Abstract: Novel spiro[dibenz(b,f)thiepin-piperidine]s and methods of preparing same are described. These compounds are useful as analgetics, tranquilizers and anticonvulsants.
Abstract: Novel phenylthiophenylpiperidines and methods of preparing same are described. These compounds are useful as analgetics, antidepressants, anticonvulsants and intermediates for preparing other pharmaceutically active compounds.
Abstract: Novel phenoxyphenylpiperidines and methods of preparing same are described. These compounds are useful as analgetics, antidepressants, anticonvulsants and intermediates for preparing other pharmaceutically active compounds.
Abstract: What is disclosed are 1,2,6,7-tetrahydroindolo[1,7-ab] [1,5]benzodiazepines of the formula ##STR1## wherein R is hydrogen, loweralkyl, or cycloalkyl; ##STR2## n is an integer from 1 to 3; R.sub.1 is hydrogen, loweralkyl, or phenylloweralkyl;R.sub.2 is hydrogen or loweralkyl;or R.sub.1 and R.sub.2 may be taken together with the nitrogen to which they are attached to form pyrrolidinyl, piperidino, morpholino, or phenylpiperazinyl; andR.sub.3 is loweralkyl; and the pharmaceutically acceptable acid addition salts thereof.These compounds are useful as antidepressants and as analgesic and anti-inflammatory agents.
Type:
Grant
Filed:
November 2, 1978
Date of Patent:
March 11, 1980
Assignee:
American Hoechst Corporation
Inventors:
Edward J. Glamkowski, James M. Fortunato
Abstract: A light-sensitive coating composition and a light-sensitive photomechanical structure, such as a printing plate or a photoresist is produced by coating a suitable planar substrate with a condensation product of an organic isocyanate and a polymeric resin having functional groups reactive with the isocyanate, such as a phenol-formaldehyde resin, and a light-sensitive diazo compound, such as the esters and amides of quinone diazides, the coating being softenable by exposure to light and subsequent treatment with a conventional liquid printing plate developer, such as an aqueous alkaline solution and/or an organic solvent.
Abstract: What is disclosed are ##STR1## wherein X is hydrogen, halogen or trifluoromethyl;Y is hydrogen, halogen or trifluoromethyl;R is hydrogen, loweralkyl, cycloalkyl, phenyl, halophenyl, furyl, pyridinyl, 4-methylpiperazin-1-ylethyl or phenylloweralkyl;R.sup.1 is hydrogen;n and m are independently 0 or 1, but n is not 0 when m is 1, and the bonds between ring positions 1 and 2 and between positions 6 and 7 are respectively saturated when n and m are 1 and are unsaturated when n and m are 0;pharmaceutically acceptable acid addition salts thereof; methods of preparing said compounds; pharmaceutical compositions including said compounds; methods of treatment using the compounds; and intermediates therefor.These compounds are useful as analgesic and anti-inflammatory agents, as well as intermediates for the preparation of other pharmaceutically active compounds.
Type:
Grant
Filed:
November 2, 1978
Date of Patent:
January 29, 1980
Assignee:
American Hoechst Corporation
Inventors:
Edward J. Glamkowski, James M. Fortunato
Abstract: A composition for short cut, synthetic polymeric staple fibers that are u in a wet lay application for the production of nonwovens is disclosed and claimed herein along with a fiber having the finish thereon and the process for dispersing the fiber in an aqueous medium. Synthetic polymeric filaments are cut into staple lengths, generally in a range of from about 1/4 to about 3 inches in length, and are dispersed in an aqueous medium in conjunction with a composition that includes as an essential ingredient, an ethoxylated primary emulsifier that contains at least five moles of ethylene oxide, and exhibits a surface tension of at least 30 dynes per centimeter in a 0.10 weight percent aqueous solution at 25 degrees Centigrade plus or minus 2 degrees Centigrade. Optionally, a lubricant may be added to the finish composition to improve processability of the fiber during manufacture. The lubricant should be compatible with the primary emulsifier.
Type:
Grant
Filed:
August 19, 1976
Date of Patent:
December 18, 1979
Assignee:
Hoechst Fibers Industries, Division of American Hoechst Corporation
Abstract: A process, and intermediates for the preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid are described. The acid possesses antiinflammatory and analgesic activity.
Type:
Grant
Filed:
September 5, 1978
Date of Patent:
November 20, 1979
Assignee:
American Hoechst Corporation
Inventors:
Arthur R. McFadden, Richard C. Allen, Thomas B. K. Lee
Abstract: Novel aminoalkylpyrrolobenzoxazalkanes, physiologically tolerable acid addition salts thereof, method of preparing same and novel intermediates in the preparation thereof are described. These compounds are useful as analgesic agents and tranquilizers.
