Abstract: The present invention relates to a method and a system for optical imaging of an object in transmission configuration. The method and system obtain contour coordinates of the object using source/detector configurations references and acquire optical data from a region of interest (ROI) of the object. Then, the method and system apply a weighting factor to said optical data as a function of the contour coordinates, and reconstruct an image of the ROI using the weighted optical data and photon diffusion equation.
Type:
Application
Filed:
December 21, 2007
Publication date:
September 11, 2008
Applicant:
ART, Advanced Research Technologies Inc.
Inventors:
Salim Djeziri, Niculae Mincu, Frederic Leblond, Olga Guilman, Xavier Intes, Mario Khayat
Abstract: A mechanism is provided for detecting a defect in a populated sample having a thickness dimension substantially smaller than the length and width dimensions thereof, the populated sample having a first side and an opposite second side, at least said first side of said populated sample having one or more Surface Mounted Components. The mechanism exploits a standard thermographic image which may be used in a detection method comprising 1) directing a thermal wave at said second side of said populated sample 2) recording a thermographic image of the first side of said populated sample once a surface thereof reaches a predetermined transit temperature or a predetermined transit time period has elapsed; and 3) analysing the obtained thermographic image by comparing the so obtained thermographic image with a standard thermographic image.
Abstract: There is provided a method and system for positioning a mammal for optical imaging in which a digital image of the mammal is obtained using a camera and a region of interest is selected using the digital image. The selected region is registered with an optical imaging system and the mammal is positioned in the imaging system to image the selected region of interest.
Type:
Grant
Filed:
July 23, 2003
Date of Patent:
April 29, 2008
Assignee:
ART, Advanced Research Technologies, Inc.
Inventors:
William F. Long, Yves Bérubé-Lauzière, Laura McIntosh
Abstract: The present invention relates to the use of collagen and MHC-like compounds to down regulate immune responses. Methods for administration of such compounds that induce immune tolerance are described. The invention is important in the context of allograft rejection, transplantation, graft rejection, pleural disease and immunotolerance.
Type:
Grant
Filed:
September 13, 2002
Date of Patent:
March 25, 2008
Assignee:
Advanced Research and Technology Institute
Abstract: The present invention relates to a method for wavelength selection in a multi-wavelength TPSF or CW-based optical imaging system. This consists of identifying several chromophores in a highly turbid medium and selecting optimized wavelengths whereby using these wavelengths optimizes the deduction of the chromophore concentrations. Such chromophore concentrations may be combined to deduce other properties of the turbid medium.
Type:
Grant
Filed:
January 16, 2004
Date of Patent:
October 23, 2007
Assignee:
ART, Advanced Research Technologies, Inc.
Inventors:
David Jonathan Hall, Mathias Kohl-Bareis
Abstract: The present invention provides a method of preparing a multicolor quantum dot-tagged bead, a multicolor quantum dot-tagged bead, a conjugate thereof, and a composition comprising such a bead or conjugate. Additionally, the present invention provides a method of making a conjugate thereof and methods of using a conjugate for multiplexed analysis of target molecules.
Type:
Application
Filed:
December 4, 2006
Publication date:
July 12, 2007
Applicant:
Advanced Research and Technology Institute, Inc.
Abstract: Methods and apparatuses for determining the depth and concentration of fluorophores in a turbid medium are disclosed. The method advantageously provides for a rapid estimation of the depth of the flurophore using characteristics of a temporal point spread function. The concentration of the flurophore can be determined using the method of the present invention by combining a calculated depth of the flurophore with a measurement of the intensity of the emitted fluorescence. The intensity can be accurately measured by the apparatus disclosed herein which combine back-reflection and trans-illumination geometries for the source of light injecting and detection.
Type:
Application
Filed:
October 29, 2004
Publication date:
July 12, 2007
Applicant:
ART, Advanced Research Technologies Inc.
Inventors:
David Hall, Guobin Ma, Frederic Lesage, Pascal Gallant
Abstract: The invention relates to novel nucleic acids encoding a fibroblast growth factor-23(FGF23) and proteins encoded thereby, mutations in which are associated with autosomal dominant rickets (ADHR). The invention further relates to methods of diagnosing and treating hypophosphatemic and hyperphosphatemic disorders comprising inhibiting or stimulating, respectively, the biological activity of FGF23 in a patient. The invention also relates to methods of treating osteoporosis, dermatomyositis, and coronary artery disease comprising stimulating the biological activity of FGF23 in a patient.
Type:
Grant
Filed:
July 10, 2001
Date of Patent:
May 29, 2007
Assignees:
Advanced Research and Technology Institute, Ludwig-Maximilians-Universitat Muchen
Inventors:
Michael Econs, Ken White, Tim Matthias Strom, Thomas Meitinger
Abstract: The invention relates generally to compositions of and methods for obtaining mu opioid receptor polypeptides. The invention relates as well to polynucleotides encoding mu opioid receptor polypeptides, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, recombinant opioid receptor polypeptides, and antibodies immunoreactive with mu opioid receptors. The invention includes as well, methods for using the isolated, recombinant receptor polypeptide in assays designed to select and improve substances capable of interacting with mu opioid receptor polypeptides for use in diagnostic, drug design and therapeutic applications.
Type:
Grant
Filed:
July 27, 2000
Date of Patent:
August 29, 2006
Assignee:
Advanced Research and Technology Institute
Abstract: There is provided an improved method for enhancing fluorescence images of an object, such as a biological tissue, by selectively eliminating or reducing unwanted fluorescence from fluorophores other than the fluorophore of interest. The method is based on the measurement of the lifetime of fluorophores while preserving information related to the fluorescence intensity of the fluorophore of interest.
