Abstract: An optical microtoroid resonator including one or more nanoparticles attached to a surface of the resonator and capable of receiving an input signal from a far-field source (via free-space transmission) and outputting light propagating within the optical apparatus. A method for coupling light into and out of an optical resonator using a nanoparticle or nanoparticles to interface with spatially separated far-field optical elements.

Abstract: Methods for detecting single nucleotide polymorphisms in nucleotide sequences using LAMP reactions are provided herein. Generally, two sets of LAMP primers, a wild-type primer that matches expected DNA sequences and an SNP primer that matches the expected SNP DNA are provided. One method includes providing the wild-type primer and the SNP primer in separate wells of a multi-well microfluidic array device, adding the sample nucleotide sequence into the wells seeded with the primers, and initiating LAMP reactions within the wells. The method includes observing the reaction differential between the primers and determining the status of the DNA with regard to that particular SNP. A second method includes providing the primers with tags in a mixture, adding the sample nucleotide sequence to the mixture, and initiating LAMP reactions.

Abstract: Various embodiments for fast prototyping of morphologies and controllers related to locomotion for a robotic device are disclosed.

Abstract: This invention relates to compositions and methods for treating, ameliorating and preventing the toxic effects of venom poisoning. In particular, the invention provides compositions comprising carbon monoxide releasing molecules (CORM) or compositions comprising CORM and iron releasing molecules (IRM) for one or more of enhancing coagulation, reducing fibrinolysis, and/or inactivating venom related metalloproteinase activity in a subject suffering from or at risk of suffering from venom poisoning.

Abstract: The present invention provides a method for authenticating distributed peripherals on a computer network using an array of physically unclonable functions (PUF). As each PUF is unique, each PUF is able to generate a plurality of challenge response pairs that are unique to that PUF. The integrated circuits of the PUF comprise a plurality of cells, where a parameter (such as a voltage) of each cell may be measured (possibly averaged over many readings). The plurality of cells in the PUF may be arranged in a one, two or more dimensional matrix. A protocol based on an addressable PUF generator (APG) allows the protection of a network having distributed peripherals such as Internet of things (IoT), smart phones, lap top and desk top computers, or ID cards. This protection does not require the storage of a database of passwords, or secret keys, and thereby is immune to traditional database hacking attacks.

Abstract: A pH treatment and method for extraction of leachable resources and pollutants from sludge. A volume of wastewater sludge is initially dewatered followed by adding pH adjusting agents to the dewatered sludge to remove acid/base-soluble contaminants. The acid/base-soluble contaminants are flushed out or dewatered from the treated product. Treated sludge can then be sent to storage and held for beneficial uses.

Abstract: A rapid antibiotic susceptibility test (AST) based on the detection and quantification of the movement of single bacterial cells with a plasmonic imaging and tracking (PIT) technology. The PIT-based AST detects changes in the metabolic activity of the bacterial cells long before cell replication, and allows rapid AST for both cultivable and non-cultivable strains. PIT tracks 3D movement with sub-nanometer resolution and millisecond temporal resolution. PIT also allows simultaneous measurement of the binding kinetic constants of antibiotics and bacterial metabolic state after the introduction of antibiotics.

Abstract: The present invention provides methods and systems for manipulating radiance data obtained from a radiance sensor that includes a lenslet array and a photodetector array, where the manipulation of the radiance data uses one or more algorithms or mathematical transformations applied by a software program. Manipulating the measured radiance data computationally produces the same optical effects of a desired optical system without having to insert the optical system into the optical path of the electromagnetic radiation. The manipulated radiance data is then used to generate an image.

Abstract: An array of magnetic nanoparticle (MNP) spin torque oscillators (STOs) is described. Each STO is comprised of a uniform, chemically synthesized, spherical nanoparticle which couples to current flowing along a surface. The particles are organized into an array by a self-assembly technique with uniform spacing and close proximity to allow strong electrical and magnetic coupling between particles. The coupling of the nanoparticles to the surface current drives the oscillations by spin-torque, and for phase locking and data input. The uniform, spherical shape of the particles allows the oscillations to be achieved at low currents and with low power dissipation. The MNP-STOs may be used as a basis for massively parallel computing, microwave oscillators, or other applications.

