Patents Assigned to Agilent Technologies, Inc.
  • Publication number: 20230303398
    Abstract: There is disclosed a method of producing etched non-porous particles. The method includes, in some examples, coating a non-porous particle with a hydrophilic polymer and treating the coated particle with acid or base. Also provided is etched non-porous particles capable of separating a variety of analytes, including biomolecules.
    Type: Application
    Filed: May 18, 2023
    Publication date: September 28, 2023
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventor: Ta-Chen WEI
  • Publication number: 20230264118
    Abstract: A chromatography column includes a first flow distributor, a second flow distributor, and a media chamber having an inlet and an outlet. The second flow distributor is different from the first flow distributor. The first flow distributor is secured to the inlet of the media chamber and the second flow distributor is secured to the outlet of the media chamber.
    Type: Application
    Filed: September 23, 2021
    Publication date: August 24, 2023
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: Norwin Rolf Leonhard VON DOEHREN, Wilroy E. BENNEN
  • Publication number: 20230220542
    Abstract: The invention provides metal liquid chromatography components with uniformly coated internal surfaces and methods for achieving the same. The invention addresses the problem of corrosion or interference of metal components in the flow path for LC analyses in which the sample interacts with metal ions or surfaces. The invention also alleviates the difficulties in coating very long metal tubes and very small metal channels with an inert, continuous coating that adheres well to metal surfaces. The metal flow path is rendered inert by the coating, and thus compatible with bioanalytical separations, for example, by using a vapor phase deposition process to coat the inner surfaces with a coating that continuously covers all metal surfaces in the flow path.
    Type: Application
    Filed: March 22, 2023
    Publication date: July 13, 2023
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: Elizabeth CARR, Karen L. SEAWARD, Kevin P. KILLEEN
  • Patent number: 11686311
    Abstract: A fluid pump includes a pump head and a motor coupled by a drive shaft. The pump head includes a pump inlet, a pump outlet, and a pumping stage in which a movable pump element is driven by the drive shaft. The motor includes a motor rotor and a motor stator. A connector couples the motor rotor and the drive shaft. The connector includes a plate rotatable with the drive shaft, fan blades attached to the plate for establishing a flow of air for cooling the motor, and one or more counterweights attached to the plate for reducing or eliminating imbalance created by certain forces generated by the pump during operation.
    Type: Grant
    Filed: June 7, 2022
    Date of Patent: June 27, 2023
    Assignee: Agilent Technologies, Inc
    Inventors: Vannie Lu, George Galica, Aileen Cheang
  • Publication number: 20230192364
    Abstract: In some examples, an instrument closure may include an instrument closure retainer to retain the instrument closure onto a container. The instrument closure may further include a sensor retainer including a plurality of apertures for transfer or removal of material, respectively, into or from the container. The sensor retainer may further include a sensor mount to retain a sensor.
    Type: Application
    Filed: November 30, 2022
    Publication date: June 22, 2023
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: Patrick MATZ, Matthias KAMUF, Manuel VAN VENROOY, István MOLNAR, Tobias ANHAUS
  • Patent number: 11667992
    Abstract: A tip including an alloy of platinum and an alloying element chosen from gold, palladium, ruthenium, osmium, iron, cobalt, nickel, copper, zinc, silver, chromium, manganese, titanium, niobium, scandium, vanadium, yttrium, zirconium, molybdenum, tantalum, tungsten, technetium, cadmium, hafnium, rhenium, less than 5 wt. % of iridium, less than 5 wt. % of rhodium, greater than 20 wt. % iridium, greater than 20 wt. % rhodium, and a combination thereof, relative to the total weight of the alloy is disclosed. An interface cone can include a base and the tip.
    Type: Grant
    Filed: July 19, 2021
    Date of Patent: June 6, 2023
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: James Dellis, Lawrence McCanney, Gareth Pearson
  • Patent number: 11667711
    Abstract: Provided are chimeric or recombinant antibodies (Ab), or antigen binding fragments thereof, or monomeric or dimeric antigen binding proteins, that can specifically bind to human LAG-3 polypeptides, including human LAG-3 polypeptides expressed on the surface of lymphocytes such as activated T cells that have infiltrated tumors or tumor infiltrating lymphocytes (TILs), and methods for making and using them.
