Abstract: The present application involves a method and a system for using electrical stimulation and/or chemical stimulation to treat depression. More particularly, the method comprises surgically implanting an electrical stimulation lead and/or catheter that is in communication with a predetermined site which is coupled to a signal generator and/or infusion pump that release either an electrical signal and/or a pharmaceutical resulting in stimulation of the predetermined site thereby treating the mood and/or anxiety.
Abstract: In one embodiment, a method of fabricating an implantable stimulation paddle comprises: providing a sheet of conductive material coupled to a first insulative layer; laser removing portions of the conductive material to form a pattern of conductive material, the pattern of conductive material including a plurality of isolated metal traces; providing a second insulative layer over the pattern of conductive material so that the pattern of conductive material is interposed between the first and second insulative layers; and exposing portions of the metal traces to form electrodes on the paddle for delivering electrical stimulation.
Abstract: A system and/or method treating for a neurological disorder by brain region stimulation. The system and/or method comprises a probe and a device to provide stimulation. The probe has a stimulation portion implanted in communication with a predetermined brain region site. The stimulation portion of the probe may be implanted in contact with a predetermined brain region.
Abstract: In one embodiment, an introducer is provided for implanting an electrical stimulation lead to enable electrical stimulation of nerve tissue. The introducer includes an outer sheath and an inner penetrator. The outer sheath may accommodate insertion of the electrical stimulation lead and may be inserted into a human body near the nerve tissue. The inner penetrator is removably housed within the outer sheath and includes an inner channel configured to accommodate a guide wire, a tip end having a shape and size substantially conforming to that of the guide wire, a body region having a shape and size substantially conforming to that of the outer sheath, and one or more transition regions substantially connecting the tip end with the body region. At least a portion of the transition regions of the inner penetrator may flex to substantially follow flexures in the guide wire during advancement of the inner penetrator.
Type:
Grant
Filed:
June 1, 2012
Date of Patent:
June 11, 2013
Assignee:
Advanced Neuromodulation Systems, Inc.
Inventors:
Timothy S. Jones, Terry Daglow, Peter B. Hegi, Thomas K. Hickman
Abstract: In one embodiment, a method for facilitating programming of an implantable pulse generator (IPG) by an external programming device, the method comprises: receiving input from a user by the external programming device to calibrate electrode combinations at a plurality of locations along one or more stimulation leads implanted within the epidural space of a patient; controlling the IPG by the external programmer to apply stimulation to the patient via the electrode combinations; receiving input from a user by the external programming device that indicates values of a respective perception stimulation threshold at each location of the plurality of locations; receiving input from a user by the external programming device that indicates values of a respective bilateral stimulation threshold at each location of the plurality of locations; calculating positions by the external programming device of each of the plurality of locations using the perception stimulation thresholds and the bilateral stimulation thresholds
Abstract: A method for treating a patient with a neurological or psychiatric disorder, comprising applying stimulation to at least a portion of the patient's subcaudate white matter of the subcaudate area under conditions effective to provide the patient with at least a partial relief from the neurological or psychiatric disorder. The stimulation may be electrical and/or pharmacological.
Abstract: Disclosed are systems and methods which provide voltage conversion in increments less than integer multiples of a power supply (e.g., battery) voltage. A representative embodiment provides power supply voltage multipliers in a binary ladder distribution to provide a desired number of output voltage steps using a relatively uncomplicated circuit design. By using different sources in various combinations and/or by “stacking” different sources in various ways, the voltage multiplier circuit may be used to provide desired voltages. In order to minimize the number of components used in a voltage converter of an embodiment, a capacitive voltage converter circuit uses one or more storage capacitors in place of pump capacitors in a voltage generation cycle. Also, certain embodiments do not operate to generate an output voltage until the time that voltage is needed.
Type:
Grant
Filed:
May 14, 2012
Date of Patent:
May 21, 2013
Assignee:
Advanced Neuromodulation Systems, Inc.
