Patents Assigned to Ambrx
  • Modified Human Plasma Polypeptide or Fc Scaffolds and Their Uses
    Publication number: 20120190827
    Abstract: Modified human plasma polypeptides or Fc and uses thereof are provided.
    Type: Application
    Filed: August 11, 2011
    Publication date: July 26, 2012
    Applicant: AMBRX, INC.
    Inventors: Joseph SHEFFER, Thea NORMAN, Richard D. DIMARCHI, Anna-Maria A. HAYS PUTNAM, Feng TIAN, Stephanie CHU, Denise KRAWITZ, Ho Sung CHO
  • Modified Leptin Polypeptides and Their Uses
    Publication number: 20120149636
    Abstract: Modified human leptin polypeptides and uses thereof are provided.
    Type: Application
    Filed: February 5, 2009
    Publication date: June 14, 2012
    Applicant: AMBRX, INC.
    Inventors: Vadim Kraynov, Anna-Maria A. Hays Putnam, Nick Knudsen, Jason Pinkstaff, Heather Myler, Lorraine Sullivan
  • MODIFIED HUMAN INTERFERON POLYPEPTIDES AND THEIR USES
    Publication number: 20120142896
    Abstract: Modified interferon polypeptides with at least one non-naturally-encoded amino acid and uses thereof are provided.
    Type: Application
    Filed: December 8, 2011
    Publication date: June 7, 2012
    Applicant: AMBRX, INC.
    Inventors: Ho Sung CHO, Thomas O. DANIEL, Anna-Maria A. HAYS, Troy E. WILSON
  • Biosynthetic Polypeptide Fusion Inhibitors
    Publication number: 20120142890
    Abstract: Modified biosynthetic polypeptide fusion inhibitors, methods for manufacturing, and uses thereof are provided.
    Type: Application
    Filed: October 30, 2007
    Publication date: June 7, 2012
    Applicant: AMBRX, INC.
    Inventors: Roberto MARIANI, Bruce E. KIMMEL
  • Methods for expression and purification of recombinant human growth hormone
    Patent number: 8178108
    Abstract: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH comprising non-naturally encoded amino acids and hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: May 15, 2012
    Assignee: Ambrx, Inc.
    Inventors: Ying Buechler, Ricky Lieu, Michael Ong, Stuart Bussell, Nick Knudsen, Ho Sung Cho
  • Modified human growth hormone formulations with an increased serum half-life
    Patent number: 8178494
    Abstract: Formulations of modified growth hormone polypeptides are provided, including human growth hormone polypeptides with one or more non-naturally encoded amino acids with an increased half-life.
    Type: Grant
    Filed: October 25, 2007
    Date of Patent: May 15, 2012
    Assignee: AMBRX, Inc.
    Inventors: Anna-Maria Hays, Ying Buechler, David C. Litzinger
  • Formulations of human growth hormone comprising a non-naturally encoded amino acid
    Patent number: 8163695
    Abstract: Formulations of modified human growth hormone polypeptides are provided.
    Type: Grant
    Filed: October 25, 2007
    Date of Patent: April 24, 2012
    Assignee: Ambrx
    Inventors: Anna-Maria A. Hays, Ying Buechler, David C. Litzinger
  • Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
    Patent number: 8153758
    Abstract: Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: April 10, 2012
    Assignee: Ambrx, Inc.
    Inventors: Zhenwei Miao, Junjie Liu, Thea Norman
  • Modified human growth hormone
    Patent number: 8143216
    Abstract: Modified growth hormone polypeptide and uses thereof are provided.
    Type: Grant
    Filed: October 25, 2007
    Date of Patent: March 27, 2012
    Assignee: Ambrx, Inc.
    Inventors: Ho Sung Cho, Thomas O. Daniel, Richard D. DiMarchi, Anna-Maria A. Hays, Troy E. Wilson, Bee-Cheng Sim, David C. Litzinger
  • MODIFIED RELAXIN POLYPEPTIDES AND THEIR USES
    Publication number: 20120046229
    Abstract: Modified relaxin polypeptides and their uses thereof are provided
    Type: Application
    Filed: August 17, 2011
    Publication date: February 23, 2012
    Applicant: AMBRX, INC.
    Inventors: Vadim KRAYNOV, Nick KNUDSEN, Amha HEWET, Kristine DE DIOS, Jason PINKSTAFF, Lorraine SULLIVAN
  • Modified human interferon polypeptides and their uses
    Patent number: 8119603
    Abstract: Modified human interferon polypeptides and uses thereof are provided.
    Type: Grant
    Filed: January 28, 2005
    Date of Patent: February 21, 2012
    Assignee: AMBRX, Inc.
