Abstract: A heat exchanger 10 includes a conduit 12 for conveying cooling fluid relative to a body to be cooled. A heat transfer arrangement 62 is arranged in communication with an interior of the conduit 12, the heat transfer arrangement 62 and the conduit 12 together defining an assembly that is mountable adjacent the body to be cooled, convective heat exchange occurring, in use, due to movement of the cooling fluid relative to the body and the heat transfer arrangement 62 of the assembly and radiant heat exchange occurring between the body and at least part of the heat transfer arrangement 62 of the assembly.

Abstract: Provided herein are substituted pyrimidine and triazine derivatives, including bicyclic pyrimidine derivatives, their pharmaceutical compositions, their preparation, and their use as agents or drugs for cancer therapy, either alone or in combination with radiation and/or other anticancer drugs. In one embodiment, the pyrimidine and triazine derivatives are morpholino-pyrimidine, morpholino-triazine, pyridyl-pyrimidine, and pyridyl-triazine derivatives which are selective irreversible inhibitors of the p110? isoform of PI3K.

Abstract: The present invention relates to yeast strains and, in particular, to yeast strains for use in fermentation processes. The invention also relates to methods of fermentation using the yeast strains of the invention either alone or in combination with other yeast strains. The invention further relates to methods for the selection of yeast strains suitable for fermentation cultures by screening for various metabolic products and the use of specific nutrient sources.

Abstract: The invention relates to SSL7 mutants which have no, or at least reduced, ability to bind to IgA. The mutants have significant application in the purification or isolation of C5 from samples and in the identification or detection, including quantitation, of C5 in samples. Use of the mutants has the benefit of minimising or preventing simultaneous isolation and/or detection of IgA in a sample, simplifying and improving methods relying on wild type SSL7.

Abstract: A method of slowing the progression of myopia in a person, comprises applying to the eye of the person contact lens or lenses each including a vision correction area for correcting in use the myopic vision of a wearer, and a myopic defocus area having a less negative focal power, to simultaneously present a controlled myopic defocus to the retina both when viewing in the distance and also when viewing at near. Contact lenses and their use are also claimed.

Abstract: The inventions relate generally to vesiculin peptides and vesiculin peptide chains, and fragments, variants and derivatives thereof, related compositions and formulations and their preparation and use, nucleic acids encoding such vesiculin peptides and vesiculin peptide chains, and fragments, variants and derivatives thereof and related vectors and host cells, hybridomas and antibodies, and methods for the prevention and treatment of conditions, diseases and disorders that would be improved, eased, or lessened by the administration of a composition of the invention, including but not limited to glucose metabolism diseases.

Abstract: The invention relates to methods of use of SET1 proteins or functional equivalents thereof. More particularly the invention relates to the use of SET1 proteins or functional equivalents thereof in procedure, for identification and/or isolation of IgA and the scrum complement factor C5.

Abstract: A system (10) for controlling an industrial plant (12) comprises automatic control equipment (14) comprising a plurality of measurement sensors (16) for sensing predetermined variables associated with components of the industrial plant (12). The sensors (16) generate measured data relating to operation of the components of the industrial plant (12). A database (20) contains operational data, including observational data, regarding the industrial plant (12). A processor (18) is in communication with the automatic control equipment (14) and the database (20) for receiving the measured data from the sensors (16) of the automatic control equipment (14) and the operational data from the database (20). The processor (18) manipulates the measured and operational data to provide an evolving description of a process condition of each component over time, along with output information relating to operational control of the industrial plant (12) and for updating the database (20).

Abstract: An inductively coupled power transfer system has a power pick-up that uses an asymmetrical magnetically permeable core (103, 105, 106, 107). Such cores have been found to provide a significant increase in the output power for given losses and given core volume when transferring power from a primary conductive path (101) to a secondary coil (104) provided on the core.

Abstract: Contact lenses and methods for preventing or slowing progression of myopia are described. The contact lenses include a vision correction area and a myopic defocus area. Various examples of the contact lenses are described. Methods include providing the present contact lenses, or applying one or more of the contact lenses to an eye or eyes of a person. The contact lenses and methods are particularly useful in children.

Abstract: The compound 3-ethyl-6-[3-(4-morpholinyl)propoxy]-1,2,4-benzotriazine 1,4-dioxide and pharmacologically acceptable salts thereof. A method of treating cancer in a subject is also described in which 3-ethyl-6-[3-(4-morpholinyl)propoxy]-1,2,4-benzotriazine 1,4-dioxide or a pharmacologically acceptable salt thereof is administered to tumor cells in a hypoxic environment. Also described is a method of radiosensitising in a subject tumor cells of solid tumors in hypoxic conditions by administering to the subject a pharmaceutical composition containing 3-ethyl-6-[3-(4-morpholinyl)propoxy]-1,2,4-benzotriazine 1,4-dioxide or a pharmacologically acceptable salt thereof in an amount sufficient to produce radiosensitivity in the tumor cells, and subjecting the tumor cells to radiation.