Inventors:
Benjamin A Tranchina, John H Erickson, Anthony J Varrichio
Abstract: In one embodiment, a pulse generator for generating electrical stimulation for delivery to a patient, comprises: a hermetically sealed housing containing pulse generating circuitry; a header coupled to the housing for receiving one or more stimulation leads, wherein feedthrough wires are provided to conduct electrical pulses from the pulse generating circuitry to the header; the header comprising a plurality of connectors for electrically connecting to each terminal of the one or more stimulation leads, wherein an inductive winding is disposed around or adjacent to each of the connector structures and is electrically connected between the respective connector structure and a corresponding feedthrough wire to limit MRI induced heating of a respective electrode of the one or more stimulation leads.
Abstract: Test procedures for determining a neural stimulation threshold of a patient. In one embodiment, the procedure includes applying a test stimulation signal to the patient and monitoring the patient for a response to the test stimulation signal. The procedure can further include determining a first neural stimulation threshold and calculating a second neural stimulation threshold. The first neural stimulation threshold corresponds to the lowest intensity test stimulation signal that evokes a patient response. The second neural stimulation threshold corresponds to a treatment stimulation signal directed toward affecting a neural activity within the patient.
Abstract: The invention relates to a stimulation device for creating complex or multi-purpose tissue stimulation. Many typical stimulation devices suffer from deficiencies in providing complex stimulation patterns. Using a circuitry operable or programmable to repeat and skip stimulation settings, a complex stimulation set may be created. The repeating and skipping functionality may be implemented in hardware or software. In this manner, complex stimulations may be derived from simple circuitries. Furthermore, these stimulations may be used to treat pain, stimulate bone growth, and control motor disorders, among others.
Abstract: In one embodiment, an implantable pulse generator for electrically stimulating a patient comprises: a metallic housing enclosing pulse generating circuitry; a header mechanically coupled to the metallic housing, the header adapted to seal terminals of one or more stimulation leads within the header and to provide electrical connections for the terminals; the header comprising an inner compliant component for holding a plurality of electrical connectors, the plurality of electrical connectors electrically coupled to the pulse generating circuitry through feedthrough wires, wherein the plurality of electrical connectors are held in place in recesses within the compliant inner component, the header further comprising an outer shield component adapted to resist punctures, the outer shield component fitting over at least a portion of the inner compliant component.
Abstract: A system and/or method for treating auditory dysfunction by somatosensory system stimulation. The system and/or method comprises a probe and a device to stimulate the probe. The probe has a stimulation portion implanted in communication with a predetermined peripheral nerve site. The stimulation portion of the probe may be implanted in contact with a peripheral nerve dorsal root ganglia, cranial nerve or dermatome area, for example C2 dermatome area or a trigeminal dermatome area. The stimulation portion may be a laminotomy, paddle, surgical, or multiple electrode lead. The device to stimulate the probe may be implanted subcutaneously or transcutaneously.
Abstract: System and method for automatically optimizing the stimulus parameters and/or the configuration of electrodes to provide neural stimulation to a patient, the system includes an electrode array having a support member configured to be implanted into the patient and a plurality of therapy electrodes carried by the support member. The system can also have a pulse system operatively coupled to the therapy electrodes to deliver a stimulus to the therapy electrodes, and a sensing device configured to be attached to a sensing location of the patient. The sensing device generates response signals in response to the stimulus. The system can also include a controller that generates command signals that define the stimulus delivered by the pulse system, evaluates the response signals from the sensing device, and determines a desired configuration for the therapy electrodes and/or a desired stimulus to be delivered to the therapy electrodes.
Type:
Grant
Filed:
June 4, 2012
Date of Patent:
April 2, 2013
Assignee:
Advanced Neuromodulation Systems, Inc.
Inventors:
Bradford Evan Gliner, Jeffrey Balzer, Andrew D. Firlik
Abstract: The present application relates to a new stimulation design which can be utilized to treat neurological conditions. The stimulation system produces a burst mode stimulation which alters the neuronal activity of the predetermined site, thereby treating the neurological condition or disorder. The burst stimulus comprises a plurality of groups of spike pulses having a maximum inter-spike interval of 100 milliseconds. The burst stimulus is separated by a substantially quiescent period of time between the plurality of groups of spike pulses. This inter-group interval may comprise a minimum of 5 seconds.
