Abstract: A computer-based imaging technique for three dimensional modeling of root canal shape and accurate measuring of root canal length is provided. A direct digital radiology (DDR) system that replaces film by an electronic sensor is used to acquire radiographic images of the root canal. The DDR system allows instant radiographic imaging with significantly less patient exposure than conventional film-based radiography. Additionally, since the images are captured in digital form, a computer is used for processing. In accordance with one aspect of the present invention, two digital images of the dentition from two different angles are acquired. The root canal in each image, along with the direction of projection will define a surface in 3-D space. The intersection of two surfaces will represent the root canal in 3-D. Once the 3-D shape of the root canal is reconstructed, the length of the root canal can be obtained by computing the length of the 3-D curve.

Abstract: The present invention relates generally to methods and compositions for the diagnosis, modeling and treatment of tau-related pathologies. In particular, the present invention shows that mutations in the tau gene lead to neurofibrillary tangle formation. More specifically gene mutations are described that lead to alterations in ratios of tau isoforms are shown to lead to the formation of abnormal tau filaments.

Abstract: Disclosed herein are the methods of using the H4-1BB protein, ligands to this protein, and various mAbs either directed against H4-1BB or other molecules that can be used therapeutically. The nature and importance of the H4-1BB molecule provides the ligands and related co-stimulatory molecules the ability to enhance or suppress T-cell activation and proliferation. By treating T-cells that have expressed receptor protein H4-1BB with one of the four anti-H4-1BB monoclonal antibodies disclosed herein activation or inhibition of the immune response is seen. Also disclosed herein is cDNA for the human receptor H4-1BB. The cDNA of the human receptor H4-1BB is about 65% homologous to the mouse cDNA 4-1BB and was isolated by using probes derived from murine cDNA 4-1BB. A fusion protein for detecting cell membrane ligands to human receptor protein H4-1BB was developed.

Abstract: An arrangement for performing chromatography with a mobile phase and a chromatographic bed having a stationary phase is provided. The arrangement includes a support assembly configured to support the stationary phase. The support assembly has a sealed cavity configured so that when the support assembly is supporting the stationary phase a portion of the chromatographic bed and the stationary phase extends into the sealed cavity. The arrangement further includes a bladder having a void defined therein. The bladder is positioned within the sealed cavity. The arrangement also includes a fluid positioned within the void of the bladder so that the bladder is urged toward the stationary phase within the sealed cavity. The arrangement further includes an anode positioned in contact with the mobile phase.

Abstract: Materials and methods for selectively adsorbing proteins are disclosed. Under the invention, controlled pore glass is treated with a polyelectrolyte layer which comprises at least one polymer having a cationic portion which is electrostatically attracted to the porous outer surface of the glass. The constituents of the polyelectrolyte are preferably selected to have an affinity for the predetermined protein to facilitate adsorption thereof on the polyelectrolyte treated glass. Advantageously, the materials of the present invention can be utilized to immobilize enzymes and also to separate proteins from other components in a medium.