Patents Assigned to Arkray, Inc.
  • Patent number: 10788441
    Abstract: A measuring method of measuring a concentration of a target ingredient in a sample by using a sensor including an interdigitated array electrode that includes a first electrode and a second electrode, and a reagent layer on the interdigitated array electrode, the measuring method includes: applying a voltage to between the first electrode and the second electrode; measuring a first current value of an electric current flowing between the first electrode and the second electrode; measuring a second current value of the current flowing between the first electrode and the second electrode; calculating the concentration of the target ingredient in the sample, based on a third current value; calculating a correction value, based on the first current value and the second current value; and a step of correcting the concentration of the target ingredient in the sample, based on the correction value.
    Type: Grant
    Filed: August 9, 2016
    Date of Patent: September 29, 2020
    Assignees: ARKRAY, Inc., Ultizyme International Ltd.
    Inventors: Hisashi Kaneda, Yasuhide Kusaka, Koji Sode
  • Patent number: 10775345
    Abstract: An analytical method and an analytical system capable of more accurate analysis, in which a sample is analyzed by a capillary electrophoresis technique in which a voltage is applied to a sample solution introduced to a micro flow path, a separation analysis is performed for a component contained in the sample solution, and an optically measured value corresponding to an elapsed time after starting a measurement is measured. The analytical method comprises: a process of determining an interface arrival time point, based on the optically measured value when an interface between the sample solution and a migration liquid reaches a predetermined measurement position in the micro flow path; and a process of identifying the component contained in the sample solution using the optically measured value at the elapsed time after the interface arrival time point.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: September 15, 2020
    Assignee: ARKRAY, Inc.
    Inventor: Masao Kawano
  • Patent number: 10746687
    Abstract: The disclosure provides target component measurement methods and target component measurement apparatus for measuring target components including glucose.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: August 18, 2020
    Assignee: ARKRAY, Inc.
    Inventor: Hisashi Kaneda
  • Patent number: 10731200
    Abstract: A method of quantifying ammonia, which method includes: performing a first reaction in which a test liquid containing ammonia is reacted with ATP and L-glutamic acid in the presence of glutamine synthetase to produce ADP; performing a second reaction in which the produced ADP is reacted with glucose in the presence of ADP-dependent hexokinase to produce glucose-6-phosphate; performing a third reaction in which the produced glucose-6-phosphate is reacted with an oxidized NAD compound in the presence of glucose-6-phosphate dehydrogenase to produce a reduced NAD compound; and quantifying the reduced NAD compound to quantify ammonia.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: August 4, 2020
    Assignee: ARKRAY, Inc.
    Inventors: Takehiro Funamoto, Masaki Murakami
  • Patent number: 10712311
    Abstract: One embodiment of the invention provides: a microchip including a sample collection section and an analysis section, in which the sample collection section and the analysis section are imparted with both hydrophilicity and a positively-charged layer; an analysis system including the microchip; and a method of producing the microchip. The microchip includes: a sample collection section for collecting a sample; and an analysis section for analyzing the sample. In the microchip, a cationic polymer bonded with a hydrophilization substance is immobilized on inner walls of the sample collection section and the analysis section.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: July 14, 2020
    Assignee: ARKRAY, Inc.
    Inventors: Takanari Shigemitsu, Naotsugu Onuma
  • Patent number: 10697922
    Abstract: Disclosed is a biosensor with improved humidity resistance that can be used as a glucose sensor or a lactate sensor. The biosensor includes: an insulative substrate; an electrode system having a working electrode and a counter electrode provided on the substrate; and a reagent layer provided on the electrode system. The reagent layer contains an oxidoreductase and 1-methoxy-5-methylphenazinium ethyl sulfate. This biosensor can be used as a glucose sensor or a lactate sensor.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: June 30, 2020
    Assignee: ARKRAY, Inc.