    Type: Grant
    Filed: May 26, 2021
    Date of Patent: June 6, 2023
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Morten Draeby Sorensen, Tine Hagedorn-Olsen
  • Publication number: 20230160865
    Abstract: Methods and systems for sensing headspace vial presence are described herein. In one embodiment, a system can include a sample probe, a fluid source in fluid communication with the sample probe, one or more of a pressure sensor and a flow sensor in fluid communication with the sample probe, and a processor configured to: (a) receive a first set of signals from the one or more of the pressure and flow sensors, execute an ejection procedure to remove a sample vial from the sample probe, receive a second set of signals from the one or more of the pressure sensor and the flow sensor during step (b), (d) detect whether the ejection procedure is successful from the first set of signals and the second set of signals, and (e) in response to the detecting, initiate one or more actions selected from the group consisting of: a remediation and an alert.
    Type: Application
    Filed: April 9, 2021
    Publication date: May 25, 2023
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: Jonathan Michael FRENTZEL, Thomas E. PRICE, Jared M. BUSHEY, Paul C. DRYDEN
  • Patent number: 11646185
    Abstract: Systems, computer-readable media, and methods using mass spectrometry to analyze a sample are provided. For example, a method includes: acquiring a precursor ion spectrum; analyzing the precursor ion spectrum to identify precursor ions that preliminarily match one or more peptides that each belong to at least one protein of interest for the analysis; selecting each of the identified precursor ions in an order according to a ranking protocol for maximizing the number of proteins that are identified in the sample; for each selected precursor ion: acquiring a corresponding product ion spectrum, determining whether the acquired product ion spectrum matches one of the peptides that belong to the set of proteins of interest, and identifying a matched peptide as being present in the sample; and identifying proteins of interest that are present in the sample based on the peptides that are identified as being present in the sample.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: May 9, 2023
    Assignee: Agilent Technologies, Inc.
    Inventor: Javier E. Satulovsky
  • Patent number: 11639925
    Abstract: The present disclosure relates to methods and apparatus for measuring of multiple physiological properties of biological samples, such as measuring biological flux.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: May 2, 2023
    Assignee: Agilent Technologies, Inc.
    Inventors: Andrew C Neilson, Paul D McGarr
  • Publication number: 20230131152
    Abstract: A sample separation network includes a server node, a plurality of client nodes coupled with the server node, a plurality of sample separation devices coupled with the server node, wherein each of the sample separation devices includes device-specific control software configured for controlling specifically the respectively assigned sample separation device, wherein at least one of the server node and the client nodes includes generic control software configured for generically controlling sample separation devices in a non-device-specific way, and wherein at least one of the server node and the client nodes and the sample separation devices is configured for loading device-specific control software from a sample separation device to at least one of the server node and the client nodes upon connection of said sample separation device to the sample separation network.
    Type: Application
    Filed: March 15, 2021
    Publication date: April 27, 2023
    Applicant: Agilent Technologies, Inc.
    Inventors: Thomas Romanowski, Frank Maar, Bruce James Dolby, Stefan Huber
  • Publication number: 20230127124
    Abstract: A high-voltage (HV) power supply outputs an output voltage based on a control signal produced by a dual analog/digital feedback loop. The control signal is determined at least in part by an error amplifier that receives a measurement signal, proportionally attenuated from the output voltage, and a digital-to-analog converter (DAC) output signal. An analog-to-digital converter (ADC) also receives the measurement signal and transmits it in digitized form to a digital processor. The digital processor calculates a digital DAC data signal based on the measurement signal, and on a digital set-point input signal corresponding to a set-point voltage value of the output voltage desired to be outputted from the high-voltage source. A DAC receives the DAC data signal and converts it to the DAC output signal transmitted to the error amplifier.
    Type: Application
    Filed: December 20, 2022
    Publication date: April 27, 2023
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventor: David Deford
  • Publication number: 20230126290
    Abstract: An ion source may include an ionization chamber to be maintained at atmospheric-pressure. The ion source may further include a reduced-pressure chamber to be maintained at sub-atmospheric pressure, and an ion transfer device comprising an inlet in the ionization chamber and an outlet in the reduced-pressure chamber. The ion transfer device may define an ion path from the inlet to the outlet. The ion transfer device may be positioned to emit ions and neutral gas molecules from the outlet as an expanding beam comprising a low-gas density zone enveloped by a high-gas density region that includes a gas density that is higher than the low-gas density zone. The ion source may be utilized, for example, for ion mobility spectrometry (IMS), mass spectrometry (MS), and hybrid IM-MS.
    Type: Application
    Filed: September 16, 2022
    Publication date: April 27, 2023
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: Ruwan T. KURULUGAMA, Kenneth R. NEWTON
  • Patent number: 11635065
    Abstract: A solvent supply system for supplying a composite includes a first supply path with a first pump unit, the first supply path being adapted for supplying a first solvent to a mixing unit, the first pump unit operating periodically, and a second supply path with a second pump unit, the second supply path being adapted for supplying a second solvent to the mixing unit, the second pump unit operating periodically. The mixing unit is adapted for mixing the first and the second solvent and for supplying a composite solvent. The solvent supply system further includes a control unit adapted for controlling operation of the first and the second pump unit.
