Patents Assigned to Alcon
  • Sulfonamides useful as carbonic anhydrase inhibitors
    Patent number: 5378703
    Abstract: Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.
    Type: Grant
    Filed: February 18, 1993
    Date of Patent: January 3, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: Thomas R. Dean, Hwang-Hsing Chen, Jesse A. May
  • Process for cleaning and disinfecting contact lenses
    Patent number: 5370744
    Abstract: An improved process for cleaning and disinfecting contact lenses with a single solution is described. The process utilizes the cleaning effect of a cleaning agent in combination with the solvent action of water and physical agitation of the lens (i.e., by means of rubbing) to achieve a degree of cleaning which is comparable to or better than prior processes which utilize surfactant-cleaners. The cleaning agent is selected from polycarboxylates, polysulfonates and polyphosphates. The preferred cleaning agent is citrate. The process also offers greater convenience, relative to many prior systems for cleaning and disinfecting contact lenses, since the need to utilize additional products to clean the lenses is eliminated.
    Type: Grant
    Filed: August 27, 1993
    Date of Patent: December 6, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventors: Masood Chowhan, Thierry Bilbault, Ronald P. Quintana
  • Angiostatic steroids and methods and compositions for controlling ocular hypertension
    Patent number: 5371078
    Abstract: Angiostatic steroids for use in controlling ocular hypertension are disclosed. Pharmaceutical compositions of the angiostatic steroids and methods for their use in treating ocular hypertension, including controlling the ocular hypertension associated with primary open angle glaucoma, are disclosed. In addition, the combination of the compounds with glucocorticoids for the prevention of elevated IOP during the treatment of inflammation is disclosed.
    Type: Grant
    Filed: September 8, 1992
    Date of Patent: December 6, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventors: Abbot F. Clark, Raymond E. Conrow
  • Compositions and method comprising substituted glycosides as mucus membrane permeation enhancers
    Patent number: 5369095
    Abstract: The use of substituted glycosides to enhance the penetration of drugs across mucus covered epithelial tissues of humans and animals is disclosed, including enhanced penetrations of topically applied ophthalmic drugs through the corneal epithelium of said humans and animals.
    Type: Grant
    Filed: March 12, 1993
    Date of Patent: November 29, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventors: Tai-Lee Kee, Jack M. Shaw
  • Heat sterilization of labile antibiotics
    Patent number: 5360593
    Abstract: Disclosed is a process for heat sterilizing pharmaceuticals, cosmetics, foodstuffs and other materials, which are labile to oxidation by atmospheric oxygen at elevated temperature and labile to other degradative changes through interaction with volatiles raised by exposure of the material to elevated temperature, comprising heating, for a given length of time, the material to be sterilized at a temperature required to achieve a predetermined degree of sterilization in a gaseous medium substantially devoid of oxygen; typically such a gaseous medium comprises a non reactive gas, such as, nitrogen, which is otherwise innocuous and capable of being purged at the end of the sterilization process at a pressure sufficient to facilitate the distribution of heat throughout the material being treated by convection.
    Type: Grant
    Filed: October 22, 1993
    Date of Patent: November 1, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventor: Krishna M. Bapatla
  • Method of preparing human conjunctival mast cells for mast cell stabilization assays
    Patent number: 5360720
    Abstract: By allowing the mast cell enriched population of human conjunctival tissue cells to incubate for a minimum of about forty (40) hours post enzymatic digestion, the treatment window between spontaneous histamine release and anti-human IgE stimulated histamine release is increased. Culturing the human conjunctival tissue mast cells decreases the spontaneous release of histamine and increases the anti-IgE stimulated histamine release, greater than ten fold over spontaneous, at time points over forty (40) hours. This treatment window is sufficient to detect a compound's stabilizing or anti-allergic activity.
    Type: Grant
    Filed: October 8, 1993
    Date of Patent: November 1, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventors: Steven T. Miller, John M. Yanni
  • Pharmaceutical compositions and methods of treatment of the cornea following ultraviolet laser irradiation
    Patent number: 5360611
    Abstract: Methods for treating the cornea following UV laser irradiation and resulting photoablation of corneal tissue are disclosed. The methods include administration of compositions of a non-steroidal antiinflammatory to the eye. Compositions for use in treating the cornea are also disclosed.
    Type: Grant
    Filed: August 4, 1993
    Date of Patent: November 1, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventors: Stella M. Robertson, Herman M. Kunkle, Jr.
  • Methods and compositions for controlling intraocular pressure with transition metal complexes
    Patent number: 5356932
    Abstract: Compositions and methods for controlling intraocular pressure using transition metal complexes are disclosed. Topical ophthalmic and systemic administration of the transition metal complexes is disclosed.
    Type: Grant
    Filed: August 9, 1993
    Date of Patent: October 18, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventors: Hans R. Moll, Mark T. DuPriest, Daniel Kuzmich
  • Process for preparation of calcitriol lactone and related intermediates
    Patent number: 5354872
    Abstract: A process for synthesizing (23S,25R)-calcitriol lactone and related Vitamin D analogs comprises reacting protected enantiomerically pure glycidol or 2-alkylglycidol with protected De-A,B-8.beta.-hydroxy-24-nor-cholan-23-al, removing the protective groups from the epimeric product mixture and separating the epimers, to give a hydrindane tetrol product, followed by oxidation and protection of the hydrindane tetrol product, reacting the tetrol product with the lithium salt of (3S)-(3.alpha.,5.beta.,Z)-2-(2-methylene-3,5-bis-((1,1-dimethylethyl)dimet hylsilyloxy)cyclohexy lidene)ethyl diphenyl phosphine oxide and removing the final protective groups. Certain intermediate compounds also show biological activity as angiostatic agents.
