Patents Assigned to Ajinomoto Co., Inc.
  • OFF-FLAVOR SUPPRESSING AGENT
    Publication number: 20220279826
    Abstract: Off-taste suppressing agents for an oral product containing an off-taste substance added thereto, wherein the agent contains at least one compound selected from the group consisting of (A) a compound represented by the following formula (I): wherein each symbol is as defined in the present specification, (B) cyclotene, and (C) a fatty acid having a carbon atom number of 3 or 4 are capable of effectively suppressing off-tastes due to off-taste substances, and the like.
    Type: Application
    Filed: May 13, 2022
    Publication date: September 8, 2022
    Applicant: AJINOMOTO CO., INC.
    Inventors: Kyoko KANNO, Ryo KITADA, Seiji KITAJIMA
  • Food for improving intraintestinal environment
    Patent number: 11426347
    Abstract: A food for improving intestinal environment by promoting proliferation of intestinal bifidobacteria is described herein. The food for improving intestinal environment can contain a combination of (1) an enteric composition containing an amino acid or a salt thereof and (2) an indigestible polysaccharide or a composition containing an indigestible polysaccharide.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: August 30, 2022
    Assignee: AJINOMOTO CO., INC.
    Inventors: Keishi Kameyama, Momoka Tsuneyoshi
  • METHOD FOR PRODUCING DERIVATIVE OF ORGANIC SUBSTANCE AND METHOD FOR ANALYZING SAMPLE CONTAINING ORGANIC SUBSTANCE
    Publication number: 20220267264
    Abstract: Derivatives of an organic substance containing one or more groups selected from the group consisting of sulfanyl, selanyl and sulfino may be produced by reacting an organic substance containing one or more groups selected from the group consisting of sulfanyl, selanyl and sulfino with an olefin compound containing an ethylene structure having at least two electron-withdrawing groups except halogen atoms under an acidic condition to form a derivative of the organic substance
    Type: Application
    Filed: March 22, 2022
    Publication date: August 25, 2022
    Applicant: Ajinomoto Co., Inc.
    Inventor: Masashi HARADA
  • POWDER SURFACE TREATMENT METHOD, SURFACE TREATING AGENT COMPOSITION USED THEREFOR, AND SURFACE-TREATED POWDER
    Publication number: 20220267609
    Abstract: The present invention provides a powder surface treatment method comprising (i) a step for mixing 0.001-20 parts by mass of a surface treating agent composition with 100 parts by mass of a power, and (ii) a step for adding an acidic liquid, followed by mixing, wherein the surface treating agent composition contains (a)-(d) below: (a) one or more selected from among an N-acyl amino acid having a carbon chain length of C8-C22 and a salt thereof; (b) one or more selected from among monohydric and polyhydric alcohols; (c) water; and (d) one or more selected from among (dl) an amino acid having an isoelectric point of 7.5-11, and (d2) a compound which generates an ion selected from among an aluminum ion, a magnesium ion, a calcium ion, a zinc ion, a zirconia ion, and a titanium ion, in the surface treating agent composition.
    Type: Application
    Filed: March 3, 2022
    Publication date: August 25, 2022
    Applicant: AJINOMOTO CO., INC.
    Inventor: Wataru WAKUI
  • EVALUATING METHOD FOR PHARMACOLOGICAL ACTIONS OF IMMUNE CHECKPOINT INHIBITORS, CALCULATING METHOD, EVALUATING APPARATUS, CALCULATING APPARATUS, EVALUATING PROGRAM, CALCULATING PROGRAM, RECORDING MEDIUM, EVALUATING SYSTEM, AND TERMINAL APPARATUS
    Publication number: 20220268790
    Abstract: An evaluating method includes an evaluating step of evaluating a pharmacological action of an immune checkpoint inhibitor in a subject to be evaluated, using (i) a concentration value of at least one metabolite among Glu, Arg, Orn, Cit, His, Val, Phe, Tyr, Met, Pro, Asn, Leu, Lys, Thr, Ile, Gln, Ala, Ser, a-ABA, Trp, Gly, AnthA, hAnthA, hIAA, hKyn, hTrp, IAA, ILA, Kyn, KynA, NFKyn, NP, PA, QA, Serot, and XA in blood of the subject to be evaluated, or (ii) a value of a formula calculated using the concentration value and the formula including an explanatory variable to be substituted with the concentration value.
    Type: Application
    Filed: April 27, 2022
    Publication date: August 25, 2022
    Applicant: AJINOMOTO CO., INC.
    Inventors: Sachise KARAKAWA, Tomoyuki TAGAMI, Rumi NISHIMOTO, Shinya KIKUCHI, Akira IMAIZUMI, Koichi AZUMA, Tomoaki HOSHINO, Takaaki TOKITO, Hidenobu ISHII, Norikazu MATSUO
  • MUSCLE QUALITY IMPROVEMENT AGENT
    Publication number: 20220249592
    Abstract: Agents containing ?-glutamyl peptide can prevent a decline in muscle quality and improve muscle quality even when exercise is limited, and further, can effectively enhance the effect of exercise even when the exercise is of a level free of undue efforts.
