Abstract: There is provided a method for increasing lean meat, improving the lean meat to fat ratio and improving amino acid utilization in warm-blooded animals by administering an effective amount of an alpha-2 adrenergic receptor antagonist.
Type:
Grant
Filed:
December 8, 1997
Date of Patent:
December 19, 2000
Assignee:
American Cyanamid Company
Inventors:
Ralph M. Cleale, IV, Mark H. Pausch, John R. Hadcock
Abstract: This invention relates to matrix metalloproteinase (MMP) inhibiting compounds of the formula: ##STR1## where R.sup.1 is C.sub.1 -C.sub.12 alkyl, straight or branched and optionally substituted by halogen, hydroxy, C.sub.1 -C.sub.6 alkoxy, amino, carboxyl, C.sub.1 -C.sub.6 alkoxycarbonyl, carboxamido, nitrile, mono- or di-(C.sub.1 -C.sub.6)alkylamino, thio, C.sub.1 -C.sub.6 alkylthio, aryl, --Oaryl or --OCH.sub.2 aryl where aryl is optionally substituted with C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, carboxy, halogen, cyano, nitro, carboxamido, or hydroxy; and C.sub.1 -C.sub.6 alkanesulfonyloxy. R.sup.2 is .alpha.-OH or .beta.-OH and R.sup.6 is H or R.sup.2 and R.sup.6 together are carbonyl; the chemical intermediates; and processes for the preparation of these compounds and the intermediates thereto.Matrix metalloproteinases (MMP) are a family of zinc-containing calcium dependent proteinases, including stromelysins, collagenases, and gelatinases.
Abstract: A process for the preparation of dialkyl phenylmalonates of formula I, ##STR1## wherein R, R.sup.1, L.sup.1 and L.sup.2 have the meaning given in the claims which comprises treating an phenylbromide of formula II ##STR2## with a dialkyl malonate of formula III ##STR3## in an inert solvent in the presence of a base and a copper salt, wherein 1.0 mole of the phenylbromide of formula II is treated with the enolate obtained from 2.0 to 4.0 moles of the dialkyl malonate of formula III and 2.0 to 3.8 moles of the base.
Abstract: There are provided compositions and methods comprising compounds of formula I: ##STR1## wherein R.sup.1, A, B, X, Y and Z have the meaning given in claim 1, for the control of insect and acarid pests.
Type:
Grant
Filed:
March 22, 1999
Date of Patent:
November 28, 2000
Assignee:
American Cyanamid Company
Inventors:
William Wakefield Wood, Linda Fleming, Salvatore John Cuccia
Abstract: An affinity chromatographic matrix for purification of a biological material is provided having an ionically charged polymeric ligand such as glycoaminoglycan non-covalently bound directly by an ionic bond to an oppositely ionically charged group on a chromatographic matrix. Having the ligand non-covalently bound to the matrix by an ionic bond, allows the ligand to be easily washed off the matrix and replaced for subsequent purifications without having to replace the matrix. A biological material in a crude mixture is purified by non-covalently binding the material to the bound ligand and dissociating the material from the ligand. Matrices that may be used include crosslinked agarose, crosslinked dextran, crosslinked cellulose, crosslinked dextran and bisacrylamide, or matrices based on silica or plastic polymers. The charged group may be a quaternary amine or diethylaminoethyl group.
Abstract: An improved process for the preparation of 6-(perfluoroalkyl)uracil compounds having the structural formula I ##STR1## from 2-(N,N-disubstituted)amino-4-(perfluoroalkyl)-1,3-oxazin-6-one compounds having the structural formula II ##STR2##
Type:
Grant
Filed:
February 16, 1999
Date of Patent:
October 31, 2000
Assignee:
American Cyanamid Company
Inventors:
Richard Anthony Rampulla, Venkataraman Kameswaran, Peter John Wepplo
Abstract: The present invention concerns a formulation for an oral veterinary composition containing a fluoroquinolone antimicrobial agent or a pharmaceutically acceptable salt thereof, and a method of treating a microbial infection in a ruminant. The present veterinary composition, when administered orally to a ruminating animal (e.g., a cow or a feedlot calf), allows the fluoroquinolone to be readily and extensively absorbed from the rumen into the circulating blood and provides an unexpectedly extended duration of therapeutic antimicrobial blood level.
Type:
Grant
Filed:
September 23, 1998
Date of Patent:
October 24, 2000
Assignee:
American Cyanamid Company
Inventors:
Douglas W. Danielson, Eric Nichols, Brent Husband
Abstract: There is provided a process for the preparation of 2-aryl-5-(perfluoroalkyl)pyrrole compounds from N-(arylmethylene)-1-chloro-1-(perfluoroalkyl)methylamine compounds. The 2-aryl-5-(perfluoroalkyl)pyrrole compounds are useful for the control of insect and acarid pests, and may also be used to prepare other pesticidal arylpyrrole compounds.In addition, the present invention provides N-(arylmethylene)-1-chloro-1-(perfluoroalkyl)methylamine compounds which are useful as intermediates in the preparation of arylpyrrole compounds.
Abstract: The novel compounds of formula I: ##STR1## wherein R, A, X.sup.1, X.sup.2, X.sup.3, Z and m have the meaning given in claim 1, and the agronomically acceptable salts or N-oxides thereof, and herbicidal compositions containing such compounds as active ingredients.
