Abstract: Polyester resins containing a structural unit represented by the following general formula (1), and has an aromatic oxycarbonyl group at its terminal: (in the formula, XCs each independently represent a divalent organic group containing at least one aromatic ring, XDs each independently represent a divalent organic group, m is an average value of the number of repetitions, and is a number satisfying 0<m?10, and * indicates a bond), afford a cured product exhibiting excellent dielectric properties and also favorable mechanical properties in combination with a cross-linkable resin.
Abstract: An agricultural or horticultural composition is provided. A composition containing a culture broth of a Bacillus bacterium having prephenate dehydratase (PD) resistant to feedback inhibition by phenylalanine.
Abstract: A method of making a microwavable frozen dumpling, whereby a raw dumpling containing a dough and one or more filling ingredients is boiled to form a boiled dumpling, and the boiled dumpling is frozen to form the microwavable frozen dumpling. The dough of the microwavable frozen dumpling includes a rice flour, an oil, and a modified cellulose polymer, and has a moisture content of at least 52.0 wt. %. A method of preparing a cooked dumpling is also provided, whereby the microwavable frozen dumpling is heated in a microwave oven without covering the microwavable frozen dumpling.
Abstract: Provided is a technology for improving the flavor of food. The flavor of food is improved by adding the following ingredient (A): (A) a cell wall-containing fraction of a gram-positive bacterium.
Abstract: Resin compositions including (A) a compound containing a radical polymerizable group having a carbodiimide structure, and at least any one of (B) a compound containing a radical polymerizable group not having a carbodiimide structure and (C) a thermosetting resin can afford a cured product having excellent mechanical strength and plating adhesion property.
Abstract: Described herein is an enzyme useful for producing a target peptide, capable of producing the target peptide without requiring ATP. More specifically, provided herein is a modified enzyme includes an amino acid sequence such as a modified amino acid sequence including a mutation of one or more of the following amino acid residues: E81, I127, I136, T139, F140, G142, W143, I147, I181, I201, Q219, T229, M244, A249, P255, E256, I260, S293, N294, Y295, and I299 in an amino acid sequence of SEQ ID NO: 1, and having the following property (a) or (b) enhanced relative to an enzyme of the amino acid sequence of SEQ ID NO: 1: (a) imidazole dipeptide production activity; or (b) thermal stability.
Type:
Application
Filed:
March 27, 2024
Publication date:
July 18, 2024
Applicant:
AJINOMOTO CO., INC.
Inventors:
Mizuki Tamori, Uno Tagami, Hiroyuki Nozaki
Abstract: A plant protein-containing food may be prepared by the addition of a high molecular rapeseed protein and transglutaminase to a plant protein-containing composition.
Abstract: The present invention provides a sporulation inhibitor of Clostridium perfringens containing at least one inorganic compound at a concentration that allows Clostridium perfringens to settle in vivo, wherein the inorganic compound is at least one salt selected from the group consisting of K, Na, Mg, Ca, and Fe, and the inorganic compound is coated with a protective layer containing hydrogenated vegetable oil.
Abstract: A method for measuring a response of an olfactory receptor to a substance is provided. The test substance and the olfactory receptor are contacted under such a condition that response of adenosine receptor to the test substance is reduced, and response of the olfactory receptor to the test substance is measured.
Abstract: A method for producing an intermediate antibody regioselectively modified, which comprises: (1) mixing a solution comprising an antibody material and a solution comprising a reagent for regioselectively modifying an antibody in a micromixer to form a mixture comprising the antibody material and the reagent, wherein the reagent comprises a compound comprising an affinity substance to an antibody and a reactive group to an antibody; and (2) passing the mixture through a reaction channel to allow the antibody material and the reagent to react in the reaction channel to form a solution comprising an intermediate antibody regioselectively modified, wherein the processes (1) and (2) are continuously performed in a flow microreactor, is capable of rapidly producing a desired antibody derivative regioselectively having a functional substance or functional substances.
Type:
Application
Filed:
March 7, 2024
Publication date:
July 4, 2024
Applicant:
Ajinomoto Co., Inc.
Inventors:
Yutaka MATSUDA, Yuichi NAKAHARA, Kei YAMADA, Keisuke KATO, Yuta ENDO, Brian Alan MENDELSOHN
Abstract: The present invention provides a technique enabling modification of a soluble protein and in particular regioselective modification of a soluble protein. More specifically, the present invention provides a compound having an affinity substance to a soluble protein, a cleavable portion, and a reactive group represented by the following Formula (I): A-L-B-R??(I) wherein A is an affinity substance to a soluble protein; L is a cleavable linker which is a divalent group comprising a cleavable portion; B is (a) a divalent group comprising a bioorthogonal functional group or (b) a divalent group comprising no bioorthogonal functional group; and R is a reactive group to the soluble protein; or a salt thereof.