    Type: Grant
    Filed: May 17, 2021
    Date of Patent: April 25, 2023
    Assignee: Agilent Technologies, Inc.
    Inventors: Klaus Witt, Konstantin Shoykhet
  • Patent number: 11635412
    Abstract: An apparatus for separating a fluidic sample includes a fluid drive arrangement including fluid drive units for driving a mobile phase along a flow path to a sample separation unit, a sample accommodation volume for accommodating the fluidic sample and selectively fluidically coupleable with or decoupleable from the flow path, and a control unit. The control unit is configured to control pressure decoupling of at least part of at least one of the fluid drive units from the flow path, and enable the partially pressure-decoupled fluid drive unit(s) to pressurize the sample accommodation volume before fluidically coupling the sample accommodation volume with the flow path and/or to de-pressurize the sample accommodation volume after fluidically coupling the sample accommodation volume with the flow path for preparing a subsequent intake of fluidic sample in the sample accommodation volume.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: April 25, 2023
    Assignee: Agilent Technologies, Inc
    Inventor: Konstantin Shoykhet
  • Patent number: 11631575
    Abstract: In an inductively coupled plasma-mass spectrometry (ICP-MS) system, ions are transmitted into a collision/reaction cell. A DC potential is applied at an exit of the cell at a first magnitude to generate a DC potential barrier effective to prevent the ions from exiting the cell. The DC potential barrier is maintained during a confinement period to perform an interaction. After the confinement period, analyte ions or product ions are transmitted to a mass spectrometer by switching the exit DC potential to a second magnitude effective to allow the analyte ions or product ions to pass through the cell exit as a pulse. The analyte ions or product ions are then counted during a measurement period. The interaction may be ion-molecule reactions or ion-molecule collisions.
    Type: Grant
    Filed: October 30, 2020
    Date of Patent: April 18, 2023
    Assignee: Agilent Technologies, Inc.
    Inventors: Noriyuki Yamada, Erina Shimizu
  • Patent number: 11630090
    Abstract: A sample dispatcher for a fluid separation apparatus includes a sampling path including a sampling volume, a sampling unit, and a retaining unit. The sampling unit receives a fluidic sample, and the sampling volume temporarily stores an amount of the received sample. The retaining unit receives and retains from the sampling volume at least a portion of the stored sample, and has different retention characteristics for different components of the sample. A switching unit is coupled to the sampling path, a sampling fluid drive, a mobile phase drive, and a separating device. In a feed injection configuration of the switching unit, the mobile phase drive, the separating device, and the sampling path are coupled together in a coupling point for combining a flow from the sampling fluid drive containing the fluidic sample retained by the retaining unit with a flow of the mobile phase from the mobile phase drive.
    Type: Grant
    Filed: July 30, 2020
    Date of Patent: April 18, 2023
    Assignee: Agilent Technologies, Inc.
    Inventors: Thomas Ortmann, Thomas Glauner
  • Publication number: 20230110390
    Abstract: In some examples, a filter assembly may include a filter including a first gasket having a first channel adjacent to a first side of the filter and a second gasket having a second channel adjacent to a second side of the filter. The first gasket and the second gasket may include a beveled surface adjacent to the filter. The first channel and the second channel may include a diameter of from about 0.01 mm to about 0.5 mm. A finger tightening system may securely hold the filter without any leaks.
    Type: Application
    Filed: June 29, 2021
    Publication date: April 13, 2023
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: Alan D. LOUX, Lucas SERGE, Manuel VAN-VENROOY, Thomas HARRISON, Matthias KAMUF
  • Patent number: 11604197
    Abstract: Methods for identifying compounds that modulate cellular responses stimulated by IgE, which include providing an impedance-based system that monitors cell-substrate impedance of cells on a substrate; introducing cells to the substrate of the system; adding at least one test compound and IgE to the cells, wherein the at least one test compound is suspected of modulating cell responses stimulated by the IgE; adding an antigen to the cells; monitoring the cell-substrate impedance of cells on the substrate; and analyzing the cell-substrate impedance to evaluate whether the at least one test compound alters a cellular response to stimulation with the IgE.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: March 14, 2023
    Assignee: Agilent Technologies, Inc.
    Inventors: Xiao Xu, Yama A. Abassi, Xiaobo Wang, Jiangbo Gan
  • Patent number: D983406
    Type: Grant
    Filed: April 15, 2021
    Date of Patent: April 11, 2023
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Olga Schikurski, Manuel Van-Venrooy, Tiantian Li