    Inventors: Ho Sung Cho, Thomas O. Daniel, Anna-Maria Hays, Troy E. Wilson
  • Modified Human Plasma Polypeptide or Fc Scaffolds and Their Uses
    Publication number: 20120041180
    Abstract: Modified human plasma polypeptides or Fc and uses thereof are provided.
    Type: Application
    Filed: July 18, 2011
    Publication date: February 16, 2012
    Applicant: AMBRX, INC.
    Inventors: Joseph SHEFFER, Thea NORMAN, Richard D. DIMARCHI, Anna-Maria A. HAYS PUTNAM, Feng TIAN, Stephanie CHU, Denise KRAWITZ, Ho Sung CHO
  • Modified interferon beta polypeptides and their uses
    Patent number: 8114630
    Abstract: Modified interferon beta polypeptides and uses thereof are provided.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: February 14, 2012
    Assignee: Ambrx, Inc.
    Inventors: Vadim Kraynov, Nick Knudsen, Anna-Maria A. Hays Putnam, Denise Krawitz, Jason Pinkstaff, Heather Myler
  • Modified human interferon polypeptides with at least one non-naturally encoded amino acid and their uses
    Patent number: 8097702
    Abstract: Modified interferon polypeptides with at least one non-naturally-encoded amino acid and uses thereof are provided.
    Type: Grant
    Filed: October 19, 2007
    Date of Patent: January 17, 2012
    Assignee: Ambrx, Inc.
    Inventors: Ho Sung Cho, Thomas O. Daniel, Anna-Maria A. Hays, Troy E. Wilson
  • Pegylated human interferon polypeptides
    Patent number: 8093356
    Abstract: Modified human interferon polypeptides and uses thereof are provided, including PEGylated human interferon polypeptides with one or more non-naturally encoded amino acids.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: January 10, 2012
    Assignee: Ambrx, Inc.
    Inventors: Anna-Maria A. Hays, Bruce E. Kimmel, Ho Sung Cho, Bee-Cheng Sim, David C. Litzinger, Roberto Mariani, Vadim Kraynov, Nick Knudsen, Thomas O. Daniel, Alan Koder, Stuart Bussell, Junjie Liu, Zhenwei Miao, Theresa Morrow
  • Process of producing non-naturally encoded amino acid containing high conjugated to a water soluble polymer
    Patent number: 8080391
    Abstract: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: December 20, 2011
    Assignee: AMBRX, Inc.
    Inventors: Ying Buechler, Ricky Lieu, Michael Ong, Stuart Bussell, Nick Knudsen, Ho Sung Cho
  • Accelerants for the modification of non-natural amino acids and non-natural amino acid polypeptides
    Patent number: 8071809
    Abstract: Disclosed herein are accelerants for the formation of oxime-containing compounds from the reaction of a carbonyl-containing compound and a hydroxylamine-containing compound. The oxime-containing compound, the carbonyl-containing compound and the hydroxylamine-containing compound can each be a non-natural amino acid or a non-natural amino acid polypeptide. Also disclosed is the use of such accelerants to form oxime-containing compounds, the resulting oxime-containing compounds, and reaction mixtures containing such accelerants.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: December 6, 2011
    Assignee: Ambrx, Inc.
    Inventors: Feng Tian, Zhenwei Miao
  • Modified Human Growth Hormone
    Publication number: 20110294161
    Abstract: Modified growth hormone polypeptide and uses thereof are provided.
    Type: Application
    Filed: February 25, 2011
    Publication date: December 1, 2011
    Applicant: AMBRX, INC.
    Inventors: Ho Sung CHO, Thomas O. DANIEL, Richard D. DIMARCHI, Anna-Maria HAYS, Troy E. WILSON, Bee-Cheng SIM, David C. LITZINGER
  • COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES
    Publication number: 20110288279
    Abstract: Disclosed Herein are Non-Natural Amino Acids and Polypeptides that Include at Least One non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
    Type: Application
    Filed: July 7, 2011
    Publication date: November 24, 2011
    Applicant: Ambrx, Inc.
    Inventors: Zhenwei Miao, Junjie Liu, Thea Norman, Russell Driver
  • Modified human plasma polypeptide or Fc scaffolds and their uses
    Patent number: 8053560
    Abstract: Modified human plasma polypeptides or Fc and uses thereof are provided.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: November 8, 2011
    Assignee: Ambrx, Inc.
    Inventors: Joseph Sheffer, Thea Norman, Richard D. Dimarchi, Anna-Maria A. Hays Putnam, Feng Tian, Stephanie Chu, Denise Krawitz, Ho Sung Cho