Abstract: Pyrazolo[1,5-a]pyridines are described, including methods for their preparation, and their use as agents or drugs for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.

Abstract: A pick-up is provided for an Inductively Coupled Power Transfer (ICPT) system having a parallel tuned resonant pick-up circuit. The pick-up has a plurality of independently controllable power supply outputs. This allows a first output to supply a high voltage load (e.g. 300V-550V) and one or more additional outputs for supplying other loads such as control circuitry which may only require 24V. The one or more additional outputs may be supplied via a current transformer connected in series with the resonant pick-up circuit. Control for each output may be achieved by partially or completely decoupling the pick-up from a primary conductive path of the ICPT system.

Abstract: Nitroaniline-based unsymmetrical mustards of the general formula (I) are provided, together with methods of preparation and methods for their use as prodrugs for gene-dependent enzyme prodrug therapy (GDEPT) and cell ablation therapy in conjunction with nitroreductase enzymes as hypoxia selective cytotoxins and as anticancer agents.

Abstract: Aniline copolymers and the synthesis thereof for use as antimicrobial (antibacterial, antifungal or antiviral material) material of for the manufacture of antimicrobial objects, suitable for use in the health, food, packaging, water, paint, wood, textile, poultry, glass, paper, rubber, ceramic, seafood, sports, plastic and agricultural industries. The copolymer may be for example (A): where for example R3=H5—CO2H, —CO2Me, or —CO2Et. R is typically H or a C1-C6 alkyl, x is an integer between 1 and 0 and m indicates the degree of polymerisation. Preferred copolymers are copolymers of aniline with 3-aminobenzoic acid, 2-aminobenzoic acid and ethyl 3-aminobenzoate.

Abstract: A method of slowing the progression of myopia in a person, comprises applying to the eye of the person contact lens or lenses each including a vision correction area for correcting in use the myopic vision of a wearer, and a myopic defocus area having a less negative focal power, to simultaneously present a controlled myopic defocus to the retina both when viewing in the distance and also when viewing at near. Contact lenses and their use are also claimed.

Abstract: The present invention relates generally to nitro-1,2-dihydro-3H-benzo[e]indoles and related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.

Abstract: The invention relates to methods of preparing compounds of formula (II) wherein Z represents —OR1 or N(R2)R2a—, where R1 is lower alkylene (C1-C6), R2 is lower alkyl or H and R2a is lower alkylene (C1-C6) or H; Q is absent when R2a is H and is otherwise selected from the group consisting of H, —OH and protected forms of —OH; one of X and Y is halogen and the other is —OSO2R3, where R3 is selected from the group consisting of lower alkyl (C1-C6), phenyl and CH2phenyl. The method comprises the steps of: (a) reacting a compound of formula (I) with aziridineethanol or a 2-[(2-haloethyl)amino]ethanol in the presence of a metal halide, to form a compound of the formula (III) wherein one of X and E is halogen and the other is hydroxy, and (b) reacting the compound of formula (III) with an alkyl- or arylsulfonyl halide or alkyl- or arylsulfonyl anhydride to obtain a compound of the formula (II).

Abstract: A biophysical virtual model of a body or body section of a human subject contains measured parameter values, scan data and images from surface or full body imaging systems, and also descriptive and subject identification data. Data in the model are applied to customize external objects ergonomically to fit a subject, by adjustment or by selection when the objects are configured for one or a group of subjects. The database can be centralized and/or mobile devices carried by users can supply model data to external apparatus. Where a parameter value needed for a subject is unknown, the statistical distribution of the database and the correlation of parameters can supply a probable value and level of certainty. In connection with values that are known for an individual, complexities inherent in the combination of plural parameters can be collected in the model and used in later security screens to confirm the identity of a subject.

Abstract: A microfabricated device (10) includes a structure (12) defining a closed fluid delivery channel (14), the channel (14) having an inlet (16) and an opposed outlet (18). A conducting polymer actuator (20) is arranged within the fluid delivery channel (14). At least a part of the actuator (20) is configured to vary its cross sectional area in a direction transverse to a direction of fluid flow in the channel (14). An actuator control arrangement (22) is carried by the structure (12) for controlling the actuator (20) to cause the actuator (20) to expand and contract cyclically and sequentially along the length of the actuator (20) to vary the cross sectional area of the channel (14) cyclically and sequentially to effect a peristaltic pumping action to deliver fluid from the inlet (16) of the channel (14) to the outlet (18) of the channel (14).