    Inventor: Hisashi Kaneda
  • Publication number: 20200160094
    Abstract: An information processing device includes a categorizing section and a display control section. The categorizing section extracts a material component image identified as a material component from plural images obtained by imaging a sample fluid containing plural types of material element, and categorizes the extracted material component image serving as a detected component by predetermined category. The display control section performs control to re-categorize a material component image serving as the detected component already categorized into a different category, such that, when selection of a movement destination category is received in a state in which a first image list of detected components is being displayed, in a subsequent state in which the first image list and a second image list for the movement destination are being displayed at the same time, a material component image selected from the first image list is moved to the second image list.
    Type: Application
    Filed: November 8, 2019
    Publication date: May 21, 2020
    Applicants: ARKRAY, Inc., SUMITOMO LIFE WELFARE AND CULTURE FOUNDATION
    Inventors: Koji FUJIMOTO, Shinya NAKAJIMA, Kenichi NAGAO
  • Patent number: 10656069
    Abstract: A flow cell including a flow channel through which a sample fluid and a sheath fluid flow, a sample flow channel that introduces the sample fluid into the flow channel, and at least one sheath flow channel that introduces the sheath fluid into the flow channel. The flow channel includes a flow merging section where the sample flow channel and the sheath flow channel merge, a flattened section that is disposed downstream of the flow merging section, that is formed in line with one wall face of wall faces facing across the flow merging section, and that is shallower in depth than the flow merging section, and a tapered section that connects the flow merging section with the flattened section and that gradually decreases in depth on progression downstream.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: May 19, 2020
    Assignee: ARKRAY, Inc.
    Inventor: Shigeki Masuda
  • Publication number: 20200134287
    Abstract: An information processing device includes a categorizing section configured to extract a material component image identified as a material component from plural images obtained by imaging a sample fluid containing a plurality of types of material components and flowing through a flow cell, and to categorize the extracted material component image by predetermined category, a count derivation section configured to derive a count of the material component per standard visual field, or derive a count per unit liquid volume of the material component contained in the sample fluid, for each of the categories based on the number of material component images categorized by the categorizing section, and a generation section configured to generate an all-component image in which the material component images are arranged according to the counts that have been derived by the count derivation section for each of the categories.
    Type: Application
    Filed: October 15, 2019
    Publication date: April 30, 2020
    Applicant: ARKRAY, Inc.
    Inventors: Koji FUJIMOTO, Shinya NAKAJIMA, Kenji NAKANISHI
  • Patent number: 10619178
    Abstract: The disclosure relates to a biosensor including electrodes, a hydrophilic region or layer, and a reagent layer that contains an enzyme and a mediator, and methods of producing thereof.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: April 14, 2020
    Assignee: ARKRAY, Inc.
    Inventor: Kazuo Fukuda
  • Publication number: 20200110080
    Abstract: A molecular recognition element comprising a target molecule-recognizing portion, and a direct electron transfer-type oxidoreductase linked to the target molecule-recognizing portion.
    Type: Application
    Filed: October 2, 2019
    Publication date: April 9, 2020
    Applicants: ARKRAY, Inc., Ultizyme International Ltd.
    Inventors: Koji Sode, Yuka Takahashi, Junko Shimazaki, Masashi Tsukada, Yosuke Murase
  • Patent number: 10605772
    Abstract: An analytical tool for use in analysis of a sample is provided. The analytical tool includes a first unit and a second unit. The first unit has an analysis portion where analysis is performed. The second unit, configured to be coupled with the first unit, has a liquid reservoir for confining a particular liquid used for the analysis of the sample. When the first unit and the second unit are coupled, a fluid passage for conducting the particular liquid from the liquid reservoir into the first unit is formed by only a part of the first unit, or only a part of the second unit, or a combination of respective parts of the first unit and the second unit.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: March 31, 2020
    Assignee: ARKRAY, Inc.
    Inventor: Naotsugu Onuma
  • Patent number: 10597725
    Abstract: The present disclosure provides a novel primer reagent for detecting a plurality of variants of the ALK fusion gene.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: March 24, 2020
    Assignee: ARKRAY, Inc.
