Patents Assigned to Agilent Technologies
  • Publication number: 20240295559
    Abstract: In alternative embodiments, provided are immunohistochemistry (IHC) methods for determining and scoring reproducibly the extent of nuclear expression of protein Ki-67 (also known as MK167) in a tissue sample. In alternative embodiments, provided are methods for diagnosing, treating or ameliorating or assessing the risk of recurrence for a cancer or a tumor using an IHC method as provided herein. In alternative embodiments, provided are kits comprising components and instructions for practicing methods as provided herein.
    Type: Application
    Filed: September 8, 2021
    Publication date: September 5, 2024
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: Mark VERARDO, Mariana CAJAIBA, Debra HANKS, Lauren JACOBSON, Gitte NIELSEN, Claudia GOTTSTEIN, Aaron M. GRUVER
  • Patent number: 12079313
    Abstract: Novel tools and techniques are provided for implementing software licensing management and authentication. In various examples, a computing system might receive a request for an unlock code for a requested service from a user using a client device on which a first software is executed, the request comprising a generated unique identifier associated with the requested service and/or the first software. The generated unique identifier comprises licensing information associated with the requested service and/or the first software. In response to receiving the generated unique identifier, the computing system might determine whether the user should have access to the requested service using the first software based at least in part on the licensing information. If so, the computing system might generate an unlock code associated with the requested service using the first software, might deduct cost associated with the licensing information, and might send the unlock code to the user.
    Type: Grant
    Filed: May 21, 2020
    Date of Patent: September 3, 2024
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Dustin Bingham, Charles Manfredi
  • Patent number: 12078619
    Abstract: An injector, for injecting a fluidic sample in at least one selected one of a first sample separation apparatus and a second sample separation apparatus, includes a valve arrangement fluidically connectable to the first sample separation apparatus and the second sample separation apparatus, a sample accommodation volume for accommodating the fluidic sample, and a control unit configured for controlling the valve arrangement so that fluidic sample in the sample accommodation volume is selectively injectable into the selected first sample separation apparatus and/or second sample separation apparatus.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: September 3, 2024
    Assignee: Agilent Technologies, Inc.
    Inventor: Thomas Ortmann
  • Patent number: 12066428
    Abstract: Methods of assessing cytolysis of cancer cells are provided, which include: providing a cell-substrate impedance monitoring device operably connected to an impedance analyzer, adding target cells characterized as cancer cells to a well of the device adding effector cells to the well to form a test well, where the effector cells are immune cells obtained or derived from a same patient as the target cells; monitoring cell-substrate impedance of the test well before and after adding the effector cells and optionally deriving an impedance-based parameter from the impedance; and determining effectiveness of effector cell killing of the target cells by comparing the impedance or impedance-based curves over time.
    Type: Grant
    Filed: October 29, 2020
    Date of Patent: August 20, 2024
    Assignee: Agilent Technologies, Inc.
    Inventors: Xiaobo Wang, Yama A. Abassi, Nan Li, Lincoln Muir, Xiao Xu
  • Patent number: 12059683
    Abstract: An implement for eliminating headspace in the testing space(s) (T9 or MPWell) of a test tube (T) or microtiter plate (MP), and methods of using such implements to measure oxygen concentration in a test sample. The implement projects into a test chamber (T9 or MPWell) to displace a portion of a fluid sample within the test chamber (T9 or MPWell) and has longitudinally extending grooves (109 and 229) through which the displaced fluidic content can be discharged from the test chamber (T9 or MPWell).
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: August 13, 2024
    Assignee: Agilent Technologies, Inc.
    Inventors: Ian M. Hayes, James N. Hynes
  • Patent number: 12055526
    Abstract: A sampling unit for handling a sample fluid includes a sample container having a length and being configured for receiving and storing the sample fluid, and a sample segment dispatching unit configured for providing a plurality of individual sample packages of the fluidic sample, each contained in a respective volume segment along the length of the sample container, and for individually dispatching each of the plurality of individual sample packages for further processing in a fluid processing unit. The sample unit may be utilized, for example, for injecting the sample packages into a mobile phase stream for transporting to a sample separating unit such as a chromatography column.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: August 6, 2024
    Assignee: Agilent Technologies, Inc.
