the prediction period, c) determining the range of applicable setpoints in which each setpoint value is selected so that the variation of each state variable satisfies the maximum theoretical variation thereof, d) determining the value of an internal combustion setpoint and the value of an electric setpoint, in the range of applicable setpoints, for which the Hamiltonian function is lowest.

Abstract: The present disclosure relates to a driver-assistance system for controlling a speed of a vehicle dependent on at least two further vehicles in front of the vehicle, the driver-assistance system including a control system and a sensor system for detecting a respective further speed of the respective further vehicle, wherein the control system is configured to perform a weighting of the further speeds to each other and to determine a target speed of the vehicle dependent on the respective further speed and dependent on the weighting of the further speeds and to control the speed of the vehicle dependent on the target speed.

Abstract: A subframe for a motor vehicle has a frame body made of shell components and at least one mounting sleeve. Each mounting sleeve has a sleeve body with a longitudinal passage and a sleeve head with a passage opening. According to the present disclosure, the sleeve head is a cold extruded part, wherein the passage opening in the sleeve head is produced in the sleeve head during cold extrusion. The sleeve head is positioned on the front side on the sleeve body.

Abstract: An overhead crane monitoring system is for monitoring an overhead crane (1). The overhead crane (1) includes a travelling body (2) that travels along rails (4), a traverse trolley (3) that travels in a direction perpendicular to a travelling direction of the travelling body (2) along the travelling body (2), and a hoisting device (5) mounted on the traverse trolley (3). The overhead crane monitoring system includes a panoramic camera (6) disposed at one end portion of the travelling body (2). The panoramic camera (6) records an image in an overlooking posture. The image recorded by the panoramic camera (6) is displayed on a wide display (21) installed in a remote operation room. This enables providing an operator with an image appropriate for remotely operating the overhead crane (1).

Abstract: A particle that includes a core and one or more layers. The core includes a fertilizer element. The one or more layers may include a polycation polymer and/or a polyanion polymer. Compositions include a plurality of particles and methods of using the particles and compositions containing the same.

Abstract: The present invention relates to a cathepsin K inhibitor having the structure as shown in formula (0) and/or formula (II), wherein cyanopyrimidine or a keto group as an electrophilic group is a key group to exert a good inhibitory effect on cathepsin K. Further provided are a preparation method therefor and use thereof. The provided cathepsin K inhibitor has a relatively high inhibitory effect and selectivity, and is expected to be used for treating diseases including thyroid diseases, cardiovascular diseases, bone diseases and gum diseases.

Abstract: The present disclosure relates to cyclic oligopeptides that bind to interleukin-13 (IL-13) which are useful therapeutically in methods of treating or preventing IL-13-associated skin disorders or conditions. The present disclosure also provides methods to treat or prevent IL-13-associated skin disorders or conditions with the IL-13-binding cyclic oligopeptides. The present disclosure further provides methods to produce the IL-13-binding cyclic oligopeptides.

Abstract: Disclosed are monoclonal antibodies and antigen binding fragments that specifically bind a coronavirus spike protein, such as SARS-CoV-2. Also disclosed is the use of these antibodies for inhibiting a coronavirus infection. In addition, disclosed are methods for detecting a coronavirus in a biological sample, using the disclosed antibodies.

Abstract: Provided herein are methods for processing natural rubber, also referred to as latex, without the use of ammonia. The methods provided herein may comprise one or more of the following steps: (a) a collection step wherein liquid latex is collected from a plant and, preferably, is filtered to remove impurities from the environment; (b) a stabilization step wherein a liquid latex composition is refrigerated and/or contacted with a stabilizing agent; (c) a preservation step wherein the liquid latex composition is contacted with a preserving agent; (d) a pH adjustment step wherein the liquid latex composition is contacted with a pH adjusting agent; (e) a storage step wherein the liquid latex composition is stored for a period of time; and (f) a coagulation step wherein the liquid latex composition is contacted with a coagulation agent, thereby forming a solid latex composition.

Abstract: A heat integration process and system for a chemical recycling facility is provided that can lower the carbon footprint and global warming potential of the facility. More particularly, one or more heat transfer media may be used to recover heat energy from a waste plastic pyrolysis effluent and redistribute the recovered heat energy throughout the chemical recycling facility. Furthermore, at least a portion of the pyrolysis oil produced by the pyrolysis process may be used to liquefy at least a portion of the waste plastics. Thus, the global warming potential of the chemical recycling facility may be optimized and lowered due to the heat integration process and system herein.

Abstract: Provided herein are systems and methods for processing biomolecules (e.g., nucleic acid molecules, proteins) from a sample. A method for processing biomolecules may comprise barcoding the probe-nucleic acid molecule complex or derivatives thereof. Such a method can comprise performing a nucleic acid reaction, e.g., extension, denaturation, and amplification. The methods described herein may be performed within a partition, such as a droplet or well.

Abstract: The present inventive concept relates to area-selective deposition (ASD) area-selective atomic layer deposition (AS-ALD) processes, and applications thereof. Methods of selectively depositing metal oxides and metal oxynitrides, such as TiO2 and TiON, on nitride (SiN) as a growth area vs. oxide (SiO2) as a nongrowth area, and applications thereof in, for example, self-aligned block (SAB) patterning and self-aligned multiple patterning (SAMP) processes are described.

Abstract: A well 1 is drilled or exists that passes through the earth's surface 2 and underlying rocks 3 to connect with a subterranean hydrocarbon reservoir 4 that contains hydrocarbons 5 and commonly brine 6 (which can include formation, interstitial, connate and injected water). Well 1, (there may be a plurality of well 1's) allows the contents of reservoir 4, either hydrocarbons 5 or brine 6, to flow to the surface.

Abstract: The invention relates to a thermal supply network (1000) for a process plant, in particular for a painting plant, comprising a fluid connection for supplying consumers (200, 220; 300, 302, 304, 306; 320, 322, 324) arranged therein with heat and/or cold via a heat transfer fluid in the fluid connection, in which at least two consumers (200, 300, 320; 220, 302, 304, 306, 322, 324) are connected fluidically in series, wherein the first consumer (200, 300, 320) is fluidically connected at least temporarily, by means of its first outlet (205, 305, 325) for the heat transfer fluid, to a second consumer (220, 302, 304, 306, 322, 324) via the second inlet (223) thereof.

Abstract: An air-conditioning apparatus according to a first aspect includes a heat source device, an air-conditioning unit, a hot water supply unit, and control circuitry configured to perform a first alternate operation of alternately performing a heating operation and a hot water supply operation when a heating request and a hot water supply request are received at the same time, and to perform a second alternate operation of alternately performing a cooling operation and the hot water supply operation when a cooling request and the hot water supply request are received at the same time, in which the control circuitry is configured to perform control to make a first continuous operation time of the hot water supply operation in the first alternate operation different from a second continuous operation time of the hot water supply operation in the second alternate operation.