Abstract: Provided herein are methods for identifying and treating subjects having conditions involving aberrant Ku70/80 activity. In particular, the invention relates to small-molecules which function as inhibitors of Ku70/80 protein and the non-homologous end-joining (NHEJ) pathway, and their use as therapeutics for the treatment of cancer and other diseases.

Abstract: System and methods for a data-driven security game framework that models an attacker based on exploit market data actively mined from the darknet to develop strategies for the defender are disclosed.

Abstract: Implementations described and claimed herein involve a shoulder exoskeleton having a spherical parallel manipulator with a plurality of parallel linear actuators connected to a base coupled to a user's arm. A passive slip mechanism is operatively coupled to the spherical parallel manipulator as well as being coupled to the user's arm. The slip mechanism increases system mobility and prevents joint misalignment caused by the translational motion of the user's glenohumeral joint from introducing mechanical interference.

Abstract: Aspects disclosed in the detailed description include memory compression in a deep neural network (DNN). To support a DNN application, a fully connected weight matrix associated with a hidden layer(s) of the DNN is divided into a plurality of weight blocks to generate a weight block matrix with a first number of rows and a second number of columns. A selected number of weight blocks are randomly designated as active weight blocks in each of the first number of rows and updated exclusively during DNN training. The weight block matrix is compressed to generate a sparsified weight block matrix including exclusively active weight blocks. The second number of columns is compressed to reduce memory footprint and computation power, while the first number of rows is retained to maintain accuracy of the DNN, thus providing the DNN in an efficient hardware implementation without sacrificing accuracy of the DNN application.

Abstract: Provided herein are compositions and methods for treating and preventing lung injury (e.g. ventilation induced lung injury). In particular, the invention relates to compositions and methods for treating and preventing airway disease by activating the NRF2 pathway.

Abstract: Methods, devices, and systems according to present principles provide ways to diagnose frailty and assess the severity of its clinical status—e.g., non-frail, pre-frail, and frail, especially as measured and quantified during activities of daily living. Systems and methods according to present principles objectively quantify physical activity behaviors and identify specific motor tasks, which indicate clinical frailty syndrome behaviors such as flopping, cautious-sitting, non-uniform walking fluctuations, cognitive decline, slowness, weakness, and exhaustion. Additionally, the systems and methods allow improved sensitivity and specificity of frailty identification by further assessing physiological parameters such as heart rate, respiration rate, and skin temperature in response to, or recovery from, specific activities.

Abstract: A new access networking framework is provided for supporting small cell deployments based on the sharing of network resources. A smart gateway framework flexibly accommodates eNB connections and dynamically assigns uplink transmission resources to the eNBs. Novel techniques are also introduced for sharing the small cell infrastructures among multiple operators through virtualization and SDN based reconfiguration.

Abstract: The present invention relates to kits and methods of modifying the prokaryotic genome a Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas system that utilized one nicking Cas nuclease and crRNAs. The kid and methods delete or replace portions of the prokaryotic genome. In some embodiments, an entire gene or multiple genes may be deleted or replaced.

Abstract: Laser-induced fluorescence based optical system and method configured to precisely quantify the relative abundances of calcium (Ca) isotopes in a sample. Optionally, a diode laser is used as a laser source, with its output frequency shifted by two electro-optical modulators to optically excite fluorescence in the calcium-containing sample. The amounts of fluorescence emitted by the various isotopes are measured and compared.

Abstract: Methods are provided for detecting non-human candidate DNA within a plasma sample from a human subject. A method of diagnosing and characterizing a bacterial infection may include the steps of obtaining a plasma sample from a subject suspected of having a bacterial infection, extracting cell-free DNA (cfDNA) from the plasma sample, performing whole genome sequencing on the cfDNA to obtain sequencing data, aligning the sequencing data with a human genome to identify human DNA and non-human DNA, removing the human DNA from the sequencing data, assigning the non-human DNA to a candidate pathogen DNA, selecting a subset of the non-human DNA based on a fragment length of the non-human DNA, and determining the presence of the candidate pathogen DNA within the subset of the non-human DNA.

Abstract: A light emitting device includes a first electrode, a hole transporting layer in contact with the first electrode, a second electrode, an electron transporting layer in contact with the second electrode; and an emissive layer between the hole transporting layer and the electron transporting layer. The emissive layer includes a metal-assisted delayed fluorescent (MADF) emitter, a fluorescent emitter, and a host, and the MADF emitter harvests electrogenerated excitons and transfers energy to the fluorescent emitter.