Patents Assigned to Agilent Technologies
  • Target enrichment and labeling for multi-kilobase DNA
    Patent number: 10308979
    Abstract: This disclosure provides a method comprising: a) clamping the top and bottom strands of a double stranded DNA molecule to produce a duplex in which the top and bottom strands are linked; b) denaturing the duplex to produce a denatured product; and c) renaturing the denatured product in the presence of a labeled oligonucleotide that is complementary to a sequence of nucleotides in the double stranded DNA molecule, thereby producing a D-loop-containing product. Kits for performing the method and products made by the method are also provided.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: June 4, 2019
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Brian Jon Peter, Robert A. Ach, Zoltan Timar, Joel Myerson, Jeffrey Robert Sampson, Holly Hogrefe
  • Column assembly for a gas chromatograph
    Patent number: 10302605
    Abstract: A column assembly for gas chromatography, which is coolable by a fluid, includes a capillary column, a heating element for heating at least a portion of the capillary column, and a tube having a lumen and in contact with at least one of the capillary column and the heating element. When energized, the heating element raises the temperature of the capillary column. To lower the temperature of the capillary column, a fluid flows through the tube, and heat is transferred from the capillary column to the fluid in the tube.
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: May 28, 2019
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventor: Robert V. Mustacich
  • Sealing configuration with metal-coated structure
    Patent number: 10300403
    Abstract: A sealing configuration is configured for sealingly coupling a first fluid flow path of a first device to a second fluid flow path of a second device. The sealing configuration comprises a contact surface comprising a structure configured for increasing a surface pressure when coupling the first device to the second device. The contact surface comprises a metal coating configured for increasing sealing.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: May 28, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Hans-Georg Haertl, Joachim-Richard Wagner
  • Fluidic valve with contactless force transmission for pressing together stator and rotor
    Patent number: 10302213
    Abstract: A fluidic valve for switching between different fluid coupling states includes a stator having at least one fluidic stator interface, a rotor having at least one fluidic rotor interface, wherein the rotor is rotatable relative to the stator to thereby switch the fluidic valve between a plurality of different fluid coupling states between the at least one fluidic stator interface and the at least one fluidic rotor interface, and a force transmission mechanism configured for pressing the stator and the rotor together by a contactless force transmission to provide for a fluid tight sealing between the stator and the rotor.
    Type: Grant
    Filed: October 18, 2016
    Date of Patent: May 28, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Tony Ziegler, Manfred Berndt
  • Angular synchronization of stationary and orbiting plate scroll blades in a scroll pump using a metallic bellows
    Patent number: 10294939
    Abstract: Parts of a pump head of a scroll pump facilitate an assembly process in which the stationary and orbiting scroll blades of the pump are angularly aligned or synchronized with one another. A metallic bellows of the pump head provides a primary means of synchronizing the stationary and orbiting scroll blades. The assembly process may be carried out using a fixture configured to be mountable to an assemblage including the bellows and the orbiting plate scroll. The fixture has a reference feature, and the orbiting plate scroll or the frame has another reference feature that can be aligned with the reference feature of the fixture, in the circumferential direction of the bellows, during the course of the assembly process.
    Type: Grant
    Filed: March 19, 2016
    Date of Patent: May 21, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: John Calhoun, George Galica, Vannie (Yucong) Lu, James Pierce
  • Plurality of transposase adapters for DNA manipulations
    Patent number: 10287622
    Abstract: The present invention relates to transposase adapters and uses thereof, including uses in preparing DNA molecules, in vitro amplification, sequencing of nucleic acids, and screening of DNA libraries for sequences of interest as well as nucleic acid delivery.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: May 14, 2019
    Assignee: Agilent Technologies, Inc.
    Inventor: Alexander S. Belyaev
  • Tandem collision/reaction cell for inductively coupled plasma-mass spectrometry (ICP-MS)
    Patent number: 10290482
    Abstract: A tandem collision/reaction cell for an inductively coupled plasma-mass spectrometry (ICP-MS) system includes a first ion guide, a second ion guide, and an intermediate electrode in the vicinity of an exit end of the first ion guide. A DC potential barrier is applied to the intermediate electrode. The cell may provide two or more stages of an ion-molecule collision process.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: May 14, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Noriyuki Yamada, Erina Shimizu, Yu Okamoto
  • Uninterrupted fluid flow while modulating fluid
    Patent number: 10281058
    Abstract: A fluid processing device (10) for processing fluid, wherein the fluid processing device (10) comprises a first fluid drive unit (20) configured for driving a first fluid along a first flow path (85), a second fluid drive unit (20?) configured for driving a second fluid along a second flow path (86), and a fluidic switch (90) fluidically coupled to the first flow path (85) and to the second flow path (86) and configured for being switchable for transferring first fluid from the first flow path (85) into the second flow path (86) without interruption of fluid flow along at least one of the first flow path (85) and the second flow path (86).
