Abstract: Provided are a continuous blood glucose measurement device and an applicator, wherein the continuous blood glucose measurement device is produced in a state in which a body attachment unit has been assembled inside an applicator, so as to minimize a user's additional work of attaching the body attachment unit to the body, thereby enabling the body attachment unit to be attached to the body only by simply activating the applicator. Particularly, the present invention provides a continuous blood glucose measurement device and an applicator, wherein the continuous blood glucose measurement device: includes a wireless communication chip in a body attachment unit so as to enable communication with an external terminal, thereby enabling simple and convenient use thereof, without additional work for connecting a separate transmitter, and easier maintenance; and is activated by a user's operation after the body attachment unit is attached to the body.

Abstract: A system and method electronically manages sleep related data obtained by a diagnostic device. The system and method may include collecting sleep data from a patient using a diagnostic device. The sleep data may be stored in a sleep data file and delineated as multiple sleep sessions. A user may access the stored sleep data by selecting a particular sleep session. The sleep data for the selected sleep session may then be extracted from the sleep data file and presented to the user as a combination of image tiles, JavaScript elements, and an event indicator.

Abstract: In an X-ray imaging procedure, an input image and an input mask image are generated on the basis of first and second detector data of an X-ray flat panel detector. By applying noise suppression, a mask signal image and a signal image are generated on the basis thereof. By calculating the difference between the signal image and the mask signal image, a subtraction image is generated. The subtraction image is scaled so that a number of pixels is increased in a first image direction. A results image is generated in which the scaled subtraction image and a noise image are added together.

Abstract: An intravascular imaging probe including a multiple material support member or chassis, and associated devices, systems, and methods are provided. According to one embodiment, an intraluminal ultrasound imaging catheter includes a flexible elongate member configured to be positioned within a body lumen of a patient, a support member coupled to a distal portion of the flexible elongate member, and an ultrasound scanner assembly positioned around the support member. The support member includes a hollow inner member comprising a first material, and a first annular member positioned around a perimeter of the hollow inner member at a proximal portion of the hollow inner member. The first annular member extends radially outward from the hollow inner member and includes a second material that is different from the first material.

Abstract: A disposable or reusable length adjustable tubular retractor, a surgical system, and a tube breaker for adjusting the length of the length adjustable tubular retractor are provided. The length adjustable tubular retractor includes a cylindrical body and at least one or a plurality of grooves or through slots or a combination thereof circumferentially disposed along the cylindrical body at predetermined positions. Each of the at least one or a plurality of grooves, through slots, or a combination thereof is configured such that the cylindrical body is breakable at each of the predetermined positions to form a size-selected length adjustable tubular retractor. A surgical system includes the length adjustable tubular retractor and a retractor handle.

Abstract: Surgical anchors and related systems and methods that utilize sutures or other flexible, elongated members to actively deploy a deformable anchor body in a manner that facilitates better deployment of the anchor in the bone, resulting in better fixation and resistance to pull out.

Abstract: Systems and methods are disclosed for receiving imaging data of a joint, determining gap parameter information based on the imaging data, generating a graphical user interface (GUI) configured to display a three-dimensional element comprising a plurality of sub-elements, determining which of the plurality of sub-elements correspond to the determined gap parameter information, and generating a display of the GUI, wherein at least one sub-element is associated with the determined gap parameter information.

Abstract: A method of performing an ultrasound-guided procedure may include (a) providing a medical device that has (i) a therapeutic distal tip configured to percutaneously alter internal tissue or bone at a treatment site of a patient; (ii) a source of biocompatible fluid; and (iii) a delivery system configured to selectively deliver a quantity of the biocompatible fluid, with echogenic microbubbles therein, to an area external and adjacent to the therapeutic distal tip. The method may further include subcutaneously advancing the therapeutic distal tip toward the treatment site; delivering a quantity of biocompatible fluid with echogenic microbubbles to the area; observing, via ultrasound, an anatomic structure proximate the treatment site and dispersion of the echogenic microbubbles at the area; and based on a nature and location of the dispersion, steering the therapeutic distal tip relative to the anatomic structure, and continuing to advance the therapeutic distal tip toward the treatment site.