    Type: Grant
    Filed: May 28, 1993
    Date of Patent: October 11, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventor: Raymond E. Conrow
  • Preparation of carbonic anhydrase inhibitors
    Patent number: 5344929
    Abstract: A process for synthesizing carbonic anhydrase inhibitors is disclosed.
    Type: Grant
    Filed: February 18, 1993
    Date of Patent: September 6, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventors: William D. Dean, Paul W. Zinke, Steven J. Sproull, Michael E. Deason, Raymond E. Conrow, Anura P. Dantanarayana
  • Use of borate-polyol complexes in ophthalmic compositions
    Patent number: 5342620
    Abstract: Aqueous ophthalmic compositions containing water-soluble borate-polyol complexes are useful in aqueous ophthalmic compositions containing polyvinyl alcohol. These compositions provide the benefits of a borate buffering system, such as enhanced antimicrobial activity, without the problems associated with the use of borate and pol, such as formation of borate-polyvinyl alcohol complexes which are water-insoluble.
    Type: Grant
    Filed: September 7, 1993
    Date of Patent: August 30, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventor: Masood Chowhan
  • Method for injecting viscous fluid into the eye to lift retinal membrane
    Patent number: 5328481
    Abstract: A method for injecting viscous material into the eye. In the injection into the eye, sufficient material is injected to separate a membrane from the retina so that intraocular scissors may be manipulated between the membrane and the retina to cut the attachment points. The membrane is then aspirated away. The injection is done using a standard glue injector with a one-shot and a continuous mode. The glue injector is pneumatically coupled through a sterile filter and a custom adaptor to a sterile syringe storing the material to be injected.
    Type: Grant
    Filed: September 16, 1991
    Date of Patent: July 12, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventor: Carl C. T. Wang
  • Topical ophthalmic compositions comprising 4-(3-substituted amino-2-hydroxypropoxy)-1,2,5-thiadiazoles and methods for their use
    Patent number: 5320839
    Abstract: Topical ophthalmic compositions comprising certain thiadiazoles are useful in the treatment of glaucoma and ocular hypertension. The thiadiazoles are slightly less potent than timolol; however, they have greatly reduced systemic side effects as compared to timolol.
    Type: Grant
    Filed: August 10, 1993
    Date of Patent: June 14, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventors: Louis DeSantis, Jr., Robert J. Adamski
  • Use of nonionic surfactant to enhance the cleaning effect of pancreatin on contact lenses
    Patent number: 5318717
    Abstract: A contact lens cleaning solution containing an enzyme having proteolytic activity and a surfactant, and optionally also a chelating agent and urea, and a method of cleaning contact lenses utilizing this solution are described. The solution and method effectively remove deposits of proteinaceous material, mucins, lipids and calcium located either on or beneath the surface of the lens.
    Type: Grant
    Filed: July 17, 1992
    Date of Patent: June 7, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventor: Rolf Schafer
  • B.sub.2 adrenegic agonists and use thereof in the treatment of glaucoma
    Patent number: 5314916
    Abstract: Compounds having beta-2 adrenergic agonist activity and the use of these compounds in controlling intraocular pressure are disclosed. The compounds are believed to be useful in controlling intraocular pressure by increasing the outflow of aqueous humor. The compounds are considered to be less likely to cause cardiovascular side effects and various other side effects associated with stimulation of beta-1 receptors, relative to epinephrine.
    Type: Grant
    Filed: April 19, 1993
    Date of Patent: May 24, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventors: Billie M. York, Evan P. Kyba
  • Polymeric antimicrobials and their use in pharmaceutical compositions
    Patent number: 5300287
    Abstract: Novel polymeric antimicrobials having spacer moieties between amine and/or ammonium moieties have good antifungal activity. These compounds are useful in pharmaceutical and cosmetic compositions as preservatives and in contact lens care compositions as preservatives and/or disinfectants.
    Type: Grant
    Filed: November 4, 1992
    Date of Patent: April 5, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventor: Joonsup Park
  • Intraocular lens folder
    Patent number: D349342
    Type: Grant
    Filed: February 2, 1993
    Date of Patent: August 2, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventors: Stephen J. Van Noy, Robert Hambleton
  • Cutting tip wrench
    Patent number: D351095
    Type: Grant
    Filed: February 2, 1993
    Date of Patent: October 4, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventors: Peter D. Casica, Hardy A. Feierabend, James R. Dennewill, Stephen W. Haines
  • Surgical handpiece shell
    Patent number: D351227
    Type: Grant
    Filed: February 9, 1993
    Date of Patent: October 4, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventors: Douglas M. Patton, Steven T. Ewing
  • Surgical console for ophthalmic surgery
    Patent number: D352106
    Type: Grant
    Filed: September 2, 1992
    Date of Patent: November 1, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventors: Douglas M. Fanney, Long O. Nguyen, Robert Peterson, Paul C. Pynckel, Miles A. Conklin, Kenneth Mori, Douglas M. Patton