Abstract: The present invention provides devices and methods to separate and concentrate target protein species at a microliter scale and to generate reagents to those variants with exquisite selectivity for specific protein isoforms using only picograms of target material.

Abstract: A primary ion source subassembly for use with a secondary ion mass spectrometer may include a unitary graphite ionizer tube and reservoir base. A primary ion source may include a capillary insert defining an ionizer aperture. An ionizer aperture may be centrally arranged in an outwardly protruding conical or frustoconical surface, and may be overlaid with a refractory metal coating or sheath. Parameters including ionizer surface shape, ionizer materials, ionizer temperature, and beam stop plate orifice geometry may be manipulated to eliminate ghost images. A graphite tube gasket with a dual tapered surface may promote sealing of a source material cavity.

Abstract: An autozeroed comparator controls a frequency fsw of the input voltage inputted to a DC/DC converter. A digital frequency synchronization circuit is connected to the autozeroed comparator so as to form a phase locked loop, wherein the DES circuit controls the hysteretic window of the autozeroed comparator so as to lock fsw to a clock reference frequency. A plurality of slave phase circuits may be connected to the master phase circuit including the DFS circuit and the autozeroed comparator. Duty cycle calibration circuits adjust a duty cycle signal applied to each of the slave phase circuits, in response to average current measured in the slave phase circuits, so that each slave phase circuit is synchronized with the master phase circuit. A 6 A 90.5% peak efficiency 4-phase hysteretic quasi-current-mode buck converter is provided with constant frequency and maximum ±1.5% current mismatch between the slave phases and the master phase.

Abstract: Methods for synthetic antibodies, methods for making synthetic antibodies, methods for identifying ligands, and related methods and reagents.

Abstract: A product formed from a first material including a geopolymer resin material, a geopolymer material, or a combination thereof by contacting the first material with a fluid and removing at least some of the fluid to yield a product. The first material may be formed by heating and/or aging an initial geopolymer resin material to yield the first material before contacting the first material with the fluid. In some cases, contacting the first material with the fluid breaks up or disintegrates the first material (e.g., in response to contact with the fluid and in the absence of external mechanical stress), thereby forming particles having an external dimension in a range between 1 nm and 2 cm.

Abstract: The present invention provides methods for treating or limiting development of age-related macular degeneration, as well as methods for identifying compound suitable for such use.

Abstract: The disclosure features dendritic tags, and methods and systems for fabricating and using such tags. The methods can include obtaining at least one image of a dendritic tag attached to an article, analyzing the at least one image to identify a set of features associated with the dendritic tag, and comparing the set of features to stored information to identify the article.

Abstract: Some embodiments include a method. The method can include providing a scintillator structure. Providing the scintillator structure can include providing a scintillator support layer, providing a scintillator layer, and coupling the scintillator layer to the scintillator support layer. Meanwhile, the scintillator support layer has a substantially non-planar surface, the scintillator layer having a first surface and a second surface opposite the first surface and being configured to scintillate, and the first surface of the scintillator layer is coupled to the substantially non-planar surface of the scintillator support layer such that the second surface of the scintillator layer has a contour of the substantially non-planar surface of the scintillator support layer. Other embodiments of related methods and systems are also disclosed.

Abstract: Measuring the number of glomeruli in the entire, intact kidney using non-destructive techniques is of immense importance in studying several renal and systemic diseases. In particular, a recent Magnetic Resonance Imaging (MRI) technique, based on injection of a contrast agent, cationic ferritin, has been effective in identifying glomerular regions in the kidney. In various embodiments, a low-complexity, high accuracy method for obtaining the glomerular count from such kidney MRI images is described. This method employs a patch-based approach for identifying a low-dimensional embedding that enables the separation of glomeruli regions from the rest. By using only a few images marked by the expert for learning the model, the method provides an accurate estimate of the glomerular number for any kidney image obtained with the contrast agent. In addition, the implementation of our method shows that this method is near real-time, and can process about 5 images per second.

Abstract: The disclosure features methods for generating a unique identifier, the methods including providing a dendritic structure, reading the dendritic structure to provide a signal, and generating a unique identifier from the signal.

Abstract: Some embodiments include a method. The method can include providing a carrier substrate, providing a release layer over the carrier substrate, and providing a device substrate over the carrier substrate and the release layer. Providing the device substrate can include bonding the device substrate to the carrier substrate, and bonding the device substrate to the release layer. Further, providing the release layer can include bonding the release layer to the carrier substrate. Meanwhile, the release layer can include polymethylmethacrylate, and the device substrate can be bonded to the carrier substrate with a first adhesion strength, the device substrate can be bonded to the release layer with a second adhesion strength less than the first adhesion strength, and the release layer can be bonded to the carrier substrate with a third adhesion strength greater than the second adhesion strength. Other embodiments of related methods and devices are also disclosed.

