Abstract: Herein described is a construct for epigenomic modification of genes composed of: (a) a Krüppel-associated box zinc finger protein or homologous, (b) a DNA region capable of binding to the target gene or homologous, (c) a human DNA methyltransferase DNMT3A or homologous and (d) a murine DNA methyltransferase Dnmt3L or homologous, wherein components a), b), c) and d) are linked to each other either directly or via at least one linker. The construct is a designer epigenome modifier that can be used to silence genes coding for a protein in leukocytes that avoids the internalization of HI viruses in immune cells.
Type:
Grant
Filed:
April 11, 2018
Date of Patent:
July 27, 2021
Assignee:
Albert-Ludwigs-Universitaet Freiburg
Inventors:
Toni Cathomen, Claudio Mussolino, Tatjana I. Cornu, Tafadzwa Mlambo, Sandra Nitsch, Jamal Alzubi, Marianna Romito
Abstract: A method for the magnetic resonance examination of a measurement object is described, in which a measurement sequence is used in which the magnetic resonance response to the transmitted signal during transmission is measured. It is provided that a correction signal corresponding to the transmitted signal be generated and be used for correction of the response signal. To this end, the correction signal is modulated by a phase value and an amplitude value. The phase value and the amplitude value are automatically and iteratively customized for optimum correction of the response signal by an optimization method using a respective present state value of the measurement signal. Further, a radio-frequency unit (1) is described that can be used to carry out the method according to the invention.
Abstract: The present invention relates to a method for producing renal cells, comprising overexpressing Hnf1b and Pax8, and optionally Hnf4a and/or Emx2 in differentiated cells.
Type:
Grant
Filed:
January 25, 2017
Date of Patent:
June 29, 2021
Assignee:
Albert-Ludwigs-Universitaet Freiburg
Inventors:
Soeren Lienkamp, Michael Kaminski, Sebastian Arnold, Gerd Walz
Abstract: The present invention relates to a method for identifying ?T-cell (or ?T-cell) receptors chains or parts thereof that mediate an anti-tumor or anti-infection response by identifying amino acid sequences comprising ?T-cells (or ?T-cell) receptors chains or parts thereof that are shared between different donors.
Abstract: In a method (100 to 208) in which hyperpolarizable tracer molecules (20, 88 to 98) are hydrogenated and then optionally also hyperpolarized for magnetic resonance imaging, it is provided that, in a first method step (104, 202), a hydrogen solution (10, 12, 4) having a saturation factor of at least 50% be prepared and that the hydrogenation reaction (186 to 190, 206) not be triggered until a subsequent, second method step (106, 204). An apparatus (1) with which the method of the invention (100 to 208) is executable is also provided.
Type:
Application
Filed:
August 14, 2019
Publication date:
June 3, 2021
Applicant:
Albert-Ludwigs-Universität Freiburg
Inventors:
Andreas SCHMIDT, Jan-Bernd Hovener, Jurgen HENNIG, Stephan BERNER
Abstract: An implantable electrode arrangement includes an electrically insulating carrier structure and an electrically conductive layer including an electrically conductive thin film layer. The electrically conductive thin film layer is structured to form at least one implantable electrode. The at least one implantable electrode has a local fractalization through a self-similar structuring chosen such that a mechanical resonance of the electrode in response to electric excitation with an excitation voltage is minimized.
Type:
Application
Filed:
October 9, 2020
Publication date:
April 15, 2021
Applicant:
Albert-Ludwigs-Universität Freiburg
Inventors:
Jennifer Schulte, Thomas Stieglitz, Max Eickenscheidt
Abstract: The present invention discloses a matrix comprising a modified polysaccharide consisting of repeating disaccharide units whereby in at least 11% of the disaccharide units one primary alcohol group is oxidized into a carboxylic acid group.
Abstract: A miniaturized microsystem device including at least one of electrical, optical and mechanical components in a hermetically or non-hermetically sealed housing with respect to air humidity or encapsulated, which contains a desiccant. The humidity-dependent lifetime of the arrangement is determined by measuring the absorptivity of the desiccant.
Type:
Grant
Filed:
September 8, 2017
Date of Patent:
March 30, 2021
Assignee:
ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG
Inventors:
Linda Rudmann, Michael Langenmair, Juan Sebastian Ordonez, Thomas Stieglitz
Abstract: A semiconductor layer and a method and an apparatus for its manufacturing are disclosed. The semiconductor layer includes at least one compound of the formula M1aM21-aN, where M1 is selected from group 13 of the periodic table and M2 is selected from the group comprising scandium, yttrium, erbium, and europium and where the parameter a is selected between 0.01 and 0.99. The method includes supplying a first precursor into a reaction chamber, the first precursor including at least M2 and being supplied to the reaction chamber at a molar flow rate of at least 1·10?6 mol/min by providing the first precursor by means of a first bubbler from which it is evaporated and supplied to the reaction chamber, the temperature of the first bubbler being more than 90° C.
Type:
Application
Filed:
August 27, 2020
Publication date:
March 4, 2021
Applicants:
Albert-Ludwigs-Universität Freiburg, Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
Inventors:
Stefano LEONE, Christian MANZ, Hanspeter MENNER, Joachim WIEGERT, Jana LIGL
Abstract: The present invention relates to an aqueous or hydro-alcoholic suspension of chitosan, dispersed cellulose nanofibers, and an acid, which is suitable for obtaining a hydrogel composite comprising a network of chitosan and cellulose nanofibers. The suspension of the invention is useful for tissue regeneration and the hydrogel of the invention is useful as bioresorbable and biocompatible implant.
