Patents Assigned to Alcon
  • Use of diamines to disinfect and clean contact lenses
    Patent number: 5415837
    Abstract: Certain alkenyl diamines, the use of same for disinfecting and cleaning contact lenses and preserving ophthalmic products, and associated ophthalmic compositions are described.
    Type: Grant
    Filed: October 25, 1993
    Date of Patent: May 16, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: Rolf Schafer, Ronald L. Schlitzer, Nissanke L. Dassanayake
  • Use of TGF-.beta..sub.3 to reduce the formation of scar tissue in response to corneal trauma
    Patent number: 5411940
    Abstract: The use of TGF-.beta..sub.3 to reduce the formation of scar tissue as a result of trauma to the cornea of the eye is described. The invention is particularly directed to the use of TGF-.beta..sub.3 to reduce the formation of scar tissue in connection with ophthalmic surgical procedures involving the cornea, such as laser irradiation of the cornea. A composition containing TGF-.beta..sub.3 is applied to the site of the trauma to alter the production and composition of extracellular matrix synthesized by fibroblasts, and thereby reduce the formation of scar tissue and consequent impairment of vision.
    Type: Grant
    Filed: September 29, 1993
    Date of Patent: May 2, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: Jon C. Nixon, Billie M. York
  • Hyaluronic acid compositions and methods
    Patent number: 5409904
    Abstract: Disclosed are solutions useful in surgery comprising a viscous or viscoelastic substance in an aqueous vehicle which is characterized as physiologically compatible; also disclosed are methods of using such solutions, implanting such viscous or viscoelastic substances, while minimizing the traumatic effect of surgery at the cellular level.
    Type: Grant
    Filed: November 16, 1992
    Date of Patent: April 25, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: Gerald Hecht, Ole J. Lorenzetti
  • Ophthalmic composition
    Patent number: 5407926
    Abstract: Pharmaceutical compositions useful in the treatment of ophthalmic inflammation and methods of treating ophthalmic inflammation with those compositions are disclosed. The compositions contain a combination of a glucocorticoid and an angiostatic steroid. The angiostatic steroid substantially prevents any significant increases in intraocular pressure which might otherwise be experienced by the patient as a side effect of the glucocorticoid component of the compositions. The therapeutic interaction of the two components therefore allows the potent anti-inflammatory properties of the glucocorticoids to be utilized without fear of elevating intraocular pressure.
    Type: Grant
    Filed: October 23, 1992
    Date of Patent: April 18, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventor: Abbot F. Clark
  • Use of carrageenans in topical ophthalmic compositions
    Patent number: 5403841
    Abstract: Topical ophthalmic compositions of carrageenans which are administrable as a drop but which become more viscous or gel upon instillation in the eye are disclosed. Methods for use of the compositions as topical ophthalmic vehicles for pharmaceutically active agents, and alone as lubricants or tear supplements, are also disclosed.
    Type: Grant
    Filed: August 18, 1993
    Date of Patent: April 4, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: John C. Lang, Jamieson C. Keister, Paul J. T. Missel, Dimitri J. Stancioff
  • Physiological tear compositions and methods for their preparation
    Patent number: 5403598
    Abstract: Non-preserved physiological tear compositions comprise the ionic components of normal human tear film in substantially the same amounts and proportions. Novel methods of preparation of these compositions and novel packaging allow the maintenance of the bicarbonate concentration in these compositions.
    Type: Grant
    Filed: January 6, 1994
    Date of Patent: April 4, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: Robert E. Beck, Haresh G. Bhagat, Philip D. Gressel, Fred M. Killinger
  • Pharmaceutical compositions and methods of treatment of the cornea in conjunction with laser irradiation
    Patent number: 5401509
    Abstract: Methods for preventing and treating corneal haze resulting from exposure of the eye to laser irradiation are disclosed. The methods include administration of compositions of wound healing modulators to the eye. Compositions for use in preventing and treating the corneal haze are also disclosed.
    Type: Grant
    Filed: July 25, 1994
    Date of Patent: March 28, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: Stella M. Robertson, Herman M. Kunkle, Jr.
  • Pharmaceutical compositions and methods of treatment of the cornea following laser irradiation
    Patent number: 5401510
    Abstract: Methods for preventing and treating corneal haze resulting from exposure of the eye to laser irradiation are disclosed. The methods include administration of compositions of wound healing modulators to the eye. Compositions for use in preventing and treating the corneal haze are also disclosed.
    Type: Grant
    Filed: July 25, 1994
    Date of Patent: March 28, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: Stella M. Robertson, Herman M. Kunkle, Jr.
  • Quaternary ammonium siloxane compounds and methods for their use
    Patent number: 5399737
    Abstract: Novel quaternary ammonium siloxane compounds and methods for their use are disclosed.
    Type: Grant
    Filed: April 4, 1994
    Date of Patent: March 21, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: Joonsup Park, Joseph J. Falcetta
  • Use of amidoamines in ophthalmic compositions
    Patent number: 5393491
    Abstract: Certain amidoamines, the use of same for disinfecting and cleaning contact lenses and preserving ophthalmic products, and associated ophthalmic compositions are described.
    Type: Grant
    Filed: September 22, 1993
    Date of Patent: February 28, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: Nissanke L. Dassanayake, Ronald L. Schlitzer, Joonsup Park
  • Sulfonamides useful as carbonic anhydrase inhibitors
    Patent number: 5378703
    Abstract: Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.
