Patents Assigned to Armour Pharmaceutical Company
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Patent number: 4497731Abstract: Two new peptides are disclosed which have biological activity of the same type as known calcitonins, which have a shorter amino acid chain than natural calcitonins and which are substitution analogs of the natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.Type: GrantFiled: April 4, 1983Date of Patent: February 5, 1985Assignee: Armour Pharmaceutical CompanyInventors: Ronald C. Orlowski, Jay K. Seyler
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Patent number: 4495097Abstract: Two new peptides are disclosed which have biological activity of the same type as known calcitonins and which have a shorter amino acid chain than natural calcitonins and are also substitution analogs of the natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.Type: GrantFiled: April 4, 1983Date of Patent: January 22, 1985Assignee: Armour Pharmaceutical CompanyInventors: Ronald C. Orlowski, Jay K. Seyler
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Patent number: 4486410Abstract: Antihemophilic factor (AHF), a blood component necessary for clotting of normal whole blood, is extracted from cryoprecipitate containing AHF and fibrinogen as its principal components by: rapidly raising and thereafter lowering the temperature of the cryoprecipitate suspension to selectively denature the fibrinogen in the suspension; and separating the AHF-rich supernatant from the denatured fibrinogen.Type: GrantFiled: February 9, 1984Date of Patent: December 4, 1984Assignee: Armour Pharmaceutical CompanyInventor: Joseph D. Fisher
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Patent number: 4478829Abstract: Disclosed are readily reconstitutable lyophilized fibronectin formulations containing fibronectin, a neutral salt, a carbohydrate and a surface active agent.Type: GrantFiled: March 30, 1984Date of Patent: October 23, 1984Assignee: Armour Pharmaceutical CompanyInventors: Ricardo H. Landaburu, Robert H. Yue, David L. Farb, Bernard N. Violand
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Patent number: 4478825Abstract: Antihemophilic factor (AHF), a blood protein component necessary for clotting of normal whole blood, is extracted and concentrated from a cryoprecipitate suspension containing AHF and fibrinogen as its principal components by: selectively precipitating fibrinogen from a water-ethanol solution and removing the ethanol therefrom.Type: GrantFiled: October 14, 1983Date of Patent: October 23, 1984Assignee: Armour Pharmaceutical CompanyInventor: James W. Bloom
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Patent number: 4469632Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which have a D-amino acid in position 24 instead of the natural L-amino acid. Also resin peptides are disclosed which may be converted to peptides having such biological activity, and processes for producing said resin peptides and said calcitonin peptides.Type: GrantFiled: September 24, 1982Date of Patent: September 4, 1984Assignee: Armour Pharmaceutical CompanyInventors: Ronald C. Orlowski, Jay K. Seyler
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Patent number: 4451395Abstract: Two new peptides are disclosed which have biological activity of the same type as known calcitonins and which have a shorter amino acid chain than natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.Type: GrantFiled: November 8, 1982Date of Patent: May 29, 1984Assignee: Armour Pharmaceutical CompanyInventors: Ronald C. Orlowski, Jay K. Seyler
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Patent number: 4444681Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which are substitution analogs of natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.Type: GrantFiled: September 24, 1982Date of Patent: April 24, 1984Assignee: Armour Pharmaceutical CompanyInventors: Glenn L. Stahl, Ronald C. Orlowski
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Patent number: 4434155Abstract: Basic aluminum bromides having a basicity of about 5/6 have been found to be readily soluble in cosmetic solvents such as anhydrous ethanol, to have a high degree of compatibility with halogenated hydrocarbons, and to have excellent astringent characteristics. These properties make the 5/6 basic aluminum bromides particularly suitable for use in anti-perspirant compositions, especially the aerosol sprays.Type: GrantFiled: November 9, 1970Date of Patent: February 28, 1984Assignee: Armour Pharmaceutical CompanyInventors: John L. Jones, Andrew M. Rubino
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Patent number: 4430155Abstract: A process and improved apparatus are provided for producing macrospherical particles. The particles themselves have increased wall thicknesses and higher densities than particles produced by conventional means and are thus not subject to deep lung penetration. The produced particles are also of controlled (narrow) particle size distribution. Such particles are particularly well adapted for use as anti-perspirants. The process for producing the particles comprises providing a solution containing the materials from which the particles are made, dispersing the solution along a plurality of radially disposed bristles by centrifugal force into discrete liquid droplets and drying the solution droplets in a stream of heated air. The improved apparatus comprises mounting a rotatable atomizer having a plurality of bristles inside a spray drying chamber.Type: GrantFiled: June 15, 1982Date of Patent: February 7, 1984Assignee: Armour Pharmaceutical CompanyInventors: James F. Kozischek, M. Donner Martin, Jr.