    Inventors: Stephan Buckenmaier, Konstantin Shoykhet
  • Publication number: 20240254982
    Abstract: An autoclaving microplate washing system for cells and non-adhering three-dimensional (3D) cell cultures includes one or more pumps for controlling the dispensing of washing fluid and the evacuation of fluid from microwells to gently wash the cells. A method of controlling the autoclaving microplate washing system includes controlling the one or more pumps for dispensing and evacuation.
    Type: Application
    Filed: April 11, 2024
    Publication date: August 1, 2024
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: Christopher MANY, Brad LARSON, Byron SMITH, Brian STRUHAMMER
  • Patent number: 12049615
    Abstract: A system for electronically and optically monitoring biological samples, the system including: a multi-well plate having a plurality of wells configured to receive a plurality of biological samples, each of the wells having a set of electrodes and a transparent window on a bottom surface of the well that is free of electrodes; an illumination module configured to illuminate the wells; a cradle configured to receive the multi-well plate, the cradle having an opening on the bottom that exposes the transparent windows of the wells; and an optical imaging module movable across different wells of a same multi-well plate to capture images through the windows.
    Type: Grant
    Filed: March 31, 2023
    Date of Patent: July 30, 2024
    Assignee: Agilent Technologies, Inc.
    Inventors: Nan Li, Xin Yao, Longbin Fang, Lingbo Kong, Qiting Ye, Caixia Yang, Brandon Lamarche, Xiaobo Wang
  • Patent number: 12050163
    Abstract: Paraffin-embedded tissue is prepared removing paraffin from the tissue. The paraffin is removed by generating an electric field effective to produce plasma and direct charged species of the plasma to the paraffin, thereby rendering the paraffin responsive to the electric field. The electric field may move the paraffin out from the tissue due to electrostatic force. Movement of the paraffin may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. Movement of the paraffin also may be assisted by applying a solvent and/or heat energy to the tissue.
    Type: Grant
    Filed: October 28, 2022
    Date of Patent: July 30, 2024
    Assignee: Agilent Technologies, Inc.
    Inventors: Adrienne Mccampbell, Victor Lim
  • Publication number: 20240248580
    Abstract: In some examples, linear and non-linear range-based plot pane selection may include receiving data that is to be displayed. Based on an increase or a decrease in a size of a range selector, a selection of a range of plot panes may be received from a plurality of available plot panes to display the data. Based on the received selection of the range of plot panes, a display of the data may be generated in plot panes included in the range of plot panes. The size of the range selector may be non-linearly proportional to the available plot panes to display the data.
    Type: Application
    Filed: January 19, 2023
    Publication date: July 25, 2024
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventor: Rainer JAEGER
  • Publication number: 20240238952
    Abstract: In some examples, a multi-device removal and installation tool may include a device removal tool including a first side having a first receiver with a first dimension that removably receives a first device, and a second side having a second receiver with a second dimension that removably receives a second device. The first dimension may be different from the second dimension. Further, the first receiver may include a plurality of separators to separate a surface of the first receiver from a surface of the first device.
    Type: Application
    Filed: March 28, 2024
    Publication date: July 18, 2024
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventor: Alan D. LOUX
  • Patent number: 12037640
    Abstract: Methods and kits for next-generation sequencing are disclosed. In some embodiments, the present methods comprise sequencing an insert and sequencing an insert without an intervening denaturation step. Decreased sequencing signal from insert sequences, the use of unlabeled nucleotides to form double stranded insert constructs, and the use of synthesis blocking nucleotides are also discussed.
    Type: Grant
    Filed: January 8, 2021
    Date of Patent: July 16, 2024
    Assignee: Agilent Technologies, Inc.