    Type: Application
    Filed: April 22, 2022
    Publication date: August 11, 2022
    Applicant: AJINOMOTO CO., INC.
    Inventors: Kyoko MIURA, Yoshiro KITAHARA, Haruka OHASHI
  • BENZALDEHYDE PRODUCTION METHOD
    Publication number: 20220251611
    Abstract: A method for producing benzaldehyde is provided. Benzaldehyde is produced by a method including a step of using amino acid deaminase (AAD), 4-hydroxymandelate synthase (HMAS), (S)-mandelate dehydrogenase (SMDH), and benzoylformate decarboxylase (BFDC) over a time period, wherein the producing step is carried out in the presence of catalase during a portion of said time period.
    Type: Application
    Filed: April 27, 2022
    Publication date: August 11, 2022
    Applicant: AJINOMOTO CO., INC.
    Inventors: Yasuaki Takakura, Takuto Ono, Olga Igonina, Keiko Koenuma, Hiroyuki Nozaki
  • Method for Producing Protein
    Publication number: 20220251622
    Abstract: A method for producing an objective protein using animal cells as an expression host is provided. The objective protein is produced by culturing animal cells having an objective protein-producing ability under conditions where the phosphoric acid concentration and/or the potassium concentration in the culture medium is increased.
    Type: Application
    Filed: April 27, 2022
    Publication date: August 11, 2022
    Applicant: AJINOMOTO CO., INC.
    Inventors: Yasumichi Koseki, Takahiro Katayama, Yusuke Ooya, Fumi Ogata, Kiyoshi Hirakawa, Takuya Higuchi
  • Recombinant activin A precursor protein
    Patent number: 11401311
    Abstract: Provided is a recombinant activin A precursor protein that has human activin A activity. Also provided is a novel method for producing human activin A. The present invention pertains to a recombinant activin A precursor protein that includes a human mature activin A sequence and a non-human activin A prodomain, wherein said recombinant activin A precursor protein is not a naturally occurring activin A precursor protein. The present invention also pertains to a method for producing a human activin A using the aforesaid recombinant activin A precursor protein.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: August 2, 2022
    Assignee: AJINOMOTO CO., INC.
    Inventors: Hiroto Hirano, Kenichiro Ito
  • Modified Phenylalanine Dehydrogenase
    Publication number: 20220235333
    Abstract: The present invention provides a unit and a method useful for more precise phenylalanine measurement. More specifically, the present invention provides a modified phenylalanine dehydrogenase that includes a mutation of at least one amino acid residue so as to improve the characteristics (for example, substrate specificity, solubility, and phenylalanine dehydrogenase activity) of a phenylalanine dehydrogenase related to measurement of phenylalanine, a method for analyzing phenylalanine by measuring phenylalanine contained in a test sample using the modified phenylalanine dehydrogenase, and others.
    Type: Application
    Filed: April 6, 2022
    Publication date: July 28, 2022
    Applicant: AJINOMOTO CO., INC.
    Inventors: Moemi Tatsumi, Kazutoshi Takahashi, Uno Tagami, Hiroki Yamaguchi
  • OLIGONUCLEOTIDE MANUFACTURING METHOD
    Publication number: 20220235090
    Abstract: The present invention aims to provide a more stable and efficient method for producing oligonucleotide, particularly, oligonucleotide having various functional groups linked to the 3?-terminal and the like.
    Type: Application
    Filed: March 14, 2022
    Publication date: July 28, 2022
    Applicant: AJINOMOTO CO., INC.
    Inventors: Ken YAMASHITA, Kunihiro HIRAI, Satoshi KATAYAMA, Taisuke ICHIMARU, Daisuke TAKAHASHI, Naoko HIROSE
  • Surfactant and Composition
    Publication number: 20220226217
    Abstract: The present invention provides a surfactant that has good foaming, foam quality, and solubility even having a pH equivalent to that of the skin, which is weakly acidic, has a low viscosity with high handleability, and can be useful in a product such as a personal care product, for example, a cosmetic. More specifically, the present invention provides a surfactant including an N-monounsaturated acyl acidic amino acid or a salt thereof, wherein the N-monounsaturated acyl is an acyl having 10 to 16 carbon atoms.
    Type: Application
    Filed: April 5, 2022
    Publication date: July 21, 2022
    Applicant: AJINOMOTO CO., INC.
    Inventor: Shuhei Kosono
  • Method for producing L-methionine using a bacterium of the genus
    Patent number: 11390896
    Abstract: The present invention provides a method for producing L-methionine by fermentation using a bacterium belonging to the genus Pantoea which has been modified to overexpress the rarD gene or a mutant gene thereof.
    Type: Grant
    Filed: October 27, 2020
    Date of Patent: July 19, 2022
    Assignee: AJINOMOTO CO., INC.
    Inventor: Mikhail Kharisovich Ziyatdinov
  • METHOD FOR PROTECTING PROTEIN FROM HEAT DAMAGE AND REDUCING RUMEN DEGRADABILITY OF METHIONINE
    Publication number: 20220217999
    Abstract: Protein-containing feedstuffs which contain at least one protein feed material and either methionine or at least one feed product which contains methionine are resistant to reduction of digestibility as a result of heat damage during drying.
