Patents Assigned to Alcon
  • LOW DENSITY LIPOPROTEIN RECEPTOR-MEDIATED siRNA DELIVERY
    Publication number: 20090131358
    Abstract: The invention provides interfering RNA molecule-ligand conjugates useful as a delivery system for delivering interfering RNA molecules to a cell in vitro or in vivo. The conjugates comprise a ligand that can bind to a low density lipoprotein receptor (LDLR) or LDLR family member. Therapeutic uses for the conjugates are also provided.
    Type: Application
    Filed: November 14, 2008
    Publication date: May 21, 2009
    Applicant: ALCON RESEARCH, LTD.
    Inventor: Jon E. Chatterton
  • USE OF TRPV1 RECEPTOR ANTAGONISTS FOR TREATING DRY EYE AND OCULAR PAIN
    Publication number: 20090131449
    Abstract: Methods of treating symptoms of dry eye by administering inhibitors of transient receptor potential cation channel, subfamily V, member 1 (TRPV1) are disclosed. Methods of preventing or alleviating ocular pain by administering TRPV1 inhibitors are also disclosed.
    Type: Application
    Filed: November 18, 2008
    Publication date: May 21, 2009
    Applicant: ALCON RESEARCH, LTD.
    Inventors: John M. Yanni, Daniel A. Gamache
  • Monitoring Thermal Conditions To Vary Operation of an Ultrasonic Needle Tip of a Surgical Instrument
    Publication number: 20090124960
    Abstract: A method and apparatus to operate a surgical instrument in response to a thermal condition being detected that warrants curtailment of further operation. When the thermal condition is reached, command signals are generated that cause a needle of the surgical instrument to either have its vibrational speed slowed, have its vibrational movement stopped, or have it withdrawn from its relative position. The detection is of infrared radiation wavelengths and is carried out with either a thermal imaging device of a thermal recognition device. A corresponding temperature of the detected infrared radiation wavelengths is compared to a critical temperature to determine whether the thermal condition has been reached.
    Type: Application
    Filed: January 8, 2009
    Publication date: May 14, 2009
    Applicant: ALCON, INC.
    Inventor: Richard J. Mackool
  • Complement C1Q Inhibitors For The Prevention And Treatment Of Glaucoma
    Publication number: 20090117098
    Abstract: The invention concerns in one embodiment a method of treating glaucoma or elevated intraocular pressure comprising administering a pharmaceutically effective amount of a composition comprising a Complement C1q inhibitor. In another embodiment, the invention concerns a composition for the treatment of elevated intraocular pressure and glaucoma, the composition comprising a pharmaceutically effective amount of a Complement C1q inhibitor.
    Type: Application
    Filed: October 31, 2008
    Publication date: May 7, 2009
    Applicant: ALCON RESEARCH, LTD.
    Inventors: Allan R. SHEPARD, Abbot F. Clark, Peter G. Klimko, Martin B. Wax
  • CHELATING SILICON-BASED POLYMERS
    Publication number: 20090118456
    Abstract: The present invention relates to novel silicon-based polymers, particularly silicon-based polymers having citrate groups, and their use as chelating agents, for forming and as stabilizers.
    Type: Application
    Filed: August 2, 2006
    Publication date: May 7, 2009
    Applicants: MCMASTER UNIVERSITY, ALCON RESEARCH LTD.
    Inventors: Michael Brook, Ferdinand Gonzaga, Hongjian Tian, Howard Ketelson
  • Aspiration control
    Patent number: 7524299
    Abstract: A microsurgical system capable of controlling aspiration via a vacuum control mode, a suction control mode, or a flow control mode.
    Type: Grant
    Filed: June 21, 2005
    Date of Patent: April 28, 2009
    Assignee: Alcon, Inc.
    Inventors: Mark A. Hopkins, Shawn X. Gao
  • Tubing fitting
    Patent number: 7523967
    Abstract: A tubing fitting for use in microsurgery including a female tubing fitting and a male tubing fitting. The female tubing fitting has an external surface with a pair of opposing projections disposed thereon and an internal bore. The male tubing fitting has a second internal bore and a collar at least partially surrounding the second internal bore. The collar has an internal surface with two pairs of opposing sloping ramps disposed thereon. The pairs of opposing sloping ramps are arranged so as to create a pair of opposing spaces for removably receiving the pair of opposing projections.
