Abstract: A method of measuring a biological process, the method including the steps of: (a) determining a probability density function for a series of repeated measurements of the biological process; (b) approximating the probability density function utilising a parametric formula; (c) determining a maximum likelihood estimator for the parametric formulation of the probability density function; and (d) utilising the maximum likelihood estimator for subsequent measurements of the biological process.

Abstract: The invention provides kinase inhibitors of Formula I: wherein either: (1) R1 is H, and (a) R2 is (3-chlorobenzyl)oxy- and R3 is chloro; (b) R2 and R3, together with the carbon atoms to which they are attached, form 1-(3-fluorobenzyl)-1H-pyrazole; (c) R2 is 2-pyridinylmethoxy and R3 is chloro; (d) R2 and R3 are both chloro; (e) R2 is chloro and R1 is bromo; (f) R2 and R3 are both bromo; (g) R2 is fluoro and R3 is ethynyl; (h) R2 is chloro and R3 is ethynyl; (i) R2 is bromo and R3 is ethynyl; (j) other than when R1 is in the 3-position in combination with R3, in the 4-position, R2 is bromo and R3 is fluoro; (k) R2 is 2-pyridinylmethoxy and R3 is fluoro; or (l) R2 is 2-pyridinylmethoxy and R1 is bromo; or (2) at least one of R1, R2 and R3 is selected from benzyloxy, 3-chlorobenzyloxy and 2-pyridinylmethoxy and when at least one of R1, R2 and R3 is not benzyloxy, 3-chlorobenzyloxy or 2-pyridinylmethoxy, each of the others is independently selected from H, halogen, and C2-C4 alkynyl, with the proviso tha

Abstract: A method is provided for controlling a resonant circuit (1) of an ICPT system. The resonant circuit has a controlled variable reactance (2), and a predetermined perturbation is introduced in the magnitude of variable reactance. The change in a property of the resonant circuit in response to the perturbation is sensed, and the variable reactance is varied to alter the resonant frequency of the circuit in response to the sensed change.

Abstract: An arrangement for supplying a load with electrical energy from a power source comprises a textile, woven floor covering (101) with longitudinally running warp threads and transversely running weft threads, three or more current conductors (106) that are spaced apart and substantially parallel to one another being woven in either as warp threads or as weft threads, the current conductors replacing part of a filling warp, a binding warp or the weft threads during the weaving operation. The arrangement also comprises a feed for the connection of the current conductors (106) to the power source and a coupling device (130) for picking up electrical energy from the current conductors (106) in the floor covering (101) and transporting it further to the load when the coupling device (130) is brought into a power pick-up area of the floor covering (101).

Abstract: A system and method is provided for determining the capacitance between electrodes of an artificial muscle or dielectric elastomer actuator (DEA). The method comprises measuring the voltage difference between the electrodes of the DEA, the first derivative of that voltage with respect to time, and the total instantaneous current through the DEA, then calculating the capacitance of the DEA as the difference between the total instantaneous current through the DEA and the product of the voltage between the electrodes and an error term, divided by the first derivative of the voltage between the electrodes with respect to time. The capacitance may then be used to derive estimates of the leakage current, charge upon the DEA, and/or the physical state of the DEA, thereby implementing self-sensing to allow closed-loop feedback control of DEA actuation.

Abstract: An array of actuators is provided which is adapted for sequential actuation by way of mechano-sensitivity propagating actuation through the array, triggering each actuator upon deformation thereof caused by an adjacent actuator or a load in the form of a fluid or a solid object. Actuation is thus coordinated with minimal computational overhead. Also provided is an actuator suitable for use in such an array, a method of controlling an actuator, and a method of controlling an array of mechano-sensitive actuators.

Abstract: The invention relates to isolated peptides comprising at least the amino acid sequence YDRREY (SEQ ID NO:1) or a derivative thereof, nucleic acid encoding the peptides, pharmaceutical compositions and methods for modulating ? 7 integrin function, including methods for treatment of inflammatory disorders, antibodies directed to the peptides and methods for identification of integrin ?7 functional interactors.

Abstract: A power pick-up for an Inductively Coupled Power Transfer (ICPT) system is provided having a resonant pick up circuit. The natural frequency of the pick-up circuit may be varied by controlling the conductance or capacitance of a variable reactive in the resonant circuit. The load being supplied by the pick-up circuit is sensed, and the effective capacitance or inductance of the variable reactive component is controlled to vary the natural resonant frequency of the pick-up circuit to thereby control the power flow into the pick-up to satisfy the power required by the load.

Abstract: A method is provided for controlling the output voltage of a pickup in an inductive power transfer (IPT) system without any additional form of communications for feedback from the pickup to the power supply. The method comprising the steps of deriving an estimate of the output voltage of the pickup from the voltage across the primary conductive path, and adjusting the current in the primary conductive path so that the estimated pick-up output voltage matches a required pick-up output voltage. In particular, an estimate of the pickup output voltage is derived from the magnitude and phase angle of the voltage in the primary conductive path.