Type:
Grant
Filed:
April 4, 1978
Date of Patent:
September 25, 1979
Assignee:
American Hoechst Corporation
Inventors:
Richard C. Effland, Larry Davis, Wolfgang Schaub
Abstract: Novel aminoalkylpyrrolobenzoxazalkanes, physiologically tolerable acid addition salts thereof, method of preparing same and novel intermediates in the preparation thereof are described. These compounds are useful as analgesic agents and tranquilizers.
Type:
Grant
Filed:
April 4, 1978
Date of Patent:
September 25, 1979
Assignee:
American Hoechst Corporation
Inventors:
Richard C. Effland, Larry Davis, Wolfgang Schaub
Abstract: Novel Spiro[dihydrobenzofuran-piperidine and pyrrolidine]s and methods of preparing same are described. These compounds are useful as analgetics and tranquilizers and as intermediates.
Type:
Grant
Filed:
April 14, 1978
Date of Patent:
August 28, 1979
Assignee:
American Hoechst Corporation
Inventors:
Richard C. Effland, Joseph T. Strupczewski, Beth A. Gardner
Abstract: Novel N-[3-benzoylpropyl]spiro[dihydrobenzofuran-piperidine and pyrrolidine]s and methods of preparing same are described. These compounds are useful as analgetics and tranquilizers.
Type:
Grant
Filed:
April 14, 1978
Date of Patent:
August 28, 1979
Assignee:
American Hoechst Corporation
Inventors:
Richard C. Effland, Joseph T. Strupczewski, Beth A. Gardner
Abstract: A composition for finishing lithographic printing plates having an oil phase which preferentially adheres to the image areas and an aqueous phase which desensitizes the metal carrier and aids in maintaining its hydrophilic character upon storage.
Abstract: A process, and intermediates for the preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid are described. The acid possesses antiinflammatory and analgesic activity.
Type:
Grant
Filed:
September 5, 1978
Date of Patent:
July 10, 1979
Assignee:
American Hoechst Corporation
Inventors:
Arthur R. McFadden, Richard C. Allen, Thomas B. K. Lee
Abstract: Light sensitive coating compositions containing a dyestuff, which compositions exhibit improved adhesion to transparent film substrates, are disclosed. For example, the adhesion between a polyester base film and a light sensitive coating composition containing a light sensitive diazo material, a resinous binder and a dyestuff is improved by additionally incorporating into the composition an effective amount of an adhesion promoter based on a copolyester obtained by the esterification and subsequent polymerization of a lower alkylene glycol with a mixture of terephthalic acid, isophthalic acid, and at least one acyclic dicarboxylic acid. These coating compositions may be readily removed from the base film by appropriate lithographic developer solutions without substantial residual staining of the film by the dyestuff present in the coating composition.
Abstract: This invention relates to an improvement in a material adapted for imagewise exposure to actinic light comprising a transparent or translucent support having a positive-acting quinone diazide light-sensitive coating composition in direct contact with one surface thereof, the improvement comprising that the surface of said coating in direct contact with said support is substantially photodecomposed, and that a gradient exists in said coating wherein the percentage of undecomposed light-sensitive quinone diazide increases with increasing distance from said support. The invention also relates to a method for preparing the novel material.
Abstract: A process, and intermediates for the preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid are described. The acid possesses antiinflammatory and analgesic activity.
Type:
Grant
Filed:
September 5, 1978
Date of Patent:
May 8, 1979
Assignee:
American Hoechst Corporation
Inventors:
Arthur R. McFadden, Richard C. Allen, Thomas B. K. Lee
Abstract: A process, and intermediates for the preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid are described. The acid possesses antiinflammatory and analgesic activity.
Type:
Grant
Filed:
September 5, 1978
Date of Patent:
May 8, 1979
Assignee:
American Hoechst Corporation
Inventors:
Arthur R. McFadden, Richard C. Allen, Thomas B. K. Lee
Abstract: A method and apparatus for adding ink receptive areas to or removing ink receptive areas from printing plates in which a consumable stylus, such as a graphite pencil "lead," or a non-consumable stylus, such as a copper wire, is brought into contact with the printing plate.
Abstract: Water soluble, metallized monoazo dyestuffs are shown, which in the form of their free acids correspond to the general formula ##STR1## where M is copper or chromium, x is methyl or methoxy and n is 0 or an integer of 1 to 2. The new dyestuffs are useful for dyeing and printing cotton and linen and other fibrous materials and they exhibit good fastness properties to light and wet processing and in addition display excellent build-up properties.