Patents Assigned to Armour Pharmaceutical Company
  • Patent number: 5202246
    Abstract: Disclosed are methods of inactivating pyrogen producing organisms and pyrogenic substances in immobilized solid matrices which are used in the production and/or purification of biomedical and pharmaceutical products and materials by contacting the solid matrices with pyrogen inactivating solutions.
    Type: Grant
    Filed: November 18, 1991
    Date of Patent: April 13, 1993
    Assignee: Armour Pharmaceutical Company
    Inventors: Robert Kruse, Sudhish Chandra, Fred Feldman
  • Patent number: 4876241
    Abstract: A method of inactivating pathogens in proteinaceous biological and pharmaceutical products which comprises: mixing the product in an aqueous solution with one or more primary stabilizers selected from the group consisting of sugars and sugar alcohols and one or more secondary stabilizers selected from the group consisting of sodium acetate, potassium acetate, lithium acetate, magnesium acetate, ammonium acetate, barium acetate, sodium sulfate, ammonium sulfate, lithium sulfate, potassium sulfate and magnesium sulfate; and subjecting said aqueous solution to a pathogen inactivating process.
    Type: Grant
    Filed: May 18, 1988
    Date of Patent: October 24, 1989
    Assignee: Armour Pharmaceutical Company
    Inventors: Fred Feldman, Mark S. Klekamp, Michael E. Hrinda, Arthur B. Shaw, Sudhish Chandra
  • Patent number: 4758657
    Abstract: Disclosed is a process for purifying Factor VIII:C in high yield and potency from source material containing Factor VIII:C, Factor VIII:R and other plasma proteins and factors comprising the steps of: adsorbing Factor VIII:C onto a hydrophobic interaction matrix, separating unwanted proteins from Factor VIII:C and eluting Factor VIII:C by a solution containing a surface active agent.
    Type: Grant
    Filed: July 11, 1985
    Date of Patent: July 19, 1988
    Assignee: Armour Pharmaceutical Company
    Inventors: David L. Farb, Ricardo H. Landaburu
  • Patent number: 4746728
    Abstract: New peptides are disclosed which have biological activity of the same type as the known calcitonins and which have a glycine at position 8 instead of the natural valine found in that position. In addition these new peptides do not have a leucine in position 19. The position 19 leucine is omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: May 5, 1986
    Date of Patent: May 24, 1988
    Assignee: Armour Pharmaceutical Company
    Inventors: Ronald C. Orlowski, Jay K. Seyler
  • Patent number: 4659804
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a disulfide bond connecting the cysteines at positions one and seven. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin partially protected peptides.
    Type: Grant
    Filed: November 1, 1984
    Date of Patent: April 21, 1987
    Assignee: Armour Pharmaceutical Company
    Inventors: Ronald C. Orlowski, Jay K. Seyler, Robert L. Colescott, Glenn L. Stahl, Takashi Enkoji, James E. Geever, Everett Flanigan
  • Patent number: 4639511
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a leucine in position 19. The position 19 leucine is omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: November 12, 1985
    Date of Patent: January 27, 1987
    Assignee: Armour Pharmaceutical Company
    Inventors: Ronald C. Orlowski, Jay K. Seyler
  • Patent number: 4639509
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which have an alanine in positions 16 and 19 instead of the natural leucine or phenylalanine found in those positions. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: March 28, 1985
    Date of Patent: January 27, 1987
    Assignee: Armour Pharmaceutical Company
    Inventors: Ronald C. Orlowski, Glenn L. Stahl, Robert L. Colescott
  • Patent number: 4639510
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which have an S-acetamidomethyl cysteine at one and an alanine at seven, or an alanine at one and an S-acetamidomethyl cysteine at seven. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin-type peptides.
    Type: Grant
    Filed: October 4, 1985
    Date of Patent: January 27, 1987
    Assignee: Armour Pharmaceutical Company
    Inventors: Ronald C. Orlowski, Jay K. Seyler, Glenn L. Stahl
  • Patent number: 4622388
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a serine in position 2 nor an asparagine in position 3. Both serine 2 and asparagine 3 are omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: November 12, 1985
    Date of Patent: November 11, 1986
    Assignee: Armour Pharmaceutical Company
    Inventors: Ronald C. Orlowski, Jay K. Seyler
  • Patent number: 4622386
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have cysteines at positions one and seven. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin-type peptides.
