Patents Assigned to Agilent Technologies, Inc.
  • Patent number: 10661250
    Abstract: In embodiments, a packing material for supported liquid extraction has a sorbent media that includes synthetic silica particles. In embodiments, the synthetic silica particles can have physical properties relating to one or more of particle surface area, shape, size, or porosity. In one embodiment, synthetic silica particles have a surface area less than about 30 m2/g. In another embodiment, the synthetic silica particles have an approximately uniform particle shape. In further examples, synthetic silica particles have a particle size in a range of about 30-150 ?m inclusive or greater than about 200 ?m. In another embodiment, synthetic silica particles are arranged to have a pore size greater than about 500 Angstroms. In an embodiment, an apparatus for supported liquid extraction includes a container and a sorbent media that includes synthetic silica particles. In a further embodiment, a method for extracting target analytes through supported liquid extraction is provided.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: May 26, 2020
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Kunqiang Jiang, Derick Lucas, Bruce Richter
  • Patent number: 10662465
    Abstract: The invention provides methods and compositions for hybridizing at least one molecule to a target. The composition comprises at least one nucleic acid sequence, formamide, and a hybridization solution, wherein the concentration of formamide is less than or equal to 25%.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: May 26, 2020
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventor: Steen Hauge Matthiesen
  • Patent number: 10662424
    Abstract: Provided herein is a method for fabricating transformable or transfectable molecules that includes an assembly reaction containing a variety of pre-made cassettes possessing ends that hybridize to one another, transforming or transfecting said molecules into a desired host cell and then selecting a transformed/transfected host cell containing plasmid molecules composed of said the cassettes. A kit for performing the method is also provided.
    Type: Grant
    Filed: October 2, 2013
    Date of Patent: May 26, 2020
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Jeffrey Carl Braman, Peter James Sheffield, Gavin Fischer
  • Patent number: 10656402
    Abstract: A scanning apparatus having a stage adapted to hold a specimen to be imaged and to move the specimen in a first direction, and a light source that includes a tunable laser that generates a light beam having an illumination wavelength that varies as a function of an input signal is disclosed. The apparatus includes an imaging system having a scanning assembly that includes a focusing lens that focuses the light beam to a measurement point on the specimen, a first mirror that moves in a second direction relative to the stage such that the focusing lens maintains a fixed distance between the focusing lens and the stage, and a displacement sensor that measures a distance between the scanning assembly at a mapping point on the specimen, and a light detector that measures an intensity of light leaving the measurement point on the specimen.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: May 19, 2020
    Assignee: Agilent Technologies, Inc.
    Inventors: Andrew Ghetler, Richard P. Tella
  • Patent number: 10655177
    Abstract: The invention provides methods and compositions for hybridizing at least one molecule to a target. The invention may, for example, utilize a of cyclic and/or non-cyclic solvent that is non-toxic and may eliminate or reduce the amount of formamide in the hybridization composition.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: May 19, 2020
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventor: Steen Hauge Matthiesen
  • Patent number: 10648970
    Abstract: The present invention lies in the field of visualization and quantification of immobilized targets in samples using immunochemical means. In particular, the invention relates to a method and reagents for detection, visualization and quantification of a molecular target in immunostained histological samples using particular compositions of the target specific binding agent. Methods and compositions of the invention are suitable for any assay that uses a target visualization system in histological samples based on detection of the target by the target specific binding agent. The methods and compositions are useful for evaluation of targets that are biomarkers of diseases in medical diagnostic.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: May 12, 2020
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Jesper Lohse, Kristian Jensen, Rikke Malene Krusenst Jerna-Hafstrom, Kirsten Damgaard Hoff, Lars Christian Jacobsen
  • Publication number: 20200144046
    Abstract: Systems and methods for controlling mass filtering of polyatomic ions in an ion beam passing through an inductively coupled plasma mass spectrometer (ICP-MS). Polyatomic ion mass data representative of the exact mass of a polyatomic ion having a target isotope is determined. A control signal is generated based on the determined polyatomic ion mass data and output to an ICP-MS to filter based on mass the polyatomic ions in the ion beam traveling through the ICP-MS to an ion detector.
    Type: Application
    Filed: August 20, 2019
    Publication date: May 7, 2020
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: Naoki Sugiyama, Amir Liba, Mark Lee Kelinske, Glenn David Woods
  • Patent number: 10642354
    Abstract: An environmental chamber having an interior compartment, an augmented display, and a controller is disclosed. The interior compartment is adapted for isolating an experimental setup from an environment external to the interior compartment. The augmented display is positioned to allow a user in the external environment to view the interior compartment and an image generated on the augmented display. The controller generates the image. The image includes information about a component within the interior compartment. The augment display can include a touch-enabled display screen that allows the user to interact with controller.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: May 5, 2020
    Assignee: Agilent Technologies, Inc.
    Inventor: Robert H. Kincaid
  • Patent number: 10641746
    Abstract: An injector, for injecting a fluidic sample into a flow path between a fluid drive and a sample separation unit, includes a sample accommodation volume, a sample drive, and a fluidic valve switchable to selectively couple the volume with the flow path or decouple the volume from the flow path. In an injection switching state, the fluid drive, the separation unit and the sample drive are coupled by the valve so that fluid driven by the sample drive and flowing from the volume to the separation unit and further fluid driven by the fluid drive and flowing from the fluid drive to the separation unit are combined at a fluidic connection upstream of the separation unit. A control unit controls a pressure of the fluid and/or the further fluid during injecting.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: May 5, 2020
    Assignee: Agilent Technologies, Inc.
