Abstract: The present invention relates to an analysis tool including a reagent portion and electrodes. The electrodes include a porous conductive portion where the reagent portion is formed. The porous conductive section is formed by, for instance, coating at least a part of a surface and an inner surface of a porous body with a conductive film. The porous body is, for instance, an insulating fiber mesh cloth. Preferably, the electrodes are formed in a sheet shape.

Abstract: A measured result reflecting a body condition of a user when measuring a blood sugar level can be displayed, and convenience of management of the blood sugar level of the user is improved. A blood sugar level measuring apparatus includes: a measuring unit to measure a blood sugar level of a user; a recording unit to record measurement data thereof; and a display unit capable of displaying a measured result on a display, wherein the improvement comprises: a condition flag setting unit to record, on the recording unit, a condition flag related to a body condition of the user when measuring the blood sugar level; and a display control unit to display the measured result recorded on the recording unit on the display on the basis of the condition flag set by the condition flag setting unit.

Abstract: An LDL cholesterol measurement method that can be used with a test piece is provided. The LDL cholesterol measurement method for measuring LDL cholesterol in a sample has (A) a step of providing a total-cholesterol measurement portion and a non-LDL cholesterol measurement portion for measuring non-LDL cholesterol, which is cholesterol other than LDL cholesterol; (B) a step of measuring the total cholesterol in the sample in the total-cholesterol measurement portion; (C) a step of measuring the non-LDL cholesterol in the sample in the non-LDL cholesterol measurement portion; and (D) a step of obtaining the LDL cholesterol level in the sample by subtracting the non-LDL cholesterol value measured in the step (C) from the total-cholesterol value measured in the step (B).

Abstract: A measuring method by which carboxymethylarginine can be measured with ease and with a high degree of precision is disclosed. The measuring method is a method of measuring carboxymethylarginine in a sample. The method includes treating the sample with a pretreatment agent including urea; and measuring carboxymethyl arginine in the pretreated sample by an immunological method.

Abstract: The present disclosure includes a method for simultaneously detecting a plurality of nucleotide polymorphisms, comprising detecting a plurality of nucleotide polymorphisms at a single wavelength by using a plurality of oligonucleotides labeled with a dye, each of which hybridizes to a region containing each of the plurality of nucleotide polymorphisms.

Abstract: The present invention provides a method for analyzing hemoglobin by capillary electrophoresis, that allows the apparatus to be smaller in size, allows a highly precise analysis to be obtained, and allows the analysis to be performed in a short period of time.

Abstract: The present invention provides a melting curve analyzing method that can automatically analyze whether or not a peak is present in at least one of two temperature ranges. A signal differential value (A) having a maximum absolute value is searched for among signal differential values at respective temperatures. When a temperature (t1) indicating (A) is included in a temperature range (T1) that is either one of a predetermined temperature range TH and a predetermined temperature range TL, it is determined that (A) is a first peak. Further, a signal differential value (C) that is a first signal differential value after the absolute value changed from decreasing to increasing and a signal differential value (D) having an absolute value that is greatest next to the absolute value of (A) are searched for.

Abstract: The present invention relates to a liquid chromatography apparatus X, which is provided with a deaerator 4. The liquid chromatography apparatus X is further provided with a dissolved oxygen density adjusting means for maintaining a density of dissolved oxygen in an eluting solution to be supplied to a column 60 constant. Preferably, the dissolved oxygen density adjusting means is configured so as to adjust the density of the dissolved oxygen in the eluting solution by adjusting a degree of decompression in a decompression space of the deaerator 4 based on a measurement result by temperature measurement means 40A, 40B, and 40C for measuring the temperature of the eluting solution.

Abstract: A sample analyzer which transports a rack holding a plurality of sample containers and analyzes samples includes: a first measurement apparatus which measures samples; a second measurement apparatus which is arranged downstream, in a transport direction, from the first measurement apparatus, and which measures samples; and a transporting apparatus which transports samples to a first supply position for supplying a sample to the first measurement apparatus, and to a second supply position for supplying a sample to the second measurement apparatus. The transporting apparatus linearly transports a rack from the first supply position to the second supply position, and the distance between the first supply position and the second supply position is a multiple of the distance between adjacent sample containers held in the rack.

Abstract: A sample analyzer which transports and analyzes samples, includes: a first measurement apparatus which measures samples; a second measurement apparatus which is arranged downstream, in a transport direction, from the first measurement apparatus, and which measures samples; a transporting apparatus which transports samples to a first supply position for supplying a sample to the first measurement apparatus, and to a second supply position for supplying a sample to the second measurement apparatus; and a controller which controls transportation of a sample present at the first supply position, in accordance with a processing status of a sample present at the second supply position.

Abstract: This invention is regard to an analysis device that analyze a specific component in bodily fluid extracted from the skin using an analysis tool. The analysis device comprise a laser beam oscillation section that emits a laser beam for extracting the bodily fluid from the skin, and a detection mechanism that detects whether or not the analysis tool exists at a target position. The analysis device is adapted to emit the laser beam from the laser beam oscillation section when the analysis tool is detected by the detection mechanism.