    Type: Grant
    Filed: October 26, 2005
    Date of Patent: April 28, 2009
    Assignee: Alcon, Inc.
    Inventor: Dennis L. Steppe
  • RNAi-MEDIATED INHIBITION OF STROMAL CELL-DERIVED FACTOR 1-RELATED TARGETS FOR TREATMENT OF NEOVASCULARIZATION-RELATED CONDITIONS
    Publication number: 20090105182
    Abstract: RNA interference is provided for inhibition of stromal cell-derived factor 1 (SDF1)-related targets in pathologic neovascularization-related conditions, including those cellular changes resulting from the signal transduction activity of the SDF1 targets that lead directly or indirectly to ocular neovascularization, abnormal angiogenesis, retinal vascular permeability, retinal edema, diabetic retinopathy particularly proliferative diabetic retinopathy, diabetic macular edema, exudative age-related macular degeneration, sequela associated with retinal ischemia, and posterior segment neovascularization, for example.
    Type: Application
    Filed: June 1, 2007
    Publication date: April 23, 2009
    Applicant: ALCON RESEARCH, LTD.
    Inventors: Jon E. Chatterton, David P. Bingaman
  • USE OF TNF RECEPTOR ANTAGONISTS FOR TREATING DRY EYE
    Publication number: 20090098136
    Abstract: Methods of treating dry eye by administering inhibitors of tumor necrosis factor ? (TNF?) are disclosed.
    Type: Application
    Filed: October 15, 2008
    Publication date: April 16, 2009
    Applicant: ALCON RESEARCH, LTD.
    Inventors: Daniel A. Gamache, John M. Yanni, Martin B. Wax
  • OPHTHALMIC AND OTORHINOLARYNGOLOGICAL DEVICE MATERIALS
    Publication number: 20090093603
    Abstract: Disclosed are soft, high refractive index, acrylic device materials. The materials comprise di-block or tri-block macromers containing a hydrophilic block in the polymer backbone. The materials have improved glistening resistance.
    Type: Application
    Filed: October 3, 2008
    Publication date: April 9, 2009
    Applicant: ALCON, INC.
    Inventor: Douglas C. Schlueter
  • Thermal Coefficient Driven Drug Pellet Size For Ophthalmic Injection
    Publication number: 20090093788
    Abstract: A method of injecting a mixture into an eye includes: providing the mixture in a dispensing chamber with an air gap located between the mixture and an interior surface of a dispensing chamber housing, when the mixture and dispensing chamber housing are near room temperature; bringing the dispensing chamber housing and mixture to a temperature range at which the mixture expands and is in a more liquid state; maintaining air in a needle after the mixture expands and prior to an injection; and injecting the air in the needle and the mixture into the eye.
    Type: Application
    Filed: October 1, 2008
    Publication date: April 9, 2009
    Applicant: ALCON RESEARCH, lTD.
    Inventors: Robert J. Sanchez, JR., Cesario Pereira Dos Santos
  • OPHTHALMIC AND OTORHINOLARYNGOLOGICAL DEVICE MATERIALS
    Publication number: 20090093604
    Abstract: Disclosed are soft, high refractive index, acrylic device materials. The materials contain a hydrophilic side-chain macromer for glistening resistance.
    Type: Application
    Filed: October 3, 2008
    Publication date: April 9, 2009
    Applicant: Alcon, Inc.
    Inventor: Douglas C. Schlueter
  • Method of Delivering A Rate And Temperature - Dependent Substance Into The Eye
    Publication number: 20090093789
    Abstract: A method of injecting a mixture into an eye includes: providing the mixture in a dispensing chamber with an air gap located between the mixture and an interior surface of a dispensing chamber housing, when the mixture and dispensing chamber housing are near room temperature; bringing the dispensing chamber housing and mixture to a temperature range, other than near room temperature, at which the mixture expands and is in a more liquid state; maintaining air in a needle after the mixture expands and prior to an injection; selecting a drug release rate; and injecting the mixture so as to form a shape with a surface area that results in the selected drug release rate.
    Type: Application
    Filed: October 1, 2008
    Publication date: April 9, 2009
    Applicant: ALCON RESEARCH, LTD.
    Inventors: Bruno Dacquay, Cesario Pereira Dos Santos, Casey Jean Lind, Robert J. Sanchez, JR.