Abstract: A liquid electrolyte formed by reacting phosphoric acid (H3PO4) in the liquid state with silicon tetrachloride (SiCl4), thereby forming a fluid suspension. The fluid suspension is heated to yield a liquid electrolyte including phosphoric acid (H3PO4), pyrophosphoric acid (H4P2O7), and a particulate solid comprising a silicophosphoric acid, wherein the silicophosphoric acid is an acidic molecular compound including silicon and phosphorus. A concentrated silicophosphoric acid composition prepared by removing most of the liquid from the liquid electrolyte is dissolved in water to yield a homogeneous solution. The homogeneous solution is dried to yield a solid electrolyte. In some cases, the homogenous solution is dried on a substrate to coat at least a portion of the substrate with a proton conductive solid electrolyte. A fuel cell may include the liquid electrolyte, the solid electrolyte, or the coated substrate.

Abstract: Some embodiments include a method of providing an electronic device. The method can comprise: providing a first device substrate; providing one or more first active sections over a second side of the first device substrate at a first device portion of the first device substrate; and after providing the first active section(s) over the second side of the first device substrate at the first device portion, folding a first perimeter portion of the first device substrate toward the first device portion at a first side of the first device substrate so that a first edge portion remains to at least partially frame the first device portion. The first edge portion can comprise a first edge portion width dimension smaller than a first smallest cross dimension of one or more pixel(s) of one or more semiconductor device(s) of the first active section(s). Other embodiments of related methods and devices are also disclosed.

Abstract: Some embodiments include a method of providing an electronic device. The method includes: (i) providing a carrier substrate, (ii) providing a device substrate comprising a first side and a second side opposite the first side, the device substrate having a flexible substrate, (iii) coupling the first side of the device substrate to the carrier substrate; and (iv) after coupling the first side of the device substrate to the carrier substrate, providing two or more active sections over the second side of the device substrate, each active section of the two or more active sections being spatially separate from each other and having at least one semiconductor device. Other embodiments of related methods and devices are also disclosed.

Abstract: Forming multifunctional materials and composites thereof includes contacting a first material having a plurality of oxygen-containing functional groups with a chalcogenide compound, and initiating a chemical reaction between the first material and the chalcogenide compound, thereby replacing oxygen in some of the oxygen-containing functional groups with chalcogen from the chalcogen-containing compound to yield a second material having chalcogen-containing functional groups and oxygen-containing functional groups. The first material is a carbonaceous material or a macromolecular material. A product including the second material is collected and may be processed further to yield a modified product or a composite.

Abstract: Methods and systems for prediction of fill factor in heterojunction solar cells through lifetime spectroscopy are provided. In accordance with some embodiments, methods for categorizing fill factor in a solar cell are provided, the methods comprising: determining lifetime values of the solar cell at different minority carrier concentrations; determining a lifetime curve shape for the solar cell based on the determined lifetime values; and categorizing the fill factor of the solar cell based on the determined lifetime curve shape using a hardware processor.

Abstract: Some embodiments include a method. The method can include providing a carrier substrate having an edge. Further, the method can include providing a cross-linking adhesive, and providing a flexible substrate having an edge. Further still, the method can include coupling the flexible substrate to the carrier substrate using the cross-linking adhesive such that at least a portion of the edge of the flexible substrate is recessed from the edge of the carrier substrate and such that the cross-linking adhesive has an exposed portion of the cross-linking adhesive at an offset portion of the first surface of the carrier substrate between the at least the portion of the edge of the flexible substrate and the edge of the carrier substrate. Meanwhile, the method can include etching the exposed portion of the cross-linking adhesive. Other embodiments of related methods and devices are also disclosed.

Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognizes oligomeric A? that is resistant to denaturation by SDS but does not bind monomeric, fibrillar or other oligomeric forms of A? that are generated in vitro.

Abstract: A robust method to automatically segment and identify tumor regions in medical images is extremely valuable for clinical diagnosis and disease modeling. In various embodiments, an efficient algorithm uses sparse models in feature spaces to identify pixels belonging to tumorous regions. By fusing both intensity and spatial location information of the pixels, this technique can automatically localize tumor regions without user intervention. Using a few expert-segmented training images, a sparse coding-based classifier is learned. For a new test image, the sparse code obtained from every pixel is tested with the classifier to determine if it belongs to a tumor region. Particular embodiments also provide a highly accurate, low-complexity procedure for cases when the user can provide an initial estimate of the tumor in a test image.

Abstract: Some embodiments include a dipolar antenna system to electrically power an implantable miniature device and/or to stimulate bioelectrically excitable tissue, such as, for example, through microelectronic neurostimulation. Other related systems and methods are also disclosed.