Abstract: A resonant converter is provided which may be used for supplying power to the primary conductive path of an inductively coupled power transfer (ICPT) system. The converter includes a variable reactive element in the resonant circuit which may be controlled to vary the effective inductance or capacitance of the reactive element. The frequency of the converter is stabilised to a nominal value by sensing the frequency of the converter resonant circuit, comparing the sensed frequency with a nominal frequency and varying the effective inductance or capacitance of the variable reactive element to adjust the converter frequency toward the nominal frequency.

Abstract: A resonant converter is provided which may be used for supplying power to the primary conductive path of an inductively coupled power transfer (ICPT) system. The converter includes a variable reactive element in the resonant circuit which may be controlled to vary the effective inductance or capacitance of the reactive element. The frequency of the converter is stabilised to a nominal value by sensing the frequency of the converter resonant circuit, comparing the sensed frequency with a nominal frequency and varying the effective inductance or capacitance of the variable reactive element to adjust the converter frequency toward the nominal frequency.

Abstract: A method, apparatus, and system are provided which enables the control of contactless power transfer in an inductive power transfer system using a phase control technique. The method comprises adjusting the phase of a secondary-side converter output voltage with respect to that of a primary-side converter. The magnitude of power transfer is determined by the relative phase angle, and the direction of power transfer is determined by whether the secondary converter output voltage leads or lags the input converter voltage, thereby enabling bi-directional power transfer between the primary and secondary sides of the system. According to alternative embodiments, the method may also be used for uni-directional power transfer only, and/or the secondary converter may be operated to maintain a constant relative phase angle.

Abstract: A method and system for watermarking software is disclosed. In one aspect, the method and system include providing an input sequence and storing a watermark in the state of a software object as the software object is being run with the input sequence. In another aspect, the method and system verify the integrity or origin of a program by watermarking the program. The watermark is stored as described above. In this aspect, the method and system also include building a recognizer concurrently with the input sequence and the watermark. The recognizer can extract the watermark from other dynamically allocated data and is kept separately from the program. The recognizer is adapted to check for a number. In another aspect, the software is watermarked by embedding a watermark in a static string and applying an obfuscation technique to convert the static string into executable code. In another aspect, the watermark is chosen from a class of graphs having a plurality of members and applied to the software.

Abstract: A method of slowing the progression of myopia in a person, comprises applying to the eye of the person contact lens or lenses each including a vision correction area for correcting in use the myopic vision of a wearer, and a myopic defocus area having a less negative focal power, to simultaneously present a controlled myopic defocus to the retina both when viewing in the distance and also when viewing at near. Contact lenses and their use are also claimed.

Abstract: The invention relates to novel tricyclic 1,2,4-triazine-1-oxides and novel tricyclic 1,2,4-triazine-1,4-dioxides of formula I and to related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.

Abstract: A light emitting structure comprising a hot electron source and a layer of ptoelectronic material disposed thereon and optionally p-type material disposed on the optoelectronic material. For example, a light emitting structure that comprises, in order, a polycrystalline silicon layer, a silicon dioxide layer, a zinc oxide layer and an indium tin oxide (ITO) layer. When a sufficient voltage is applied across the layers, light is generated.

Abstract: A heat exchanger 10 includes a conduit 12 for conveying cooling fluid relative to a body to be cooled. A heat transfer arrangement 62 is arranged in communication with an interior of the conduit 12, the heat transfer arrangement 62 and the conduit 12 together defining an assembly that is mountable adjacent the body to be cooled, convective heat exchange occurring, in use, due to movement of the cooling fluid relative to the body and to the heat transfer arrangement 62 of the assembly and radiant heat exchange occurring between the body and at least part of the heat transfer arrangement 62 of the assembly.

Abstract: Provided herein are novel heteroaryl compounds, compositions comprising the compounds, and methods of treatment or prevention comprising administration of the compounds. The compounds are effective in the targeting of cells defective in the von Hippel-Lindau gene and in inducing autophagic cell death. The methods are directed to treating or preventing diseases such as cancer, and in particular cancers resulting from von Hippel-Lindau disease. The compounds of the invention may be administered in combination with another therapeutic agent.

Abstract: The invention provides an actuator for an electric motor and an electric motor including said actuator. The actuator includes one or more body formed from a dielectric elastomer, each body having at least one active region that is directly or indirectly coupled to a drive means. The active regions are arranged such that, in use, actuation thereof causes driven means to move with components in at least first and second directions, preferably within a plane of the body.

Abstract: A real-time stereo image matching system for stereo image matching of a pair of images captured by a pair of cameras (12, 14). The system may be in the form of a computer expansion card (10) for running on a host computer (11). The computer expansion card comprises an external device interface (16) for receiving the image pixel data (13, 15) of the pair of images from the cameras and a hardware device (20) having logic that is arranged to implement a symmetric dynamic programming stereo matching algorithm for generating disparity map data (26) for the host computer (11).