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: May 7, 2019
    Assignee: AGILENT TECHNOLOGIES
    Inventors: Konstantin Shoykhet, Klaus Witt, Stephan Buckenmaier, Dwight Stoll
  • Quantum cascade laser with serially configured gain sections
    Patent number: 10283936
    Abstract: An apparatus that includes a gain chip assembly, an external cavity, and a controller is disclosed. The gain chip assembly includes first and second gain chips that are coupled optically such that light travels serially between the first gain chip and the second gain chip, each gain chip is electrically biased. The electrical bias of the first gain chip is independent of the electrical bias of the second gain chip. The external cavity has a tunable wavelength selective filter that is changed in response to a control signal. Light in the external cavity passes through the gain chip assembly. The controller determines the tunable wavelength selective filter, and the electrical bias of each of the gain chips so as to cause the apparatus to lase at a wavelength specified by a control signal to the controller.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: May 7, 2019
    Assignee: Agilent Technologies, Inc.
    Inventor: Guthrie Partridge
  • System and method for generating high-voltage radio frequency signals using an electronically tuned resonator
    Patent number: 10284154
    Abstract: A system for generating a radio frequency (RF) signal at a drive frequency and a high voltage. The system includes a RF amplifier to amplify the voltage of a drive signal having a selected RF frequency. The amplified drive signal is used to drive a resonator to generate the RF signal such that the resonant frequency is the same or substantially the same as the drive frequency. A resonance tuning controller compares the drive frequency and the resonant frequency. If the resonant frequency and drive frequency are different, a temperature changing element is controlled to either increase heat or decrease heat radiating toward a tuning component with a resonance parameter that varies with temperature. For example, the heat may change the capacitance of the tuning capacitor causing a change in the resonant frequency of the resonator.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: May 7, 2019
    Assignee: Agilent Technologies, Inc.
    Inventor: Michael Schoessow
  • Self cleaning gas-liquid separator for serial or parallel collection of liquid fractions
    Patent number: 10279294
    Abstract: An apparatus, process, and system are disclosed that effectively provide separation of a combined gas/liquid flow stream into its separated gas and liquid factions. The invention is primarily directed to the fields of preparative supercritical fluid chromatography (SFC) and supercritical fluid extraction (SFE), but will have other utilization and applicability where phases of dramatically different density, viscosity and volumetric flow require separation.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: May 7, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Kimber D Fogelman, Terry A Berger, Edwin E Wikfors
  • System and method for facilitating manual sorting of objects
    Patent number: 10265733
    Abstract: An apparatus that facilitates the manual sorting of objects is disclosed. The apparatus includes a display surface having a surface that can be selectively illuminated and that is adapted for receiving the objects. An identification reader reads identification information stored on the objects. A controller causes an area on the display surface corresponding to one of the objects to be illuminated based on the identification information and indicates a location to which the illuminated object is to be moved. In one aspect of the invention, the display surface includes an area adapted for positioning a receiver for the objects. The display surface provides an indication of a position in the receiver at which the one of the objects is to be placed.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: April 23, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Robert Kincaid, Melanie Tory, Joachim Schmid
  • Wideband isolation directed by ion mobility separation for analyzing compounds
    Patent number: 10267765
    Abstract: In an ion mobility-mass spectrometry (IM-MS) system, an ion mass-isolated data set is acquired by operating a mass filter to apply a mass isolation window having an m/z width such that the mass isolation window moves through a sequence of window positions, each window position being defined by an IM drift time value and an m/z ratio value. The m/z width of the mass isolation window and the sequence of window positions are determined such that the mass isolation window captures ions in a region of interest of a larger all-ions data set. The isolation window may be a wideband isolation window. In comparison to the all-ions data set, the mass-isolated data set may yield reduced ion signal interference and increased selectivity for analytes of interest.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: April 23, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Jun Wang, Ruwan T. Kurulugama, George Stafford, Gregor T. Overney
  • ESD protected tubing for removing charge from lumen
    Patent number: 10254257
    Abstract: An electrostatic discharge protected device for conducting a fluid through at least one lumen includes a tubing having a hollow interior defining the at least one lumen. The tubing includes an electrically conductive section configured for conducting electric charge, generated within the at least one lumen when the fluid flows through the at least one lumen, away from the at least one lumen.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: April 9, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Tony Ziegler, Stefan Falk-Jordan
