Patents Assigned to Ambrx
  • Modified human plasma polypeptide or Fc scaffolds and their uses
    Patent number: 7919591
    Abstract: Modified human plasma polypeptides or Fc and uses thereof are provided.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: April 5, 2011
    Assignee: Ambrx, Inc.
    Inventors: Joseph Sheffer, Thea Norman, Richard D. Dimarchi, Anna-Maria A. Hays Putnam, Feng Tian, Stephanie Chu, Denise Krawitz, Ho Sung Cho
  • Accelerants for the modification of non-natural amino acids and non-natural amino acid polypeptides
    Patent number: 7888533
    Abstract: Disclosed herein are accelerants for the formation of oxime-containing compounds from the reaction of a carbonyl-containing compound and a hydroxylamine-containing compound. The oxime-containing compound, the carbonyl-containing compound and the hydroxylamine-containing compound can each be a non-natural amino acid or a non-natural amino acid polypeptide. Also disclosed is the use of such accelerants to form oxime-containing compounds, the resulting oxime-containing compounds, and reaction mixtures containing such accelerants.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: February 15, 2011
    Assignee: Ambrx, Inc.
    Inventors: Feng Tian, Zhenwei Miao
  • Compositions of aminoacyl-tRNA synthetase and uses thereof
    Patent number: 7883866
    Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: February 8, 2011
    Assignee: Ambrx, Inc.
    Inventors: Andrew Paulsel, Ho Sung Cho
  • Modified FGF-23 Polypeptides and Their Uses
    Publication number: 20110015345
    Abstract: Modified FGF-23 polypeptides and uses thereof are provided.
    Type: Application
    Filed: March 19, 2009
    Publication date: January 20, 2011
    Applicant: AMBRX, INC.
    Inventors: Jason Pinkstaff, Anna-Maria A Hays Putnam, Kristin S Eaton
  • Compositions of aminoacyl-tRNA synthetase and uses thereof
    Patent number: 7858344
    Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: December 28, 2010
    Assignee: Ambrx, Inc.
    Inventors: Andrew Paulsel, Ho Sung Cho
  • Compositions of aminoacyl-tRNA synthetase and uses thereof
    Patent number: 7846689
    Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: December 7, 2010
    Assignee: Ambrx, Inc.
    Inventors: Andrew Paulsel, Ho Sung Cho
  • Modified Insulin Polypeptides and Their Uses
    Publication number: 20100298212
    Abstract: Modified insulin polypeptides and their uses thereof are provided
    Type: Application
    Filed: November 20, 2008
    Publication date: November 25, 2010
    Applicant: AMBRX, INC.
    Inventors: Zhenwei Miao, Denise Krawitz, Vadim Kraynov, Tian Feng, Bee-Cheng Sim, Lillian Skidmore, Anna-Maria A. Hays Putnam, Nick Knudesen, Michael Deguzman
  • Compositions of aminoacyl-tRNA synthetase and uses thereof
    Patent number: 7838265
    Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: November 23, 2010
    Assignee: Ambrx, Inc.
    Inventors: Andrew Paulsel, Ho Sung Cho
  • Compositions of aminoacyl-tRNA synthetase and uses thereof
    Patent number: 7829310
    Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: November 9, 2010
    Assignee: Ambrx, Inc.
    Inventors: Andrew Paulsel, Ho Sung Cho
  • Branched acetylene-containing poly(alkylene oxides, oxyethylated polyols or olefinic alcohols)
    Patent number: 7820766
    Abstract: The invention provides water-soluble compounds that include a polymer and at least one terminal azide or acetylene moiety. Also provided are highly efficient methods for the selective modification of proteins with PEG derivatives, which involves the selective incorporation of non-genetically encoded amino acids, e.g., those amino acids containing an azide or acetylene moiety, into proteins in response to a selector codon and the subsequent modification of those amino acids with a suitably reactive PEG derivative.
    Type: Grant
    Filed: May 6, 2010
    Date of Patent: October 26, 2010
    Assignee: Ambrx, Inc.
