Patents Assigned to Armour Pharmaceutical Company
-
Patent number: 5202246Abstract: Disclosed are methods of inactivating pyrogen producing organisms and pyrogenic substances in immobilized solid matrices which are used in the production and/or purification of biomedical and pharmaceutical products and materials by contacting the solid matrices with pyrogen inactivating solutions.Type: GrantFiled: November 18, 1991Date of Patent: April 13, 1993Assignee: Armour Pharmaceutical CompanyInventors: Robert Kruse, Sudhish Chandra, Fred Feldman
-
Patent number: 4876241Abstract: A method of inactivating pathogens in proteinaceous biological and pharmaceutical products which comprises: mixing the product in an aqueous solution with one or more primary stabilizers selected from the group consisting of sugars and sugar alcohols and one or more secondary stabilizers selected from the group consisting of sodium acetate, potassium acetate, lithium acetate, magnesium acetate, ammonium acetate, barium acetate, sodium sulfate, ammonium sulfate, lithium sulfate, potassium sulfate and magnesium sulfate; and subjecting said aqueous solution to a pathogen inactivating process.Type: GrantFiled: May 18, 1988Date of Patent: October 24, 1989Assignee: Armour Pharmaceutical CompanyInventors: Fred Feldman, Mark S. Klekamp, Michael E. Hrinda, Arthur B. Shaw, Sudhish Chandra
-
Patent number: 4758657Abstract: Disclosed is a process for purifying Factor VIII:C in high yield and potency from source material containing Factor VIII:C, Factor VIII:R and other plasma proteins and factors comprising the steps of: adsorbing Factor VIII:C onto a hydrophobic interaction matrix, separating unwanted proteins from Factor VIII:C and eluting Factor VIII:C by a solution containing a surface active agent.Type: GrantFiled: July 11, 1985Date of Patent: July 19, 1988Assignee: Armour Pharmaceutical CompanyInventors: David L. Farb, Ricardo H. Landaburu
-
Patent number: 4746728Abstract: New peptides are disclosed which have biological activity of the same type as the known calcitonins and which have a glycine at position 8 instead of the natural valine found in that position. In addition these new peptides do not have a leucine in position 19. The position 19 leucine is omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.Type: GrantFiled: May 5, 1986Date of Patent: May 24, 1988Assignee: Armour Pharmaceutical CompanyInventors: Ronald C. Orlowski, Jay K. Seyler
-
Patent number: 4659804Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a disulfide bond connecting the cysteines at positions one and seven. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin partially protected peptides.Type: GrantFiled: November 1, 1984Date of Patent: April 21, 1987Assignee: Armour Pharmaceutical CompanyInventors: Ronald C. Orlowski, Jay K. Seyler, Robert L. Colescott, Glenn L. Stahl, Takashi Enkoji, James E. Geever, Everett Flanigan
-
Patent number: 4639510Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which have an S-acetamidomethyl cysteine at one and an alanine at seven, or an alanine at one and an S-acetamidomethyl cysteine at seven. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin-type peptides.Type: GrantFiled: October 4, 1985Date of Patent: January 27, 1987Assignee: Armour Pharmaceutical CompanyInventors: Ronald C. Orlowski, Jay K. Seyler, Glenn L. Stahl
-
Patent number: 4639511Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a leucine in position 19. The position 19 leucine is omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.Type: GrantFiled: November 12, 1985Date of Patent: January 27, 1987Assignee: Armour Pharmaceutical CompanyInventors: Ronald C. Orlowski, Jay K. Seyler
-
Patent number: 4639509Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which have an alanine in positions 16 and 19 instead of the natural leucine or phenylalanine found in those positions. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.Type: GrantFiled: March 28, 1985Date of Patent: January 27, 1987Assignee: Armour Pharmaceutical CompanyInventors: Ronald C. Orlowski, Glenn L. Stahl, Robert L. Colescott
-
Patent number: 4622386Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have cysteines at positions one and seven. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin-type peptides.Type: GrantFiled: March 28, 1985Date of Patent: November 11, 1986Assignee: Armour Pharmaceutical CompanyInventors: Ronald C. Orlowski, Jay K. Seyler, Glenn L. Stahl
-