    Inventors: Daniel Thielsch, Thomas Ortmann
  • Publication number: 20200136555
    Abstract: In one embodiment, a system includes a mass analyzer, an ion source for providing ions to the mass analyzer, a detector for detecting an output of the mass analyzer, and a frequency-selectable power source. The frequency-selectable power source may include an energy supply configured to provide high-voltage radio-frequency (RF) energy to the mass analyzer at individually selectable first and second frequencies, and a frequency selector for switching between the individually selectable first and second frequencies.
    Type: Application
    Filed: October 31, 2018
    Publication date: April 30, 2020
    Applicant: Agilent Technologies, Inc.
    Inventor: Michael J. Schoessow
  • Patent number: 10633651
    Abstract: The present invention relates to nucleic acid samples for massively parallel sequencing. More particularly, the present invention relates to assay methods, compositions and kits for detecting contamination of nucleic acid identifiers such as sample barcodes.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: April 28, 2020
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Katie Leigh Zobeck, Paige Anderson, Javelin Chi, Henrik Johansson
  • Patent number: 10626441
    Abstract: Described herein is a method for adding a counter sequence to the individual polynucleotide molecules of an initial nucleic acid sample. After addition of the counter sequence, the sample may be amplified and the number of initial target molecules in the sample can be estimated by counting the number of counter sequences associated with the amplified target molecules.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: April 21, 2020
    Assignee: Agilent Technologies, Inc.
    Inventors: Robert Osborne, James Casbon, Andreas Claas, Gi Mikawa, Esther Musgrave-Brown
  • Patent number: 10618920
    Abstract: Modified silica particles are provided. Aspects of the particles include an outer layer that is composed of organically-modified silica comprising a siloxane-linked hydrophilic group, such as a charged functional group or a polar neutral functional group. The modified silica particles can form the basis of a variety of chromatography support materials. Also provided are methods of preparing the subject particles. Aspects of the methods include contacting silica particles with water, an ionic fluoride and an organosilane reagent comprising a hydrophilic moiety to produce modified silica particles wherein the hydrophilic moiety of the organosilane reagent is incorporated into an outer layer of the silica particles. Chromatography supports and kits including the subject particles and methods of using the same are also provided.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: April 14, 2020
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Wu Chen, Yingyu Li, Ta-Chen Wei, Xiaoli Wang
  • Patent number: 10620171
    Abstract: The present disclosure generally relates to improved methods for separating and analyzing compounds by liquid chromatography, particularly when coupled with mass spectrometry. The methods include the addition of an additive to a mobile phase carrying a sample. The mobile phase additive may be effective for improving peak shapes of targeted analytes in acquired data, and/or eliminating or at least reducing ion suppression. The methods are particularly suited for anionic compounds such as phosphorylated compounds.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: April 14, 2020
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Jordy J. Hsiao, Hongfeng Yin, Oscar G. Potter
  • Patent number: 10613005
    Abstract: Paraffin-embedded tissue, which may be disposed on a solid substrate, is prepared by a dry technique that removes paraffin from tissue without adding any liquid to the tissue, thereby rendering the tissue substantially free of paraffin. The dry technique may entail applying heat energy to the tissue effective to melt the paraffin and thereby render it flowable, and applying an electric field. The electric field is effective to impart electrical charge to the paraffin and to move the paraffin out from the tissue due to electrical charge repulsion or attraction, which may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. The electric field, or both the electric field and the heat energy, may be applied until the tissue is substantially free of paraffin.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: April 7, 2020
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Victor Lim, Carol T. Schembri, Adrienne Mccampbell, Nazumi Alice Yama-Dang
  • Patent number: 10613092
    Abstract: Aspects of the present disclosure provide methods for determining the eligibility of a subject having a malignancy for treatment with an anti-PD therapeutic agent based on a Combined Positive Score (CPS) for a tumor tissue sample from the subject. Compositions and kits or performing the disclosed methods are also provided.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: April 7, 2020
    Assignees: Agilent Technologies, Inc., Merck Sharp & Dohme Corp.
    Inventors: Karina Kulangara, Nancy Zhang, David Stanforth, Greg Angelides, Stephanie Waldroup, Kenneth Emancipator
  • Patent number: 10612043
    Abstract: The present invention provides a method for making a large nucleic acid having a defined sequence in vivo. The method combines recombineering techniques with a CRISPR/Cas system to permit multiple insertions of defined sequences into a target nucleic acid at one time, double stranded cleavage of target nucleic acids in which the defined sequences were not successfully inserted, and selection of successful recombinant cells. The method further includes repeating the process one or more times, using a successful recombinant from one round as the host cell for the next round.
    Type: Grant
    Filed: January 7, 2014
    Date of Patent: April 7, 2020
    Assignee: Agilent Technologies, Inc.
    Inventor: Carsten-Peter Carstens
  • Patent number: 10611818
    Abstract: The present invention relates to MHC-peptide complexes and uses thereof in the diagnosis of, treatment of or vaccination against a disease in an individual. More specifically the invention discloses MHC complexes comprising Mycobacterium tuberculosis antigenic peptides and uses there of.
    Type: Grant
    Filed: September 29, 2008
    Date of Patent: April 7, 2020
    Assignee: Agilent Technologies, Inc.
    Inventors: Jørgen Schøller, Liselotte Brix, Henrik Pedersen, Tina Jakobsen
  • Patent number: D884524
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: May 19, 2020
    Assignee: Agilent Technologies, Inc.
    Inventors: Bo Chu, Fanny Hauser, Cathrin Sohns, Qi Siegmundt-Pan
  • Patent number: D885216
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: May 26, 2020
    Assignee: Agilent Technologies, Inc.
    Inventors: Ping Hu, Fanny Hauser, Cathrin Sohns, Qi Siegmundt-Pan, Maximilian Schneider