Abstract: Methods and devices for creating and/or adding to sensations of satiety to reduce food intake. Methods include electrically stimulating the duodenum which may induce false nerve signals in the duodenal region which are normally indicative of duodenal distension (fullness) and/or the presence of food in the duodenum. The artificially generated signals may be applied in a pattern which mimics at least in part a naturally occurring pattern of duodenal signals generated responsive to eating a meal. Some artificial patterns may be exaggerated relative to the natural patterns, by occurring earlier after ingestion, and/or lasting longer after ingestion, having an exaggerated (higher) frequency response or a faster rate of frequency increase after ingestion. The applied signals may generate nerve signals going to the brain which induce a feeling of satiety.
Abstract: According to one aspect, a stimulation system is provided for electrically stimulating a predetermined site to treat a neurological condition. The system includes an electrical stimulation lead adapted for implantation in communication with a predetermined site, wherein the site is brain tissue site. The stimulation lead includes one or more stimulation electrodes adapted to be positioned in the predetermined site. The system also includes a stimulation source that generates the stimulation pulses for transmission to the one or more stimulation electrodes of the stimulation lead to deliver the stimulation pulses to the predetermined site to treat a neurological disorder or condition.
Abstract: In one embodiment, a method electrically stimulates an area in a spinal disc. The method comprises: implanting at least one steerable lead at a placement site for stimulating a spinal disc such that the lead is disposed exterior and immediately adjacent to and circumferentially along an annulus of the spinal disc, the at least one lead including a plurality of electrodes distributed along a majority of a circumference of the annulus; connecting the lead to a signal generator; and generating electrical stimulation pulses using the generator to stimulate targeted portions of the spinal disc, wherein the stimulation of the targeted portion of the spinal disc sufficiently stimulates nerve tissue within the spinal disc to prevent communication of pain signals originating in the spinal disc without damaging tissue of the spinal disc.
Type:
Grant
Filed:
December 23, 2011
Date of Patent:
January 22, 2013
Assignee:
Advanced Neuromodulation Systems, Inc.
Inventors:
Philip M. Finch, Scott F. Drees, John Erickson
Abstract: In one embodiment, a system for electrically stimulating neural tissue of a patient and for determining neurotransmitter release in response to stimulation, the system comprises: pulse generating circuitry for generating electrical pulses; at least one electrical lead for conducting electrical pulses generated by the pulse generating circuitry to neural tissue, the at least one electrical lead comprising a plurality of electrodes; at least one electrochemical sensor for sensing an extracellular level of one or several neurotransmitters; circuitry for sampling a signal from the at least one electrochemical sensor; a controller for automatically applying stimulation to neural tissue using a plurality of electrode combinations, the controller generating data related to neurotransmitter release for each of the plurality of electrode combinations; and a display for displaying neurotransmitter release for electrode combinations to a clinician.
Abstract: According to one aspect, a method of treating a patient by electrically stimulating a predetermined site to treat a neurological condition. The method includes implanting a lead into subcutaneous tissue of the C2 dermatome/C3 dermatome area.
Type:
Grant
Filed:
April 19, 2010
Date of Patent:
December 25, 2012
Assignee:
Advanced Neuromodulation Systems, Inc.
Inventors:
Mark Thimineur, Ed Kravitz, Peter Lando, Tracy Cameron, Rohan Hoare
Abstract: A method is described for the treatment of obesity or other disorders, by electrical activation or inhibition of the sympathetic nervous system. This activation or inhibition can be accomplished by electrically stimulating the greater splanchnic nerve or other portion of the sympathetic nervous system using an implantable pulse generator. This nerve activation can result in reduced food intake and increased energy expenditure. Reduced food intake may occur through a variety of mechanisms that reduce appetite and cause satiety. Increased adrenal gland hormone levels will result in increased energy expenditure. Fat and carbohydrate metabolism, which are also increased by sympathetic nerve activation, will accompany the increased energy expenditure.