Abstract: Devices, systems, and/or methods can provide compliance characteristics to fluid vessels. For example, an implant device can be advanced to a target site in a fluid vessel, such as an aorta. The implant device can include a first anchoring element, a second anchoring element, and/or a torsion element coupled between the first anchoring element and the second anchoring element. The first and/or second anchoring element of the implant device can be deployed at the target site. In one example, the implant device can be used to bias an aorta toward a twisted state for mimicking a healthy aorta and thereby improving blood flow therethrough.

Abstract: An implantable medical device for treating reflux disease in a human patient, the implantable medical device comprising a movement restriction device having an outer surface including a biocompatible material. The movement restriction device is adapted to be fully invaginated by the stomach fundus wall of the patient, such that movement of the cardiac notch of the patient's stomach towards the patient's diaphragm is restricted, thereby preventing the cardia from sliding through the patient's diaphragm opening into the patient's thorax. The implantable medical device further comprises a holding device adapted to be held by a surgical instrument, wherein the holding device is at least partly placed inside the outer wall of the implantable medical device.

Abstract: An expandable spinal fusion implant including a housing, upper and lower endplates, a wedge positioned within the housing and between the upper and lower endplates and a drive mechanism to urge the wedge distally between the upper and lower endplates to increase the separation between the endplates and expand the overall height of the distal end of the implant.

Abstract: An implant insertion tool includes an outer shaft, an inner shaft received in the outer shaft, and two arms coupled to the outer shaft and the inner shaft. The inner shaft translates within the outer shaft and has angled ramps that slide within complementary angled ramps in the two arms. The arms engage an implant for insertion into a body. When the inner shaft translates along a longitudinal axis, it causes the angled ramps to slide against the complementary angled ramps in the arms such that the two arms move laterally relative to the longitudinal axis of the outer shaft to engage and disengage the implant.

Abstract: Implant devices are provided for restoring compliance characteristics to blood vessels. An exemplary implant device includes an outer tubular frame having a diameter than varies along a longitudinal axis and a radially expandable tube disposed within the frame. Further disclosed are implant devices including a frame having an axially convex form that expands in diameter moving from first and second axial ends of the frame to a medial portion of the frame, and a cylindrical toroidal balloon member comprising one or more gas-filled chambers disposed at least partially within the frame. Further disclosed are implant devices including a tubular frame comprising a first axial segment and a second axial segment, a radially expandable tube disposed within the first axial segment of the frame, and a one-way valve disposed within the second axial segment of the frame.

Abstract: An example stimulation device for a male penis includes a pressure field generation device for generating a pneumatic alternating pressure field, and an applicator for applying the alternating pressure field to a portion of a penis that is to be stimulated. The applicator has a pressure chamber, which can receive an alternating pressure field generated by the pressure field generation device. The pressure chamber has an opening in a contact region of the applicator, so that the alternating pressure field can be applied directly to a portion of the penis that is to be stimulated via the opening. A sealing device is arranged on the applicator, which is configured to seal the pressure chamber against the environment when the applicator is applied to the penis.

Abstract: Disclosed are polymers, methods of making polymers, and compositions, focused on cross-linking heterocycles comprising a moiety of Formula I with thiols and thiolates.

Abstract: Oral pharmaceutical compositions of sodium oxybate having improved pharmacokinetic properties when administered less than two hours after eating are provided, and therapeutic uses thereof.

Abstract: Provided herein are guanidinoacetic acid or its derivatives thereof, compositions comprising the same, as well as the use thereof, particularly for topical or systematic treatment of pain, itch, eczema or other inflammatory disorders.

Abstract: Described herein are compounds that activate pyruvate kinase, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I) wherein R1, R2, Ra, Rb, Rj, Rk, and Q are as defined herein.

Abstract: Among the various aspects of the present disclosure is the provision of compositions and methods for modulating autophagy for treatment and prevention of autophagy-associated diseases, disorders, or conditions and compositions of photoreactive compounds. An aspect of the present disclosure provides for autophagy enhancing agents capable of treating or preventing diseases, disorders, or conditions in which autophagy is implicated.

Abstract: The invention relates to an oral dosage form of mifepristone of mifepristone oral formulation characterised in that said formulation comprises an amount selected from the group consisting of 75 mg, 150 mg or 300 mg mifepristone, and said formulation is for its use in the induction of labour and cervix ripening in a woman being at least 37 weeks pregnant.