Abstract: Disclosed are formulations for the treatment of cancer including inosine or a related compound in combination with an immune checkpoint inhibitor including but not limited to immune checkpoint inhibitor binding agents (including anti-CTLA4, anti-PD1, anti-LAG-3, anti-TIM-3, anti-TIGIT, anti-CD47, anti-VISTA, and anti-PD-L1), and optionally also including a reinforcing agent to boost immune response, including CAR-T, CAR-NK, tumor vaccine, oncolytic virus vaccine, TLR7/8 agonist, anti-CD47 or IL-2 receptor agonist, and optionally also including other pharmacologically immune-boosting active agents.

Abstract: In an embodiment, a stent is provided for use in blood vessels with blockage near or in a bifurcation. The stent includes a side aperture. The stent is inserted into one of the daughter branches of the bifurcation and positioned with the use of markers. The stent is then expanded so as to support the wall of the blood vessel while allowing the blood to continue to flow to both daughter branches.

Abstract: The present disclosure relates to methods and compositions for detecting mitochondrial dysfunction. In particular, the disclosure relates to reporter molecules that are cleavable by the zinc metalloprotease Metalloendopeptidase OMA1 (OMA1). In each embodiment, the reporter molecules of the invention are particularly useful for drug discovery and detection of diseases associated with mitochondrial dysfunction.

Abstract: A turbocharger for an internal combustion engine having a close coupled catalyst assembly includes a turbine housing having a toroidal-shaped low pressure exhaust gas chamber having a plurality of vanes disposed proximate the outer circumferential wall of the low pressure exhaust gas chamber. The vanes are arranged to disrupt the rotational flow of the exhaust gases as they exit the turbine housing to provide a more even flow though the catalyst element of the close coupled catalyst assembly.

Abstract: Some embodiments include a system for delivery of binaural audio to a consumer including a computing device with a processor, a non-transitory computer readable medium having stored instructions that when executed by the computing device, cause the computing device to perform operations for delivery of the binaural audio to the consumer through the consumer device. The operations can enable a delivery server to associate the consumer device with a binaural audio file associated with the event attended by the consumer. The operations can enable the consumer device to retrieve and download a binaural audio file from the delivery server, and to receive synchronization information associated with the event and the binaural audio file. The operations can also include processing the binaural audio file and delivering audio through an audio emitting device coupled to the consumer device, where the delivered audio is synchronized with the event.

Abstract: A user establishes an account with an account management system and downloads a service application on a user computing device associated with the user. The user enters a service provider location and signs into a service application. A service camera device captures a video feed of one or more users within a visual field of the service camera device and a service computing device compares movement data received from user computing devices at the service provider location against movement of detected objects in the video feed to identify one or more users in the video feed. After identifying the one or more users within the video feed of the service camera device, in response to a particular user initiating a service request at the service computing device, the service computing device identifies the particular user at the service computing device as being within a service area of the video feed.

Abstract: A system for fabricating composite parts efficiently. Pre-impregnated (prepreg) composite material is drawn as a sheet from a roll and fed by advancement rollers into a stamping and molding station in which a piece of the prepreg material is cut, on a mold, from the sheet. Pressure is applied to cause the prepreg material to conform to a surface of the mold, and the prepreg is cured with ultraviolet light. Additional layers of prepreg may be cut and cured on any layers that have already been cured on the mold. The complete part may be removed from the mold with ejector pins. Scrap prepreg may be recycled in a recycling station that separates reinforcing fiber from uncured resin.

Abstract: A wireless device may perform a plurality of scans to search for an available wireless network. The wireless device may determine a first set of information about a first environment in which the wireless device is located at a first time. The wireless device may also determine a second set of information about a second environment in which the wireless device is located at a second time. The wireless device may perform a comparison of the first set of information and the second set of information and adjust a time period between successive scans based on the comparison.

Abstract: A method to control a host vehicle includes: detecting, by a controller of the host vehicle, objects, wherein detecting objects includes receiving remote-object data, the remote-object data includes class data and location data, the objects include remote vehicles and remote infrastructure; assigning, by the controller, an object class to each of the detected objects based on the class data; assigning, by the controller, a priority value to each of the detected objects based on the object class of each of the detected objects; and assigning, by the controller, a transmission time interval (TTI) to the CSMs based on the priority value to modify the TTI of each of the CSMs in accordance with the assigned TTI; and transmitting the CSMs to the remote vehicles.