    Inventor: Troy E. Wilson
  • Formulations of human growth hormone comprising a non-naturally encoded amino acid at position 35
    Patent number: 7816320
    Abstract: Formulations of modified human growth hormone polypeptides are provided.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: October 19, 2010
    Assignee: AMBRX, Inc.
    Inventors: Anna-Maria Hays, Ying Buechler, David C. Litzinger
  • Branched Acetylene-Containing Poly(Alkylene Oxides, Oxyethylated Polyols or Olefinic Alcohols)
    Publication number: 20100217050
    Abstract: The invention provides water-soluble compounds that include a polymer and at least one terminal azide or acetylene moiety. Also provided are highly efficient methods for the selective modification of proteins with PEG derivatives, which involves the selective incorporation of non-genetically encoded amino acids, e.g., those amino acids containing an azide or acetylene moiety, into proteins in response to a selector codon and the subsequent modification of those amino acids with a suitably reactive PEG derivative.
    Type: Application
    Filed: May 6, 2010
    Publication date: August 26, 2010
    Applicant: AMBRX, INC.
    Inventor: Troy E. WILSON
  • Compositions of Aminoacyl-tRNA Synthetase and Uses Thereof
    Publication number: 20100184140
    Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.
    Type: Application
    Filed: March 15, 2010
    Publication date: July 22, 2010
    Applicant: AMBRX, INC.
    Inventors: Andrew PAULSEL, Ho Sung CHO
  • Compositions of Aminoacyl-tRNA Synthetase and Uses Thereof
    Publication number: 20100173380
    Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.
    Type: Application
    Filed: March 15, 2010
    Publication date: July 8, 2010
    Applicant: AMBRX, INC.
    Inventors: Andrew PAULSEL, Ho Sung CHO
  • Compositions of Aminoacyl-tRNA Synthetase and Uses Thereof
    Publication number: 20100174054
    Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.
    Type: Application
    Filed: March 15, 2010
    Publication date: July 8, 2010
    Applicant: AMBRX, INC.
    Inventors: Andrew PAULSEL, Ho Sung CHO
  • Compositions of Aminoacyl-tRNA Synthetase and Uses Thereof
    Publication number: 20100173379
    Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.
    Type: Application
    Filed: March 15, 2010
    Publication date: July 8, 2010
    Applicant: AMBRX, INC.
    Inventors: Andrew PAULSEL, Ho Sung CHO
  • Compositions of Aminoacyl-tRNA Synthetase and Uses Thereof
    Publication number: 20100167347
    Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.
    Type: Application
    Filed: March 15, 2010
    Publication date: July 1, 2010
    Applicant: AMBRX, INC.
    Inventors: Andrew Paulsel, Ho Sung Cho
  • Hybrid Suppressor tRNA for Vertebrate Cells
    Publication number: 20100159586
    Abstract: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided. The present invention provides vertebrate cells with translation components, e.g., pairs of orthogonal aminoacyl-tRNA synthetases (O-RSs) and orthogonal tRNA's (O-tRNA's) and individual components thereof, that are used in vertebrate protein biosynthetic machinery to incorporate an unnatural amino acid in a growing polypeptide chain, in a vertebrate cell.
    Type: Application
    Filed: September 7, 2007
    Publication date: June 24, 2010
    Applicant: AMBRX, INC.
    Inventors: Feng Tian, Thea Norman, Stephanie Chu
  • Suppressor tRNA Transcription in Vertebrate Cells
    Publication number: 20100159585
    Abstract: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided.
    Type: Application
    Filed: September 7, 2007
    Publication date: June 24, 2010
    Applicant: AMBRX, INC.
    Inventors: Feng Tian, Thea Norman, Stephanie Chu
  • Modified Human Plasma Polypeptide or Fc Scaffolds and Their Uses
    Publication number: 20100160212
    Abstract: Modified human plasma polypeptides or Fc and uses thereof are provided.
    Type: Application
    Filed: September 7, 2007
    Publication date: June 24, 2010
    Applicant: AMBRX, INC.
    Inventors: Joseph Sheffer, Thea Norman, Richard D. Dimarchi, Anna-Maria A. Hays Putnam, Feng Tian, Stephanie Chu, Denise Krawitz, Ho Sung Cho