Abstract: Beadlets comprising xanthophylls and carotenes and/or retinoids, dietary supplements comprising these beadlets and methods of use are disclosed.

Abstract: A system for positioning an eye for laser surgery includes a first and a second radiation generator positioned, respectively, to emit a first line and a second line orthogonal to the first line, the line generators positioned in a predetermined relation to a laser surgical system. A position of the eye is adjustable along an axis that is substantially perpendicular to the lines to achieve a positioning wherein the lines form a cross. The location of the cross is a preferred position for the eye relative to the laser surgical system for the laser surgery. Another embodiment comprises a first and a second spot generator positioned to project a first and a second spot onto an eye adjacent the clear cornea, between the clear cornea and the scleral rim. The eye position is adjustable for achieving a positioning wherein the spots are substantially vertically aligned.

Abstract: Inhibitors of cytokine synthesis in nonimmune, resident ocular surface cells are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.

Abstract: A surgical tool holder mounted on a surgical tray that is connected to the surgical console. The tool holder has a pair of opposing, spring-loaded gripper arms. The gripper arms will move apart under force, but rotate to a closed position when no force is applied. In the closed position, the opposing gripper arms and a small, curved-shaped gap between the gripper arms allows the tool holder to accommodate a wide variety diameters of handpieces or tools.

Abstract: Foldable intraocular lenses having a reduced risk of posterior capsule opacification are disclosed. The foldable intraocular lenses have optics that are prepared such that their surface is glassy and their bulk is rubbery.

Abstract: An orientation system for corrective eye surgery includes a camera for performing a first image mapping a patient's eye using a predetermined eye feature and software for processing the first image map to determine an edge location of the feature. A second image mapping is performed with the patient in a different position. The second image map is processed to locate the feature. In a second embodiment a pen is used to make two alignment marks on the eye. The eye is imaged with the patient in another position, and the image displayed. Software superimposes a graphical reticle onto the eye image, which is movable to align with the two alignment marks. In both cases software also calculates an orientational change to be applied to a corrective prescription for a surgical procedure to be performed on the eye with the patient in the second position.

Abstract: A method for optimizing a prescription for laser-ablation corneal treatment includes the steps of receiving a measured correction prescription for a current patient having a classification element associated therewith, the prescription having been measured using wavefront determination. A database of treatment outcomes on a plurality of previously treated patients is accessed, each treated patient outcome having associated therewith at least one classification element and comprising a preoperative wavefront-determined correction prescription and a postoperative visual profile. From the treatment outcomes in the database is calculated an average difference between the preoperative prescription and the postoperative profile for at least some of the previously treated patients having a classification element in common with the current patient. Finally the current patient correction prescription is adjusted commensurate with the calculated average difference to form an optimized prescription.

Abstract: Pyranoindazoles are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present invention.

Abstract: NF-&kgr;B inhibitors are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.

Abstract: A two-optic accommodative lens system. The first lens has a negative power and is located posteriorly against the posterior capsule. The periphery of the first optic contains a pair of clasps. The second optic is located anteriorly to the first optic and is of a positive power. The peripheral edge of the second optic contains a pair of locking arms that fit into the clasps contained on the periphery of the first optic to lock the second optic onto the first optic, but allow for rotation of the arms within the clasps. Hinge structures on the locking arms allow the second optic to move relative to the first optic along the optical axis of the lens system in reaction to movement of the ciliary muscle.

Abstract: A surgical instrument, in particular ophthalmologic clamp, includes two substantially parallel spring arms interconnected at their rear end and having a forward end terminating in clamping elements. An actuating mechanism is provided for moving the spring arms relative to one another in opposition to a spring elastic restoring force of the spring arms to thereby implement an inverse movement of the clamping elements. The actuating mechanism includes two plate-shaped operating members and four pins, whereby the pins are so disposed that two pins are connected to one operating member and the distal one of the spring arms, and two pins are connected to the other operating member and the other of the spring arms.

Abstract: Disclosed are soft, high refractive index, acrylic device materials having improved strength. The materials contain cross-linked acrylate or methacrylate microspheres.

Abstract: A method for optimizing a prescription for laser-ablation corneal treatment or ophthalmic implant includes the steps of receiving a measured correction prescription for a current patient having a classification element associated therewith, the prescription having been measured using wavefront determination. A database of treatment outcomes on a plurality of previously treated patients is accessed, each treated patient outcome having associated therewith at least one classification element and comprising a preoperative wavefront-determined correction prescription and a postoperative visual profile. From the treatment outcomes in the database is calculated an average difference between the preoperative prescription and the postoperative profile for at least some of the previously treated patients having a classification element in common with the current patient.

Abstract: Otic compositions are disclosed. The compositions contain an otic drug and a carrier comprising a low molecular weight compound. The compositions do not drain out of the ear after administration.

Abstract: Solid or semi-solid intraocular implant compositions are disclosed. The compositions contain a lipophilic compound but lack a polymeric ingredient.

Abstract: 15-fluoro substituted analogs of PGF2&agr; and methods of their use in treating glaucoma and ocular hypertension are disclosed.

Abstract: An automated, objective method for determining the accommodative range and aberration profile of an eye using a wavefront sensor that iteratively determines the change in accommodation of the lens of an eye.

Abstract: A surgical handpiece having at least two lumens or tubes mounted to a body. At least one tube is used for aspiration and at least one other tube is used to inject heated surgical fluid for liquefying a cataractous lens. A portion of the second tube is enlarged to form a pumping chamber. The pumping chamber works by boiling a small volume of the surgical fluid. As the fluid boils, it expands rapidly, thereby propelling the liquid downstream of the pumping chamber out of the second tube. The pumping chamber may use a pair of electrodes.

Abstract: Deinterlacing is applied to a composite video image that includes alternating even and odd rows of pixels. The even rows form a first image; the odd rows, a second image; these are recorded at different times, introducing a possibility of motion artifact. A first average horizontal intensity difference is computed between the first image and the second image. The first image is offset by one pixel in each horizontal direction to form a horizontally offset image, and another average horizontal intensity difference is computed. A minimum average intensity difference is determined from a comparison of the average horizontal intensity differences. The first image is shifted in a horizontal direction determined to achieve the minimum average horizontal intensity difference, and the horizontally shifted first image is combined with the second image to form an improved composite image. An analogous series of steps is carried out in a vertical direction.

Abstract: The topical use of HETE compounds to treat psoriasis is disclosed.