  • Transposase-random priming DNA sample preparation
    Patent number: 10240196
    Abstract: Provided herein, among other things, are a variety of methods for transposase-mediated tagging and amplification of short DNA fragments, e.g., between about 150 bp and 1.5 Kb in length. In some aspects, the method includes tagging the DNA fragments with a first primer sequence using barcoded transposases followed by a primer extension reaction to introduce a second primer sequence, e.g., using random or gene-specific primers. Kits for performing this method are also provided.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: March 26, 2019
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Bahram Arezi, Michael Borns, Holly Hogrefe, Connie Hansen
  • Method for unsupervised stain separation in pathological whole slide images
    Patent number: 10229495
    Abstract: A method of operating a data processing system to automatically process a color digital image of a specimen that has been stained with a first dye and a second different dye is disclosed. The method includes receiving a color image that includes a plurality of pixels, each pixel being characterized by a pixel vector having components determined by the intensity of light in each of a corresponding number of wavelength bands. A plurality of pixel vectors of the image are transformed to a hue space divided into a plurality of bins, each bin being characterized by a number of pixels that have been transformed into that bin. The data processing system automatically finds first and second color vectors characterizing the first and second dyes, respectively based on the number of pixels that were transformed into each of the bins.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: March 12, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Amir Ben-Dor, Elad Arbel
  • Apparatus and method for facilitating manual sorting of slides
    Patent number: 10217011
    Abstract: The present invention includes an apparatus and method that facilitates the manual sorting of slides into slide folders. The apparatus includes a horizontal display surface and a controller configured to receive slides and folders into which the slides are to be placed (or sorted). The controller operates components of the apparatus to selectively illuminate the display surface to guide a user in placing folders at multiple folder locations and in sorting the slides into the folders. In one aspect of the invention, the apparatus is configured to allow multiple folders to be stacked at a folder location during the slide sorting process. In these aspects, the apparatus is configured to determine number of folders stacked at each folder location.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: February 26, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Richard K. Workman, Victor Lim, Varun Raghunathan
  • Microfluidic glycan analysis
    Patent number: 10209259
    Abstract: Microfluidic devices and methods for analyzing glycan profiles of glycoproteins are provided. Some embodiments of the devices comprise a deglycosylation column for cleaving glycans, an optional cleaning column for removing proteins, a trapping column for enriching glycans, and a separation column for resolving glycans. The devices and methods significantly improve the speed and sensitivity of glycan analysis.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: February 19, 2019
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Magdalena Anna Ostrowski, Rudolf Grimm, Kevin P. Killeen, Karla M. Robotti
  • Fluid dispensing nozzle assembly
    Patent number: 10207285
    Abstract: The current document is directed to a fluid dispensing nozzle assembly for use with a multi-well synthesizer and in other reagent distribution systems. In certain implementations, a fluid dispensing nozzle assembly comprises a nozzle body with a built-in dispenser tube, a reagent inlet tube, and a fitting that securely connects the inlet tube to the nozzle body. The nozzle body with the built-in dispenser tube and the reagent inlet tube are securely attached to one another by various coupling elements or adhesive material to ensure that liquid is transmitted through the inlet tube without leaking into the nozzle body and other undesired areas.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: February 19, 2019
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventor: Gary McLuen
  • Method for supplying gas for plasma based analytical instrument
    Patent number: 10211038
    Abstract: To achieve an effective gas filtering in a plasma spectrometric apparatus using a gas of a comparatively high consumption flow rate, and to improve the analytical ability, there is provided a plasma spectrometric apparatus containing a sample introducer for producing and delivering an injector gas containing an analyte sample, a plasma generator for generating plasma into which the injector gas is introduced, and an analyzer disposed subsequent to the plasma generator for analyzing the analyte sample. The plasma spectrometric apparatus contains a first gas line for supplying gas to the sample introducer, a second gas line for supplying gas to the plasma generator, and a filter located in the first gas line for removing impurities contained in the gas.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: February 19, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Yoichi Nagata, Shusaku Tsuruga, Takeo Kuwabara, Ryosuke Tobiyama