Type:
Application
Filed:
March 13, 2019
Publication date:
February 18, 2021
Applicants:
Albert-Ludwigs-Universitaet Freiburg, Université Claude Bernard Lyon 1, Centre National de la Recherche Scientifique - CNRS, Institut Enseignement Supérieur et Recherche en Alimentation Santé Animals Sciences Agronomiques et
Inventors:
Anayancy OSORIO MADRAZO, Laurent DAVID, Alexandra MONTEMBAULT, Eric VIGUIER, Thibaut CACHON
Abstract: The present invention relates to a method for predicting the response of a structure, or a group of structures and/or a network profile, to a perturbation, in particular a perturbation caused by an agent or a combination of agents through modeling, optimizing, parameterizing, testing and/or validating of a dynamic network or of network perturbations.
Type:
Grant
Filed:
March 21, 2012
Date of Patent:
February 2, 2021
Assignees:
Albert-Ludwigs-Universität Freiburg, Northern Institute for Cancer Research
Inventors:
Kathrin Thedieck, Annika Sonntag, Daryl Shanley, Piero Dalle Pezze
Abstract: The present invention provides a polymer having antimicrobial and/or antifouling (protein-repellent) properties, a monomer that can be used in a method of producing the polymer of the invention, and a use of the polymer of the invention, including a method for coating the surface of a material, substrate or product with the polymer of the invention, as well as to products comprising the polymer of the invention and/or a coating comprising the polymer of the invention.
Type:
Grant
Filed:
November 15, 2016
Date of Patent:
January 12, 2021
Assignee:
ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG
Inventors:
Karen Lienkamp, David Boschert, Alexandra Schneider - Chaabane, Ali Al-Ahmad
Abstract: A fluidic module includes first and second measuring chambers, first and second fluid inlet channels connected to the first and second measuring chambers, respectively, and first and second fluid outlet channels connected to the first and second measuring chambers, respectively. Upon rotation of the fluidic module about a center of rotation, liquids are centrifugally driven into the first and second measuring chambers via the first and second fluid inlet channels, respectively, so that compressible media previously present within the first and second measuring chambers are compressed by the liquids driven into the first and second measuring chambers, respectively. Upon a reduction of the rotational frequency and upon an expansion, resulting therefrom, of the compressible media, the liquids present within the first and second measuring chambers are driven out of same via the first and second fluid outlet channels, respectively.
Abstract: The present invention relates to a method for combined administration of carbon monoxide (CO) to an ex-vivo fluid and monitoring of the carbon monoxide administration, said method comprising: (i) generating CO by reacting a CO releasing molecule (CORM) with a release triggering molecule; (ii) administering CO to an ex-vivo fluid by contacting the ex-vivo fluid with the CO generated in step (i) via a gas-permeable membrane; (iii) analyzing carbon monoxide and/or a carbon monoxide marker after administering in step (ii) CO to the ex-vivo fluid by complementary monitoring techniques; (iv) adjusting the CO administration based on the analysis of the carbon monoxide or the carbon monoxide marker carried out in step (iii), if necessary. It furthermore relates to an extracorporeal circuit system for use in the method of the invention.
Abstract: The present invention relates to a biodegradable multilayer nanocapsule for the delivery of at least one biologically active agent into at least one target cell consisting of at least two layers of at least two biodegradable polymers which are laid one onto the other and whereby the biologically active agent is layered onto a layer of a biodegradable polymer and covered with a further layer of a biodegradable polymer, whereby one biologically active agent is a nucleic acid.
Type:
Application
Filed:
July 25, 2018
Publication date:
December 3, 2020
Applicants:
Albert-Ludwigs-Universitaet Freiburg, Queen Mary University of London
Inventors:
Gleb SUKHORUKOV, Irina NAZARENKO, Yana TARAKANCHIKOVA, Toni CATHOMEN, Tatjana CORNU, Valentina PENNUCCI, Jamal ALZUBI
Abstract: The present invention is inter alia concerned with a method of diagnosing Alzheimer's disease in a patient, wherein said method is based on determining the amount of at least one premature mitochondrial protein. Further, the present invention relates to the use of such a protein as marker for Alzheimer's disease. Accordingly, antibodies binding to such a preprotein may be used for diagnosing Alzheimer's disease. The present invention is based on the finding that premature mitochondrial proteins accumulate in Alzheimer's disease.
Type:
Grant
Filed:
March 6, 2015
Date of Patent:
July 21, 2020
Assignee:
Albert-Ludwigs-Universität Freiburg
Inventors:
Chris Meisinger, Nora Vögtle, Dirk Mossmann, Elzbieta Glaser, Caroline Graff, René P. Zahedi
Abstract: A method for the manufacturing of platinum nanostructures showing improved properties and usable in biomedical appliances is provided. The method includes providing a solution containing hexachloroplatinate with the remainder being water and electrochemical deposition of platinum on a substrate with the platinum deposited in a nanostructured form.
Abstract: The present invention concerns cobalamin derivatives of formula (I) wherein X is a ligand having a formula selected from among: further wherein R1 is H, methyl or ethyl, and its use in diseases caused by lack of vitamin B12 support.
Abstract: A process for the manufacture of a catalyst comprising a fluorinated metal oxide is provided. A catalyst comprising a fluorinated metal oxide is provided. A catalytic hydrogenation process is also provided.
Type:
Grant
Filed:
April 21, 2017
Date of Patent:
February 4, 2020
Assignees:
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., SOLVAY SA, Albert-Ludwigs-Universität Freiburg
Inventors:
Achim Schaadt, Ingo Krossing, Mathias Feinäugle, Valentin Dybbert, Harald Hillebrecht, Thilo Ludwig, Johannes Eicher, Elias Frei