Patents Assigned to Alcon
  • 6-hydroxy-indazole derivatives for treating glaucoma
    Patent number: 6956036
    Abstract: Substituted 1-(?-alkyl-ethylamino)-1H-indazol-6-ols useful for lowering and controlling IOP and treating glaucoma are disclosed
    Type: Grant
    Filed: November 14, 2000
    Date of Patent: October 18, 2005
    Assignee: Alcon, Inc.
    Inventors: Jesse A. May, Zixia Feng, Anura P. Dantanarayana
  • Pressure sensing in surgical console
    Patent number: 6955073
    Abstract: A method of determining the accuracy of a pressure sensor in a surgical console is disclosed. The method involves actuating a linear actuator so that its plunger is linearly displaced a pre-defined amount, and measuring the force exerted by the plunger on a non-compliant member. The accuracy of the linear actuator and the plunger are determined by comparing the force measured in the measuring step to a pre-defined force.
    Type: Grant
    Filed: February 28, 2003
    Date of Patent: October 18, 2005
    Assignee: Alcon, Inc.
    Inventors: Michael D. Morgan, Gary P. Sorensen
  • Use of low molecular weight amino alcohols in ophthalmic compositions
    Patent number: 6949218
    Abstract: The use of low molecular weight amino alcohols in ophthalmic compositions is described. These compounds have been found to enhance the efficacy of anti-microbial preservatives.
    Type: Grant
    Filed: October 22, 2001
    Date of Patent: September 27, 2005
    Assignee: Alcon Manufacturing, Ltd.
    Inventor: Bahram Asgharian
  • Use of a mixture of sodium hyaluronate and chondroitin sulfate for the treatment of osteoarthritis
    Patent number: 6949525
    Abstract: This invention is related to the use of the composition formed by sodium hyaluronate and sodium chondroitin sulfate for the treatment of chondral lesions in osteoarthritis, and to the use of such composition in the manufacture of a product for such treatment.
    Type: Grant
    Filed: November 13, 2002
    Date of Patent: September 27, 2005
    Assignee: Alcon, Inc.
    Inventor: Elias Humberto Ochoa Hermida
  • Micro surgical instrument
    Patent number: 6945984
    Abstract: A microsurgical instrument is described for ophthalmologic microsurgery in the eye which comprises a housing configured as a handle with a functional unit supporting a probe and a rod co-axially supported in the probe having a head piece configured as a grasping element with two arms that can be brought into a spread apart first position and a second closed position, wherein each arm has a recess which upon closing are flush pressed together thereby forming a larger recess for unobstructed grasping, retaining and holding microstructures such as blood vessels without squeezing or pinching the microstructures.
    Type: Grant
    Filed: August 23, 2001
    Date of Patent: September 20, 2005
    Assignee: Alcon Grieshaber AG
    Inventors: Jose Garcia Arumi, Werner Maag, Oliver Jud
  • Noninvasive pressure sensing assembly
    Patent number: 6941813
    Abstract: An optical noninvasive pressure sensing assembly capable of accurately indicating relatively minute pressure changes. The present invention generally includes a light source, such as a Light Emitting Diode (LED) or normal room illumination, positioned to reflected light off of a surface of a membrane. The membrane is in contact with the fluid in which the pressure is to be measured so that changes in the pressure in the fluid cause movement of the membrane. A charge coupling device (CCD) camera captures light reflected off of the membrane and the reflected light is analyzed to determine the relative movement of the membrane based on the change in the pattern of the reflected light.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: September 13, 2005
    Assignee: Alcon, Inc.
    Inventors: Mikhail Boukhny, Xiaoxiao Zhang
  • Biguanide/quaternary ammonium containing copolymeric biocides and use thereof in pharmaceutical compositions
    Patent number: 6936640
    Abstract: Biguanide/quaternary ammonium compounds and the use of same as antimicrobial agents in pharmaceutical compositions are described. The biguanide/quaternary ammonium compounds are useful in the preservation of pharmaceutical compositions, particularly ophthalmic pharmaceutical compositions and compositions for treating contact lenses. The compounds are especially useful for disinfecting contact lenses.
    Type: Grant
    Filed: November 18, 2004
    Date of Patent: August 30, 2005
    Assignee: Alcon, Inc.
    Inventors: Nathaniel D. McQueen, Joonsup Park
  • Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma
    Patent number: 6933392
    Abstract: Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present invention.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: August 23, 2005
    Assignee: Alcon, Inc.