    Inventor: Kyeong Soo Jeong
  • Publication number: 20240229851
    Abstract: In some examples, a vessel mounting system may include a first collar and a second collar. The second collar may include a clip engageable with an edge of the first collar to engage the second collar with the first collar.
    Type: Application
    Filed: October 19, 2022
    Publication date: July 11, 2024
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: Manuel VAN VENROOY, Patrick MATZ, Alan NORMAN
  • Publication number: 20240226901
    Abstract: In some examples, a vessel mounting system may include a first collar and a second collar. The second collar may include at least one positioning member to position the second collar relative to the first collar. Further, the second collar may include at least one interlocking member to lock the second collar to the first collar.
    Type: Application
    Filed: October 19, 2022
    Publication date: July 11, 2024
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: Manuel VAN VENROOY, Patrick MATZ, Alan NORMAN
  • Publication number: 20240229850
    Abstract: In some examples, a vessel mounting system may include a first collar including at least one protrusion engageable with a groove of a vessel to align the first collar relative to the vessel. A second collar may include at least one stud disposable in a corresponding aperture of the first collar to align the second collar relative to the first collar.
    Type: Application
    Filed: October 19, 2022
    Publication date: July 11, 2024
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: Manuel VAN VENROOY, Patrick MATZ, Alan NORMAN
  • Publication number: 20240229848
    Abstract: In some examples, a vessel mounting system may include a first collar including at least one flexible member engageable with a groove of a vessel to align the first collar relative to the vessel. A second collar may include at least one clip engageable with a complementary clip of the first collar to engage the second collar with the first collar.
    Type: Application
    Filed: October 19, 2022
    Publication date: July 11, 2024
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: Manuel VAN VENROOY, Patrick MATZ, Alan NORMAN
  • Patent number: 12033843
    Abstract: Provided herein is an ion source containing a plurality of components, at least one of which is partially coated with a layer of silicon. The ion source reduces reactivity between the sample and the carrier gas, reduces or eliminates tailing in ion chromatograms, and/or improves mass spectral fidelity. Also provided are methods of using the ion source in a mass spectrometer or gas chromatograph-mass spectrometer.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: July 9, 2024
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Bruce D. Quimby, Anastasia A. Andrianova
  • Publication number: 20240203721
    Abstract: In some examples, a multi-device removal and installation tool may include a device removal tool including catch members engageable with an engagement face of a device to attach, upon engagement of the catch members with the engagement face, the device removal tool to the device. The catch members may engage the engagement face with a removal force that is sufficient to remove, upon engagement of the catch members with the engagement face, the device from an instrument. The multi-device removal and installation tool may further include a torque limit tool including a retainer having at least one protrusion, and a drive member having an inside surface and an outside surface. The torque limit tool may further include at least one detent positioned on the inside surface.
    Type: Application
    Filed: March 4, 2024
    Publication date: June 20, 2024
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventor: Alan D. LOUX
  • Patent number: 12015320
    Abstract: A magnetic coupling assembly includes a first balancing magnet positioned and surrounding drive magnets and, across a gap, a second balancing magnet and surrounding driven magnets. The drive magnets when rotated drive the driven magnets to rotate. The balancing magnets generate a repulsive force, which counterbalances an attractive force generated by the drive magnets and driven magnets. The assembly may be utilized in a pump for contactless coupling of a motor shaft to a pump shaft. The driven side of the assembly may be hermetically sealed, such as with a liquid crystal polymer boundary interposed in the gap.
    Type: Grant
    Filed: May 7, 2020
    Date of Patent: June 18, 2024
    Assignee: Agilent Technologies, Inc.
    Inventor: Ronald J. Forni
  • Patent number: D1037883
    Type: Grant
    Filed: May 12, 2023
    Date of Patent: August 6, 2024
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Patrick Matz, Matthias Kamuf, Manuel Van Venrooy, István Molnar, Tobias Anhaus