Abstract: Various types of insulated coolant lines that extend between a heat exchanger and an intravascular heat exchange catheter are disclosed.

Abstract: A closed loop heat exchange catheter can be placed in the rectum of a patient to or warm the patient.

Abstract: A system and method for treating a patient by inducing therapeutic hypothermia in the patient using an intravascular heat exchange catheter in conjunction with infusing tissue preservative substances into the patient.

Abstract: An intravascular heat exchange catheter is disclosed that has a non-straight heat exchange element.

Abstract: A system for exchanging heat with the body of a patient for cooling or warming the patient provides for automatic temperature control in accordance with the monitored temperature of the patient. The system comprises a temperature control module and temperature probes for making body core temperature measurements. The body core temperature measurements are used to control the temperature of fluid circulating within the fluid circuit.

Abstract: A patient control system uses a patient-implanted catheter in thermal communication with a fluid bath via a circulating fluid circuit. A controller automatically controls the temperature of the fluid bath as required for selectively cooling or heating the patient in accordance with patient temperature measurements. The controller thermally decouples the catheter and patient from the fluid bath during changes in fluid bath temperatures in order to overcome the effects of system thermal mass.

Abstract: A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes an inlet lumen and an outlet lumen to circulate working fluid wherein at least one of the inlet or outlet lumens is shaped to induce mixing in the body fluid flowing pass it. In one embodiment, at least one lumen is shaped to induce turbulence flow in the body fluid.

Abstract: Various intravascular heat exchange catheters are disclosed that have non-straight heat exchange elements.

Abstract: An introducer sheath for a catheter includes an angling membrane formed at its distal end and an inflate/deflate mechanism formed at its proximal end to deploy the angling membrane. The sheath further includes two hollow body shafts connected at the distal end and can concentrically accommodate the catheter inside the shafts for positioning the catheter in a patient's vena cava system. The introducer sheath is used for positioning at least a portion of the catheter in the inferior vena cava from a chest or neck insertion point. Once the catheter's heat exchange elements are firmly positioned in the inferior vena cava, the angling membrane can be deflated and the angling introducer sheath removed leaving the catheter in place.

Abstract: A method for treating cardiac arrest includes defibrillating the patient and/or ventilating the patient and/or administering a cardiac arrest drug such as epinephrine to resuscitate the patient, and then cooling the patient using one or more cooling catheter positioned in the central venous system of the patient.

Abstract: An intravenous catheter system (apparatus and method) for controlling patient temperature includes a generally tubular elongated body having lumens for circulating a heat exchange fluid in a plurality of heat exchange elements provided at spaced intervals along the length of the elongated body. The heat exchange elements preferably comprise inflatable balloons. Heat exchange occurs between the fluid in the balloons and blood in the blood vessel. Each balloon preferably is sized such that, when inflated, each balloon blocks no more than approximately 30% to 75% of the blood vessel in which it is intubated. The catheter preferably has two to four balloons, each of which may have a different shape. The catheter also preferably has three to five infusion lumens for providing access to the patient's blood at different locations in the patient's bloodstream.

Abstract: A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system.

Abstract: An intravenous catheter system (apparatus and method) for controlling patient temperature includes a generally tubular elongate body, a heat exchange element through which a heat exchange fluid circulates, and an inflation element or irregular surface positioned within the heat exchange element for promoting mixing of the circulating heat exchange fluid. The heat exchange element and inflation element preferably include inflatable balloons. The catheter preferably has two to four balloons having a substantially straight configuration, each balloon containing an inner balloon inflation element having a substantially spiral configuration. The catheter also preferably has at least one infusion lumen for providing access to the patient's blood and a guidewire lumen to accommodate a guidewire. The catheter is used in conjunction with a heat/cool system to cool a hyperthermic patient as quickly as possible, to warm a hypothermic patient as quickly as possible or to maintain normothermia.

Abstract: A heat exchange catheter having an open core includes a catheter body for use in the central vasculature of a patient. The catheter body having a balloon with at least one heat exchange lumen for exchanging heat with flowing blood. The balloon inflates from a collapsed configuration to an inflated configuration. In the inflated configuration the balloon facilitates the flow of heat exchange fluid through the heat exchange lumen, which wraps in a helical pattern to define the open core and to enable blood to flow through the open core during use of the catheter. The open core defines an inside and an outside, the heat exchange lumen has non-contiguous helical winds to allow flowing blood to mix between the inside of the open core and the outside of the open core.

Abstract: A heat exchange catheter has a catheter body with a working fluid supply lumen extending therethrough, and terminating in a helical heat exchange tube that exits the body and extends proximally back along the catheter body. Working fluid flows through the heat exchange tube to exchange heat with the central venous system of a patient when the catheter body is properly placed in the patient.

Abstract: An intravascular heat exchange catheter is disclosed that has a non-straight heat exchange element.

Abstract: The system of the present invention includes a heat exchange catheter for warming flowing blood within a blood vessel. The heat exchange catheter includes a catheter body having a proximal end and a distal end with electrodes. The electrodes generate an electric field that radiates heat to the flowing blood. The electrodes comprise discrete bands that serially align and are spaced apart from each other. Each electrode has a polarity, and for each electrode there is an adjacent electrode having an opposite polarity. A support centrally aligns the catheter body within the blood vessel.

Abstract: A method for treating cardiac arrest includes defibrillating the patient and/or ventilating the patient and/or administering a cardiac arrest drug such as epinephrine to resuscitate the patient, and then cooling the patient using one or more cooling catheter positioned in the central venous system of the patient.

Abstract: An introducer sheath for a central venous catheter includes a sheath body and a temperature sensor mounted distally on the body. Either the catheter or sheath has a heat exchange region through which coolant is circulated to effect heat exchange with the body, with the coolant temperature being controlled in response to signals from the temperature sensor. Arterial dialysis heat exchange catheters and jugular bulb heat exchange catheters are also disclosed.

Abstract: An intravenous cardiovascular guiding catheter system (apparatus and method) for controlling patient temperature includes a generally tubular elongate body having a guide lumen with a guide duct disposed at the distal tip of the catheter for providing a pathway through which medical apparatus may be advanced in the patient's circulatory system. The catheter also comprises one or more lumens for conveying a heat exchange fluid to one or more heat exchange elements that exchange heat with the patient's blood to control the patient's temperature. The catheter may have an internal heating element that heats or cools the heat exchange fluid. The catheter also preferably has one or more infusion lumens for providing access to the patient's central blood supply. The catheter may be used to treat myocardial infarction.