Abstract: A measuring apparatus for measuring a predetermined physical property of a liquid measuring sample comprises a preparing unit in which a plurality of materials including at least a liquid material are mixed; a supply route which supplies the liquid material to the preparing unit; a withdrawing unit which withdraws the measuring sample from the preparing unit into the supply route, the measuring sample being prepared to contain the liquid material supplied to the preparing unit via the supply route; and a measuring unit which measures the predetermined physical property of the measuring sample withdrawn into the supply route by the withdrawing unit.

Abstract: A cartridge is provided that can remove a residual liquid all around the leading end of a pipette, without requiring any new equipment, regardless of the viscosity of the residual liquid. This cartridge includes a plurality of tanks, each of which has an upper opening, and a liquid is introduced into or led out from at least one of the plurality of tanks 110 to 119 with a pipette. The cartridge further includes waste liquid tanks 120 to 122. The waste liquid tanks 120 to 122 each includes a capillary phenomenon generation portion. A residual liquid present at the leading end of the pipette is brought into contact with the capillary phenomenon generation portion of the waste liquid tanks, and the residual liquid is transferred to the capillary phenomenon generation portion through the capillary phenomenon to be removed from the pipette.

Abstract: The present invention provides a device that decreases deformation during manufacturing of the device, provides a firm joint without use of an adhesive, and allows chemical modification of a channel during manufacturing of the device. The device includes two joined substrates, and a concavity is formed on at least one of the opposing surfaces of the two substrates so as to make a channel, where the two substrates are joined together by a covalent bond via a crosslinking agent (A), and the crosslinking agent (A) is exposed on an inner wall surface of the channel.

Abstract: A method for storing a tetrazolium compound stably is provided. The tetrazolium compound is stored in the presence of sodium azide. The tetrazolium compound (A) and the sodium azide (B) are present at a ratio (A:B) in the range from 1:0.02 to 1:6.2. Furthermore, when the tetrazolium compound is stored as a solution, the concentration of the sodium azide is in the range from 0.08 to 3.2 mmol/L and the concentration of the tetrazolium compound is in the range from 0.5 to 8 mmol/L. As the tetrazolium compound, it is preferable to use 2-(4-iodophenyl)-3-(2,4-dinitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium salt.

Abstract: A method for taking a sample includes drawing blood into a vacuum blood collection tube and transferring at least part of the blood from the vacuum blood collection tube to a sample storage space of a dropper. The vacuum blood collection tube includes a sample storage portion and a stopper sealing the sample storage portion, and the drawing is performed by stabbing a hollow needle into the stopper. The dropper includes and internal space at least part of which is the sample storage space for storing a sample and which includes a volume changeable space defined by an elastically deformable portion having flexibility. The dropper further includes an insertion portion including a through-hole connected to the internal space, and the transfer of the sample is performed by inserting the insertion portion into a through-hole formed in the stopper by the stabbing of the hollow needl into the stopper.

Abstract: The invention provides a lancing apparatus for moving a lancet holder (32) retaining a lancet in a lancing direction (N1) from a standby position to a lancing position together with the lancet so as to cause the lancet to stick into an object. In the lancing apparatus the lancet is inserted into the lancet holder (32) in a retreating direction (N2), thus to be retained by the lancet holder. The lancet holder (32) includes a first member and a second member (33, 34) relatively movable with respect to each other, so that the first and the second members (33), (34) are relatively moved so as to fix the lancet. Preferably, the lancet holder (32) is constructed such that at least either of the first and the second members (33, 34) applies a pressing force to the lancet, so as to fix the lancet.

Abstract: An object of the present invention is to provide an amplification method that inhibits amplification caused by erroneous annealing of a primer. Primers X1 and X2 are used in amplification of a target sequence including a target site showing a polymorphism. The primer X1 includes a sequence A1? and a sequence E1. The sequence A1? is complementary to a partial sequence A1 in a template nucleic acid, and has, in its 3? region, a base x1? complementary to a first base x1 at the target site in a 5? region of the sequence A1. The sequence E1 is noncomplementary to a partial sequence B1 adjacent to the 3? end of the partial sequence A1 in the template nucleic acid, and is bound to the 5? end of the partial sequence A1?. The primer X2 includes a sequence A2?. The sequence A2? is complementary to a partial sequence A2 in the template nucleic acid, and has, in its 3? region, a base x2? complementary to a second base x2 at the target site in a 5? region of the partial sequence A2.

Abstract: An analysis chip that enables an apparatus to be small, analysis to be simple, analysis time to be short and analysis of both glycosylated hemoglobin and glucose to be highly accurate is provided. The electrophoresis chip includes an upper substrate 4, a lower substrate 1, a first introduction reservoir 2a, a first recovery reservoir 2b and a capillary channel for sample analysis 3x; the first introduction reservoir 2a and the first recovery reservoir 2b are formed in the lower substrate 1; and the first introduction reservoir 2a and the first recovery reservoir 2b are in communication with each other via the capillary channel for sample analysis 3x.

Abstract: An analysis chip that enables an apparatus to be small, analysis to be simple, analysis time to be short and analysis of both glycosylated hemoglobin and glucose to be highly accurate is provided. The electrophoresis chip includes an upper substrate 4, a lower substrate 1, a first introduction reservoir 2a, a first recovery reservoir 2b and a capillary channel for sample analysis 3x; the first introduction reservoir 2a and the first recovery reservoir 2b are formed in the lower substrate 1; and the first introduction reservoir 2a and the first recovery reservoir 2b are in communication with each other via the capillary channel for sample analysis 3x.

