Abstract: The present invention in the fields of immunology and infectious diseases relates to opsonic and protective antibodies that are specific for Gram-positive bacteria, particularly to carbohydrate structures exposed on the surface of the bacteria. The invention includes monoclonal and chimeric antibodies, as well as fragments, regions and derivatives thereof. This invention also relates to the epitope to which the antibodies of the invention bind as well as the sequences, fragments, and regions of the epitopes. Both the antibodies and peptides that encompass the epitope, and regions and fragments thereof, may be used for diagnostic, prophylactic and therapeutic applications.

Abstract: The invention relates to a method for performing a biochemical or chemical reaction for an isolated, spatially separated amplification of sample fragments during a simultaneous immobilization and spatial arrangement of the sample fragments and reaction products, the amplification products, on one or more suitable solid phases for subsequent derivatizations.

Abstract: The present invention relates to modulators of the interaction of astrin and raptor, and their uses in the treatment of mTOR related diseases, such as cancer.

Abstract: A multi-channel switching system (100) for an MRI gradient coil system is characterized in that the number of channels controlled by the power amplifiers is smaller than the number of switches and the number of channels controlled by the power amplifiers is smaller than the number of coil elements in the coil system. Current in each of the coil elements can be switched to flow in either a positive or negative direction or to bypass the respective coil element and power to the switch elements is delivered via a smaller amount of power lines using a power distribution system providing floating power to each of the switches. This allows to electrically connect matrix coil elements dynamically within a pulse sequence to generate dynamically switched magnetic field profiles and therefore reduce the number of gradient power amplifiers, gradient cables and power supplies needed.

Abstract: A receiving device and a method for operating a receiving device are provided in which a signal is divided into two separate signal parts. The two signal parts are demodulated simultaneously and, from the demodulated signals, the difference is formed. After the formation of the difference, an information item is obtained from the difference signal and compared with a predetermined information item. In the case of correspondence of the obtained information and the compared information, a wake-up signal is generated.

Abstract: The invention relates to a method for identifying aptamers, having the following steps —bringing a mixture of oligonucleotides into contact with an aptamer target structure and binding at least some of the oligonucleotides to the target structure, —separating the oligonucleotides which have been bound to the aptamer target structure from the aptamer target structure and from oligonucleotides that are not bound to the aptamer target structure, —amplifying individual oligonucleotides which were bound to the aptamer target structure in a physically separate manner and producing a plurality of physically separate amplicons, each amplicon predominantly containing one type of oligonucleotides, —specifying a specific marker for a plurality of the physically separate amplicons such that each of the marked amplicons can be uniquely identified using the specified marker of the amplicon, —sequencing oligonucleotides in a plurality of marked amplicons and assigning the marker that is specific for the amplicon to the sequ

Abstract: Disclosed in the present application are: (i) a compound inhibiting the interaction between LSD1me2 and CHD1 for use in therapy, (ii) a compound inhibiting the interaction between LSD1me2 and CHD1 for use in treating cancer, in particular pro state cancer, and (iii) a method of screening for such a compound.

Abstract: Phase segregated block-copolymer based on repeating structural elements represented by formula I wherein PHA represents at least one block based on one or more ?-hydroxy acids, PDAS represents a central block based on a dialkylsiloxane, the PDAS block has a weight average molecular weight in the range of from 4000 to 10000, the blocks PHA have a weight average molecular weight in the range of from 2000 to 10 000, the phase segregated block copolymer has a weight average molecular weight of from 40 000 to 120 000.

Abstract: The invention relates to a method for analyzing molecular properties and/or reaction conditions, comprising a step of providing a first store having a first surface, wherein a specific selection of sample molecules is directly or indirectly bonded to the surface in a defined arrangement, a step of producing at least two transfer stores, wherein at least two additional surfaces are provided, and a reaction step, selected from the group comprising a transfer reaction, an amplification reaction, and/or a derivatization reaction, whereby product molecules can arise and said product molecules and/or the sample molecules bond to the surfaces, wherein there is a clear spatial association between the sample molecules of the first store and the product molecules and/or sample molecules of the transfer stores and the first store, the transfer stores, the sample molecules, the product molecules, the transfer reaction, the amplification reaction, and/or the derivatization reaction is analyzed.

