Patents Assigned to Auspex Pharmaceuticals, Inc.
  • SUBSTITUTED PDE5 INHIBITORS
    Publication number: 20100234388
    Abstract: Provided herein are substituted PDE5 inhibitors of Formula (1), and processes of preparation and pharmaceutical compositions thereof. Also provided are methods of their use for the treatment and/or management of hypertension, erectile dysfunction, and/or the inability to maintain improved erectile function. The compounds are deuterated tadalafil derivatives.
    Type: Application
    Filed: June 8, 2007
    Publication date: September 16, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • SUBSTITUTED PHENETHYLAMINES
    Publication number: 20100222257
    Abstract: Disclosed herein are substituted phenethylamine alpha adrenergic receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: May 17, 2010
    Publication date: September 2, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • Preparation and utility of substituted imidazopyridine compounds with hypnotic effects
    Patent number: 7772248
    Abstract: The present disclosure is directed to modulators of GABAA receptors and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of sleep disorders and/or for providing a patient in need with a hypnotic, anxiolytic or anti-convulsive effect are described.
    Type: Grant
    Filed: May 30, 2007
    Date of Patent: August 10, 2010
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • Substituted amino alcohols
    Patent number: 7767860
    Abstract: Disclosed herein are substituted amino alcohol anti-mycobacterial agents and/or chelation therapy agents of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: September 3, 2008
    Date of Patent: August 3, 2010
    Assignee: Auspex Pharmaceuticals, Inc
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • SUBSTITUTED HYDROXYPHENYLAMINE COMPOUNDS
    Publication number: 20100172916
    Abstract: The present invention relates to new substituted hydroxyphenylamine based modulators of hormone and/or pigment levels, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: November 9, 2009
    Publication date: July 8, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Craig Hodulik, Soon Woo
  • DIBENZO[b,e][1,4]DIAZEPINE MODULATORS OF DOPAMINE RECEPTORS, SEROTONIN RECEPTORS, ADRENERGIC RECEPTORS, ACETYLCHOLINE RECEPTORS, AND/OR HISTAMINE RECEPTORS
    Publication number: 20100166887
    Abstract: The present invention relates to new dibenzo[b,e][1,4]diazepine modulators of dopamine receptors, serotonin receptors, adrenergic receptors, acetylcholine receptors, and/or histamine receptors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: October 21, 2009
    Publication date: July 1, 2010
    Applicant: Auspex Pharmaceuticals, Inc.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • ETHOXYPHENYLMETHYL INHIBITORS OF SGLT2
    Publication number: 20100167988
    Abstract: The present invention relates to new ethoxyphenylmethyl modulators of SGLT2, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: October 22, 2009
    Publication date: July 1, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Manouchehr M. Shahbaz
  • ISOPROPOXYPHENYLMETHYL INHIBITORS OF SGLT2
    Publication number: 20100167989
    Abstract: The present invention relates to new isopropoxyphenylmethyl inhibitors of SGLT2, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: October 23, 2009
    Publication date: July 1, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventor: Thomas G. Gant
  • 7,8,10,10A-TETRAHYDRO-6H-BENZO[C]CHROMEN-9(6AH)-ONE MODULATORS OF CANNABINOID RECEPTORS
    Publication number: 20100168086
    Abstract: The present invention relates to new 7,8,10,10a-tetrahydro-6H-benzo[c]chromen-9(6aH)-one modulators of cannabinoid receptors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: September 23, 2009
    Publication date: July 1, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Manoucherhr M. Shahbaz
  • Substituted phenethylamines
    Patent number: 7745665
    Abstract: Disclosed herein are substituted phenethylamine alpha adrenergic receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: June 3, 2008
    Date of Patent: June 29, 2010
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • OXEPINE MODULATORS OF H1 RECEPTORS AND/OR INHIBITORS OF MAST CELL DEGRANULATION
    Publication number: 20100160272
    Abstract: The present invention relates to new oxepine modulators of H1 receptors and/or inhibitors of mast cell degranulation, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: December 18, 2009
    Publication date: June 24, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Manouchehr M. Shahbaz
  • 3,4-DIMETHOXYPHENETHYLAMINE MODULATORS OF L-TYPE CALCIUM CHANNEL
    Publication number: 20100160446
    Abstract: The present invention relates to new 3,4-dimethoxyphenethylamine modulators of L-type calcium channel activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: December 18, 2009
    Publication date: June 24, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • BENZENESULFONAMIDE MODULATORS OF ALPHA-1A ADRENERGIC RECEPTORS
    Publication number: 20100160338
    Abstract: The present invention relates to new benzenesulfonamide modulators of alpha-1A adrenergic receptors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: December 18, 2009
    Publication date: June 24, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • BICYCLIC MODULATORS OF H1 RECEPTORS
    Publication number: 20100160271
    Abstract: The present invention relates to new bicyclic modulators of H1 receptor activity, pharmaceutical compositions thereof, and methods of use thereof
    Type: Application
    Filed: December 17, 2009
    Publication date: June 24, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventor: Thomas G. Gant
  • PYRIDO[1,2-a]PYRIMIDIN-4-ONE INHIBITORS OF MAST CELL DEGRANULATION
    Publication number: 20100160347
    Abstract: The present invention relates to new pyrido[1,2-a]pyrimidin-4-one inhibitors of mast cell degranulation, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: December 17, 2009
    Publication date: June 24, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventor: Thomas G. Gant
  • PYRROLIDINONE INHIBITORS OF PDE-4
    Publication number: 20100159034
    Abstract: The present invention relates to new pyrrolidinone inhibitors of PDE-4 activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: December 15, 2009
    Publication date: June 24, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • BENZISOXAZOLE MODULATORS OF D2 RECEPTOR, AND/OR 5-HT2A RECEPTOR
    Publication number: 20100159033
    Abstract: The present invention relates to new benzisoxazole modulators of D2 receptors and/or 5-HT2A receptors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: September 25, 2009
    Publication date: June 24, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Manoucherhr M. Shahbaz
  • DIAMINOQUINAZOLINE INHIBITORS OF DIHYDROFOLATE REDUCTASE
    Publication number: 20100150896
    Abstract: The present invention relates to new diaminoquinazoline inhibitors of dihydrofolate reductase activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: December 11, 2009
    Publication date: June 17, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • PYRAZOLINONE SCAVENGERS OF FREE RADICAL
    Publication number: 20100150899
    Abstract: The present invention relates to new pyrazolinone scavengers of free radicals, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: December 10, 2009
    Publication date: June 17, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • TETRAHYDROCANNABINOL MODULATORS OF CANNABINOID RECEPTORS
    Publication number: 20100152283
    Abstract: The present invention relates to new tetrahydrocannabinol modulators of cannabinoid receptors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: December 17, 2009
    Publication date: June 17, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventor: Thomas G. Gant