Abstract: An electrochemical sensor includes a base plate including one end portion and another end portion, an electrode portion formed on the one end portion of the base plate, a connecting portion, formed on the another end portion of the base plate, for electrically connecting the electrode portion to a monitoring instrument, and an attaching portion formed on the another end portion, the attached portion being employed for attaching the another end portion to the monitoring instrument in a state where the one end portion is enabled to swing relatively to the monitoring instrument.

Abstract: It is an object to provide a test instrument and an optical measurement apparatus which enable easy matching of test results when tests by optical measurement are performed with respect to a large number of patients. To the above end, a test instrument B is provided, which includes reagent retaining portions 8A, 8B, 8C retaining a reagent which reacts with a sample to produce a color reaction. The test instrument B includes a patient information entry section 64 as an example of patient identifying information region in which patient identifying information is to be written.

Abstract: The present invention provides an enhancer for enhancing the activity of oxidized protein hydrolase. The oxidized protein hydrolase activity enhancer according to the present invention contains an extract of at least one plant selected from the group consisting of Compositae Anthemis, Saururaceae Houttuynia, Rosaceae Crataegus, and Vitaceae Vitis.

Abstract: Provided is an analysis device or an analysis method, by which highly reliable analysis results can be obtained even in the circumstances where environment temperature changes, while reducing load on the user. The analysis device (1) is provided with a determining means (13) which determines whether environmental temperature measured by means of a temperature measuring means (6) is within a predetermined temperature range or not. The determining means (13) is so configured as to determine whether the environmental temperature is within the predetermined temperature range or not, even in the circumstances where information relating to a target substance in a sample cannot be obtained from the analysis device.

Abstract: A continuous analysis apparatus capable of transmitting information about components in body fluid to another apparatus such as medicine dosing apparatus more correctly without giving a user displeasure. The continuous analysis apparatus according to the present invention includes a sensing unit 2 including a sensor that is held in subcutaneous tissue for obtaining information with respect to an objective substance in a sample; and a data holding unit 3 having a storage means for storing the information obtained from the sensor or data corresponding to the information, the sensing unit and the data holding unit having configuration so that they are separably joined to each other.

Abstract: A liquid feeding method for feeding liquid in a minute flow path is provided. The minute flow path includes flow paths 43a, 43c, 43d connected to each other directly at respective first ends. The liquid feeding direction of blood S in the minute flow path is controlled by creating a high-pressure state at a second end of the flow path 43a located across the blood S, while creating a low-pressure state or a closed state at a second end of the flow paths 43d, 43c.

Abstract: An electrochemical sensor includes a base plate provided with a concave part formed on one of surfaces thereof, a fluid channel formed so that a bottom part of the concave part and the other one of the surfaces of the base plate are communicated with each other, a plurality of electrodes formed on the concave part; a reagent fixed on the electrodes, a cover which covers the concave part, and an air channel which causes the inside and outside of the concave part to be communicated with each other.

Abstract: The invention provides a probe which detects a polymorphism in the MDR1 gene. The probe has a P1 and/or a P2 oligonucleotide. The P1 oligonucleotide has a sequence that is complementary to a first base sequence, in which the first base sequence is a partial sequence of SEQ ID NO: 2 having a length of from 13 bases to 68 bases and including the 288th to 300th bases of SEQ ID NO: 2. The base complementary to the 288th base is labeled with a fluorescent dye. The P2 oligonucleotide has a sequence that is complementary to a second base sequence, in which the second base sequence is a partial sequence of SEQ ID NO: 2 having a length of from 6 bases to 93 bases and including the 300th to 305th bases of SEQ ID NO: 2. The base complementary to the 305th base is labeled with a fluorescent dye.

Abstract: A method for displaying HbA1c measurement results is provided, which makes it possible to prevent overlooking a sample that exhibits an HbA1c value at a predetermined level different from a normal value, for example, a sample that exhibits a diabetic type. The method is a display method for displaying spectrum data as results of measurement of hemoglobin A1c (HbA1c) in a sample by separation analysis, and the method includes applying one of at least two different types of designs to a peak area for HbA1c in the spectrum data, according to an amount of HbAlc in the sample, or according to the amount of HbA1c and an amount of blood glucose in the sample.

Abstract: A mutant glucose dehydrogenase having an amino acid sequence at least 80% identical to SEQ ID NO:3 and having glucose dehydrogenase activity, wherein amino acid residues corresponding to positions 326, 365 and 472 of said amino acid sequence are replaced with glutamine, tyrosine and tyrosine, respectively, and wherein said mutant glucose dehydrogenase shows an improved substrate specificity to glucose and a reduced reactivity to disaccharides.

Abstract: The invention provides a primer set for detecting a polymorphism in EGFR exon 21 L858R. The primer set has a P1 oligonucleotide and a P2 oligonucleotide and can performing amplification by using a region including the 172792nd base of SEQ ID NO: 1 as a template. As a base that is complementary to the 172792nd base of SEQ ID NO: 1, the P1 oligonucleotide has cytosine and the P2 oligonucleotide has adenine. The melting temperature of the P1 oligonucleotide is higher than the melting temperature of the P2 oligonucleotide, and/or the P1 oligonucleotide is one or more bases longer than the P2 oligonucleotide. The invention further provides a polymorphism detection primer, a polymorphism detection method using the primer set, a method of evaluating a EGFR tyrosine kinase inhibitor using the primer set, a primer used in the polymorphism detection method, and a kit including the primer set.