Abstract: The present invention provides a novel hydrolase that can industrially produce optically highly pure (1S,2S)-1-alkoxycarbonyl-2-vinylcyclopropane carboxylic acid with high efficiency at low costs, and a production method using the hydrolase.

Abstract: A 3D printer with a lift mechanism is disclosed. The 3D printer is coupled to the lift mechanism which is in turn coupled to a base or the ground. The lift mechanism comprises telescopically extendable columns comprising concentric cylinders positioned within one another, so as to extend and collapse fully, thus raising and lowering the 3D printer to a specific height. The lift mechanism further comprises extendable and lockable diagonals which connect neighboring telescopic columns at their top portions in a helical fashion. The diagonals are installed for sturdiness and support as the lift is operated, as well as to position the lift at a desired height when the diagonals are locked in place. The lift mechanism may comprise 2 telescopic cylinder columns or 3 or more telescopic cylinder columns. The lift mechanism comprises at least a first stage and an intermediate stage, and optionally a last stage.

Abstract: Production of pitavastatin calcium safely on an industrial scale with a high yield and high selectivity at low cost. A method of producing pitavastatin calcium including step (i) for acetalizing a compound represented by the formula (1) to give a compound represented by the formula (3), step (ii) for reacting a compound represented by the formula (3) with an acid to give a compound represented by the formula (4), and step (iii) for hydrolyzing a compound represented by the formula (4) and reacting same with a calcium compound.

Abstract: This disclosure relates to the production of opium poppy plants having high levels of thebaine. More particularly, the disclosure relates to the production of opium poppies having high levels of thebaine by simultaneously reducing the expression of genes encoding thebaine 6-0-demethylase (T60DM) and codeine 3-0-demethylase (CODM).

Abstract: This invention is in the field of automated 3D printing of buildings or structures and method of its operation. A 3D printer having an extendable boom arm with an extruder for extruding a concrete-based chemical solution moves with translational and rotational motion in an XOY plane. The extendable boom arm is mounted such that it is capable of height adjustment in a XOZ plane. The invention also regards a method for automated 3D printing of a building or structure using the 3D printer.

Abstract: A heat exchanger includes one or more hot medium flow regions and one or more cooling medium flow regions. Hot medium bars border the one or more hot medium flow regions and cooling medium bars border the one or more cooling medium flow regions. At least one cooling medium bar of the cooling medium bars is joined to a pair of partition sheets. The at least one cooling medium bar includes a base, a first leg, and a second leg. The first leg and the second leg each extend from the base. A cavity is provided between the first leg and the second leg. The cavity is in fluid communication with a first cooling medium flow region of the one or more cooling medium flow regions via an opening provided between the first leg and the second leg.

Abstract: Production of pitavastatin calcium safely on an industrial scale with a high yield and high selectivity at low cost. A method of producing pitavastatin calcium including step (i) for acetalizing a compound represented by the formula (1) to give a compound represented by the formula (3), step (ii) for reacting a compound represented by the formula (3) with an acid to give a compound represented by the formula (4), and step (iii) for hydrolyzing a compound represented by the formula (4) and reacting same with a calcium compound.

Abstract: The present invention relates generally to proteasome inhibiting ?-lactam compounds useful for the treatment of cancer and neurodegenerative disorders. The invention also provides pharmaceutical compositions and extended release formulations of said compounds, and medical uses of said compounds and/or pharmaceutical compositions to treat cancer and neurodegenerative disorders.

Abstract: A method for producing (2S,5S)/(2R,5R)-5-hydroxypiperidine-2-carboxylic acid represented by the formula (10) below: the method including removing the protecting group from the hydroxyl group in a compound represented by formula (7) below: (wherein P represents a protecting group, R3 represents an alkyl group containing 1 to 4 carbon atoms, and A represents an alkyl group containing 1 to 10 carbon atoms, an aryl group containing 6 to 12 carbon atoms, an alkyloxy group containing 1 to 4 carbon atoms, or an aralkyloxy group containing 7 to 20 carbon atoms) to synthesize a compound represented by formula (8) below: (wherein R3 represents an alkyl group containing 1 to 4 carbon atoms, and A represents an alkyl group containing 1 to 10 carbon atoms, an aryl group containing 6 to 12 carbon atoms, an alkyloxy group containing 1 to 4 carbon atoms, or an aralkyloxy group containing 7 to 20 carbon atoms).