Abstract: A method for secretory production of a protein containing a noncanonical amino acid is provided. Secretory production of a noncanonical amino acid-containing protein is carried out by culturing a coryneform bacterium having a genetic construct for secretory expression of a protein containing a noncanonical amino acid, which is modified to express an orthogonal pair of tRNA corresponding to the noncanonical amino acid and aminoacyl tRNA synthetase.
Type:
Application
Filed:
January 2, 2024
Publication date:
June 27, 2024
Applicant:
AJINOMOTO CO., INC.
Inventors:
Kenichi Haruna, Haruna Sato, Yoshihiko Matsuda, Kenichiro Ito
Abstract: Cheese analogues with improved meltability and/or extensibility when heated, may be obtained by causing a protease to act on a mixture containing fat and/or oil, starch, and protein.
Abstract: Magnetic pastes which include a magnetic powder (A) and a binder resin (B), in which, in the particle diameter distribution of the component (A), the 10% particle diameter (D10) is 0.2 ?m or larger and 2.0 ?m or smaller, the 50% particle diameter (D50) is 2.0 ?m or larger and 4.3 ?m or smaller, and the 90% particle diameter (D90) is 4.3 ?m or larger and 8.5 ?m or smaller, suppress the magnetic powder from being unevenly distributed, and are useful for forming inductor elements and circuit boards.
Abstract: A medicament for the prophylaxis or treatment of inflammatory diseases or fibrous diseases, may be produced by inducing mesenchymal stem cells by culturing neural crest cells in a medium composition for inducing mesenchymal stem cells from neural crest cells, comprising a basal medium and corticosteroid, the composition having a converted concentration of the corticosteroid in the medium composition of not less than 1.25 ?M.
Abstract: The present invention provides a method for producing a basic L-amino acid, for example, L-ornithine L-citrulline, L-arginine, L-histidine, and L-lysine by fermentation using a bacterium belonging to the family Enterobacteriaceae which has been modified to overexpress a gene encoding a protein having L-methionine/branched chain amino acid exporter activity.
Type:
Grant
Filed:
June 22, 2021
Date of Patent:
June 4, 2024
Assignee:
AJINOMOTO CO., INC.
Inventors:
Mikhail Kharisovich Ziyatdinov, Yulia Georgievna Rostova, Olga Nikolaevna Igonina, Andrei Viacheslavovich Kniazev
Abstract: A conjugate of an antibody and a functional substance or a salt thereof, which comprises a structural unit represented by the following formula (I): wherein Ig represents an immunoglobulin unit comprising two heavy chains and two light chains, and regioselectively forms an amide bond with a carbonyl group adjacent to Ig via an amino group in side chains of lysine residues in the two heavy chains, L1 and L2 each represent a divalent group, R1 represents a monovalent group optionally comprising a hydrophilic group, X represents a predetermined divalent group, D represents a functional substance, RA represents a side chain of a valine residue, RB represents a side chain of a citrulline residue or an alanine residue, n is 0 or 1, and an average ratio r of the amide bonds per two heavy chains is 1.5 to 2.
Type:
Application
Filed:
November 29, 2023
Publication date:
May 23, 2024
Applicant:
Ajinomoto Co., Inc.
Inventors:
Yutaka MATSUDA, Tomohiro FUJII, Ryusuke HIRAMA, Thomas MARKOTAN, Allan PRIOR, Christopher WONG, Konstantinos PLAKAS, Tomohiro WATANABE
Abstract: The present invention provides a sporulation inhibitor of Clostridium perfringens containing at least one inorganic compound at a concentration that allows Clostridium perfringens to settle in vivo, wherein the inorganic compound is at least one salt selected from the group consisting of K, Na, Mg, Ca, and Fe, and the inorganic compound is coated with a protective layer containing hydrogenated vegetable oil.
Abstract: The present invention provides a method for producing a target substance, the biosynthetic pathway of which is ATP-dependent, for example, amino acids, nucleosides, nucleotides, isoprenoids, and peptides, by fermentation of a bacterium which has been modified to overexpress a gene encoding a protein having H+-translocating membrane-bound pyrophosphatase activity, for example, the hppA gene native to R. rubrum or a variant thereof.
Type:
Grant
Filed:
April 2, 2021
Date of Patent:
April 23, 2024
Assignee:
AJINOMOTO CO., INC.
Inventors:
Ekaterina Andrianova, Maria Kharchenko, Natalia Zakataeva, Elvira Voroshilova, Aleksander Krylov, Evgeniya Malykh, Sergei Mashko, Natalia Stoynova, Mikhail Baboshin, Lyubov Golubeva, Ekaterina Kovaleva, Mikhail Shupletsov
Abstract: Compositions for cosmetics, containing (A) at least one polyaspartic acid or a salt thereof, (B) zinc pyrrolidonecarboxylate, and (C) at least one aliphatic hydroxycarboxylic acid having 1 to 10 carbon atoms or a salt thereof are useful as premixed compositions used for blending polyaspartic acid or a salt thereof and zinc pyrrolidonecarboxylate stably and conveniently in cosmetic compositions.