Abstract: The present invention relates to an analyzer (1) to be used with an analytical tool (2) mounted thereto and used for analyzing a particular component contained in a sample supplied to the analytical tool (2). The analyzer (1) includes at least one detection terminal pair (11, 12) including a first and a second detection terminals (11A, 11B, 12A, 12B) which are capable of selecting a mutually contacting state and a non-contacting state, a detector (15) for detecting the state of contact of the first and the second detection terminals (11A, 11B, 12A, 12B), and an abnormality detector (16) for detecting an abnormality of the at least one detection terminal pair (11, 12) based on the detection result by the detector (15).

Abstract: Primer sets for amplifying target regions containing sites to be detected in the UGT1A1 gene by a gene amplification method are provided, wherein the primer sets can amplify the regions specifically. Three pairs of primer sets are used including forward primers consisting of the base sequences of SEQ ID NOs: 4 or 81, 21, and 42 as well as reverse primers consisting of the base sequences of SEQ ID NOs: 13 or 91, 29 and 48, respectively. The use of these primer sets makes it possible to amplify three target regions including parts where three types of polymorphisms (UGT1A1*6, UGT1A1*27, and UGT1A1*28) of the UGT1A1 gene are generated, respectively, in the same reaction solution at the same time.

Abstract: Disclosed is a method of amplifying a polynucleotide, comprising: (a) mixing primers for amplifying the polynucleotide, a polymerase, nucleotide substrates and a template polynucleotide, and (b) amplifying the polynucleotide by polymerase reaction, wherein the polymerase has an amino acid sequence consisting of SEQ ID NO:1 or an amino acid sequence with at least 85% sequence identity to SEQ ID NO:1, and an amino acid residue corresponding to, or at position 651 of the amino acid sequence has been replaced with glutamic acid.

Abstract: The present invention provides a method for measuring a substrate concentration by accumulating an energy resulting from a reaction between a biocatalyst and a substrate recognized by the biocatalyst to a certain level; and using a dependency of an accumulation rate on the substrate concentration as an index; and a apparatus therefor. In particular, the present invention provides a method in which the measurement of the accumulation rate is carried out by measuring a frequency of an energy release in a certain amount of time when the energy accumulated in the capacitor reaches the certain level and is then released.

Abstract: Disclosed is a method of amplifying a polynucleotide, comprising: (a) mixing primers for amplifying the polynucleotide, a polymerase, nucleotide substrates and a template polynucleotide, and (b) amplifying the polynucleotide by polymerase reaction, wherein the polymerase has an amino acid sequence consisting of SEQ ID NO:1 or an amino acid sequence with at least 85% sequence identity to SEQ ID NO:1, and wherein an amino acid residue corresponding to position 653 of the amino acid sequence has been replaced with glutamic acid.

Abstract: The present invention provides a method for measuring a substrate concentration by accumulating an energy resulting from a reaction between a biocatalyst and a substrate recognized by the biocatalyst to a certain level; and using a dependency of an accumulation rate on the substrate concentration as an index; and a apparatus therefor. In particular, the present invention provides a method in which the measurement of the accumulation rate is carried out by measuring a frequency of an energy release in a certain amount of time when the energy accumulated in the capacitor reaches the certain level and is then released.

Abstract: A fusion protein of pyrroloquinoline quinone glucose dehydrogenase (PQQGDH) and a cytochrome is disclosed. PQQGDH is, for example, a water-soluble PQQGDH derived from Acinetobacter calcoaceticus. The cytochrome is, for example, an electron transfer domain of quinohemoprotein ethanol dehydrogenase from Comamonas testosteroni. The fusion protein of the present invention shows intramolecular electron transfer from PQQ, a redox center, to the cytochrome, which allow construction of a direct electron transfer-type glucose sensor which requires no electron mediators.

Abstract: A light emitter emits light with a plurality of wavelengths towards a test object held in a spectrophotometer tool. A light receiver receives the light passing through the test object. A detector detects absorbances of wavelength components from the light received by the receiver. An optical path length calculator compares, in the absorbances of the wavelength components detected, a wavelength component absorbance of light absorbed by a pigment that absorbs light with a wavelength other than a wavelength of light absorbed by an analyte in the test object and a predetermined value of the wavelength component absorbance to calculate an optical path length passing through the test object. A corrector corrects the wavelength component absorbance detected excluding the wavelength of the light absorbed by the pigment using the optical path length calculated by the optical path length calculator to calculate a corrected wavelength component absorbance in a reference optical length.

Abstract: In a measurement situation information storage unit, a plurality of sets of measurement situation information for identifying a measurement situation in which predetermined measurement is performed on a measurement target are stored in association with time periods. A measurement processing unit executes measurement on the measurement target. A display unit selects, from among the plurality of sets of measurement situation information, a set of measurement situation information corresponding to the measurement operation timing based on the time of the measurement operation timing or based on processing results obtained as a result of execution of measurement by the measurement processing unit, and causes a display to show the selected set of measurement situation information in a manner distinguishable from other measurement situation information.