Type:
Application
Filed:
December 30, 2004
Publication date:
July 6, 2006
Applicant:
ART, Advanced Research Technologies Inc.
Abstract: The present invention identifies a protein, designated the D-sequence-binding protein (D-BP), is phosphorylated at tyrosine residues and blocks AAV-mediated transgene expression in infected cells by inhibiting the leading strand viral DNA synthesis. More particularly, the present invention demonstrates that D-BP is phosphorylated by EGF-R protein tyrosine kinase. Methods of increasing transcription and promoting replication of transgenes exploiting this information are disclosed herein.
Type:
Grant
Filed:
September 1, 1998
Date of Patent:
May 30, 2006
Assignee:
Advanced Research & Technology Institute
Abstract: The TPSF-based imaging technique uses multiple wavelengths to image an object simultaneously. Acquisition time of an image can be shortened without sacrificing the effective amount or quality of raw imaging data acquired. A plurality of distinguishable wavelengths may be used simultaneously at different injection-detection positions to acquire simultaneously a plurality of TPSF-based imaging data points for the different injection-detection positions. The multiple wavelengths may provide complementary information about the object being imaged.
Type:
Grant
Filed:
January 22, 2002
Date of Patent:
May 16, 2006
Assignee:
ART. Advanced Research Technologies Inc.
Inventors:
David Hall, Richard Boudreault, Pierre A. Beaudry
Abstract: There is provided a method for optimizing wavelength selection for multiwavelength optical data acquisition of chromophores in a turbid medium. The optimization is based on the minimization of a criterion based on the variance matrix of chromophores estimate features. The method can advantageously be used to obtain physiological information from biological tissue.
Type:
Application
Filed:
September 21, 2005
Publication date:
May 4, 2006
Applicant:
ART, ADVANCED RESEARCH TECHNOLOGIES, INC.
Inventors:
Philippe St-Jean, Frederic Lesage, Xavier Intes, Frederic Leblond
Abstract: Provided in the present invention are isolated nucleotide sequences encoding EDR1 proteins, the disruption of which is associated with enhanced disease resistance in plants. The invention also provides vectors comprising said nucleotide sequences.
Type:
Grant
Filed:
May 26, 2000
Date of Patent:
February 7, 2006
Assignee:
Advanced Research & Technology Institute
Abstract: There is provided a method and system for collecting optical data for use in time resolved optical imaging wherein light is directionally propagated through free-space optics to impinge on a plurality of illumination at the surface of a biological tissue such as that comprised in small animals. Light re-emitted from the tissue is collected and directionally propagated through free space optics towards a detector to produce time resolved optical signals useful for optical image reconstructions.
Type:
Grant
Filed:
September 22, 2003
Date of Patent:
January 31, 2006
Assignee:
ART Advanced Research Technologies Inc.
Inventors:
William F. Long, Yves Bérubé-Lauzière, David J. Hall, Laura McIntosh
Abstract: The invention provides novel tetradentate enediyne ligands that are themselves thermally stable, yet react at about room temperature or slightly higher upon addition of metal ions or under photothermal conditions. In another aspect of the invention, a method of treating a disorder in a mammal comprising administering a therapeutically effective amount of a compound or composition is provided. In addition, the free ligand can be delivered to the mammal prior to complexation to metals, such that the ligand is exposed to a metal in the body and forms a metal complex in vivo. Furthermore, a metal complex of the invention can be administered to the mammal such that the complex exchanges the first metal center with another endogenous metal in order to form a second metal complex in vivo. The second metal complex is capable of forming a benzenoid diradical under physiological conditions and/or under photothermal conditions.
Type:
Grant
Filed:
October 10, 2002
Date of Patent:
January 17, 2006
Assignee:
Advanced Research and Technology Institute, Inc.
Abstract: An ion separation instrument includes an ion source coupled to at least a first ion mobility spectrometer having an ion outlet coupled to a mass spectrometer. Instrumentation is further included to provide for passage to the mass spectrometer only ions defining a preselected ion mobility range. In one embodiment, the ion mobility spectrometer is provided with electronically controllable inlet and outlet gates, wherein a control circuit is operable to control actuation of the inlet and outlet gates as a function of ion drift time to thereby allow passage therethrough only of ions defining a mobility within the preselected ion mobility range. In another embodiment, an ion trap is disposed between the ion mobility spectrometer and mass spectrometer and is controlled in such a manner so as to collect a plurality of ions defining a mobility within the preselected ion mobility range prior to injection of such ions into the mass spectrometer.
Type:
Grant
Filed:
April 25, 2001
Date of Patent:
November 1, 2005
Assignee:
Advanced Research & Technology Institute
Abstract: There is provided a method and a system for determining the concentration of chromophores and reconstructing images in turbid media, such as animal tissues, using a continuous wave optical approach. In particular the approach is based on measurements of attenuation signals and the calculation of concentrations of chromophores using a predetermined scatter law. The system comprises a continuous wave photon migration model calculator coupled to an optical source and detector for estimating concentrations of chromophores and scatter parameters used in image reconstruction.
Abstract: In a method of multi-wavelength imaging internal structures of a highly turbid medium, the internal structures are imaged at each one of a set of at least two predetermined wavelengths, to generate a corresponding set of respective images. The set of images are then merged to generate a corresponding fused image.
Type:
Application
Filed:
July 16, 2002
Publication date:
August 25, 2005
Applicant:
ART, Advanced Research Technologies Inc.
Inventors:
Pierre Beaudry, Richard Boudreault, Julie Frechette, Sonia Verreault, Pierre Galarneau