Type:
Grant
Filed:
April 7, 1999
Date of Patent:
October 10, 2000
Assignee:
American Cyanamid Company
Inventors:
Stefan Scheiblich, Thomas Maier, Helmut Siegfried Baltruschat, Thomas Hoellmueller
Abstract: The present invention is directed to recombinant genes and their encoded proteins which are recombinant flagellin fusion proteins. Such fusion proteins comprise amino acid sequences specifying an epitope encoded by a flagellin structural gene and an epitope of a heterologous organism which is immunogenic upon introduction of the fusion protein into a vertebrate host. The recombinant genes and proteins of the present invention can be used in vaccine formulations, to provide protection against infection by the heterologous organism, or to provide protection against conditions or disorders caused by an antigen of the organism. In a specific embodiment, attenuated invasive bacteria expressing the recombinant flagellin genes of the invention can be used in live vaccine formulations. The invention is illustrated by way of examples in which epitopes of malaria circumsporozoite antigens, the B subunit of Cholera toxin, surface and presurface antigens of Hepatitis B.
Type:
Grant
Filed:
February 14, 1992
Date of Patent:
October 10, 2000
Assignees:
American Cyanamid Company, The Board of Trustees of the Leland Stanford Junior University
Inventors:
William R. Majarian, Bruce A. D. Stocker, Salete M. C. Newton
Abstract: A noninfectious insect virus is described having an altered genetic element whose function is restored by genetic complementation, thereby again producing the insect infectious form of the virus. Also described is the insertion of a heterologous gene into the viral genome, such that an insect controlling or modifying substance is also produced by the virus for an improved bioinsecticidal effect and genetic stability of desired traits.
Type:
Grant
Filed:
May 28, 1993
Date of Patent:
October 10, 2000
Assignee:
American Cyanamid Company Five Giralda Farms
Abstract: The present invention provides o-aminophenyl ketone derivatives which are intermediates useful in the manufacture of herbicidal sulfamoyl urea compounds, including the crop selective herbicide 1-{[o-(cyclopropylcarbonyl)phenyl]-sulfamoyl}-3-(4,6-dimethoxy-2-pyrimidin yl)urea. Also provided is a method for the preparation of said intermediates.
Abstract: Substituted 2-hydroxybenzophenone compounds are disclosed, having the formula: ##STR1## The compounds are useful as fungicides having high systemicities.
Type:
Grant
Filed:
June 10, 1999
Date of Patent:
October 3, 2000
Assignee:
American Cyanamid Company
Inventors:
Juergen Curtze, Gerd Morschhaeuser, Henry Van Tuyl Cotter
Abstract: Adjuvants selected from liquid polyalkoxylated aliphatic alcohols, solid sodium hydrocarbyl sulfonates and polyalkoxylated trisiloxanes enhance the efficacy of fungicidal triazolopyrimidines. They can be incorporated into formulations of the fungicidal compounds or be added to spray mixtures (tank mix) as separately formulated additives in order to improve the efficacy, systemicity and spectrum of these fungicides.
Type:
Grant
Filed:
March 15, 1999
Date of Patent:
September 26, 2000
Assignee:
American Cyanamid Company
Inventors:
Michael Aven, Henry Van Tuyl Cotter, Leslie May
Abstract: This invention relates to matrix metalloproteinase (MMP) inhibiting compounds of the formula: ##STR1## where R.sup.1 is C.sub.1 -C.sub.12 alkyl, straight or branched and optionally substituted by halogen, hydroxy, C.sub.1 -C.sub.6 alkoxy, amino, carboxyl, C.sub.1 -C.sub.6 alkoxycarbonyl, carboxamido, nitrile, mono- or di-(C.sub.1 -C.sub.6)alkylamino, thio, C.sub.1 -C.sub.6 alkylthio, aryl, --Oaryl or --OCH.sub.2 aryl where aryl is optionally substituted with C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, carboxy, halogen, cyano, nitro, carboxamido, or hydroxy; and C.sub.1 -C.sub.6 alkanesulfonyloxy. R.sup.2 is .alpha.-OH or .beta.-OH and R.sup.6 is H or R.sup.2 and R.sup.6 together are carbonyl; the chemical intermediates; and processes for the preparation of these compounds and the intermediates thereto.Matrix metalloproteinases (MMP) are a family of zinc-containing calcium dependent proteinases, including stromelysins, collagenases, and gelatinases.
Abstract: The present invention provides a herbicidal compound of formula I, methods for the preparation thereof and intermediates useful therefor. ##STR1## wherein X and Y are each independently O or S; Z is N or CR.sub.4.
Type:
Grant
Filed:
November 3, 1998
Date of Patent:
September 19, 2000
Assignee:
American Cyanamid Company
Inventors:
Gary Mitchell Karp, Michael Edward Condon
Abstract: There is provided a method for the control of an Aegylops plant which comprises applying to said plant or the locus in which it is growing or to be grown a herbicidally effective amount of 2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-5-(methoxymethyl)nicotini c acid ("imazamox") or a salt thereof.
Abstract: The novel compounds of formula I: ##STR1## (R.sup.1, R.sup.2 and Hal are defined in the specification) show selective fungicidal activity. The new compounds are processed with carriers and adjuvants to form fungicidal compositions.