    Type: Application
    Filed: March 28, 2022
    Publication date: July 14, 2022
    Applicant: AJINOMOTO CO., INC.
    Inventors: Paul SUMMER, Robert REED, Tomo TAKAGI, Jessica TEKIPPE
  • Method for producing a protein and disaccharide using a
    Patent number: 11384379
    Abstract: A method for producing an objective protein and a method for producing a disaccharide are provided. An objective protein is produced by culturing Talaromyces cellulolyticus in a culture medium containing an expression inducer such as gentiobiose. A disaccharide is produced from a saccharide raw material by enzymatic conversion using a disaccharide synthesizing enzyme.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: July 12, 2022
    Assignee: AJINOMOTO CO., INC.
    Inventors: Daiki Yahagi, Erika Yoshida, Hiroaki Fukada, Mitsunori Tokura, Uno Tagami, Masayuki Sugiki
  • ADDITIVE COMPOSITION FOR RUMINANT FEEDS
    Publication number: 20220211076
    Abstract: A feed additive composition for ruminants contains a choline salt, shows high protection in the rumen, and is also superior in dissolution in the lower gastrointestinal tract, and the like. The feed additive composition for ruminants contains: (A) at least one selected from hydrogenated oil and wax, each having a melting point of higher than 50° C. and lower than 90° C., (B) 0.01-6 wt % of a surfactant, (C) 10-60 wt % of a choline salt, (D) 1-40 wt % of L-lysine or a salt thereof, (E) a hygroscopic agent, and (F) 0.1-3 wt % of a stearic acid metal salt, and the like, all weight percentages being with respect to the composition.
    Type: Application
    Filed: March 24, 2022
    Publication date: July 7, 2022
    Applicant: AJINOMOTO CO., INC.
    Inventors: Masayuki TANAKA, Susumu SHIBAHARA
  • METHOD FOR PRODUCING 2-METHYL-BUTYRIC ACID BY BACTERIAL FERMENTATION
    Publication number: 20220213515
    Abstract: The present invention provides a method for producing 2-methyl-butyric acid by fermentation using a bacterium belonging to the order Enterobacterales which has been modified to attenuate expression of a tyrB gene encoding a protein having tyrosine aminotransferase activity. The method also allows for production of a byproduct substance of 2-methyl-butyric acid during fermentation of the Enterobacterales bacterium having 2-methyl-butyric acid-producing ability.
    Type: Application
    Filed: March 24, 2022
    Publication date: July 7, 2022
    Applicant: AJINOMOTO CO., INC.
    Inventors: Natalia Viktorovna Stoynova, Elena Viktorovna Sycheva, Anna Alexandrovna Ublinskaya, Valery Vasilievich Samsonov, Alexandr Dmitrievich Kivero
  • Feed composition for improving intraintestinal environment
    Patent number: 11376215
    Abstract: A feed composition for improving intestinal environment by promoting proliferation of intestinal bifidobacteria is described herein. The feed composition for improving intestinal environment can contain a combination of (1) an enteric composition containing an amino acid or a salt thereof, and (2) an indigestible polysaccharide or a composition containing an indigestible polysaccharide.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: July 5, 2022
    Assignee: AJINOMOTO CO., INC.
    Inventors: Keishi Kameyama, Momoka Tsuneyoshi
  • METHOD FOR PRODUCING MESENCHYMAL STEM CELLS FROM LIVING BODY-DERIVED CELL SAMPLE CONTAINING MESENCHYMAL STEM CELLS
    Publication number: 20220177848
    Abstract: Mesenchymal stem cells may be efficiently obtained from a biological cell sample containing mesenchymal stem cells by: (1) culturing the biological cell sample containing mesenchymal stem cells in a serum-free medium in the presence of vitronectin or a partial peptide thereof capable of adhering mesenchymal stem cells, and (2) collecting a cell aggregate of the mesenchymal stem cells.
    Type: Application
    Filed: February 25, 2022
    Publication date: June 9, 2022
    Applicant: AJINOMOTO CO., INC.
    Inventors: Ikue HARATA, Eri HARADA, Kazuma TAKAHASHI, Fumie HONKAWA
  • CYCLIC PEPTIDE PRODUCTION METHOD
    Publication number: 20220177512
    Abstract: A method for producing a cyclic peptide, including the following step (1) and step (2): (1) a step of cyclizing a linear peptide; and (2) a step of obtaining a cyclic peptide by adding a poor solvent to a mixture of the cyclic peptide and multimeric impurity, which mixture is obtained in the above-mentioned step, and filtering off the multimeric impurity as an insoluble material can efficiently remove multimeric impurity by-produced during a cyclization reaction, improve the purity of the obtained cyclic peptide, and reduce a burden on the purification step.
    Type: Application
    Filed: December 23, 2021
    Publication date: June 9, 2022
    Applicant: AJINOMOTO CO., INC.
    Inventors: Daisuke TAKAHASHI, Tatsuji INOMATA