Abstract: An imaging system includes an eye interface device, a scanning assembly, a beam source, a free-floating mechanism, and a detection assembly. The eye interface device interfaces with an eye. The scanning assembly supports the eye interface device and scans a focal point of an electromagnetic radiation beam within the eye. The beam source generates the electromagnetic radiation beam. The free-floating mechanism supports the scanning assembly and accommodates movement of the eye and provides a variable optical path for the electronic radiation beam and a portion of the electronic radiation beam reflected from the focal point location. The variable optical path is disposed between the beam source and the scanner and has an optical path length that varies to accommodate movement of the eye. The detection assembly generates a signal indicative of intensity of a portion of the electromagnetic radiation beam reflected from the focal point location.

Abstract: A non-volatile memory system comprises a memory structure and a control circuit connected to the memory structure. The memory structure includes one or more planes of non-volatile memory cells. Each plane is divided into a plurality of partial planes. The control circuit is configured to write to and read from the memory cells by writing a partial page into a particular partial plane and reading the partial page from the particular partial plane using a set of parameters optimized for the particular partial plane.

Abstract: Various embodiments include an energy storage system for a hybrid energy system including a an energy storage device configured coupled to an inverter and controlled by a hybrid management system. The hybrid management system may be configured to use energy from the energy storage device to supplement power output of a power generation system to comply with a contract schedule of electric power output by the hybrid energy system. The hybrid management system may be configured to satisfy stable loads of an industrial application with the power generation system and to meet load swings of the industrial application with power output from the storage device. The hybrid management system may be configured to respond to an increasing desired load transient event by disclosing stored energy to follows a ramping profile that substantially matches a gas-turbine alone ramp rate of a gas turbine generator operating in a spinning reserve mode.

Abstract: A fully portable exercise system and apparatus utilized for exercising, stretching, and training multiple muscle groups of the body of a user. The apparatus has at least one closeable pocket and fixation rings for securing and carrying accessories, such as attachable handgrips, adjustable suspension straps or lines, and elastic bands. Another configuration illustrates a suspension training system comprising non-elastic suspension sub-assemblies, elastic suspension sub-assemblies and handgrips, configurable with or without the portable exercise apparatus. The apparatus and methods of use provide the user with a plurality of configurations for assisted exercise regimens and the flexibility to exercise anywhere. The apparatus is adaptable to be worn about the waist of a user, carried as a bandolier about the user's body or utilized as a releasably fixed suspension trainer.

Abstract: Methods and devices for selecting an application for download for use with hardware on a computer device may include receiving, from a remote application store, application metadata that includes at least one hardware constraint for an application in response to an application request for installation of the application. The methods and devices may include evaluating the application metadata to determine whether the at least one hardware constraint is satisfied on the computer device. The methods and devices may include installing the application when the at least one hardware constraint is satisfied on the computer device.

Abstract: In accordance with some implementations, a method for using recommendations to fulfill pre-established purchasing intent is disclosed. The method is performed on a server system having one or more processors and memory storing one or more programs for execution by the one or more processors. The server system receives a recommendation for a product or service from a first user and determines whether a second user has pre-indicated intent to purchase a product or service in a category of product or service that includes the recommended product or service. The server system then purchases the recommended product on behalf of the user without further input from the user.

Abstract: Techniques are provided for optimizing an erase operation in a memory device to compensate for erase speed variations due to blocking oxide thinning In an erase operation for a block, the channels of NAND strings in different sub-blocks can be charged up by different amounts. One approach adjusts the control gate voltage of a first select gate transistor in a NAND string. This adjusts the amount of holes generated in the channel due to gate-induced drain leakage. Another approach adjusts the control gate voltage of additional select gate transistors in the NAND string to adjust the conductivity of the adjacent channel regions. Another approach applies different bit line voltages to different rows of NAND strings in each sub-block.

Abstract: Techniques for implementing and operating a system that includes a pipe segment, which has tubing that defines a bore and a fluid conduit implemented in an annulus of the tubing, and a test head. The test head includes a shell, which defines an annulus cavity, and an inflatable bladder implemented in the annulus cavity, in which the system maintains the inflatable securing bladder in a less inflated state while pipe segment tubing is not present in the annulus cavity and increases inflation of the inflatable bladder to a more inflated state when the tubing is present in the annulus cavity to facilitate securing and sealing an open end of the pipe segment in the test head to enable integrity of the tubing to be tested at least in part by flowing a test fluid into the annulus of the tubing via a testing port on the shell.

Abstract: This document relates to data storage techniques. One example can buffer write commands and cause the write commands to be committed to storage in flush epoch order. Another example can maintain a persistent log of write commands that are arranged in the persistent log in flush epoch order. Both examples may provide a prefix consistent state in the event of a crash.