  • OPHTHALMIC AND OTORHINOLARYNGOLOGICAL DEVICE MATERIALS
    Publication number: 20090093592
    Abstract: Disclosed are soft, high refractive index, acrylic device materials. The materials comprise di-block or tri-block macromers containing hydrophilic side-chains. The materials have improved glistening resistance.
    Type: Application
    Filed: October 3, 2008
    Publication date: April 9, 2009
    Applicant: Alcon, Inc.
    Inventor: Douglas C. Schlueter
  • OPHTHALMIC AND OTORHINOLARYNGOLOGICAL DEVICE MATERIALS CONTAINING AN ALKYLPHENOL ETHOXYLATE
    Publication number: 20090088493
    Abstract: Disclosed are soft, high refractive index, acrylic device materials. The materials contain a functionalized alkylphenol ethoxylate to reduce glistenings.
    Type: Application
    Filed: October 1, 2008
    Publication date: April 2, 2009
    Applicant: ALCON, INC.
    Inventors: Water R. Laredo, Douglas C. Schlueter
  • SELF-COMPLEMENTARY AAV-MEDIATED DELIVERY OF INTERFERING RNA MOLECULES TO TREAT OR PREVENT OCULAR DISORDERS
    Publication number: 20090087413
    Abstract: The invention provides methods for delivering interfering RNA molecules to an eye of a patient to treat ocular disorders. In particular, the methods of the invention comprise the use of a self-complementary adeno-associated (scAAV) viral vector that can deliver an interfering RNA molecule to an eye of a patient to inhibit expression of a gene that is associated with an ocular disorder.
    Type: Application
    Filed: October 1, 2008
    Publication date: April 2, 2009
    Applicant: ALCON RESEARCH, LTD.
    Inventor: Allan R. Shepard
  • OPHTHALMIC AND OTORHINOLARYNGOLOGICAL DEVICE MATERIALS CONTAINING AN ALKYL ETHOXYLATE
    Publication number: 20090088544
    Abstract: Disclosed are soft, high refractive index, acrylic device materials. The materials contain a functionalized alkyl ethoxylate to reduce glistenings.
    Type: Application
    Filed: October 1, 2008
    Publication date: April 2, 2009
    Applicant: ALCON, INC.
    Inventor: Walter R. Laredo
  • Method for determining a pressure that corresponds to a flow rate through a check valve
    Patent number: 7509831
    Abstract: The present invention accommodates differences in cracking pressures between check valves by determining a pressure on the input of a check valve that corresponds to a predetermined flow rate at the output of the check valve. A container is incrementally pressurized and the vacuum at a point on the output side of the check valve is monitored. Once fluid begins to pass through the check valve, the vacuum drops. At the predetermined flow rate, the pump cannot maintain a predetermined vacuum level since it cannot exceed a maximum speed. At this point the pressure applied to the container corresponds to the predetermined flow rate. An offset is added to the pressure to determine the minimum operating pressure.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: March 31, 2009
    Assignee: Alcon, Inc.
    Inventor: Amir H. Khashayar
  • Ophthalmic Endoilluminator with Variable-Wedge Rotating-Disk Beam Attenuator
    Patent number: 7499624
    Abstract: An ophthalmic endoilluminator includes a light source, a variable-wedge rotating-disk attenuator, a condensing lens, and an optical fiber. The variable-wedge rotating-disk attenuator attenuates the light produced by the light source. The variable-wedge rotating-disk attenuator includes a wedge capable of being adjusted over a variable angle as measured through an arc of the wedge and an axle to which the wedge is attached. The axle rotates such that the wedge rotates around a pivot defined by the axle. The condensing lens focuses the attenuated light. The optical fiber carries the focused light into an eye. The variable-wedge rotating-disk attenuator is located such that it affects the intensity of a light beam transmitted into an eye.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: March 3, 2009
    Assignee: Alcon, Inc.
    Inventors: Bruno Dacquay, John C. Huculak, Ron T. Smith
  • RNAi-MEDIATED INHIBITION OF AQUAPORIN 1 FOR TREATMENT OF OCULAR NEOVASCULARIZATION
    Publication number: 20090054365
    Abstract: RNA interference is provided for inhibition of aquaporin 1 (AQP1) to treat conditions associated with neovascularization.
    Type: Application
    Filed: January 28, 2008
    Publication date: February 26, 2009
    Applicant: ALCON RESEARCH, LTD.
    Inventors: Rajkumar V. Patil, Jon E. Chatterton, Najam A. Sharif, Martin B. Wax