Abstract: In a method to associate k-space lines with echo trains of raw magnetic resonance data, parallel k-space lines orthogonally intersect a plane at respective intersection points. Each echo train has a trajectory length, and the k-space lines are associated with the echo trains such that a sum of trajectory lengths of all echo trains is minimal. The trajectory length TL of an echo train is defined by TL = ? i = 1 L - 1 ? ? P i ? P i + 1 _ wherein L is a sequence of k-space lines, Pi is an intersection point of the i-th k-space line of the echo train with the plane; and PiPi+1 is the length of the path from the i-th intersection point to the (i+1)-th intersection point.

Abstract: The invention relates to a method for detecting at least one target molecule and/or product molecule, wherein reaction components are provided in defined regions of a base surface and/or covering device. At least two defined regions with different reaction components are provided, and an amplification reaction is carried out. The invention also relates to a device for carrying out said method.

Abstract: A device and a method for calibrating the coordinate system of imaging systems having a tracking system prior or during image data acquisition, e.g. by way of magnetic resonance tomography.

Abstract: A method of producing a replicate or derivative of an array of molecules, the array having a spatial arrangement of separate samples of molecules, includes creating, for each sample, at least one spatially limited effective area which is separate from the effective areas of the other samples, a surface, provided with a binding adapter or binding properties, of a carrier bordering on the effective areas. The molecules are amplified by means of amplifying agents in the effective areas for creating replicates or derivatives of the samples. The replicates or derivatives of the samples are bound to the carrier by means of the binding adapter or the binding properties, so that a spatial arrangement of the replicates or derivatives of the samples on the carrier corresponds to the spatial arrangement of the samples in the array. The carrier having the copies of the samples is removed from the array.

Abstract: A Hall effect sensor with multiple Hall effect elements, each of the Hall effect elements having a first contact terminal, a second contact terminal, and a third contact terminal arranged along a straight line. The multiple Hall effect elements are electrically connected in series in a closed circuit. The second contact terminals of the Hall effect elements are supply voltage connections or Hall voltage pickoffs, and the applicable second contact terminal of the Hall effect element is a center contact of the Hall effect element. The Hall effect elements form two pairs, and the Hall effect elements of one pair each measure the same component of a magnetic field and an operating current is impressed on the series circuit in the two Hall effect elements of this one pair, and a supply voltage is applied to the Hall effect elements of the other pair.

Abstract: A magnetic field sensor having a Hall sensor with a first terminal contact and with a second terminal contact and with a third terminal contact and with a fourth terminal contact and with a fifth terminal contact, whereby a first switch with a control input is provided between the first terminal contact and the fifth terminal contact, and the first switch connects or disconnects the first terminal contact to/from the fifth terminal contact, and a control unit is provided and the control unit is connected to the control input of the first switch.

Abstract: The invention relates to a method for producing a microarray, wherein the production of this array is detected in real time from the accumulation of the product molecules being produced. The invention further relates to a microarray produced by this method, and to a device for the real-time detection of molecular accumulations on an array surface during the production of microarrays.

Abstract: The invention is related to a microstructure apparatus for the measurement of biological membranes, comprising a support substrate having an upper side for supporting the membrane, at least one microcavity of the support substrate for receiving an electrolyte, wherein the microcavity is open upward and ends in a microaperture in the upper side of the support substrate, wherein the microaperture has a first characteristic diameter D1 and has at least one electrode, which is at least partially arranged within the microcavity and which has a contact side for contacting an electrolyte, the contact side being arranged adjacent to the inner volume of the microcavity, characterized in that the contact side of the electrode has a characteristic diameter D2, being larger than D1. The invention further relates to a corresponding method for producing the microstructure apparatus.

Abstract: The invention relates to a device and a method for the generation of molecular microarrays. The invention relates therefore to a universal approach for the generation of protein microarrays, DNA microarrays and RNA microarrays (in general nucleic acid microarrays), by production of an output molecule from a template molecule microarray via enzymatic or chemical processes and transfer of the output molecule onto the desired molecular microarray.

Abstract: The invention relates to a method of diagnosing breast cancer and to the use of biomarkers for the detection and diagnosis of breast cancer.

Abstract: A method is presented for accelerating magnetic resonance imaging. In 3D MRI, the k-space in the phase encoding plane is divided into two symmetric parts and three asymmetric parts. Different sampling densities are applied in different parts. Images are reconstructed by iteratively minimizing a cost function when random sampling is applied in each part. A phase constraint term is added into the cost function to improve the quality of the reconstruction by exploiting the conjugate symmetry of k-space.