Patents Assigned to Ambrx
  • Non-Natural Amino Acid Replication-Dependent Microorganisms and Vaccines
    Publication number: 20130323821
    Abstract: Compositions and methods of producing vaccines, including methods wherein whole organism vaccines are provided with limited replication abilities, thereby increasing vaccine safety and efficacy, through the use of non-natural, unnatural, or non-naturally encoded amino acids.
    Type: Application
    Filed: August 9, 2013
    Publication date: December 5, 2013
    Applicant: AMBRX, INC.
    Inventors: Feng TIAN, Brad HEHLI
  • Modified animal erythropoietin polypeptides and their uses
    Patent number: 8569233
    Abstract: Modified animal erythropoietin polypeptides and uses thereof are provide.
    Type: Grant
    Filed: July 24, 2012
    Date of Patent: October 29, 2013
    Assignees: Eli Lilly and Company, AMBRX, Inc.
    Inventors: Feng Tian, Anna-Maria A. Hays Putnam, Frank Song, Stephanie Chu, Joseph Sheffer, Richard S. Barnett, Marc Siladi, Kyle Atkinson, Darin Lee, Peter C. Canning
  • Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
    Patent number: 8557781
    Abstract: Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: October 15, 2013
    Assignee: AMBRX, Inc.
    Inventors: Zhenwei Miao, Junjie Liu, Thea Norman
  • Biosynthetic Polypeptide Fusion Inhibitors
    Publication number: 20130237474
    Abstract: Modified biosynthetic polypeptide fusion inhibitors, methods for manufacturing, and uses thereof are provided.
    Type: Application
    Filed: November 13, 2012
    Publication date: September 12, 2013
    Applicant: AMBRX, INC.
    Inventors: Roberto Mariani, Bruce E. Kimmel
  • Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
    Patent number: 8476411
    Abstract: Non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides, are disclosed. The non-natural amino acids, by themselves or as a part of a polypeptide, can include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Methods for making, modifying, and purifying the non-natural amino acid polypeptides are also disclosed. Further, methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses, are disclosed.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: July 2, 2013
    Assignee: Ambrx, Inc.
    Inventors: Zhenwei Miao, Junjie Liu, Thea Norman, Russell Driver
  • Modified FGF-21 Polypeptides and Their Uses
    Publication number: 20130150564
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Application
    Filed: January 2, 2013
    Publication date: June 13, 2013
    Applicant: Ambrx, Inc.
    Inventor: Ambrx, Inc.
  • Suppressor tRNA transcription in vertebrate cells
    Patent number: 8420792
    Abstract: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided.
    Type: Grant
    Filed: September 7, 2007
    Date of Patent: April 16, 2013
    Assignee: Ambrx, Inc.
    Inventors: Feng Tian, Thea Norman, Stephanie Chu
  • Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
    Patent number: 8399614
    Abstract: Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: March 19, 2013
    Assignee: Ambrx, Inc.
    Inventors: Zhenwei Miao, Junjie Liu, Thea Norman
  • Methods of making FGF-21 mutants comprising non-naturally encoded phenylalanine derivatives
    Patent number: 8383365
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: February 26, 2013
    Assignee: AMBRX, Inc.
    Inventors: Thomas P. Cujec, Roberto Mariani, Anna-Maria A. Hays Putnam, William M. Keefe, Nick Knudsen, Lillian Skidmore (Nee Ho), Jason Pinkstaff, Vadim Kraynov
  • Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
    Patent number: 8367612
    Abstract: Non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides, are disclosed. The non-natural amino acids, by themselves or as a part of a polypeptide, can include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Methods for making, modifying, and purifying the non-natural amino acid polypeptides are also disclosed. Further, methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses, are disclosed.
    Type: Grant
    Filed: November 5, 2009
    Date of Patent: February 5, 2013
    Assignee: Ambrx, Inc.
    Inventors: Zhenwei Miao, Junjie Liu, Thea Norman, Russell Driver
  • COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES
    Publication number: 20130030160
    Abstract: Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
    Type: Application
    Filed: June 20, 2012
    Publication date: January 31, 2013
    Applicant: Ambrx, Inc.