    Inventors: Jesse A. May, Paul W. Zinke
  • Eye registration and astigmatism alignment control systems and method
    Patent number: 6929638
    Abstract: An orientation system and method for corrective eye surgery includes a camera for performing a first image mapping of a patient's eye using a predetermined eye feature and software for processing the first image map to determine an edge location of the feature. A second image mapping of the eye is performed with the patient in a different position. The second image map is processed to locate the predetermined eye feature. Correlation of the mappings is used to calculate an orientational change of the eye between the two positions. This procedure may also be performed at different times during surgery to permit “real-time” data on orientational changes undergone by the eye to be collected. In both cases the data are used to calculate an adjustment to be applied to a corrective prescription for application by the surgical procedure.
    Type: Grant
    Filed: December 11, 2003
    Date of Patent: August 16, 2005
    Assignee: Alcon RefractiveHorizons, Inc.
    Inventors: Gary Paul Gray, John Alfred Campin, Qiping Shen
  • 5ht2 agonists for controlling IOP and treating glaucoma
    Patent number: 6927233
    Abstract: Compositions and methods for controlling intraocular pressure and treating glaucoma using 1-(2-aminopropyl)-indazol-6-ol are disclosed.
    Type: Grant
    Filed: November 14, 2000
    Date of Patent: August 9, 2005
    Assignees: Alcon, Inc., Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Jesse A. May, Anura P. Dantanarayana
  • Accommodative intraocular lens
    Patent number: 6926736
    Abstract: A two-optic accommodative lens system. The first lens has a negative power and is located posteriorly against the posterior capsule. The periphery of the first optic contains a pair of clasps. The second optic is located anteriorly to the first optic and is of a positive power. The peripheral edge of the second optic contains a pair of locking arms that fit into the clasps contained on the periphery of the first optic to lock the second optic onto the first optic, but allow for rotation of the arms within the clasps. Hinge structures on the locking arms allow the second optic to move relative to the first optic along the optical axis of the lens system in reaction to movement of the ciliary muscle.
    Type: Grant
    Filed: June 4, 2003
    Date of Patent: August 9, 2005
    Assignee: Alcon, Inc.
    Inventors: Qun Peng, Yin Yang, Xiaoxiao Zhang
  • Aspheric lenses
    Patent number: 6923539
    Abstract: The present invention provides monofocal ophthalmic lenses that exhibit extended depth of field while providing sufficient contrast for resolution of an image over a selected range of defocus distances. In some embodiments, a lens of the invention can include a refractive surface having controlled surface modulations relative to a base profile. The surface modulations are designed to extend a depth of field of the lens such that a single image can be resolved, albeit with somewhat less contrast, over a range of distances greater than the focal region of a conventional lens. The ophthalmic lenses of the invention can be employed in various vision correction applications, including, but not limited to, intraocular lenses, contact lenses, instrastromal implants and other refractive devices.
    Type: Grant
    Filed: May 12, 2003
    Date of Patent: August 2, 2005
    Assignee: Alcon, Inc.
    Inventors: Michael J. Simpson, Daniel R. Carson
  • Apparatus for delivery of fluid to opthalmic surgical handpiece
    Patent number: 6921385
    Abstract: An apparatus for delivery of a surgical fluid to a surgical handpiece is disclosed. The apparatus generally includes a container and an adapter receiving one end of the container. The container holds the surgical fluid to be delivered to the handpiece. The adapter is for removably engaging a receptacle in a surgical console and for fluidly coupling with a source of pressurized fluid in a surgical console.
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: July 26, 2005
    Assignee: Alcon, Inc.
    Inventors: Don A. Clements, Lawrence W. Darnell, Ramon C. Dimalanta, Sean C. Madden, Glenn R. Sussman
  • Short form c-Maf transcription factor antagonists for treatment of glaucoma
    Publication number: 20050159432
    Abstract: The short form version of c-Maf transcription factor is up-regulated in steroid-treated and transforming growth factor beta2-treated trabecular meshwork cells, and is present at elevated levels in glaucomatous versus normal trabecular meshwork cells and in glaucomatous versus normal optic nerve head tissue. Expression of short form c-Maf transcription factor under these conditions indicates a causal or effector role for the factor in primary open-angle and steroid-induced glaucoma pathogenesis. Antagonism of short form c-Maf transcription factor expression and/or activity in the trabecular meshwork or other ocular tissue is provided for inhibiting or alleviating glaucoma pathogenesis. Antagonists include cyclin-dependent kinase 2 inhibitors.
    Type: Application
    Filed: December 21, 2004
    Publication date: July 21, 2005
    Applicant: Alcon, Inc.