    Inventor: Marifu Yamagishi
  • Patent number: 10591459
    Abstract: Provided are a measuring apparatus and method for obtaining a measurement value from a response to a signal applied to a sample, wherein the measuring apparatus includes a first measuring unit that measures a first electric response to a first signal that is input to a first pair of electrodes that can come into contact with a sample, a second measuring unit that measures a second electric response to a second signal that is input to a second pair of electrodes that can come into contact with the sample, the second signal changing its value from a first level to a second level and thereafter maintaining the second level for a certain period of time, as a peak value of a response signal with respect to the change in the second signal, and a control unit that corrects a value indicating the amount of a measuring target component of the sample, the value being obtained from the first electric response, based on the peak value of the response signal.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: March 17, 2020
    Assignee: ARKRAY, Inc.
    Inventors: Kazuo Fukuda, Hirokazu Matsuda, Akiko Okami
  • Patent number: 10583469
    Abstract: The amount of consumption of a washing solution for a nozzle and the required time for washing are reduced. A nozzle washing apparatus usable for collection of a specimen comprises a washing tank which accommodates a nozzle, a first discharge port which discharges a washing solution supplied into the washing tank from an upper portion of the washing tank, a second discharge port which discharges the washing solution supplied into the washing tank from a position lower than the first discharge port of the washing tank, a detector which detects a range of contact of an outer wall of the nozzle with the specimen, and a controller which discharges the washing solution supplied into the washing tank from one of the first discharge port and the second discharge port on the basis of a detection result obtained by the detector.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: March 10, 2020
    Assignee: ARKRAY, Inc.
    Inventor: Shinichi Ota
  • Publication number: 20200072790
    Abstract: The present disclosure provides component analysis methods including a measurement process and an analysis process.
    Type: Application
    Filed: August 20, 2019
    Publication date: March 5, 2020
    Applicant: ARKRAY, Inc.
    Inventor: Jin Yoshida
  • Publication number: 20200073018
    Abstract: [Problem to Be Solved] The present invention provides an optical element including a coating film in which the occurrence of cracks is prevented. [Solution] Provided is an optical element including: an optical crystal; and an antireflection film coating the surface of the optical crystal; in which optical element the antireflection film contains an organic compound.
    Type: Application
    Filed: August 16, 2019
    Publication date: March 5, 2020
    Applicant: ARKRAY, Inc.
    Inventor: Hirohisa UCHIDA
  • Patent number: 10577637
    Abstract: An enzyme electrode includes an electrode, and a detection layer which contacts the electrode and contains a crosslinking agent, an electrically conductive macromolecule and an enzyme transferring and receiving electrons to and from the electrode and does not contain an electron transfer subunit.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: March 3, 2020
    Assignees: ARKRAY, Inc., Ultizyme International Ltd.
    Inventors: Koji Katsuki, Hisashi Kaneda, Junko Shimazaki
  • Patent number: 10563242
    Abstract: The disclosure discloses an enzyme electrode comprising; an electrode comprising a current collector; a monolayer-forming molecule bound to the surface of the current collector; and a glucose dehydrogenase comprising a cytochrome C subunit bound to the monolayer-forming molecule; wherein electrons are transferred between the glucose dehydrogenase and the current collector by oxidation-reduction reaction of the glucose dehydrogenase.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: February 18, 2020
    Assignees: ARKRAY, Inc., Ultizyme International Ltd.
    Inventors: Yuka Takahashi, Junko Shimazaki
  • Patent number: 10561749
    Abstract: Provided is a radioactive labeled compound capable of detecting a secondary mutation of an epidermal growth factor receptor, where the compound is represented by Formula (1) or a pharmaceutically acceptable salt thereof, where R1, R2, and Y are as defined.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: February 18, 2020
    Assignees: Kyoto University, ARKRAY, Inc.
    Inventors: Hideo Saji, Hiroyuki Kimura, Anna Miyazaki, Hirokazu Matsuda, Shuichi Nakanishi