Abstract: A rights-based system is described in which vouchers are employed for creating, managing, distributing, and redeeming rights in digital contexts. A voucher is a digital, possession-based rights representation. An authorization component of the system validates the vouchers and issues corresponding tokens. Access to digital resources is provided in response to presentation of the tokens which are validated by matching voucher refresh values to corresponding values maintained by the system. New refresh values are generated and inserted in the vouchers each time they are redeemed.

Abstract: A locking device for fixing a sliding element is disclosed. The locking device employs a cylindrical membrane surrounding a sliding rod element, where both the membrane and the rod are enclosed within a housing. The rod slides freely relative to the membrane until an oil pressure is increased within the oil chamber, the oil chamber being enclosed by the membrane. The pressure within the oil chamber causes the membrane to temporarily deform and press against the rod, thus fixing the rod in a particular position. When the oil pressure is lowered below a threshold value, the membrane returns to its original shape and the rod continues to freely slide within the apparatus. The membrane is very thin yet capable of repeatable use. The membrane spans continuously along the entire portion of the rod within the fixing region of the device, thus creating a precise and powerful fixing means.

Abstract: Production of pitavastatin calcium safely on an industrial scale with a high yield and high selectivity at low cost. A method of producing pitavastatin calcium including step (i) for acetalizing a compound represented by the formula (1) to give a compound represented by the formula (3), step (ii) for reacting a compound represented by the formula (3) with an acid to give a compound represented by the formula (4), and step (iii) for hydrolyzing a compound represented by the formula (4) and reacting same with a calcium compound.

Abstract: A system and method to track time and attendance of an individual at a workplace is provided. The system includes a location tracking system that detects a presence of a portable electronic device carried by the individual, a time clock system that records clock-out registration time of the individual at the workplace, and a main controller. If the main controller receives an electronic communication indicative that the portable electronic device is located at a predefined break or non-work area, and if the main controller does not detect recording of the individual clock-out registration time at the time clock system, then main controller automatically causes an alert at the portable electronic device prompting the individual to transmit a feedback signal acknowledging need to record the clock-out registration time.

Abstract: The present invention provides an industrially-preferable method for safely producing N-benzyl-2-bromo-3-methoxypropionamide at a high yield but at low cost. The method for producing of the present invention includes: in sequence, an amidation process that causes diacrylic anhydride to react with benzylamine in a solvent to obtain N-benzylacrylamide; a bromination process that causes N-benzylacrylamide to react with bromine in a solvent to obtain N-benzyl-2,3-dibromopropionamide; and a methoxylation process that causes N-benzyl-2,3-dibromopropionamide to react with methanol in the presence of a base to obtain N-benzyl-2-bromo-3-methoxypropionamide.

Abstract: Disclosed herein is a windshield wiper assembly that is capable of securely holding a spoiler, thereby preventing poor operation of a wiping rubber member. In the windshield wiper assembly, a base part, formed at one end of the spoiler to support the wiping rubber member, is inserted into an end cap through an outer plug.

Abstract: Disclosed herein is a windshield wiper assembly configured to be easily assembled to a driving arm equipped in a vehicle. In the windshield wiper assembly, an adaptor is provided with a first coupling part, into which a side pin protruding from the side surface of the driving arm is inserted, and a first entrance of the first coupling part, into which the side pin is inserted, is open upward.

Abstract: Methods, apparatus, and data structures embodied in computer-readable media are provided for facilitating access to a service in a network. Title materials are received which include one or more of a first title object, a component of the first title object, or a reference to the first title object. The first title object is a first digital bearer instrument representing at least one right relating to the service, the first title object including a reference to the service. A second title object is identified with reference to a service registry and the reference to the service included in the first title object. The second title object is a second digital bearer instrument with which redemption of the at least one right relating to the service and represented by the first title object may be effected.

Abstract: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.