    Inventors: Allan Shepard, Nasreen Jacobson, Abbot Clark
  • Ophthalmic lubricating solution adapted for use in lasik surgery
    Patent number: 6919321
    Abstract: Ocular lubricant solutions are described. The solutions are adapted to facilitate the formation of a corneal flap during LASIK surgery. The solutions contain one or more viscosity enhancing agents (e.g., chondroitin sulfate) in a substantially salt-free, ophthalmically acceptable vehicle. Methods of lubricating the cornea to facilitate flap formation are also described.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: July 19, 2005
    Assignee: Alcon, Inc.
    Inventors: Pao-Li Wang, Uday Doshi, Masoud R. Jafari, Kerry L. Markwardt, Emerson Maddox
  • Aminobiguanides and the use thereof to disinfect contact lenses and preserve pharmaceutical compositions
    Patent number: 6916958
    Abstract: Aminobiguanides and the use of same as antimicrobial agents in pharmaceutical compositions are disclosed. The aminobiguanides are useful in the preservation of pharmaceutical compositions, particularly ophthalmic pharmaceutical compositions and compositions for treating contact lenses. The compounds are especially useful for disinfecting contact lenses.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: July 12, 2005
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Joonsup Park, Nissanke L. Dassanayake, Nathaniel D. McQueen, Ronald L. Schlitzer
  • Co-beadlet of dha and rosemary and methods of use
    Publication number: 20050147698
    Abstract: The present invention provides improved beadlet formulations useful for inclusion in dietary supplements customized for improving and maintaining ocular nutrition. In particular, the improved beadlets comprise DHA (docosahexaenoic acid); rosemary and/or its components; and excipients.
    Type: Application
    Filed: March 19, 2003
    Publication date: July 7, 2005
    Applicant: Alcon, Inc.
    Inventor: John Lang
  • Agents for treatment of diabetic retinopathy and drusen formation in macular degeneration
    Publication number: 20050137147
    Abstract: Agents that stimulate nuclear translocation of Nrf2 protein and the subsequent increases in gene products that detoxify and eliminate cytotoxic metabolites are provided in a method for treating diabetic retinopathy or drusen formation in age-related macular degeneration. The structurally diverse agents that act on the Nrf2/ARE pathway induce the expression of enzymes and proteins that possess chemically versatile cytoprotective properties and are a defense against toxic metabolites and xenobiotics. Agents include certain electrophiles and oxidants such as a Michael Addition acceptor, diphenol, thiocarbamate, quinone, 1,2-dithiole-3-thione, butylated hydroxyanisole, flavonoid other than genistein, an isothiocyanate, 3,5-di-tert-butyl-4-hydroxytoluene, ethoxyquin, a coumarin, combinations thereof, or a pharmacologically active derivative or analog thereof.
    Type: Application
    Filed: December 17, 2004
    Publication date: June 23, 2005
    Applicant: Alcon, Inc.
    Inventors: Robert Landers, David Bingaman
  • Agents for treatment of glaucomatous retinopathy and optic neuropathy
    Publication number: 20050137146
    Abstract: Agents that stimulate nuclear translocation of Nrf2 protein and the subsequent increases in gene products that detoxify and eliminate cytotoxic metabolites are provided in a method for treating glaucomatous retinopathy or optic neuropathy. The structurally diverse agents that act on the Nrf2/ARE pathway induce the expression of enzymes and proteins that possess chemically versatile cytoprotective properties and are a defense against toxic metabolites and xenobiotics. Agents include certain electrophiles and oxidants such as a Michael Addition acceptor, diphenol, thiocarbamate, quinone, 1,2-dithiole-3-thione, butylated hydroxyanisole, flavonoid, an isothiocyanate, 3,5-di-tert-butyl-4-hydroxytoluene, ethoxyquin, a coumarin, combinations thereof, or a pharmacologically active derivative or analog thereof.
    Type: Application
    Filed: December 17, 2004
    Publication date: June 23, 2005
    Applicant: Alcon, Inc.
    Inventors: Robert Landers, Iok-Hou Pang
  • Micro surgical cutting instrument configured as scissors
    Patent number: 6908476
    Abstract: A cutting instrument configured as scissors has a housing formed as a handle with a functional unit disposed therein; supported in the functional unit is a probe configured as a hollow needle which co-axially supports a rod projecting from the probe in axial direction and which comprises at its distal end a cutting device and wherein the cutting device has two cutting members provided with cutting blades that can be configured in an arc-shape or a straight shape, wherein from an open position the cutting blades correspond to each other at an acute angle, they are brought into engagement with each other to a closed position for a cutting action by means of a sliding movement of the probe relative to the scissors tip.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: June 21, 2005
    Assignee: Alcon Grieshaber AG
    Inventors: Oliver Jud, Werner Maag