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Patent number: 4422967Abstract: The purification of crude calcitonin by subjecting a crude calcitonin material to partition chromatography in which the solvent utilized is a mixture of butanol, a lower aliphatic alcohol, which is ethanol, methanol, or propanol, or mixtures thereof, acetic acid, water and ammonium acetate. In place of acetic acid and ammonium acetate, formic acid and ammonium formate may be used. The crude calcitonin of this invention is of a type known as ultimobronchial calcitonin. This includes calcitonins of the salmon and eel, whether the calcitonins of this type be obtained from natural sources or are prepared by synthesis.Type: GrantFiled: May 19, 1982Date of Patent: December 27, 1983Assignee: Armour Pharmaceutical CompanyInventors: Ronald C. Orlowski, Charles M. Groginsky, Jay K. Seyler
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Patent number: 4414149Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins which have both a D-amino acid in position 24 instead of the natural L-amino acid and are substitution analogs of the natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.Type: GrantFiled: March 4, 1983Date of Patent: November 8, 1983Assignee: Armour Pharmaceutical CompanyInventors: Ronald C. Orlowski, Jay K. Seyler
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Patent number: 4401593Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which are substitution analogs of the natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.Type: GrantFiled: February 12, 1982Date of Patent: August 30, 1983Assignee: Armour Pharmaceutical CompanyInventors: Ronald C. Orlowski, Jay K. Seyler
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Patent number: 4397780Abstract: Two new peptides are disclosed which have biological activity of the same type as known calcitonins and which are substitution analogs of natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.Type: GrantFiled: February 12, 1982Date of Patent: August 9, 1983Assignee: Armour Pharmaceutical CompanyInventors: Ronald C. Orlowski, Jay K. Seyler
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Patent number: 4391747Abstract: Peptides are disclosed which have biological activity of the same type as known calcitonins and which have a shorter amino acid chain than natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.Type: GrantFiled: February 12, 1982Date of Patent: July 5, 1983Assignee: Armour Pharmaceutical CompanyInventors: Ronald C. Orlowski, Jay K. Seyler
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Patent number: 4388235Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which have a shorter amino acid chain than natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.Type: GrantFiled: February 12, 1982Date of Patent: June 14, 1983Assignee: Armour Pharmaceutical CompanyInventors: Ronald C. Orlowski, Jay K. Seyler
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Patent number: 4385050Abstract: Peptides of the structureR.sub.1 --Ala--Arg--Ile--Glu--Asn--Glu--Glu--Glu--Gln--Ala--Gly--Leu--Asn--Arg--Ly s--Tyr--Leu--Val--R.sub.2whereinR.sub.1 is hydrogen, a peptide residue containing from 1 to 18 amino acid residues, or N-acyl, andR.sub.2 is hydrogen, an alcohol moiety of an ester, an amide, or a peptide residue containing from 1 to 10 amino acid residues,whereinthe acyl group is lower alkanoyl having from 1 to 8 carbon atoms, aroyl, or heterocarbonyl, and the alcohol moiety of the ester is an alkyl group having from 1 to 8 carbon atoms have antihypertensive activity.Type: GrantFiled: June 26, 1981Date of Patent: May 24, 1983Assignee: Armour Pharmaceutical CompanyInventors: Karl Lederis, David Stevenson, Donald B. Olsen, Charles D. Bossinger, Everett Flanigan
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Patent number: 4336187Abstract: The purification of crude calcitonin by subjecting a crude calcitonin material to partition chromatography in which the solvent utilized is a mixture of butanol, a lower alphatic alcohol which is ethanol, methanol, or propanol, or mixtures thereof, acetic acid, water and ammonium acetate. The crude calcitonin of this invention is of a type known as ultimobronchial calcitonin. This includes calcitonins of the salmon and eel, whether the calcitonins of this type be obtained from natural sources or are prepared by synthesis. Preferably, the crude calcitonins of this type, which are purified by the process herein set forth, are obtained by solid phase synthesis in which the amino acid chain is assembled by attaching a resin support to the first amino acid, adding the amino acids one-by-one in the order in which they appear in the natural calcitonin; and finally removing the resin and the protective groups used in the synthesis.Type: GrantFiled: September 22, 1980Date of Patent: June 22, 1982Assignee: Armour Pharmaceutical CompanyInventors: Ronald C. Orlowski, Charles M. Groginsky, Jay K. Seyler
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Patent number: 4304692Abstract: A new peptide which has calcitonin-like biological activity which has a shorter amino acid chain and which is chemically more stable than natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having biological activity and processes for producing said resin peptides and said peptides having biological activity.Type: GrantFiled: July 14, 1980Date of Patent: December 8, 1981Assignee: Armour Pharmaceutical CompanyInventors: John L. Hughes, Jay K. Seyler, Robert C. Liu
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Patent number: 4301045Abstract: Resin peptides useful in the preparation of peptides having biological activity, and particularly such resin peptides containing Pro--Asp--CH.sub.2 -- or Pro--Asn--CH.sub.2 -- at one end of an amino acid chain, being the resin and Pro, Asp and Asn being the residues of the amino acids proline, aspartic acid and asparagine; and processes for the preparation of such resin peptides.Type: GrantFiled: May 2, 1977Date of Patent: November 17, 1981Assignee: Armour Pharmaceutical CompanyInventors: Emil Kaiser, Robert L. Colescott