Abstract: A method of manufacturing large lens arrays from glass includes heating glass to take a form of a glass sheet of viscous liquid glass floating on liquid metal. Large lens arrays are made by the method and devices and systems are used for making the large lens arrays. The glass sheet has a lower surface in contact with the liquid metal and an upper surface on an opposite side of the glass sheet away from the liquid metal. The method applies a gas flow on the upper surface of the glass sheet to cause the upper surface of the glass sheet to form a pattern of convex lenses in response to local variations in a pressure profile of the gas flow; and cooling the glass sheet to solidify into a rigid, patterned glass sheet.

Abstract: Methods and compositions for activating TORC1 aggregate formation in a fungi or a parasite, wherein TORC1 aggregate formation inhibits growth of the fungi or parasite. TORC1 aggregate formation may be activated using small molecules or other agents, and said agents may be used to treat or prevent a disease or condition associated with the fungi and parasite. The agent may target Kog1 of TORC1, e.g., the agent may directly or indirectly inhibit Kog1 leading to aggregation of the TORC1 complex.

Abstract: Devices, systems and methods for use in confocal imaging systems are described that enable lateral and axial scans at high speeds and without a moving scanner while producing high quality images. One chromatic confocal optical head includes an illumination source, such as an addressable point source array, to provide a wide spectrum illumination including multiple wavelengths. The optical head also includes a beamsplitter to allow the light to be directed toward an object, to receive the reflected light from the object and to direct the reflected light toward a detector. The optical head further includes a pinhole mask that is positioned to receive the light that is reflected from the object after passing through the beamsplitter, and a dispersion element that is positioned to receive the light after passing through the pinhole mask, and to separate the light into multiple spectral components for reception by the detector.

Abstract: A simulation-based framework for optimizing resource allocation and layout design is disclosed.

Abstract: Provided herein are devices, systems, and methods for analyzing platelet function. In particular, provided herein are simple, portable, accurate and inexpensive small footprint platelet aggregometry devices, systems, and methods.

Abstract: Cellular targets on cancer cells have been identified that can be used with targeted molecular imaging to detect the cancer cells in vivo. Non-invasive methods for detecting cancer cells, such as metastasized cancer cells, are therefore provided. Also provided are compositions and kits for use in the disclosed methods.

Abstract: In accordance with a method of forming a waveguide in a polymer film disposed on a substrate, a plurality of regions on a polymer film are selectively exposed to a first dosage of radiation. The polymer film is formed from a material having a refractive index that decreases by exposure to the radiation and subsequent heating. At least one region of the polymer film that was not previously exposed to the radiation is selectively exposing to a second dosage of radiation. The second dosage of radiation is less than the first dosage of radiation. The polymer film is heated to complete curing of the polymer film.

Abstract: A photovoltaic (“PV”) module may comprise an array of freeform micro-optics and an array of PV cells. The PV module may be a flat panel with a nominal thickness smaller than the length and width of the flat panel. An array of lenses may be embedded in an array substrate. The lenses may be coupled to light pipes. The lenses may concentrate light through the light pipes to multi-junction cells. Diffuse light may be transferred through the array substrate to a silicon cell. The lenses and light pipes may be manufactured using a molding and drawing process.

Abstract: A system and method to assist a user to overcome an interruption of service between the brain and the legs including several subsystems configured to be progressively removed to provide decreasing levels of lower trunk and leg support.

Abstract: Systems featuring two or more encapsulation devices stacked together. The encapsulation devices house cells, such as but not limited to islet cells or stem cell derived beta cells or the like. e.g., for regulating blood glucose, or other cells or spheroids that can produce and release a therapeutic agent that is useful in the body, etc. The system may feature oxygen delivery, or in some cases no exogenous oxygen is delivered and vascularization of the device can help provide oxygen and other needed nutrient to the cells. The system of the present invention may be used in conjunction with other therapies such as an artificial pancreas. Stacking the devices with blood vessel formation around and in between them may allow for a decrease in the footprint that would be needed for implantation.

Abstract: A method of identifying single nucleotide polymorphisms (SNPs) within the NAMPT promoter that are associated with inflammatory conditions. Also provided are methods of diagnosing and treating inflammatory conditions in a subject.