    Type: Grant
    Filed: February 18, 1993
    Date of Patent: January 3, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: Thomas R. Dean, Hwang-Hsing Chen, Jesse A. May
  • Angiostatic steroids and methods and compositions for controlling ocular hypertension
    Patent number: 5371078
    Abstract: Angiostatic steroids for use in controlling ocular hypertension are disclosed. Pharmaceutical compositions of the angiostatic steroids and methods for their use in treating ocular hypertension, including controlling the ocular hypertension associated with primary open angle glaucoma, are disclosed. In addition, the combination of the compounds with glucocorticoids for the prevention of elevated IOP during the treatment of inflammation is disclosed.
    Type: Grant
    Filed: September 8, 1992
    Date of Patent: December 6, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventors: Abbot F. Clark, Raymond E. Conrow
  • Process for cleaning and disinfecting contact lenses
    Patent number: 5370744
    Abstract: An improved process for cleaning and disinfecting contact lenses with a single solution is described. The process utilizes the cleaning effect of a cleaning agent in combination with the solvent action of water and physical agitation of the lens (i.e., by means of rubbing) to achieve a degree of cleaning which is comparable to or better than prior processes which utilize surfactant-cleaners. The cleaning agent is selected from polycarboxylates, polysulfonates and polyphosphates. The preferred cleaning agent is citrate. The process also offers greater convenience, relative to many prior systems for cleaning and disinfecting contact lenses, since the need to utilize additional products to clean the lenses is eliminated.
    Type: Grant
    Filed: August 27, 1993
    Date of Patent: December 6, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventors: Masood Chowhan, Thierry Bilbault, Ronald P. Quintana
  • Compositions and method comprising substituted glycosides as mucus membrane permeation enhancers
    Patent number: 5369095
    Abstract: The use of substituted glycosides to enhance the penetration of drugs across mucus covered epithelial tissues of humans and animals is disclosed, including enhanced penetrations of topically applied ophthalmic drugs through the corneal epithelium of said humans and animals.
    Type: Grant
    Filed: March 12, 1993
    Date of Patent: November 29, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventors: Tai-Lee Kee, Jack M. Shaw
  • Heat sterilization of labile antibiotics
    Patent number: 5360593
    Abstract: Disclosed is a process for heat sterilizing pharmaceuticals, cosmetics, foodstuffs and other materials, which are labile to oxidation by atmospheric oxygen at elevated temperature and labile to other degradative changes through interaction with volatiles raised by exposure of the material to elevated temperature, comprising heating, for a given length of time, the material to be sterilized at a temperature required to achieve a predetermined degree of sterilization in a gaseous medium substantially devoid of oxygen; typically such a gaseous medium comprises a non reactive gas, such as, nitrogen, which is otherwise innocuous and capable of being purged at the end of the sterilization process at a pressure sufficient to facilitate the distribution of heat throughout the material being treated by convection.
    Type: Grant
    Filed: October 22, 1993
    Date of Patent: November 1, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventor: Krishna M. Bapatla
  • Pharmaceutical compositions and methods of treatment of the cornea following ultraviolet laser irradiation
    Patent number: 5360611
    Abstract: Methods for treating the cornea following UV laser irradiation and resulting photoablation of corneal tissue are disclosed. The methods include administration of compositions of a non-steroidal antiinflammatory to the eye. Compositions for use in treating the cornea are also disclosed.
    Type: Grant
    Filed: August 4, 1993
    Date of Patent: November 1, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventors: Stella M. Robertson, Herman M. Kunkle, Jr.
  • Method of preparing human conjunctival mast cells for mast cell stabilization assays
    Patent number: 5360720
    Abstract: By allowing the mast cell enriched population of human conjunctival tissue cells to incubate for a minimum of about forty (40) hours post enzymatic digestion, the treatment window between spontaneous histamine release and anti-human IgE stimulated histamine release is increased. Culturing the human conjunctival tissue mast cells decreases the spontaneous release of histamine and increases the anti-IgE stimulated histamine release, greater than ten fold over spontaneous, at time points over forty (40) hours. This treatment window is sufficient to detect a compound's stabilizing or anti-allergic activity.
    Type: Grant
    Filed: October 8, 1993
    Date of Patent: November 1, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventors: Steven T. Miller, John M. Yanni
  • Methods and compositions for controlling intraocular pressure with transition metal complexes
    Patent number: 5356932
    Abstract: Compositions and methods for controlling intraocular pressure using transition metal complexes are disclosed. Topical ophthalmic and systemic administration of the transition metal complexes is disclosed.
    Type: Grant
    Filed: August 9, 1993
    Date of Patent: October 18, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventors: Hans R. Moll, Mark T. DuPriest, Daniel Kuzmich
  • Surgical console for ophthalmic surgery
    Patent number: D352106
    Type: Grant
    Filed: September 2, 1992
    Date of Patent: November 1, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventors: Douglas M. Fanney, Long O. Nguyen, Robert Peterson, Paul C. Pynckel, Miles A. Conklin, Kenneth Mori, Douglas M. Patton
  • Surgical handpiece tip protector
    Patent number: D354283
    Type: Grant
    Filed: April 20, 1993
    Date of Patent: January 10, 1995
    Assignee: Alcon Laboratories, Inc.
    Inventors: George W. Rhen, Jr., Gregory A. Auchter