    Inventors: Zhenwei MIAO, Junjie Liu, Thea Norman, Russell Driver
  • MODIFIED ANIMAL ERYTHROPOIETIN POLYPEPTIDES AND THEIR USES
    Publication number: 20130017995
    Abstract: Modified animal erythropoietin polypeptides and uses thereof are provide.
    Type: Application
    Filed: July 24, 2012
    Publication date: January 17, 2013
    Applicants: ELI LILLY AND COMPANY, AMBRX, INC.
    Inventors: Feng TIAN, Anna-Maria A. HAYS PUTNAM, Frank SONG, Stephanie CHU, Joseph SHEFFER, Richard S. BARNETT, Marc E. SILADI, Kyle ATKINSON, Darin LEE, Peter C. CANNING
  • COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES
    Publication number: 20120315686
    Abstract: Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
    Type: Application
    Filed: May 9, 2012
    Publication date: December 13, 2012
    Applicant: Ambrx, Inc.
    Inventors: Zhenwei MIAO, Junjie Liu, Thea Norman
  • Modified interferon beta polypeptides and their uses
    Patent number: 8329869
    Abstract: Modified interferon beta polypeptides and uses thereof are provided.
    Type: Grant
    Filed: January 6, 2012
    Date of Patent: December 11, 2012
    Assignee: Ambrx, Inc.
    Inventors: Vadim Kraynov, Nick Knudsen, Anna-Maria A. Hays Putnam, Denise Krawitz, Jason Pinkstaff, Heather Myler
  • MODIFIED PORCINE SOMATOTROPIN POLYPEPTIDES AND THEIR USES
    Publication number: 20120283172
    Abstract: Modified porcine somatotropin polypeptides and uses thereof are provided.
    Type: Application
    Filed: December 21, 2010
    Publication date: November 8, 2012
    Applicant: AMBRX, INC.
    Inventors: John W. Wallen, III, Nick Knudsen, Vadim Kraynov
  • MODIFIED BOVINE SOMATOTROPIN POLYPEPTIDES AND THEIR USES
    Publication number: 20120283171
    Abstract: Modified bovine somatotropin polypeptides and uses thereof are provided.
    Type: Application
    Filed: December 21, 2010
    Publication date: November 8, 2012
    Applicant: Ambrx, Inc.
    Inventor: Anna-Maria A. Hays Putman
  • Modified animal erythropoietin polypeptides and their uses
    Patent number: 8278418
    Abstract: Modified animal erythropoietin polypeptides and uses thereof are provide.
    Type: Grant
    Filed: September 25, 2009
    Date of Patent: October 2, 2012
    Assignee: Ambrx, Inc.
    Inventors: Feng Tian, Anna-Maria A. Hays Putnam, Frank Song, Stephanie Chu, Joseph Sheffer, Richard S. Barnett, Marc E. Siladi, Kyle Atkinson, Darin Lee, Peter C. Canning
  • Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
    Patent number: 8263740
    Abstract: Non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides are disclosed. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. The non-natural amino acid polypeptides are further modified post-translationally. The non-natural amino acid polypeptides and modified non-natural amino acid polypeptides have many uses, including therapeutic, diagnostic, and other biotechnology uses.
    Type: Grant
    Filed: February 6, 2008
    Date of Patent: September 11, 2012
    Assignee: AMBRX, Inc.
    Inventors: Zhenwei Miao, Junjie Liu, Thea Norman, Russell Driver
  • MODIFIED INTERFERON BETA POLYPEPTIDES AND THEIR USES
    Publication number: 20120197006
    Abstract: Modified interferon beta polypeptides and uses thereof are provided.
    Type: Application
    Filed: January 6, 2012
    Publication date: August 2, 2012
    Applicant: AMBRX, INC.
    Inventors: Vadim KRAYNOV, Nick KNUDSEN, Anna-Maria A. HAYS PUTNAM, Denise KRAWITZ, Jason PINKSTAFF, Heather MYLER
  • Modified human interferon polypeptides and their uses
    Patent number: 8232371
    Abstract: Modified interferon polypeptides with at least one non-naturally-encoded amino acid and uses thereof are provided.
    Type: Grant
    Filed: December 8, 2011
    Date of Patent: July 31, 2012
    Assignee: Ambrx, Inc.
    Inventors: Ho Sung Cho, Thomas O. Daniel, Anna-Maria A. Hays Putnam, Troy E. Wilson