Abstract: The present invention relates to the control of pest infestation by inhibiting or reducing the expression of certain genes implicated in cotton leaf curl virus disease (CLCuD), by simultaneously targeting viral RNA involved in viral replication and movement. More specifically, the invention relates to a method for substantially simultaneously targeting the AC1 gene of a begomovirus and (2) the betasatellite and non-coding region. Strategies using small hairpin RNA (shRNA) constructs are described herein to achieve viral-mediated gene silencing, and an exemplary embodiment is disclosed, for targeting the replication-associated protein gene (AC1) and non-coding region found in numerous species and strains of the cotton leaf curl disease begomovirus complex, and a coding and adjacent non-coding region of the associated betasatellites.

Abstract: Identification and evaluation of a set of first-in-class potent inhibitors targeting a new cancer target, Grb2-associated binder-1 (GAB1), which integrates signals from different signaling pathways and is frequently over-expressed in cancer cells. Intensive computational modeling is utilized to understand the structure of the GAB1 pleckstrin homology (PH) domain and screened five million compounds. Upon biological evaluation, several inhibitors were found that induced large conformational changes of the target structure exhibited strong selective binding to GAB1 PH domain. Particularly, these inhibitors demonstrated potent and tumor-specific cytotoxicity in breast cancer cells. This targeting GAB1 signaling may be used for cancer therapy, especially for triple negative breast cancer patients.

Abstract: Described herein are assays and kits capable of specifically detecting Enterocytozoon hepatopenaei (EHP) in a nucleic acid sample. In some embodiments, the nucleic acid sample is obtained from shrimp tissue, shrimp feed, or a feed ingredient.

Abstract: A design and implementation of a new optical architecture: space, time, and angular division multiplexed image transfer by Digital Micromirror Device. The method, like various multiplexing methods employed in communication engineering, enables image transfer via an angular band-limited data channel such as an optical image guide by dynamically redistributing a signal into multiple domains such as space, time, angle, wavelength, and polarization.

Abstract: A vertical external cavity surface emitting laser (VECSEL) based system in a linear single cavity configuration is configured to deliver light in higher-order Hermite-Gaussian transverse modes with Watt-level output power. Simultaneous and independent lasing of spatially-restructurable multiple high-order transverse modes that are collinearly-propagating at the output of such laser cavity is facilitated with the use of an optical pumping scheme devised to control positions of location at which the gain medium of the system is pumped (e.g., locations of focal spots of multiple pump beams on the gain-medium chip). An external astigmatic mode converter is utilized to convert such high-order Hermite-Gaussian modes into corresponding Laguerre-Gaussian modes.

Abstract: A light projection system includes an angle-dependent pattern projection device projecting light of multiple patterns into corresponding multiple directions, and a waveguide comprising an input and an output, configured to accept the light from the angle-dependent pattern projection device and emit the light through the output, whereby the light from each of the multiple patterns takes a unique path through the waveguide. The waveguide is built into a headset display device, and the output of the waveguide couples light emitted through the output to an eye.

Abstract: The present invention provides methods for increasing stability and efficiency of organic perovskite materials for use in various electronic devices. In particular, methods of the invention use a non-peripheral substituted phthalocyanine for passivating defects in organic perovskite materials, thereby increasing its stability and efficiency relative to the same material in the absence of said non-peripheral substituted phthalocyanine.

Abstract: Disclosed herein is a method for promoting reduction of heat stress in animals, as well as a composition for use in the disclosed method. The composition comprises a glucan, silica, mineral clay, mannan, and optionally an endoglucanohydrolase, and may be administered to an animal that is susceptible to or suffers from heat stress.

Abstract: A gain fiber assembly for use in optical fiber amplification systems such as fiber amplifiers and fiber lasers utilizes an active or “bare” fiber that has a single glass cladding with an outer diameter of less is less than 80 ?m and preferably less than 60 ?m or even 40 ?m. A passive double-clad input fiber is stripped of the outer cladding and tapered to match the outer diameter of the bare fiber. A glass-fluid or glass-vacuum interface along the taper provides guidance of the pump into and along the cladding of the bare fiber and a NA>1 for a vacuum or gasses and an NA>0.8 for liquids. This allows for much shorter fiber lengths to reach max signal power and higher pump conversion efficiencies.