Patent number: 4622388Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a serine in position 2 nor an asparagine in position 3. Both serine 2 and asparagine 3 are omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.Type: GrantFiled: November 12, 1985Date of Patent: November 11, 1986Assignee: Armour Pharmaceutical CompanyInventors: Ronald C. Orlowski, Jay K. Seyler
-
Patent number: 4605515Abstract: New peptides ae disclosed which have biological activity of the same type as known calcitonins and contains only twenty-three amino acids rather than the normally occurring thirty-two amino acids. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.Type: GrantFiled: October 24, 1984Date of Patent: August 12, 1986Assignee: Armour Pharmaceutical CompanyInventors: Ronald C. Orlowski, Glenn L. Stahl
-
Patent number: 4605514Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a leucine in position 4. The position 4 leucine is omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.Type: GrantFiled: September 24, 1984Date of Patent: August 12, 1986Assignee: Armour Pharmaceutical CompanyInventors: Ronald C. Orlowski, Jay K. Seyler, Glenn L. Stahl
-
Patent number: 4604358Abstract: This invention relates to a method for producing a plasminogen preparation which has been pasteurized to produce a hepatitis safe injectable plasminogen. The method comprises: adding to an aqueous solution of plasminogen the protective agent of methyl lysine ester, or ethyl lysine ester or a hydrochloride salt thereof which has antifibrinolytic acitivity to thereby attach the agent to plasminogen and form a modified plasminogen; and subjecting the resulting modified agent to a heat treatment of at least 60.degree. C. for at least 10 hours. Further, the protective agent may be separated from the modified plasminogen by affinity chromatography.Type: GrantFiled: April 11, 1985Date of Patent: August 5, 1986Assignee: Armour Pharmaceutical CompanyInventors: Joseph D. Fisher, Chin C. Huang
-
Patent number: 4604237Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a threonine in position 21. The position 21 threonine is omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.Type: GrantFiled: November 20, 1984Date of Patent: August 5, 1986Assignee: Armour Pharmaceutical CompanyInventors: Ronald C. Orlowski, Jay K. Seyler, Glenn L. Stahl
-
Patent number: 4604238Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which have a shorter amino acid chain than natural calcitonins and are also substitution analogs of the natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.Type: GrantFiled: December 10, 1984Date of Patent: August 5, 1986Assignee: Armour Pharmaceutical CompanyInventors: Ronald C. Orlowski, Jay K. Seyler, Glenn L. Stahl
-
Patent number: 4528132Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which have an alanine in position 16 instead of the natural leucine or phenylalanine found in that position. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.Type: GrantFiled: January 13, 1984Date of Patent: July 9, 1985Assignee: Armour Pharmaceutical CompanyInventors: Ronald C. Orlowski, Glenn L. Stahl, Robert L. Colescott
-
Patent number: 4524062Abstract: Antiperspirant/deodorant stick composition which comprises: a powdered antiperspirant agent the particles of which are enrobed in a coating material, contained in a cologne stick base.Type: GrantFiled: February 22, 1983Date of Patent: June 18, 1985Assignee: Armour Pharmaceutical CompanyInventors: Dennis Laba, John J. Margres, Jr., Kristin Burkhardt
-
Patent number: 4508709Abstract: Factor VIII:C is purified by chromatographic absorption on aminohexyl agarose at a pH above 5.5 up to about 8, and preferably 6.5 to 7.2, and a conductivity of about 25 to about 35 mS/cm.Type: GrantFiled: December 5, 1983Date of Patent: April 2, 1985Assignee: Armour Pharmaceutical CompanyInventors: Godfrey W. Amphlett, Michael E. Hrinda
-
Patent number: 4497732Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which have a longer amino acid chain than natural calcitonins, specifically, the peptide chain of the disulfide ring is enlarged. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.Type: GrantFiled: October 21, 1983Date of Patent: February 5, 1985Assignee: Armour Pharmaceutical CompanyInventors: Jay K. Seyler, Glenn L. Stahl, Ronald C. Orlowski
-
Patent number: D289548Type: GrantFiled: December 26, 1984Date of Patent: April 28, 1987Assignee: Armour Pharmaceutical CompanyInventors: Ardis R. Lavender, Michael Diker