    Type: Grant
    Filed: March 28, 1985
    Date of Patent: November 11, 1986
    Assignee: Armour Pharmaceutical Company
    Inventors: Ronald C. Orlowski, Jay K. Seyler, Glenn L. Stahl
  • Patent number: 4605514
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a leucine in position 4. The position 4 leucine is omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: September 24, 1984
    Date of Patent: August 12, 1986
    Assignee: Armour Pharmaceutical Company
    Inventors: Ronald C. Orlowski, Jay K. Seyler, Glenn L. Stahl
  • Patent number: 4605515
    Abstract: New peptides ae disclosed which have biological activity of the same type as known calcitonins and contains only twenty-three amino acids rather than the normally occurring thirty-two amino acids. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: October 24, 1984
    Date of Patent: August 12, 1986
    Assignee: Armour Pharmaceutical Company
    Inventors: Ronald C. Orlowski, Glenn L. Stahl
  • Patent number: 4604238
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which have a shorter amino acid chain than natural calcitonins and are also substitution analogs of the natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: December 10, 1984
    Date of Patent: August 5, 1986
    Assignee: Armour Pharmaceutical Company
    Inventors: Ronald C. Orlowski, Jay K. Seyler, Glenn L. Stahl
  • Patent number: 4604358
    Abstract: This invention relates to a method for producing a plasminogen preparation which has been pasteurized to produce a hepatitis safe injectable plasminogen. The method comprises: adding to an aqueous solution of plasminogen the protective agent of methyl lysine ester, or ethyl lysine ester or a hydrochloride salt thereof which has antifibrinolytic acitivity to thereby attach the agent to plasminogen and form a modified plasminogen; and subjecting the resulting modified agent to a heat treatment of at least 60.degree. C. for at least 10 hours. Further, the protective agent may be separated from the modified plasminogen by affinity chromatography.
    Type: Grant
    Filed: April 11, 1985
    Date of Patent: August 5, 1986
    Assignee: Armour Pharmaceutical Company
    Inventors: Joseph D. Fisher, Chin C. Huang
  • Patent number: 4604237
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a threonine in position 21. The position 21 threonine is omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: November 20, 1984
    Date of Patent: August 5, 1986
    Assignee: Armour Pharmaceutical Company
    Inventors: Ronald C. Orlowski, Jay K. Seyler, Glenn L. Stahl
  • Patent number: 4528132
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which have an alanine in position 16 instead of the natural leucine or phenylalanine found in that position. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: January 13, 1984
    Date of Patent: July 9, 1985
    Assignee: Armour Pharmaceutical Company
    Inventors: Ronald C. Orlowski, Glenn L. Stahl, Robert L. Colescott
  • Patent number: 4524062
    Abstract: Antiperspirant/deodorant stick composition which comprises: a powdered antiperspirant agent the particles of which are enrobed in a coating material, contained in a cologne stick base.
    Type: Grant
    Filed: February 22, 1983
    Date of Patent: June 18, 1985
    Assignee: Armour Pharmaceutical Company
    Inventors: Dennis Laba, John J. Margres, Jr., Kristin Burkhardt
  • Patent number: 4508709
    Abstract: Factor VIII:C is purified by chromatographic absorption on aminohexyl agarose at a pH above 5.5 up to about 8, and preferably 6.5 to 7.2, and a conductivity of about 25 to about 35 mS/cm.
    Type: Grant
    Filed: December 5, 1983
    Date of Patent: April 2, 1985
    Assignee: Armour Pharmaceutical Company
    Inventors: Godfrey W. Amphlett, Michael E. Hrinda
  • Patent number: 4497732
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which have a longer amino acid chain than natural calcitonins, specifically, the peptide chain of the disulfide ring is enlarged. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: October 21, 1983
    Date of Patent: February 5, 1985
    Assignee: Armour Pharmaceutical Company
    Inventors: Jay K. Seyler, Glenn L. Stahl, Ronald C. Orlowski
  • Patent number: D289548
    Type: Grant
    Filed: December 26, 1984
    Date of Patent: April 28, 1987
    Assignee: Armour Pharmaceutical Company
    Inventors: Ardis R. Lavender, Michael Diker